The toxicity effect of four pesticides (Neomyl, Gastrotox, Round up and Topsin) were evaluated against the brown garden snail, Eobania vermiculata and the glassy clover snail, Monacha obstructa land snails using leaf dipping and poison bait technique under laboratory conditions.The toxicological studies on Eobania vermiculata snail by poison bait technique reaveled that Gastrotox exibited the highest toxic effect followed by Neomyl and Round up. While, Topsin gave the least effect in this respect. Their LC50 values were ( 0.16, 0.31, 1.25 and 2.03% ), respectively. The relative potency of Gastrotox was 0.19, 0.56 and 0.59 times than of Topsin, Neomyl and Round up and the slope values were 1.97, 1.69, 1.64 and 2.4, respectively.On the other hand, the activity of the same tested chemicals against Monacha obstructa and the same technique showed that Gastrotox was the most potent one followed by Neomyl, Round up and Topsin. Their LC50 values were ( 0.18, 0.33, 1.48 and 2.48% ), respectively. Also, it noticed that the relative potency of Gastrotox was 0.37, 0.56 and 0.81 times than of Topsin, Neomyl and Round up and the slope values were 1.7, 1.72, 1.59 and 1.86, respectively.The molluscicidal activity of Neomyl, Topsin and Round up using dipping technique against Eobania vermiculata illustrated that Neomyl exibited the highest toxic effect followed by Round up. While, Topsin gave the least effect in this respect. Their LC50 values were 0.24, 0.98 and 1.71 and the relative potency of Neomyl was 0.98 and 1.71 times than of Round up and Topsin. Also, the slope values were 0.58, 0.42 and 0.056, respectively.Concerning the activity of the previous tested chemicals against Monacha obstructa results indicated that Round up was the most potent one followed by Neomyl. But, Topsin gave the least effect and their LC50 values were 0.23, 0.26 and 2.23, respectively. The relative potency of Round up was 0.52 and 0.20 times than of Neomyl and Topsin. Also, the slope values were 1.71, 1.87 and 1.83, respectively