The effects of nitrous oxide analgesia were tested objectively in 20 volunteer dental students. Baseline pulse rate, respiration, blood pressure, and psychomotor ability were established before induction and were monitored throughout the experiments. Small but significant changes in blood pressure, pulse rate, and respiration were observed after administration of N 2 O; coordination and psychomotor ability were impaired but tolerance of continuous direct current electrical stimulation increased. The safe administration of N 2 O in dentistry requires that no less than 25% oxygen be used at any time, that the patient remain conscious throughout the procedure, and that the excitement stage of anesthesia be avoided. Under these conditions, N 2 O analgesia is beneficial in the treatment of an apprehensive patient.
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