Direct Modulation Research Articles

Tailoring the Direct Current Modulation Response of Electrically Pumped Semiconductor Nano-Laser Arrays

Semiconductor nano-lasers have been a topic of interest from the perspective of advancing the capabilities of photonic integration. Nano-lasers are perceived as the means to achieve improved functionality in photonic integrated circuits. The properties and performance of nano-lasers have been examined by means of simulations and laboratory measurements. Nano-lasers lend themselves to integration to form dense arrays in both one and two dimensions. In a recent work, a theoretical treatment was presented for the dynamic behaviour of stand-alone electrically pumped nano-laser arrays. In this work, the response of nano-laser arrays to direct current modulation is examined. As in previous works, attention is given to two prototype array geometries: a linear three-element linear array and an equilateral triangular array. Large one-dimensional arrays can be built by repeating this elementary linear array. Two-dimensional photonic integrated circuits can incorporate the triangular arrays studied here. Such prototypical configurations offer opportunities to tailor the modulation response of the nano-laser arrays. The principal factors which provide that capability are the coupling strengths between lasers in the arrays and the direct modulation parameters. The former are fixed at the design and manufacture stage of the array whilst the latter can be chosen. In addition, the enhancement of the spontaneous emission rate via the so-called Purcell effect in nano-lasers offers a device-specific means for accessing a range of modulation responses. Two-dimensional portraits of the regimes of differing modulation responses offer a convenient means for determining the dynamics that may be accessed by varying the laser drive current. It is shown by these means that a rich variety of modulation responses can be accessed in both linear and triangular arrays.

Epigallocatechin Gallate Modulates Microglia Phenotype to Suppress Pro-inflammatory Signalling Cues and Inhibit Phagocytosis

Microglia are crucial players in the pathogenesis of late-onset Alzheimer’s disease (AD), with evidence for both deleterious and beneficial effects. Identifying interventions to modulate microglial responsiveness, promote amyloid β (Aβ) clearance, disrupt plaque formation, or dampen excessive inflammation has therapeutic potential. Bioavailable flavonoids, such as the flavan 3-ols, are of interest due to their antioxidant, metal chelating, signalling, and anti-inflammatory potential. Primary microglia were treated with a series of structurally related flavanol 3-ols to assess effects on phagocytosis, cytokine release, and transcriptional responses by RNA sequencing. Data indicated that the extent of hydroxylation and the presence of the galloyl moiety were strong determinants of flavan 3-ol activity. Epigallocatechin gallate (EGCG) was the most effective flavan-3-ol tested and strongly inhibited phagocytosis of Aβ independent of any metal chelating properties, suggesting a more direct modulation of microglia responsiveness. EGCG was broadly anti-inflammatory, reducing cytokine release and downregulating transcription, particularly of components of the microglia extracellular matrix such as MMP3 and SerpinB2. Collectively, this brings new insight into the actions of flavonoids on microglial responsiveness with potential implications for the therapeutic use of EGCG and structurally related flavanol-3-ols in AD.

Evidence of brain target engagement in Parkinson’s disease and multiple sclerosis by the investigational nanomedicine, CNM-Au8, in the REPAIR phase 2 clinical trials

BackgroundImpaired brain energy metabolism has been observed in many neurodegenerative diseases, including Parkinson’s disease (PD) and multiple sclerosis (MS). In both diseases, mitochondrial dysfunction and energetic impairment can lead to neuronal dysfunction and death. CNM-Au8® is a suspension of faceted, clean-surfaced gold nanocrystals that catalytically improves energetic metabolism in CNS cells, supporting neuroprotection and remyelination as demonstrated in multiple independent preclinical models. The objective of the Phase 2 REPAIR-MS and REPAIR-PD clinical trials was to investigate the effects of CNM-Au8, administered orally once daily for twelve or more weeks, on brain phosphorous-containing energy metabolite levels in participants with diagnoses of relapsing MS or idiopathic PD, respectively.ResultsBrain metabolites were measured using 7-Tesla 31P-MRS in two disease cohorts, 11 participants with stable relapsing MS and 13 participants with PD (n = 24 evaluable post-baseline scans). Compared to pre-treatment baseline, the mean NAD+/NADH ratio in the brain, a measure of energetic capacity, was significantly increased by 10.4% after 12 + weeks of treatment with CNM-Au8 (0.584 units, SD: 1.3; p = 0.037, paired t-test) in prespecified analyses of the combined treatment cohorts. Each disease cohort concordantly demonstrated increases in the NAD+/NADH ratio but did not reach significance individually (p = 0.11 and p = 0.14, PD and MS cohorts, respectively). Significant treatment effects were also observed for secondary and exploratory imaging outcomes, including β-ATP and phosphorylation potential across both cohorts.ConclusionsOur results demonstrate brain target engagement of CNM-Au8 as a direct modulator of brain energy metabolism, and support the further investigation of CNM-Au8 as a potential disease modifying drug for PD and MS.

Ultra-compact mode converter based on longitudinal refractive index modulation

Mode converter (MC) is a crucial device in optical information processing based on mode division multiplexing. Recently, MCs based on metasurface have attracted much attention due to their compact footprints. However, this type of MCs is usually achieved by introducing refractive index modulation in the transverse direction. As a result, many interfaces are unavoidable, which is the primary origin of high loss and narrow bandwidth. In this paper, we propose a new mechanism of ultra-compact, high efficiency, and broadband MC based on longitudinal refractive index modulation. The proposed dielectric modulation only introduces a few longitudinal pixels in the waveguide, resulting in weak scattering and weak resonance refractive index modulation with low crosstalk, and large bandwidth. By adopting the inverse design algorithm, the specified TE0-TE1 and TE0-TE2 mode conversions are obtained with superior performances including the ultra-compact footprint, high conversion efficiency, and low crosstalk over a wide bandwidth. This method could be extended to other desired mode conversions and also has excellent potential in optical integrated circuits and optical information processing.

Long noncoding RNA-mediated epigenetic regulation of auxin-related genes controls shade avoidance syndrome in Arabidopsis.

The long noncoding RNA (lncRNA) AUXIN-REGULATED PROMOTER LOOP (APOLO) recognizes a subset of target loci across the Arabidopsis thaliana genome by forming RNA-DNA hybrids (R-loops) and modulating local three-dimensional chromatin conformation. Here, we show that APOLO regulates shade avoidance syndrome by dynamically modulating expression of key factors. In response to far-red (FR) light, expression of APOLO anti-correlates with that of its target BRANCHED1 (BRC1), a master regulator of shoot branching in Arabidopsis thaliana. APOLO deregulation results in BRC1 transcriptional repression and an increase in the number of branches. Accumulation of APOLO transcription fine-tunes the formation of a repressive chromatin loop encompassing the BRC1 promoter, which normally occurs only in leaves and in a late response to far-red light treatment in axillary buds. In addition, our data reveal that APOLO participates in leaf hyponasty, in agreement with its previously reported role in the control of auxin homeostasis through direct modulation of auxin synthesis gene YUCCA2, and auxin efflux genes PID and WAG2. We show that direct application of APOLO RNA to leaves results in a rapid increase in auxin signaling that is associated with changes in the plant response to far-red light. Collectively, our data support the view that lncRNAs coordinate shade avoidance syndrome in A. thaliana, and reveal their potential as exogenous bioactive molecules. Deploying exogenous RNAs that modulate plant-environment interactions may therefore become a new tool for sustainable agriculture.

Quercetin inhibits calcium oxalate crystallization and growth but promotes crystal aggregation and invasion

Recent evidence has shown an association between kidney stone pathogenesis and oxidative stress. Many anti-oxidants have been studied with an aim for stone prevention. Quercetin, a natural flavonol, is one among those eminent anti-oxidants with satisfactory anti-inflammatory property to cope with renal tissue injury in kidney stone disease. Nevertheless, its direct effect (if any) on calcium oxalate (CaOx) crystals and the stone formation mechanism had not been previously explored. This study has addressed the ability of quercetin at various concentrations (2.5, 5, 10, 20, 40, 80 and 160 μM) to directly modulate CaOx crystallization, growth, aggregation, adhesion on kidney cells, and invasion through the matrix. The data have shown that quercetin significantly inhibits CaOx crystallization and crystal growth but promotes crystal aggregation in concentration-dependent manner. However, quercetin at all these concentrations do not affect CaOx adhesion on kidney cells. For the invasion, quercetin at all concentrations constantly promotes CaOx invasion through the matrix without concentration-dependent pattern. These discoveries have demonstrated for the first time that quercetin has direct but dual modulatory effects on CaOx crystals. While quercetin inhibits CaOx crystallization and growth, on the other hand, it promotes CaOx crystal aggregation and invasion through the matrix. These data highlight the role for quercetin in direct modulation of the CaOx crystals that may intervene the stone pathogenesis.

Direct Optical Modulation of RF Radiation Patterns in a Loaded Dielectric Resonator

Here we demonstrate the direct optical modulation of RF radiation patterns in a high permittivity (ϵ ∼ 80) cylindrical dielectric resonator antenna (DRA) loaded with a silicon superstrate. A hybrid mode (HEM <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11δ</sub> ) is excited via microstrip. The far-field radiation pattern is characterized with an angle-dependent RF radiation measurement setup, and the near-field is measured using an optically induced conductance technique. We show that when light is incident upon the superstrate, the optically generated electron-hole-pairs (EHPs) in the silicon superstrate modulate and inhibit the far-field RF radiation. We compare our experimental results with finite element method simulations and show excellent agreement. Finally, we perform a proof of principle experiment to mix optically modulated signals with the baseband RF far-field radiation, paving the pathway for future free space optical/RF hybrid communications setups and modulation schemes as well as phase circuitry-free RF beam shaping and steering.

Direction modulation based on planar rectangular non‐linear frequency diverse array

AbstractSince its inception, the frequency diverse array (FDA) has attracted extensive attention and research because of its unique properties. However, most of the research primarily focuses on linear geometry FDA, with fewer studies on planar FDA. This letter proposes a design method based on planar rectangular FDA (PRFDA), which adjusts the frequency of each array element nonlinearly so that the beam direction of planar rectangular FDA can change linearly or nonlinearly with time, forming the desired transmit beampattern. Theoretical analysis and simulation results verify the effectiveness of the proposed method.

Enhanced Secure Wireless Transmission Using IRS-Aided Directional Modulation

Enhanced Secure Wireless Transmission Using IRS-Aided Directional Modulation

Study on Electrically Modulated Quasi-Continuous Wave Fe: ZnSe Solid-State Laser with Hundred-Hertz.

Iron-doped binary chalcogenide crystals are very promising for tunable solid-state lasers operating over the 3~5 μm spectral range. Fe: ZnSe is one of the most important gain crystals with the obvious advantages of material characteristics and conversion efficiency. By adjusting the output mode of the pump source, an Fe: ZnSe laser can operate in two modes at liquid nitrogen temperatures: continuous wave (CW) and pulse output. In terms of CW output, the Fe: ZnSe laser obtained a maximum 2.63 W continuous power output which was confined to the power of the pump source. An optical-to-optical efficiency of 47.05% was acquired. Direct electrical modulation was applied to the pump source. The highest average power of the quasi-CW laser, whose central wavelength is 4.02 μm, has a value of 253 mW with an optical-to-optical efficiency of 42.88% and a full width at half maximum (FWHM) of 23 nm when the pulse frequency is 100 Hz of 10% duty factor. The output waveform is consistent with the modulation waveform applied to the pump source. We report to the first of our knowledge an electrically modulated quasi-CW Fe: ZnSe laser in the pulse regime, equipped with features of compactness in structure, ignoring additional modulators, convenience in control, high efficiency, and sustainable operation, of great interest for solving numerous scientific and applied problems.

Potential cGAS-STING pathway functions in DNA damage responses, DNA replication and DNA repair

The major innate immune responder to the DNA of pathogens is the cyclic GMP-AMP (cGAMP) synthase (cGAS) - stimulator of interferon genes (STING) pathway. Most prominently, the outcome of cGAS signalling is the activation of inflammatory transcription through interferon regulatory factor 3 (IRF3) and nuclear factor kappa B (NF-kB). In addition, the cGAS-STING pathway can lead to the direct modulation of cellular processes independently of transcription, such as activation of autophagy. Under unperturbed conditions, several mechanisms are in place to prevent the activation of cGAS by self-DNA, chiefly its sequestration on chromatin, which interferes with binding to stimulatory DNA. However, under conditions of genotoxic stress and chromosomal instability, this inhibition breaks down, resulting in the activation of cGAS, which drives sterile inflammation, as well as cell fate and immune responses in cancer. Recently, several studies have suggested that cGAS, STING, or downstream pathway components can also regulate the DNA damage response, DNA damage checkpoint signalling, DNA repair and DNA replication. Here, I review these proposed mechanisms, and discuss some unanswered questions relating to them.

Macroscopic model and statistical model to characterize electromagnetic information of a digital coding metasurface.

A digital coding metasurface is a platform connecting the digital space and electromagnetic wave space, and has therefore gained much attention due to its intriguing value in reshaping wireless channels and realizing new communication architectures. Correspondingly, there is an urgent need for electromagnetic information theory that reveals the upper limit of communication capacity and supports the accurate design of metasurface-based communication systems. To this end, we propose a macroscopic model and a statistical model of the digital coding metasurface. The macroscopic model uniformly accommodates both digital and electromagnetic aspects of the meta-atoms and predicts all possible scattered fields of the digital coding metasurface based on a small number of simulations or measurements. Full-wave simulations and experimental results show that the macroscopic model is feasible and accurate. A statistical model is further proposed to correlate the mutual coupling between meta-atoms with covariance and to calculate the entropy of the equivalent currents of digital coding metasurface. These two models can help reconfigurable intelligent surfaces achieve more accurate beamforming and channel estimation, and thus improve signal power and coverage. Moreover, the models will encourage the creation of a precoding codebook in metasurface-based direct digital modulation systems, with the aim of approaching the upper limit of channel capacity. With these two models, the concepts of current space and current entropy, as well as the analysis of information loss from the coding space to wave space, is established for the first time, helping to bridge the gap between the digital world and the physical world, and advancing developments of electromagnetic information theory and new-architecture wireless systems.

Discovery of a novel cardiac-specific myosin modulator using artificial intelligence-based virtual screening

Direct modulation of cardiac myosin function has emerged as a therapeutic target for both heart disease and heart failure. However, the development of myosin-based therapeutics has been hampered by the lack of targeted in vitro screening assays. In this study we use Artificial Intelligence-based virtual high throughput screening (vHTS) to identify novel small molecule effectors of human β-cardiac myosin. We test the top scoring compounds from vHTS in biochemical counter-screens and identify a novel chemical scaffold called ‘F10’ as a cardiac-specific low-micromolar myosin inhibitor. Biochemical and biophysical characterization in both isolated proteins and muscle fibers show that F10 stabilizes both the biochemical (i.e. super-relaxed state) and structural (i.e. interacting heads motif) OFF state of cardiac myosin, and reduces force and left ventricular pressure development in isolated myofilaments and Langendorff-perfused hearts, respectively. F10 is a tunable scaffold for the further development of a novel class of myosin modulators.

Synthesis of Directional Modulation LFM Radar Waveform for Sidelobe Jamming Suppression

Synthesis of Directional Modulation LFM Radar Waveform for Sidelobe Jamming Suppression

DDR-Based PWM technique for fixed frequency three-phase to variable frequency K-phase power conversion using QZSDMC

This research presents a novel direct AC-to-AC topology for converting power from three phases (3φ) to five phases (5φ). The power conversion is handled by a Quasi Z Source Direct Matrix Converter (QZSDMC). This device is made up of a regular Direct Matrix Converter (DMC) and a pseudo Z-source impedance network that are serially connected. The proposed QZSDMC receives alternating current power in 3φ at a fixed voltage and frequency and outputs it in 5φ at a variable voltage and frequency to a standalone system. You can switch between buck and boost mode with a couple of switch flips. The shoot-through Duty Ratio value might help us understand the voltage transferal ratio. The authors suggested a unique control mechanism based on Direct Duty Ratio Pulse Width Modulation (DDRPWM) in this work. The method described here is only relevant when the amount of output phases is odd, not even. The paper uses MATLAB tools and experimental results to show the proposed system's operational principle in detail and prove its viability. Here, buck and boost conditions in all four quadrant modes with the proposed QZSDMC architecture, and the voltage gain constraint are addressed. It is more dependable, more efficient, and less expensive than a traditional back-to-back converter (B2BC).

Small signal modulation of photonic crystal surface emitting lasers

We report the small-signal characterization of a PCSEL device, extracting damping factors and modulation efficiencies, and demonstrating -3 dB modulation bandwidths of up to 4.26 GHz. Based on modelling we show that, by reducing the device width and improving the active region design for high-speed modulation, direct modulation frequencies in excess of 50 GHz are achievable.

Physical Layer Security for Frequency Diverse Array-Based Dual-Hop Spatial Modulation

In this paper, we design the physical layer security of a dual-hop spatial modulation system provided the relay node transmits its own private information. Meanwhile, the quadrature virtual channel spatial modulation (QVCSM) is proposed to enhance the physical layer security in the second hop. To achieve system security in both angle and range dimensions, the frequency diverse array (FDA) is used in the relay node with a decode-and-forward (DF) protocol. Moreover, the baseband directional modulation (DM) and artificial noise (AN) are jointly utilized to suppress the received signal at the passive eavesdropper. Additionally, the Ergodic secrecy rate of the proposed system is analyzed, whereas the closed-form expressions for tight upper bounds on the bit error rates (BERs) of the source and relay are derived for both the destination and eavesdropper. The simulation results show that the proposed FDA relay design outperforms the traditional phase array (PA) relay system in terms of the system secrecy rate. In contrast to the quadrature spatial modulation (QSM) method, the proposed designs achieve an improved suppression performance of the eavesdropper.

Voltage-controlled magnetic solitons motion in an anisotropic ferromagnetic nanowire

The precise manipulation of magnetic solitons remains a challenge and is considered a crucial process in magnetic storage. In this paper, we investigate the control of velocity and spatial manipulation of magnetic solitons using the voltage-controlled magnetic anisotropy effect. A long-wave model, known as the generalized derivative nonlinear Schrödinger (GDNLS) equation, is developed to describe the dynamics of magnetic solitons in an anisotropic ferromagnetic nanowire. By constructing the Lax pair for the GDNLS equation, we obtain the exact solutions including magnetic dark solitons, anti-dark solitons, and periodic solutions. Moreover, we propose two approaches to manipulate magnetic solitons: direct voltage application and inhomogeneous insulation layer design. Numerically results show the direct modulation of soliton velocity by a constant voltage, while time-varying voltage induces periodic oscillations. Investigation of Gaussian-type defects reveals soliton being trapped beyond a critical defect depth. These results provide a theoretical basis for future applications in magnetic soliton-based memory devices.

Neuromodulators as Interdomain Signaling Molecules Capable of Occupying Effector Binding Sites in Bacterial Transcription Factors

Hormones and neurotransmitters are important components of inter-kingdom signaling systems that ensure the coexistence of eukaryotes with their microbial community. Their ability to affect bacterial physiology, metabolism, and gene expression was evidenced by various experimental approaches, but direct penetration into bacteria has only recently been reported. This opened the possibility of considering neuromodulators as potential effectors of bacterial ligand-dependent regulatory proteins. Here, we assessed the validity of this assumption for the neurotransmitters epinephrine, dopamine, and norepinephrine and two hormones (melatonin and serotonin). Using flexible molecular docking for transcription factors with ligand-dependent activity, we assessed the ability of neuromodulators to occupy their effector binding sites. For many transcription factors, including the global regulator of carbohydrate metabolism, CRP, and the key regulator of lactose assimilation, LacI, this ability was predicted based on the analysis of several 3D models. By occupying the ligand binding site, neuromodulators can sterically hinder the interaction of the target proteins with the natural effectors or even replace them. The data obtained suggest that the direct modulation of the activity of at least some bacterial transcriptional factors by neuromodulators is possible. Therefore, the natural hormonal background may be a factor that preadapts bacteria to the habitat through direct perception of host signaling molecules.

Finite direct projective modules

In this paper, we introduce the notion of finite direct projective modules, which is a generalization of direct projective modules; counter-example is given. We study the properties of finite direct projective modules with respect of their summands. We characterized von Neumann regular rings in terms of the endomorphism ring of finite direct projective modules. Also, we find connections among Rickart modules, [Formula: see text] modules, direct projective modules, finite direct projective modules and endoregular modules.