Direct Neighbourhood Research Articles

Spatially mapping the single-cell immune landscapes of melanoma brain metastases using imaging mass cytometry.

e21517 Background: Up to 60% of metastatic melanoma patients develop brain metastases, and 5% develop leptomeningeal disease (LD), which presents with the worst prognosis of any melanoma brain metastasis (MBM) infiltration pattern. Median survival duration for MBM is ~12 months, however for LD patients it can be < 10 weeks. The spatial immune landscape of MBM with and without LD remains poorly understood. Methods: To spatially characterize the tumor microenvironment (TME) of MBM, we performed CyTOF Imaging Mass Cytometry (CyTOF-IMC) on a highly multiplexed panel of 35 antibodies for 21 MBMs (13 with LD, 8 without LD). We performed a novel cell segmentation, cell type assignment and identification approach to identify cell lineages to spatially characterize the TME of MBMs, segmenting and classifying 130,000 cells into 19 cell types. Results: We found enrichment of dendritic cells in the direct neighbourhood of melanoma cells of patients with LD (p = 0.019) and trends towards elevation of anti-tumoral monocyte populations in the TME of patients without LD. To investigate survival outcomes, we divided our cohort into long (≥365days) and short-survivors ( < 365 days), and found significant elevation of anti-tumoral T-cell populations (Total T-cells, CD8+ T-cells, CD4+ T-cells and CD3+CD4-CD8- T-cells, p < 0.05), and closer proximity of T-cells (CD8+ & CD4+ T-cells) to melanoma cells (p < 0.05). Survival analysis using median cell-proportion for each T-cell subset showed statistically significant (p < 0.05) survival differences between patients with high and low cell-proportions of CD8+ T-cells and CD4+ T-cells, with similar trends observed for a subset of patients (n = 13) with LD and a subset of patients treated with ICIs (n = 10), and results were confirmed by a Cox Regression Model. Cellular neighborhood (CN) analysis was performed generating N = 12 stable CNs. We found patients with higher proportions of CN9 (M1-like-microglia/M2-like-microglia/melanoma), CN10 (M1-like-macrophages/M2-like-macrophages/melanoma) and CN12 (Cytotoxic-T-cells/Helper-T-cells/melanoma) was associated with longer overall survival after diagnosis with MBM (p < 0.01). Conclusions: Proportion and proximity of anti-tumoral monocyte and T-cell populations may play a key role in modulating tumor response and overall survival for patients with MBM, including for patients with LD or for patients treated with ICIs.

Geographic network effects to engage people in the energy transition: The case of PV in Switzerland

With the energy transition and CO2 emissions reduction as a priority on the international policy agenda, governments worldwide are trying to engage the population in investing in renewable energies. In this paper, we study the role of information access and peer effects in the photovoltaics sector in the case of the Swiss canton of Vaud. Based on a representative survey of the population of two districts, Nyon and Jura-Nord Vaudois, we show that being a homeowner and knowing someone who has installed PV cells in your social group significantly increase the probability of putting up PV cells. A direct neighbourhood effect was found, meaning that if a neighbour has installed a PV cell, the probability of the inhabitants in the two case study regions installing one themselves increases significantly. Our results show that spatial proximity is an important factor in the transmission of information between peers. Besides pure geographical distance, additional aspects such as administrative boundaries, shared language or degree of urbanisation play a role in the way the information network is presented. These insights indicate that professional experts and neighbours are important points of reference in the decision to invest in PV, and that regional networks are key for the active spreading of information on renewable technologies. Thus, we recommend using these connections to actively promote PV.

Green Space at New Housing Estates: Flat Price Versus Accessibility to Good Quality Greenery

Green areas positively affect human health. It applies in particular to greenery in a direct neighbourhood of the housing. We analysed new housing estates in Poznan, Poland. Greenery quality was assessed according to developed factors, based on data about the area of the greenery in comparison with the area covered by hardscapes within the site; pre-existing greenery inventories; new greenery inventories; green area functions and accessibility. In the second stage of research, we compared data about greenery quality to information concerning economic value of the statistic flat in the estate. The average area of greenery in relation to the area of the plot was 40.16% for prestigious investments and 41.62% for less prestigious ones. The median value of WU (‘Socialisation rate’ indicator designed for this research) for prestigious investments was 0.035 and for less prestigious investments it was 0.226. The research showed that the price of flats does not affect the quality of residential greenery. Less prestigious (cheaper) flats have the same or even better access and quality of greenery in the estate. Developers do not take actual actions in the field of environmental compensation, which leads to lowering of the quality of greenery and public space.

The Missing Scale: “Eastern Europe” in Hungary’s Geostrategic Representations

Since 2010, with Viktor Orbán’s return to power, Hungary has progressively turned into an antidemocratic regime through a well-thought process of state and democracy capture. This slide has come along with chimeric narratives about national identity. Consecutive narratives about the nation and the country’s sense of belonging have given the impression that Hungary is moving on the map, as the Orbán regime has been locating itself more and more explicitly against the West. During the migration crisis, ‘Central Europe’ was at the centre of Orbán’s cultural map, as he extrapolated his ideology to the East-Central European macro-region, hoping to turn it into a region against the European establishment. Budapest’s tactical moves in the Western Balkans have gained importance as Orbán is increasingly isolated in the EU community. On the global scale, the regime has mixed trade and diplomacy with tying political alliances in Central Asia and beyond. These narratives do not result in a system. However, there is a common denominator in Orbán’s consecutive discourses on Hungary’s geopolitical place and role: anti-Western and anti-EU convictions flow through the opportunistic contradictions of national propaganda. In a contradictory way, only an EU member state could proceed to state and democracy capture and become famous for it, giving the impression that the small, peripherical Eastern European state is more important than it is. It is an EU member that has fallen into Russia’s arms to propagate pro-Kremlin narratives in and outside the EU. In this paper, I will examine the geopolitical narratives used by the Orbán regime and show how Budapest’s very sense of scale has got lost in the process. Indeed, it is Hungary’s precarious location on the map that the regime seems to have forgotten about and has reached this point at the time of renewed Russian aggression in Hungary’s direct neighbourhood.

386 The Adaptive Response of Old ABCB5+ MSCs is Changed Upon Exposure to LPS

Mesenchymal stem cells (MSCs) are endowed with the unique capacity to raise an adaptive response to environmental cues. This allows MSCs to control their direct neighbourhood and endogenous tissue niche. Upon exposure of MSCs with infection mimicking lipopolysaccharide (LPS), MSCs completely shift their transcriptome with the release of neutrophil activating chemokines. The LPS induced transcriptomic shift resulted in a significant increase in neutrophil expulsed DNA traps (NETs) and proteolytic enzymes. This adaptive response guarantees the defense from bacterial attack. Wound healing decreases with age and propensity for infection increases. Therefore, we addressed the question whether MSCs from old healthy donors (> 65 years) unlike young healthy donors (< 30 years) may change their adaptive response upon LPS exposure towards a reduced microbicidal response. Cultured ABCB5+ MSCs from young and old donors treated with LPS revealed differences in the time kinetic of NF-κB translocation from the cytoplasm to the nucleus. By contrast to ABCB5+ MSCs from young donors, ABCB5+ MSCs from old donors depicted a significantly delayed back regulation of nuclear NF-κB translocation, supported by an overshooting increase of p-p65. This correlates with a higher and longer persisting expression of NF-κB target genes like IL-6 in MSCs of elderly individuals compared to young individuals. Notably, ABCB5+ MSCs from young donors depict higher expression levels of IL-8 and IL-10 compared to old donors. Of note, LPS primed ABCB5+ MSCs from young donors can activate neutrophils by producing NETs to a higher level in comparison to old donors. NE activity indicative for microbicidal NET formation from co-cultures of LPS primed ABCB5+ MSC from young donors with PMA stimulated neutrophils is significantly higher and LPS-concentration-dependent compared to old donors. Collectively, MSCs from old individuals reveal a dysregulated anti-bacterial response which is supported by an impressively reduced killing ability of gram negative bacteria and at least in part explained higher susceptibility for severe bacterial infections in elderly.

Winter Diet of Great Cormorants Phalacrocorax carbo in the River Geul, The Netherlands: The Importance of Common Small Riverine Fish Species

Since 2006, Great Cormorants Phalocrocorax carbo sinensis have wintered in the area of the river Geul, a right-bank tributary of the river Meuse, in the province of Limburg in the south of The Netherlands. Although the number of birds there is relatively small (approximately 30 birds), the local sports fishery sector is concerned about the possible impact on wild Brown Trout Salmo trutta, particularly on the young year-classes, through predation by wintering Cormorants. The number of birds, as well as their estimated fish consumption, was studied in the winter of 2012. Analysis of 70 diet samples (pellets) taken from the roost local to the area, showed that predation was primarily on young year classes of cyprinids, like Roach Rutilus rutilus. These cyprinids, and probably also the few trout consumed, were thought to have been mainly taken from farmed fish ponds in the direct neighbourhood of the river Geul. Besides predation of larger cyprinids, the Cormorants also took abundant small riverine fish species (2–10 cm) like Rhine Sculpin Cottus rhenanus and smaller cyprinid species like Minnow Phoxinus phoxinus and Gudgeon Gobio gobio. These riverine fishes have increased recently due to ameliorated water quality. The estimated fish consumption by Cormorants in the present study suggests limited or no impact on Brown Trout during winter.

The Continental Intercalary in Algeria: Analysis, Survey and Perspectives for Green Agriculture Development

The Northern Sahara Aquifer System (NSAS) is a complex system that includes several aquifers overlying most areas. The Continental Intercalary, also known as the "Albian groundwater" is an aquifer with impressive characteristics. It extends over three countries: Algeria, Tunisia and Libya. Intended for crop irrigation, the boreholes drilled in this Algerian aquifer, the boreholes carried out on this aquifer are artesian in their totality, with flows and pressures reaching in some places considerable values, of the order of 0,4 m3.s-1 for the flow and 3.106 Pa for the pressure. These two parameters are necessary to appreciate the energy potential of the Albian groundwater. A survey of the Continental Intercalary was carried out to study its energy potential. We were able to gather all possible data concerning the boreholes in the Algerian aquifer part. The study covered 295 boreholes that were identified and well documented, spread over 3 regions in southern Algeria. The water from the artesian boreholes in the Albian groundwater is transported to storage basins (for drinking water supply, irrigation and industry) for later use, or distributed directly to users after lowering the temperature of the water in the cooling towers. In these operations, all the hydraulic energy is lost and external energy is required from the electricity grid to meet the needs. The cumulative energy potential of all the boreholes identified has reached the theoretical value of 168GWh/year, the equivalent of 14520 toe (ton of oil equivalent) that are lost annually. Best management of this natural resource will not only enable resilient and sustainable management of the production systems and the environment, but also the energy needed to cool the water, as well as the energy needed for the maintenance of the boreholes and the facilities in the direct neighbourhood.

Sea Defence Project and a UNESCO World Heritage Monument in Coastal Ghana

Coastal erosion, sand and gravel mining, and open defecation threaten the sustainability and outstanding universal value (OUV) of heritage monuments dotted along the coast of Ghana. A sea defence project has been embarked upon in some areas in Ghana to, among other reasons, safeguard coastal resources, including the historic heritage monuments—castles and forts. This study examined the implications of the project for the sustainability and OUV of a UNESCO World Heritage Site (WHS) along the Ghanaian coastline. The study used a qualitative research design. In‐depth interviews and focus group discussions were conducted to collect data from key stakeholders and analyzed using the thematic method. It became evident that the project has helped reduce oceanic effects, sand and gravel mining hazards, and open defecation in the direct neighbourhood of the site. These have increased the resilience and protective capacity of the monument and enhanced the aesthetic value and sanitation at the site, thereby shoring up the integrity and authenticity of the site and culminating in its enhanced sustainability and OUV. UNESCO, the State Party, Ghana Museums and Monuments Board, Municipal Authority, and Community Leaders should ensure that the advantages that have accrued to the site from the sea defence project are safeguarded and maximized. Additionally, the project should be extended to other coastal areas in the country where similar monuments are located to enable those monuments to derive similar benefits for sustainable development. The study contributes to understanding the protective and aesthetic nexus between coastal engineering and sustainable coastal heritage management.

Does the Local Presence of Asylum Seekers Affect Attitudes toward Asylum Seekers? Results from a Natural Experiment

AbstractThe influx of refugees to Europe is a topic that dominates the political and media agenda. Furthermore, the installation of asylum-seeker centres (ASCs) has made asylum seekers and refugees highly visible in the everyday life of many European citizens. Drawing on theories of ethnic threat and intergroup contact, we examine how geospatial proximity to ASCs translates into threat or contact in an everyday context and how this affects attitudes toward asylum seekers. By taking advantage of a natural experiment, where the ASCs are assigned to city districts as-if at random, as well as innovating measures of outgroup exposure and geospatial proximity, we find that, although higher numbers of asylum seekers in one’s own neighbourhood are related to an increased perception of their local presence, the actual presence of asylum seekers does not lead to more negative attitudes or a greater threat perception, nor to more frequent contact. It is only when the number of asylum seekers in one’s own direct neighbourhood suddenly increases that attitudes toward asylum seekers deteriorate.

NATO po skončení studené války

The article analyses the process of the NATO enlargement after 1990. It starts by a detailed analysis of the secret negotiations which have been started just after the end of the Cold War. In the light of the institutional liberalism, the NATO enlargement is a positive process which satisfied especially new member states. But in the light of the American neorealism, this process resulted into profound changes in the balance of the security threats and into a large militarisation and tension at the new Eastern frontier of NATO in a direct neighbourhood with the Russia. New military units with the modern arms systems are deployed over there and we are witnessing a growing number of dangerous military incidents. As a result, the contemporary situation needs new political negotiations between two competitors and a shift from the contemporary negative Peace towards the positive Peace.

Discontinuous solutions of the unsteady boundary-layer equations for a rotating disk of finite radius

Abstract

Pre-existing lithospheric weak zone and its impact on continental rifting – The Mid-Polish Trough, Central European Basin System

The large portion of Central and NW Europe was subjected to widespread continental rifting since the Carboniferous-Permian transition. This process led to nucleation of several large depocentres, coalescing from the late Permian onwards into the extensive Central European Basin System (CEBS), that grew and evolved until the regional-scale Late Cretaceous inversion. Development of deep grabens from Germany to the Netherlands and the North Sea was connected with volcanism and crustal thinning. The exception makes the Mid-Polish Trough (MPT), trending NW-SE across Poland along the Teisseyre-Tornquist Zone (TTZ) at the margin of the East European Craton (EEC). The MPT is underlain by relatively thick lithosphere and its formation was not associated with volcanic activity in the direct neighbourhood. To investigate this anomaly, we compiled grids for key horizons defining the crustal architecture, separately for NW European and Polish sectors of the CEBS. Seismic reflection and well data were used to build the base Permian grid, whereas deep seismic refraction and reflection data along with constrained gravity inversion were employed to construct the top basement and Moho grids. Based on a dense net of seismic refraction profiles, the additional top Ediacaran grid was created solely for the Polish part of the CEBS. Our data show distinct crystalline crust thinning SW of the TTZ (β factor = 3.68) expressed in both shallowing of Moho and deepening of the crystalline basement. We interpret this feature as a fossilised crustal neck inherited after an Ediacaran rifting preceding the break-up of Rodinia. The early Permian rifting moderately contributed to the crustal thinning (β factor = 1.4), overprinting the primary rifted margin geometry. The 8 km deep MPT developed in front of a pre-existing crustal neck that obstructed further propagation of extensional deformation. Lithospheric mantle beneath a rift axis was probably too strong to accommodate extension but the thinner lithosphere farther west was weak enough to be stretched. Therefore, the location of the pre-existing weakness zone relative to a change in lithosphere thickness may localise a rift graben and shift the magmatism away from the surface expression of the rift. Thus, our study demonstrates that fossil crustal architecture was a key factor controlling the amount, distribution, and style of continental rifting.

City Space Recycling: The Example of Brownfield Redevelopment

In many parts of the world the manufacturing and mining industries have left a huge mark on the spatial structure of entire regions, as well as individual cities. Urban tissue has been growing for years around the dynamically developing industrial plants and mines during the period of intensive industrialization. As a result of industrial restructuring, abandoned and degraded post-industrial areas created problematic places in the structure of cities. Moreover, many of them are located in the direct neighbourhood of the centers of these cities, in the strict urban fabric. Nowadays, in the era of balancing urban development, creating compact, smart and eco cities, one of the important problems faced by city authorities, architects and urban planners is solving the issue of optimal shaping of city structure, including revitalization of post-industrial areas. The article deals with the subject of transforming brownfield areas into modern urban tissue, related to the surrounding areas, and at the same time referring to its industrial heritage. For this purpose, a number of studies were carried out, including comparative analyzes. Therefore, five examples of projects from Europe related to the transformation of brownfield sites for the purposes of industrial and technology parks were selected. This list includes two examples of Polish parks located in Upper Silesia and three examples of areas located in Germany in the Metropolis of the Ruhr Area. Selected areas were analyzed and evaluated in terms of a number of parameters in order to identify the most important factors positively influencing transformations and problem areas requiring the most attention. Based on the results of the case study, a model concept for post-industrial area development was prepared for the purposes of developing an industrial and technological park and recreational areas, complementing the leisure offer for the surrounding residential areas. The location in former Baildon ironworks in Katowice in Upper Silesia was chosen as the place of the conceptual design. Upper Silesia is known as one of the most urbanized and industrialized regions of Poland, which is still struggling with the negative effects of industrial restructuring. Research results indicate that the areas of former mines and production plants, thanks to their strengths, can be attractively transformed into other functions to become again a showcase of the entire city, providing an incentive to learn about the industrial history of the region. The introduction of a diversified program and giving a new character to areas with huge investor potential, helps to return the city to areas of great social, economic and spatial importance.

(Transnationale) Migrationserfahrung in den Lebensgeschichten deutscher Ansiedler. Literarische Erinnerung an die Ansiedlung von Deutschen in Großpolen/ in der Provinz Posen/ in der Ostmark

Abstract The incorporation of Greater Poland [in Polish: Wielkopolska] into the Kingdom of Prussia was the beginning of a direct neighbourhood of Poles and Germans in a relatively small area. This paper shall present the experiences of Prussian / German settlers in the Poznań Province which are based on autobiographical literary texts authored by officials and teachers (with their families) who came to this region. While reading these memoirs one can infer that they made efforts to “familiarise” new and ethnically foreign elements in the annexed territory. They cultivated and promoted their own culture here while concurrently not being too eager to participate in the culture and social life of the Polish locals. They manifest characteristic features typical of the colonist’s attitude. On the one hand, they present the country they colonise as foreign. On the other hand, they depict indigenous people whom they describe as individuals standing on a lower levelcivilisation-wise compared to the German “culture-bearers” who came here [“Kulturträger”]. The key issue in the discussed literary material of the long-term mobility of German families of officials and teachers allows to consider the following issues: How do the authors present migration to the Poznań Province and its effects? What stood in the way of building a sense of belonging and relationship between representatives of different nationalities in a new place? What does the studied autobiographical material say about the phenomenon of transnationality? Can one talk about transnational practices or their elements based on the specificity of the Poznań Province?

The Strength of Considering Tie Strength in Social Interest Profiling

With the emergence of social networking platforms and great amount of generated content, analyzing people interactions and behaviour raises new opportunities for several applications such as user interest profiling. In this context, this paper highlights the importance of considering relationship strength to infer more refined and relevant interests from user’s direct neighbourhood. We propose WeiCoBSP, a Weight-aware Community-Based Social Profiling approach that leverages strength of ego-friend and friend-friend relationships. The former, describing connections with the profiled user, allows to identify most relevant people from whom to infer worthwhile interests. The latter qualifies connections among user’s neighbourhood and enables depicting the most realistic community structure of the network. We present an empirical evaluation performed on real world co-authorship networks, validating our approach. Experimental results demonstrate the ability of WeiCoBSP to infer user’s interest accurately, improving greatly the unweighted CoBSP process but also results of experiments assessing separately ego-friend and friend-friend relationships strength.

Models of morphological transformations of centres of the largest Polish cities after World War II

ABSTRACT This paper examines the topic of changes in central parts of large cities in Poland that have occurred in the post-war period, which can be divided into two stages with different factors shaping urban space. The rebuilding of cities in Poland following destruction brought by WWII was one of the elements of building the socialist city. This process was frequently planned, often steered, unlike the dynamic processes initiated along with the political and socio-economic transformation of the 1990s, which took place already under market economy conditions. Three categories of city centres were distinguished according to the scope of rebuilding and the direction of post-war morphological changes: cities where changes were slight (Łódź, Kraków), partly reconstructed cities (Wrocław, Poznań), rebuilt and completely reconstructed cities (Gdańsk, Szczecin, Warszawa). In the post-war period, the city centres in question were characterized by diverse forms and scope of rebuilding of war damage, scale of expansion of the transport network, decline of the industrial function, development of large commercial complexes in the direct neighbourhood of the old centre, expansion of the office function and buildings and revitalization and revalorization of historical fabric.

Ameryka Łacińska w polityce zagranicznej Brazylii – niedokończony projekt przywództwa regionalnego

The purpose of the article is to discuss the place and role of Latin America in Brazil’s foreign policy. The article leads to the conclusion that, starting from the 1990s, Latin America, a region that was marginalized for many years, gained an important place in Brazilian policy. The construction of the South American community has become an instrument of strengthening regional leadership, although due to the lack of a coherent strategy towards the direct neighbourhood, it proved to be short-lived.

Evolution of the lamin protein family at the base of the vertebrate lineage.

Lamin proteins are major constituents of the nuclear lamina. They are required for fundamental nuclear activities, as evidenced by the large number of laminopathies. Mutations in the human lamin A/C gene exhibit a broad spectrum of clinical manifestations. Most non-vertebrates including the nearest relatives of the vertebrates have only a single lamin gene. In jawed vertebrates (Gnathostomata), four lamin subtypes (B1, B2, LIII, and A) are found. Lampreys and hagfish form the two orders of jawless vertebrates, Agnatha, which represent the sister group of the Gnathostomata at the base of the vertebrate lineage. Lamin sequence information of lampreys and hagfish sheds light on the evolution of the lamin protein family at the base of the vertebrate lineage. In the genomes of the lamprey (Petromyzon marinus) and the hagfish (Eptatretus burgeri), only three lamin genes are present, a lamin A gene is lacking. The presence of an LIII gene in both, lampreys and hagfish, proves that the distinguishing features of this gene had been established before the agnathan/gnathostome split. The other two agnathan lamins, LmnI and LmnII, deviate strongly in their sequences from those of the gnathostome lamins. For none of these two agnathan lamins can orthology be established to one of the gnathostome lamin types. In the direct chromosomal neighbourhood of all three hagfish lamin genes, a MARCH3 paralog is found. This can be interpreted as further evidence that the vertebrate lamin genes have arisen in the course of the two rounds of whole genome duplication that took place at the base of the vertebrate lineage.

Structural joint inversion on irregular meshes

SUMMARY Structural joint inversion of several data sets on an irregular mesh requires appropriate coupling operators. To date, joint inversion algorithms are primarily designed for the use on regular rectilinear grids and impose structural similarity in the direct neighbourhood of a cell only. We introduce a novel scheme for calculating cross-gradient operators based on a correlation model that allows to define the operator size by imposing physical length scales. We demonstrate that the proposed cross-gradient operators are largely decoupled from the discretization of the modelling domain, which is particularly important for irregular meshes where cell sizes vary. Our structural joint inversion algorithm is applied to a synthetic electrical resistivity tomography and ground penetrating radar 3-D cross-well experiment aiming at imaging two anomalous bodies and extracting the parameter distribution of the geostatistical background models. For both tasks, joint inversion produced superior results compared with individual inversions of the two data sets. Finally, we applied structural joint inversion to two field data sets recorded over a karstified limestone area. By including geological a priori information via the correlation-based operators into the joint inversion, we find P-wave velocity and electrical resistivity tomograms that are in accordance with the expected subsurface geology.

Rank Criteria Improved Confidence-based centroid scheme for Non Line of Sight node localizations in vehicular networks

The location verification of the vehicles interacting during the process of communication needs to be cooperatively determined under Non Line Of Sight (NLOS) situations for facilitating risk free environment with the least degree of congestion. The vehicular nodes in NLOS conditions possess the possibility of introducing channel congestion and broadcast storm into the network either intentionally or unintentionally during the event of emergency message dissemination in the vehicular network. Thus, the NLOS vehicular nodes of the network need to be detected through direct interaction and neighbourhood collaboration such that the rate of emergency message dissemination is sustained to the maximum degree. In this paper, a Rank Criteria Improved Confidence-based Centroid Scheme (RCICCS) is proposed for potential localization of NLOS nodes. This proposed RCICCS scheme uses an integrated cost, computed using the primitive cost and penalty cost in order to increase the effectiveness in localizing NLOS nodes. Thus effective location of NLOS nodes is determined based on rank criterion-based neighbor confidence measure that are iteratively enhanced during the process of perturbation using the method of gradients. The experimental analysis of the proposed RCICCS scheme confirmed a remarkable enhancement rate of emergency message delivery and neighbourhood awareness under NLOS conditions.