Alcoholic beverages and liquor products are susceptible to contamination throughout the production process by potentially harmful substances, among which plastic related compounds are of particular concern due to the lack of knowledge regarding their occurrence and effects on human health. The present study aimed to survey several liquor products collected in Canada for the presence of common bisphenols, phthalates, and other plastic related compounds, and to develop and apply a direct-injection non-targeted HPLC-QToF MS method for investigating suspected and unanticipated chemical constituents in a variety of high-proof alcohol products in various types of packaging. Overall, the targeted analysis detected no bisphenols in any of the liquor products (n = 37), while DEHP and DEHA were frequently detected, at levels up to nearly 300 and 95 ng/mL, respectively. For the first time, DPP was detected in vodka, BBzP detected brandy, and DEHA in vodka, rum, whiskey, whisky, gin, and brandy. The non-targeted workflow was validated for the targeted compound list and the identity of 3 additional compounds outside the original scope, liquiritigenin, ethylparaben, and ethylvanillin, was confirmed. Overall, the type of packaging type did not have a significant impact on the chemical contaminant profile of the liquors, however, the product type and production process seemed to play a role in the contaminant profile. The methodology developed provides for a fast and simple way of analyzing liquor products for purposes of contaminant surveillance, comparison, as well as for characterization. To our knowledge, this is the first report for applying LC-MS on the non-targeted analysis of plastic-related contaminants in high-proof alcoholic beverages.