Direct Comparison Research Articles

Working with digital textbooks or printed materials: A study with boys and girls on conditional probability

AbstractThe integration of dynamic visualisations, feedback formats and digital tools is characteristic of state-of-the-art digital mathematics textbooks. Although there already is evidence that students can benefit from these technology-based features in their learning, the direct comparison between the use of a comparable digital and printed resource has not yet been sufficiently investigated. We address this research gap by contrasting the use of an enriched digital textbook that includes these features and comparable printed materials without them. To do so, we investigate the achievement of 314 students in a pretest-posttest control group design in a five-hour series of lessons on conditional probability. Using the Rasch model and mixed ANOVA, the results indicate that students can benefit from digital textbook features, especially compared to the use of comparable printed materials. In line with other studies on mathematical achievement and the use of digital resources, our study also shows differences between boys and girls. It seems that particularly girls benefit from the use of the digital textbook, whereas, for the boys, it does not seem to make a difference what kind of resources they use. The group and gender differences are discussed against the background of other studies considering that, especially in Bayesian situations, the way statistical situations are visualised can be decisive for a student’s performance.

Mangrove tree height growth monitoring from multi-temporal UAV-LiDAR

Quantifying the mangrove height growth rate is important for understanding mangrove growth as well as its coupling with the other ecosystems and the climate. However, research on this topic has been limited due to the lack of multi-temporal data on mangrove tree height (TH) and methods for tree-level analysis. This study investigates the use of multi-year UAV-LiDAR data for mangrove TH growth characterization. We evaluated the UAV-LiDAR data by comparing it with field measured THs, observing a deviation ranging between −9 and +11 cm. Notably, the deviation was minimal at only 1 cm when comparing datasets collected using the same LiDAR sensor, indicating the validity of adopting multi-year UAV-LiDAR data for mangrove TH growth analysis. Methodologically, we assessed a tree-based approach and a grid-based approach. The tree-based approach is considered more feasible as it mirrors field measurements, allowing for direct comparisons with field surveys. In addition, statistically significant differences were revealed in TH growth rates among mangrove species and clumpiness groups (p < 0.001), while the invasion of Spartina alterniflora did not significantly affect the growth rates. This paper presents the inaugural effort in mangrove TH growth quantification using multi-temporal UAV-LiDAR data, showcasing the potential of this quickly emerging remote sensing technique in individual mangrove change analysis. We proposed a recommended framework for UAV-LiDAR-based TH growth rate measurement. The limitations and uncertainties embedded in the data sources, methodology, and results interpretation were also discussed.

Domestication signatures in the non-conventional yeast Lachancea cidri.

Evaluating domestication signatures beyond model organisms is essential for a thorough understanding of the genotype-phenotype relationship in wild and human-related environments. Structural variations (SVs) can significantly impact phenotypes playing an important role in the physiological adaptation of species to different niches, including during domestication. A detailed characterization of the fitness consequences of these genomic rearrangements, however, is still limited in non-model systems, largely due to the paucity of direct comparisons between domesticated and wild isolates. Here, we used a combination of sequencing strategies to explore major genomic rearrangements in a Lachancea cidri yeast strain isolated from cider (CBS2950) and compared them to those in eight wild isolates from primary forests. Genomic analysis revealed dozens of SVs, including a large reciprocal translocation (~16 kb and 500 kb) present in the cider strain, but absent from all wild strains. Interestingly, the number of SVs was higher relative to single-nucleotide polymorphisms in the cider strain, suggesting a significant role in the strain's phenotypic variation. The set of SVs identified directly impacts dozens of genes and likely underpins the greater fermentation performance in the L. cidri CBS2950. In addition, the large reciprocal translocation affects a proline permease (PUT4) regulatory region, resulting in higher PUT4 transcript levels, which agrees with higher ethanol tolerance, improved cell growth when using proline, and higher amino acid consumption during fermentation. These results suggest that SVs are responsible for the rapid physiological adaptation of yeast to a human-related environment and demonstrate the key contribution of SVs in adaptive fermentative traits in non-model species.IMPORTANCEThe exploration of domestication signatures associated with human-related environments has predominantly focused on studies conducted on model organisms, such as Saccharomyces cerevisiae, overlooking the potential for comparisons across other non-Saccharomyces species. In our research, employing a combination of long- and short-read data, we found domestication signatures in Lachancea cidri, a non-model species recently isolated from fermentative environments in cider in France. The significance of our study lies in the identification of large array of major genomic rearrangements in a cider strain compared to wild isolates, which underly several fermentative traits. These domestication signatures result from structural variants, which are likely responsible for the phenotypic differences between strains, providing a rapid path of adaptation to human-related environments.

Numerical modelling of Cz-β-Ga2O3 crystal growth in reactive atmosphere

The present study focuses on computer modeling of Cz- β-Ga2O3 crystal growth while also addressing the issue of minimizing Ir crucible oxidation. To accomplish this objective, a comprehensive framework was developed that combines thermodynamic equilibrium calculations with a CFD numerical model. This integrated approach is designed to simulate the impact of SO2 gas concentration in the chamber atmosphere. The primary goal of this numerical model is to assess deviations from the stoichiometric ratio in the Ga2O3 melt by examining the processes taking place at the free surface of the melt and their effects on its stoichiometry. These processes include the dissociation of the Ga2O3 melt into Ga and O ions, as well as the evaporation of volatile species from the melt surface.Simulations were conducted for both 2-inch and 4-inch crystals, with varying concentrations of SO2 and CO2 in an Ar atmosphere, facilitating a direct comparison between the two gases. The study's findings indicate that the optimal concentration of SO2 in the atmosphere should be approximately 40%, whereas for CO2, the optimal concentration is around 9%. Significantly reduced concentrations of both SO2 and CO2 were achieved by increasing the free melt surface area. Notably, the atmosphere with a SO2 concentration exhibited a substantial 30% reduction in the O concentration surrounding the crucible, underlining the advantages of using SO2 as a viable alternative to CO2.

Comparison of Low Dose Recombinant Factor VIIa and 4-Factor Prothrombin Complex Concentrate for Treatment of Bleeding Related to Cardiac Surgery.

Background: Recombinant factor VIIa (rFVIIa) and prothrombin concentrate complex (PCC) are used for uncontrolled bleeding in cardiac surgery (CS), however, there are limited direct comparisons of these agents. Objective: To evaluate the efficacy and safety of rFVIIa and PCC in CS related bleeding. Methods: This retrospective study included adult CS patients who received either low dose rFVIIa (<30mcg/kg) or 4-factor PCC. The primary outcome was transfusion requirements of packed red blood cells (pRBC) within 6 hours of factor administration. Secondary efficacy outcomes included transfusion requirements 0-18hours, doses of additional factor product, thrombotic events, and acute kidney injury (AKI). Results: A total of 179 patients were included (n = 78 rFVIIa; n = 101 PCC). Of patients who received blood products, there was no difference in the requirement of pRBCs within 6 hours (73.8 vs 68.9%, P = .5359) or in the median amount of pRBC transfused (500mL vs 640mL, P = .0723) in the rFVIIa and PCC groups respectively. Patients in the PCC group were more likely to require additional factor products (24.4% vs 47.5%, P = .0015), develop AKI (12.8% vs 25.7%, P = .0325), have longer ICU lengths of stay [2 (IQR 1-5) vs 4 (IQR 2-6), P = .0487] and greater in-hospital mortality (2.6% vs 10.9%, P = .033). There was no difference in thrombotic events. Conclusion: Although, there was no difference in pRBC transfusion requirements between PCC and rFVIIa, more patients in the PCC group required additional factor products and had increased adverse effects. Further comparisons of PCC and rFVIIa are warranted.

Standardised quantitative assays for anti-SARS-CoV-2 immune response used in vaccine clinical trials by the CEPI Centralized Laboratory Network: a qualification analysis

Accurate quantitation of immune markers is crucial for ensuring reliable assessment of vaccine efficacy against infectious diseases. This study was designed to confirm standardised performance of SARS-CoV-2 assays used to evaluate COVID-19 vaccine candidates at the initial seven laboratories (in North America, Europe, and Asia) of the Coalition for Epidemic Preparedness Innovations (CEPI) Centralized Laboratory Network (CLN). Three ELISAs (pre-spike protein, receptor binding domain, and nucleocapsid), a microneutralisation assay (MNA), a pseudotyped virus-based neutralisation assay (PNA), and an IFN-γ T-cell ELISpot assay were developed, validated or qualified, and transferred to participating laboratories. Immune responses were measured in ELISA laboratory units (ELU) for ELISA, 50% neuralisation dilution (ND50) for MNA, 50% neutralisation titre (NT50) for PNA, and spot-forming units for the ELISpot assay. Replicate assay results of well characterised panels and controls of blood samples from individuals with or without SARS-CoV-2 infection were evaluated by geometric mean ratios, standard deviation, linear regression, and Spearman correlation analysis for consistency, accuracy, and linearity of quantitative measurements across all laboratories. High reproducibility of results across all laboratories was demonstrated, with interlaboratory precision of 4·1-7·7% coefficient of variation for all three ELISAs, 3·8-19·5% for PNA, and 17·1-24·1% for MNA, over a linear range of 11-30 760 ELU per mL for the three ELISAs, 14-7876 NT50 per mL for PNA, and 21-25 587 ND50 per mL for MNA. The MNA was also adapted for detection of neutralising antibodies against the major SARS-CoV-2 variants of concern. The results of PNA and MNA (r=0·864) and of ELISA and PNA (r=0·928) were highly correlated. The IFN-γ ELISpot interlaboratory variability was 15·9-49·9% coefficient of variation. Sensitivity and specificity were close to 100% for all assays. The CEPI CLN provides accurate quantitation of anti-SARS-CoV-2 immune response across laboratories to allow direct comparisons of different vaccine formulations in different geographical areas. Lessons learned from this programme will serve as a model for faster responses to future pandemic threats and roll-out of effective vaccines. CEPI.

Rethinking the Healthcare Facilities: The Role of the Buffer Space.

A working group conducted a survey on the use of the principle of buffer space (BS), which in case of emergencies, could benefit healthcare settings. The aim of the preliminary investigation is to define new research lines in hospitals' functional design. The global experience of the COVID-19 pandemic highlighted challenges faced by hospitals when responding promptly to emergencies, including spatial reorganization and suspension of ordinary medical activities for ensuring adequate management of the emergency surge of patients. The group designed questionnaires to be administered to healthcare staff and healthcare designers aimed at understanding varied conceptions and features of BSs. Content across the two surveys overlapped significantly, allowing for direct comparisons of responses, while also including tailored questions in relation to the respective experience and skills of the two groups of respondents. 102 healthcare professionals and 56 designers took part to the survey. Analysis of the responses permitted for initial recommendations regarding BS typology including (a) proximity to the emergency department (ED), intensive care units (ICUs), and inpatient wards (IWs); (b) location within hospitals but separate from other medical areas; (c) need for independent access; (d) organizational and spatial features similar to ED, ICUs, and IWs; (e) existing as a fully flexible operational space; and (f) BS bed capacity to be approximately 12% of ED beds. Although the analysis is related to the Italian context, the expansion of this preliminary research to alternate healthcare facilities and geographic areas is necessary for reaching a wide consensus by different professionals on this field. It serves as a starting point for future investigations regarding the implementation of BS in hospital settings.

Physico-chemical properties of illite in the organic matter (OM)-rich claystone of Nankai Trough contrast with coeval OM-poor claystone: IODP Expedition 348

Naturally occurring microbially induced smectite-to-illite (Sm-I) reaction is of great interest to understand the control for the conventional Sm-I transformation, the source of bioavailable iron (Fe) in sediments, and the evolution of the microbial community in the deep biosphere. Direct comparisons of physico-chemical properties of illite-like phases including collapsed high-charge smectite and transient phase, and mature illite were performed for the organic matter (OM)-rich claystone in contrast with those of coeval OM-poor claystone (2163 m–2217 m below sea floor) buried at Nankai Trough (Integrated Ocean Discovery Program Site C0002). These clay layers are interbedded with 70°–90° dipping angle, such that they have nearly identical burial conditions of temperature, time, and fluid geochemistry except for OM content, one of the significant controls that can fuel heterotrophic microbial Fe (III) reduction. Unlike the abiotic Sm-I reaction, the local variations in the crystal structure, elemental composition, and oxidation states of Fe for the illite and illite-like phases in the OM-rich claystone suggest that illitization is promoted through the reduction of structural Fe (III) in smectite by microbial activity, however the effects of OM cannot be ruled out.

Flexible grouping patterns in a western and eastern chimpanzee community.

Primate social organizations, or grouping patterns, vary significantly across species. Behavioral strategies that allow for flexibility in grouping patterns offer a means to reduce the costs of group living. Chimpanzees (Pan troglodytes) have a fission-fusion social system in which temporary subgroups ("parties") change in composition because of local socio-ecological conditions. Notably, western chimpanzees (P. t. verus) are described as showing a higher degree of bisexual bonding and association than eastern chimpanzees, and eastern female chimpanzees (P. t. schweinfurthii) are thought to be more solitary than western female chimpanzees. However, reported comparisons in sociality currently depend on a small number of study groups, particularly in western chimpanzees, and variation in methods. The inclusion of additional communities and direct comparison using the same methods are essential to assess whether reported subspecies differences in sociality hold in this behaviorally heterogeneous species. We explored whether sociality differs between two communities of chimpanzees using the same motion-triggered camera technology and definitions of social measures. We compare party size and composition (party type, sex ratio) between the western Gahtoy community in the Nimba Mountains (Guinea) and the eastern Waibira community in the Budongo Forest (Uganda). Once potential competition for resources such as food and mating opportunities were controlled for, subspecies did not substantially influence the number of individuals in a party. We found a higher sex-ratio, indicating more males in a party, in Waibira; this pattern was driven by a greater likelihood in Gahtoy to be in all-female parties. This finding is the opposite of what was expected for eastern chimpanzees, where female-only parties are predicted to be more common. Our results highlight the flexibility in chimpanzee sociality, and caution against subspecies level generalizations.

NO3− as an electron acceptor elevates antibiotic resistance gene and human bacterial pathogen risks in managed aquifer recharge (MAR): A comparison with O2

Managed aquifer recharge (MAR) stands out as a promising strategy for ensuring water resource sustainability. This study delves into the comparative impact of nitrate (NO3−) and oxygen (O2) as electron acceptors in MAR on water quality and safety. Notably, NO3−, acting as an electron acceptor, has the potential to enrich denitrifying bacteria, serving as hosts for antibiotic resistance genes (ARGs) and enriching human bacterial pathogens (HBPs) compared to O2. However, a direct comparison between NO3− and O2 remains unexplored. This study assessed risks in MAR effluent induced by NO3− and O2, alongside the presence of the typical refractory antibiotic sulfamethoxazole. Key findings reveal that NO3− as an electron acceptor resulted in a 2 times reduction in dissolved organic carbon content compared to O2, primarily due to a decrease in soluble microbial product production. Furthermore, NO3− significantly enriched denitrifying bacteria, the primary hosts of major ARGs, by 747%, resulting in a 66% increase in the overall abundance of ARGs in the effluent of NO3− MAR compared to O2. This escalation was predominantly attributed to horizontal gene transfer mechanisms, as evidenced by a notable 78% increase in the relative abundance of mobile ARGs, alongside a minor 27% rise in chromosomal ARGs. Additionally, the numerous denitrifying bacteria enriched under NO3− influence also belong to the HBP category, resulting in a significant 114% increase in the abundance of all HBPs. The co-occurrence of ARGs and HBPs was also observed to intensify under NO3− influence. Thus, NO3− as an electron acceptor in MAR elevates ARG and HBP risks compared to O2, potentially compromising groundwater quality and safety.

The Strengths and Weaknesses of Costco's Business and Financial Model as well as the Potential Risk of Costco's International Development and Outlook

People are inseparable from buying necessities in their daily life; however, they may not pay much attention to the products they purchase, such as the strategy that the product company uses and the business risk the company might face. Therefore, the study focuses on one of the American sizable company-Costco, to analyze the necessities people purchase from Costco and the advantages and disadvantages of Costco's operation and financial model, as well as its risk and future expectation. A series of online research, Data research, directional comparison, and chart method combined with the calculation of average price, net income, etc., indicate that Costco has an excellent operating effect in the market and has become the second-largest retailer in the United States due to its unique membership system and management model. In addition, Costco also extensively develops international trade to expand its influence and sales force. However, Costco still has some potential risks. For instance, Costco will face different risks for its international business under diversified cultural backgrounds. This study focuses on the risks and suggestions of Costco's development in China. Finally, combined with the development of science and technology, it puts forward Costco's automation measures and the idea of developing e-commerce and looks forward to the future of Costco.

Comparison of the efficacy of fish oil and probiotic supplementation on glucose and lipid metabolism in patients with type 2 diabetes: a systematic review and network meta-analysis.

Abnormalities in glucose and lipid metabolism contribute to the progression and exacerbation of type 2 diabetes mellitus (T2DM). Fish oil and probiotics are dietary supplements that have the potential to improve glucose and lipid metabolism. However, their efficacy remains unclear in T2DM patients. PubMed, Embase, and the Cochrane Library were retrieved to collect randomized controlled trials (RCTs) on the efficacy of fish oil or probiotic supplementation in T2DM patients from the database inception to December 13, 2023. Primary outcome indicators encompassed glycated hemoglobin (HbA1c), homeostatic model assessment for insulin resistance (HOMA-IR) and blood lipid profile (triglyceride (TG) and total cholesterol (TC). Secondary outcome indicators included inflammatory markers such as tumor necrosis factor -α (TNF-α) and adipocytokine (including leptin and adiponectin). The R software was used for statistical analysis, and GraphPad Prism was used for figure rendering. A total of 60 RCTs involving 3845 T2DM patients were included in the analysis. The results showed that the probiotics (Bifidobacterium, Lactobacillus, Lactococcus, Propionibacterium, etc.) were more effective in reducing HOMA-IR than fish oil (Surca = 0.935). Bifidobacterium demonstrated the highest efficacy in reducing HbA1c levels (Surca = 0.963). Regarding lipid metabolism, fish oil was superior to probiotics in lowering TG and TC levels (Surca values of 0.978 and 0.902, respectively). Furthermore, fish oil outperformed probiotics in reducing TNF-α (Surca = 0.839) and leptin (Surca = 0.712), and increasing adiponectin levels (Surca = 0.742). Node-splitting analysis showed good consistency (P > 0.05 for direct, indirect, and network comparison across various interventions). In T2DM patients, fish oil was more effective than probiotics in regulating lipid metabolism. Probiotics outperformed fish oil in regulating glucose metabolism particularly; specifically, Bifidobacterium showed higher efficacy in reducing blood glucose.

In-vivo correlations of fluorescent or radioisotope glucose-analogs in imaging cancer metabolism.

To investigate the impact of different tracer modifications on the imaging of cancer metabolism, focusing on the comparison of fluorescent glucose-analog tracers (2-NBDG and 2-DG-750) and the radiolabeled tracer 18F-FDG in both in-vitro and in-vivo settings. We conducted an in-vitro comparative study using four cancer cell lines, each with unique glucose uptake characteristics. The study involved direct comparison of three tracers: 2-NBDG, 2-DG-750 and 18F-FDG, examining their internalization behaviors, metabolic functionality and localization effects in cancer metabolism imaging. The study revealed that each tracer exhibits distinct internalization behaviors correlated with imaging label size and type. 18F-FDG showed the highest uptake efficiency. Fluorescent molecules were found to accumulate in tumors primarily due to hydrophobic interactions and possible aggregation, indicating inefficiency in metabolism and suitability for imaging metabolic phenomena when compared to radiolabeled biomolecules. Our findings demonstrate that despite certain impracticalities, nuclear imaging, particularly using radiolabeled biomolecules like 18F-FDG, offers significant potential for accurately capturing biological phenomena. This is crucial for future advancements in both clinical and research settings. The study emphasizes the limitations of fluorescent molecules in imaging metabolic activities due to their inefficient metabolism and aggregation tendencies.

De-risking 1st line chemotherapy-free immune checkpoint inhibitor (ICI) use for patients with advanced gastroesophageal cancer (aGEJ) with tumor mutational burden (TMB).

407 Background: ICI + chemotherapy (chemo-ICI) is becoming an increasingly common 1st line regimen for patients with aGEJ. However, direct outcome comparison between biomarker-enriched groups receiving chemo-ICI vs. ICI monotherapy (mono-ICI) is limited in phase III trials. We sought to evaluate if TMB might identify patients for whom mono-ICI vs. chemo-ICI might be de-risked. We prospectively hypothesized that (1) patients with TMB &lt;10 mut/mB would have more favorable outcomes receiving ICI-chemo vs. mono-ICI and (2) patients with TMB ≥10 mut/mB would have diminished additional benefit from chemo-ICI vs. mono-ICI. Methods: This study included patients with aGEJ who received 1st line chemo-ICI or mono-ICI and tumor tissue genomic profiling by Foundation Medicine. Patient data was obtained by the nationwide (US-based) de-identified Flatiron Health-Foundation Medicine gastric real-world clinico-genomic database (FH-FMI CGDB), originating from approximately 280 US cancer clinics (January/2011–March/2023). Real-world progression-free survival (rwPFS) and overall survival (rwOS) were compared between patients receiving chemo-ICI vs. mono-ICI by Cox models, adjusted by propensity scores accounting for disease stage at diagnosis, ECOG PS, PD-L1 score and microsatellite instability (MSI) status. Comparisons of the explanatory power of TMB (&lt;10 vs. ≥10 mut/mB) vs. MSI status (MSI-H vs MSS) were performed by likelihood ratio test (LRT). Results: A total of 263 patients (176 receiving chemo-ICI and 87 mono-ICI) were included in the study. Patients with TMB &lt;10 mut/mB had more favorable outcomes receiving chemo-ICI vs. mono-ICI for rwPFS (median 5.8 vs. 1.9 months, hazard ratio [HR]: 0.44, 95% confidence interval [CI] 0.26-0.76), p=0.0029) and rwOS (median 11.1 vs. 7.9 months, HR: 0.68, 95% CI 0.40-1.15, p=0.1489). Patients with TMB ≥10 mut/mB did not have reduced benefit from mono-ICI; curiously less favorable outcomes were observed with chemo-ICI vs. mono-ICI for rwPFS (HR: 3.27, 95% CI 1.19-8.97, p=0.0212) and rwOS (HR: 3.56, 95% CI 1.14-11.08, p=0.0286). Evaluating only the mono-ICI group, the LRT indicated that when TMB was added to a model evaluating only MSI status, there was an improvement in ICI outcome prediction (p=0.006 for rwPFS and p=0.003 for rwOS), but not when MSI was added to TMB (p=0.91 for rwPFS and p=0.40 for rwOS). Conclusions: aGEJ patients with TMB &lt;10 mut/mB had more favorable outcomes receiving chemo-ICI vs. mono-ICI. In the TMB ≥10 mut/mB we did not observe more favorable outcomes among patients receiving chemo-ICI vs. mono-ICI. Curiously, we observed more favorable outcomes among those receiving mono-ICI in the TMB ≥10 mut/mB group. Among patients receiving mono-ICI, TMB better predicted mono-ICI outcomes compared to MSI status alone.

The impact of patient scoliosis-specific exercises for adolescent idiopathic scoliosis: a systematic review and meta-analysis of randomized controlled trials with subgroup analysis using observational studies.

Adolescent idiopathic scoliosis (AIS) is a common pediatric spinal deformity frequently treated with patient scoliosis-specific exercises (PSSE). The purpose of this study is to perform a systematic review and meta-analysis of randomized controlled trials and sensitivity analysis of observational studies to determine the impact of PSSE on outcomes for AIS. A systematic review and meta-analysis on impact of PSSE for patients with AIS was performed. Databases used included PubMed, CINAHL, MEDLINE, Cochrane, and ScienceDirect database inception to October 2022. Inclusion criteria included use of PSSE, patient population of AIS, and full text. A total of 26 articles out of 628 initial retrieved met final inclusion criteria (10 randomized controlled trials (RCTs), 16 observational studies). Total included patients (n = 2083) had a frequency weighted mean age of 13.2 ± 0.9years and a frequency weighted mean follow-up of 14.5 ± 20.0months. Based on only data from RCTs with direct comparison groups (n = 7 articles), there was a statistically significant but clinically insignificant improvement in Cobb angle of 2.5 degrees in the PSSE group (n = 152) as compared to the control group (n = 148; p = 0.017). There was no statistically significant improvement in Cobb angle when stratified by small curve (< 30 degrees) or large curve (> 30 degrees) with PSSE (p = 0.140 and p = 0.142, respectively). There was no statistically significant improvement in ATR (p = 0.326) or SRS-22 score (p = 0.370). PSSE may not provide any clinically significant improvements in Cobb angle, ATR, or SRS-22 scores in patients with AIS. PSSE did not significantly improve Cobb angle when stratified by curve size. Level I.

Modeling and Accuracy Assessment of Determining the Coastline Course Using Geodetic, Photogrammetric and Satellite Measurement Methods: Case Study in Gdynia Beach in Poland

The coastal environment represents a resource from both a natural and economic point of view, but it is subject to continuous transformations due to climate change, human activities, and natural risks. Remote sensing techniques have enormous potential in monitoring coastal areas. However, one of the main tasks is accurately identifying the boundary between waterbodies such as oceans, seas, lakes or rivers, and the land surface. The aim of this research is to evaluate the accuracy of coastline extraction using different datasets. The images used come from UAV-RGB and the Landsat-9 and Sentinel-2 satellites. The method applied for extracting the coast feature involves a first phase of application of the Normalized Difference Water Index (NDWI), only for satellite data, and consequent application of the maximum likelihood classification, with automatic vectorization. To carry out a direct comparison with the extracted data, a coastline obtained through a field survey using a Global Navigation Satellite System (GNSS) device was used. The results are very satisfactory as they meet the minimum requirements specified by the International Hydrographic Organization (IHO) S-44. Both the UAV and the Sentinel-2 reach the maximum order, called the Exclusive order (Total Horizontal Uncertainty (THU) of 5 m with a confidence level of 95%), while the Landsat-9 falls into the Special order (THU of 10 m with a confidence level of 95%).

Evaluation of seven satellite-based and two reanalysis global terrestrial evapotranspiration products

Although comprehensive evaluation of different types of global terrestrial evapotranspiration (ET) products has been conducted, the satellite remote sensing techniques have prompted the development of several available global ET products, warranting a reassessment as products continue to evolve. Recently, we produced the long-term Global LAnd Surface Satellite (GLASS) ET product, but there is a lack of comparison and evaluation with other ET products and EC observations on a global scale. In this study, we evaluated the accuracy and uncertainty of seven satellite-based (GLASS-AVHRR, GLASS-MODIS, BESS, FLUXCOM, GLEAM, MOD16, and PML_V2) and two reanalysis (ERA5 and MERRA2) global terrestrial ET products at multiple scales for selecting the most suitable ET products and developing large-scale ET models. At the point scale, their accuracy was evaluated through direct comparison with in situ observations from 230 global flux towers. The results indicate that no single ET product can provide the most accurate ET estimates for all land cover types, although GLASS-MODIS [coefficient of determination (R2) of 0.51, Kling–Gupta efficiency (KGE) of 0.68] and FLUXCOM [R2 of 0.51, KGE of 0.66] outperform the seven other products [0.54 =< KGE =< 0.66, 0.35 =< R2 =< 0.50] at all sites. At the basin scale, the accuracy of ET products was assessed through 36 large river basins. The R2 values between all ET products and the water balance-derived ET (WBET) are >0.88, while the accuracies of the nine ET products differ in some sense. The three-cornered hat (TCH) method and comparison analysis are applied to assess the uncertainty of nine ET products at the pixel level. The TCH outputs reveal that GLASS-AVHRR and GLASS-MODIS are the two products with the lowest relative uncertainty, while MERRA2 has the largest relative uncertainty. Our results imply that there is no single ET product performing best in all respects. The selection of ET products for scientific research should consider their performance differences in spatial scale as well as the influence of land cover and climate conditions.

Twenty years of network meta-analysis: Continuing controversies and recent developments.

Network meta-analysis (NMA) is an extension of pairwise meta-analysis (PMA) which combines evidence from trials on multiple treatments in connected networks. NMA delivers internally consistent estimates of relative treatment efficacy, needed for rational decision making. Over its first 20 years NMA's use has grown exponentially, with applications in both health technology assessment (HTA), primarily re-imbursement decisions and clinical guideline development, and clinical research publications. This has been a period of transition in meta-analysis, first from its roots in educational and social psychology, where large heterogeneous datasets could be explored to find effect modifiers, to smaller pairwise meta-analyses in clinical medicine on average with less than six studies. This has been followed by narrowly-focused estimation of the effects of specific treatments at specific doses in specific populations in sparse networks, where direct comparisons are unavailable or informed by only one or two studies. NMA is a powerful and well-established technique but, in spite of the exponential increase in applications, doubts about the reliability and validity of NMA persist. Here we outline the continuing controversies, and review some recent developments. We suggest that heterogeneity should be minimized, as it poses a threat to the reliability of NMA which has not been fully appreciated, perhaps because it has not been seen as a problem in PMA. More research is needed on the extent of heterogeneity and inconsistency in datasets used for decision making, on formal methods for making recommendations based on NMA, and on the further development of multi-level network meta-regression.

Accurate vertical nanoelectromechanical measurements

Piezoresponse Force Microscopy (PFM) is capable of detecting strains in piezoelectric materials down to the picometer range. Driven by diverse application areas, numerous weaker electromechanical materials have emerged. The smaller signals associated with them have uncovered ubiquitous crosstalk challenges that limit the accuracy of measurements and that can even mask them entirely. Previously, using an interferometric displacement sensor (IDS), we demonstrated the existence of a special spot position immediately above the tip of the cantilever, where the signal due to body-electrostatic (BES) forces is nullified. Placing the IDS detection spot at this location allows sensitive and BES artifact-free electromechanical measurements. We denote this position as xIDS/L=1, where xIDS is the spot position along the cantilever and L is the distance between the base and tip. Recently, a similar approach has been proposed for BES nullification for the more commonly used optical beam deflection (OBD) technique, with a different null position at xOBD/L≈0.6. In the present study, a large number of automated, sub-resonance spot position dependent measurements were conducted on periodically poled lithium niobate. In this work, both IDS and OBD responses were measured simultaneously, allowing direct comparisons of the two approaches. In these extensive measurements, for the IDS, we routinely observed xIDS/L≈1. In contrast, the OBD null position ranged over a significant fraction of the cantilever length. Worryingly, the magnitudes of the amplitudes measured at the respective null positions were typically different, often by as much as 100%. Theoretically, we explain these results by invoking the presence of both BES and in-plane forces electromechanical forces acting on the tip using an Euler–Bernoulli cantilever beam model. Notably, the IDS measurements support the electromechanical response of lithium niobate predicted with a rigorous electro-elastic model of a sharp PFM tip in the strong indentation contact limit [deff≈12pm/V, Kalinin et al., Phys. Rev. B 70, 184101 (2004)].

Analyzing the Automatic Power Level Control Effect of a Signal Generator in RF Power Sensor Calibration by a Direct Comparison Transfer Method and a Millimeter Wave Application.

Most calibration laboratories prefer the Direct Comparison Transfer Method (DCTM) for a reliable and accurate calibration of power sensors in the radio frequency (RF) scope. Most studies suggest using this calibration method, with its automatic power level control (APLC) of RF signal generators. The APLC is preferred to keep the output power level of the signal generator the same, while the power sensor is calibrated and the reference power sensor is connected to the measurement system. The known APLC mechanisms are also explained for the DCTM, and a comparison of the calibration factor values carried out with and without the automatic power level control process in the DCTM is also given in this study. RF power sensor calibrations with coaxial and waveguide connector types are examined with DCTM in this study as well. This study shows that the DCTM, unless with APLC, should be applied for the waveguide power sensor's calibration at millimeter wave frequencies.