Diode Laser Treatment Research Articles

Efficacy and Safety of Non-Ablative Dual Wavelength Diode Laser Therapy for Genitourinary Syndrome of Menopause: A Single-Center Prospective Study.

This study evaluates the efficacy and safety of non-ablative diode laser therapy for genitourinary syndrome of menopause (GSM) in post-menopausal women unable to use hormonal therapies. A pilot prospective study was conducted from September 2023 to April 2024, involving 22 post-menopausal women aged 45-73years. Participants underwent three sessions of diode laser treatment with the Leonardo® dual-wavelength Diode laser. Assessments were made at baseline, 3months, and 6months post-treatment. Main outcome measures included Visual Analog Scale (VAS) scores for GSM symptoms, Vaginal Health Index Score (VHIS), and sexual function evaluated using the Female Sexual Function Index (FSFI-6), Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12), and Sexual Quality of Life-Female (SQOL-F) questionnaire. Significant improvements were observed in VHIS, increasing from 12 to 19.27 at 6months (p<0.001). GSM symptoms improved significantly: vaginal dryness scores decreased from 7.72±2.37 to 3.72±2.53, burning sensation scores dropped from 6.00±3.22 to 1.90±1.81, and dyspareunia scores reduced from 8.09±2.11 to 3.90±2.58 (all p<0.016). Sexual function improved, indicated by FSFI-6 scores increasing from 12.27±7.29 to 19.30±6.24 (p<0.016) and SQOL-F scores rising from 63.18±22.93 to 71.45±23.31. No adverse events were reported. Non-ablative diode laser therapy is effective and safe for managing GSM symptoms in post-menopausal women, offering significant symptom relief and enhancing sexual health without serious side effects. Further research with a larger cohort and extended follow-up is needed to confirm these findings. Clinical Trials ID NCT06503003.

Initial experience of 980‐nm diode laser treatment for recurrent non‐muscle‐invasive bladder cancer

IntroductionLaser ablation using a 980‐nm wavelength diode laser, which is a new‐generation laser, for recurrent bladder cancer is known to have a lower incidence of complications and recurrence than conventional transurethral resection of bladder tumor surgery. This is the first study to report the use of 980‐nm diode laser ablation for recurrent non‐muscle‐invasive bladder cancer in Japan.Case presentationA 73‐year‐old man underwent transurethral laser ablation for the treatment of recurrent non‐muscle‐invasive bladder cancer. Laser irradiation was performed using LEONARDO DUAL (diode laser/980‐nm wavelength) and a 400‐μm BARE laser fiber. Pathological evaluation indicated low‐grade urothelial carcinoma, pTa. The patient was discharged on the second postoperative day with no perioperative or postoperative complications.ConclusionThis case suggests the potential of transurethral laser ablation for treating recurrent non‐muscle‐invasive bladder cancer.

Protecting celtuce (Lactuca sativa L. var. augustana) slices against storage-induced oxidative stress and discoloration by using diode laser exposure

Diode laser irradiation is a novel approach applied to preserve the quality of fresh commodities and minimise oxidative processes, including browning in fresh-cut products. The objective of this study was to investigate the efficacy of diode laser treatment in enhancing the quality of celtuce slices during refrigerated storage at 4 °C. The celtuce slices were subjected to a 660 or 450 nm diode laser for 5 min and then stored for 10 d. Both laser treatments hindered the progression of weight loss and firmness increase in the celtuce slices. The use of a 450 nm diode laser effectively prevented the development of browning and preserved the surface colour by inhibiting the increase in a* and overall colour difference values, as compared to other treatments, during storage for 10 d. The diode laser treatment suppressed the increase in oxidative stress by lowering the levels of MDA, H2O2, and O-2 while retaining a high level of DPPH scavenging activity, AsA, and antioxdant enzyme activities, including SOD, CAT, APX, and GR, in comparison to the untreated slices. The treatment enhanced chlorophylls content due to the up-regulation of LsHEMA1 gene and down-regulation of LsNYC1 gene. The treatment also inhibited factors involving enzymatic browning reaction by suppressing PAL activity, total phenols content, PPO activity and LsPPO gene expression. These suggest that the blue diode laser exposure at 450 nm for 5 min is an effective approach hindering oxidative stress and discoloration of celtuce slices during storage.

The efficacy of diode laser and subgingival air polishing with erythritol in treatment of periodontitis (clinical and microbiological study)

BackgroundThere is insufficient clinical and microbiological evidence to support the use of diode laser and air-polishing with erythritol as supplements to scaling and root planning(SRP). The aim of the current study is to evaluate the clinical and microbiologic efficacy of erythritol subgingival air polishing and diode laser in treatment of periodontitis.MethodsThe study encompassed twenty-four individuals seeking periodontal therapy and diagnosed with stage I and stage II periodontitis. Eight patients simply underwent SRP. Eight more patients had SRP followed by erythritol subgingival air polishing, and eight patients had SRP followed by diode laser application. At baseline and six weeks, clinical periodontal parameters were measured, including Plaque Index (PI), Gingival Index (GI), periodontal Probing Depth (PPD), and Clinical Attachment Level (CAL). The bacterial count of Aggregatibacter actinomycetemcomitans(A.A), Porphyromonas gingivalis (P.G) was evaluated at different points of time.ResultsThe microbiological assessment revealed significant differences in the count of A.A. between the laser and erythritol groups immediately after treatment, indicating a potential impact on microbial levels. However, the microbial levels showed fluctuations over the subsequent weeks, without statistically significant differences. Plaque indices significantly decreased post-treatment in all groups, with no significant inter-group differences. Gingival indices decreased, and the laser group showed lower values than erythritol and control groups. PPD and CAL decreased significantly across all groups, with the laser group exhibiting the lowest values.ConclusionThe supplementary use of diode laser and erythritol air polishing, alongside SRP, represents an expedited periodontal treatment modality. This approach leads to a reduction in bacteria and improvement in periodontal health.Trial registrationThis clinical trial was registered on Clinical Trials.gov (Registration ID: NCT06209554) and released on 08/01/2024.

The Microstructure, Surface Topography and Wear Resistance of Cold-Sprayed (Cr3C2-25(Ni20Cr))-(Ni-graphite) Composite Coatings Modified by Diode Laser Treatment

Cold-sprayed composite coatings have several advantages; however, some properties, such as hardness and abrasion resistance, are lower than those in plasma- or HVOF-sprayed deposits. This work showed that the use of surface diode laser processing allowed the development of (Cr3C2-25(Ni20Cr))-(Ni-graphite) cermet coatings with good adhesion to the steel substrate, and increased properties in the near-surface zone, below which the properties of cold-sprayed coatings were retained. Studies of the microstructure in the micro/nanoscale of the laser-treated coatings showed strong grain refinement after surface treatment. Cr7C3 carbide of various shapes and sizes was formed in the structure; while, a several hundred nanometre layer of Cr2O3 oxide appeared on the coating surface. The changes occurring in the microstructure have resulted in increased mechanical and tribological properties of the laser-treated zone of deposits.

Infrared diode laser enhances human periodontal ligament stem cells behaviour on titanium dental implants

Low level laser treatment (LLLT) is known for its photobiostimulatory and photobiomodulatory characteristics, which stimulate cell proliferation, increase cellular metabolism, and improve cellular regeneration. The objective of the present research was to assess the possible influence of infrared diode laser irradiation on the behaviour, attachment, and osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) seeded on different types of dental implants. Two distinct types of implants, one subjected to laser surface treatment and the other treated with acid etching, were longitudinally divided into two halves and submerged in six wells culture plates. Both implants were subjected to infrared diode laser treatment, and subsequently, the morphology and attachment of cells were examined using scanning electron microscopy (SEM) after 14 and 21 days. The behaviour of (hPDLSCs) towards two types of implants, when exposed to osteogenic medium and low-level laser therapy (LLLT), was assessed using quantitative real-time polymerase chain reaction to measure the expression of stemness markers and osteogenic markers. The scanning electron microscopy (SEM) demonstrated that the application of infrared diode laser irradiation substantially improved the attachment of cells to both types of implants. The stemness gene markers were significantly down regulated in cells seeded on both surfaces when challenged with osteogenic media in relation to control. At 14 days, early osteogenic markers, were upregulated, while late osteogenic markers, were downregulated in both challenged groups. At the 21-day mark, hPDLSCs seeded on an acid-etched implant exhibited increased expression of all osteogenic markers in response to stimulation with osteogenic media and infra-red diode laser, in contrast to hPDLSCs seeded on a laser surface treated implant under the same conditions. Finally, the findings of our research revealed that when subjected to infrared diode laser, human periodontal ligament stem cells cultured on both types of implants demonstrated improved cellular attachment and differentiation. This suggested that infrared diode laser enhanced the activity of the cells surrounding the implants. Hence, the use of infrared diode laser could be pivotal in improving and expediting the clinical osseointegration process around dental implants.

Subthreshold micropulse diode laser treatment in diabetic macular edema: biological impact, therapeutic effects, and safety.

To introduce the treatment of diabetic macular edema (DME) with subthreshold micropulse diode laser (SMPL), to summarize the biological impact, therapeutic effects, and safety of this treatment, and to discuss the response to DME when SMPL is combined with anti-vascular endothelial growth factor (anti-VEGF) or steroid. The literature search was performed on the PubMed database, with a selection of English-language articles published from 2000 to 2023 with the following combinations of search terms: diabetes macular (o) edema, micropulse laser or subthreshold micropulse laser, anti-vascular endothelial growth factor, and steroid. SMPL is a popular, invisible retinal laser phototherapy that is inexpensive, safe, and effective in the treatment of DME. It can selectively target the retinal pigment epithelium, reduce the expression of pro-inflammatory factors, promote the absorption of macular edema, and exert a similar and lasting clinical effect to traditional lasers. No significant difference was found in the therapeutic effects of SMPL between different wavelengths. However, HbA1c level and pretreatment central macular thickness (CMT) may affect the therapeutic outcomes of SMPL. SMPL has a slow onset and produces lasting clinical effects similar to conventional photocoagulation. It has been reported that SMPL combined with the intravitreal anti-VEGF injection can significantly reduce the number of injections without influencing the therapeutic effect, which is essential for clinical applications and research. Although 577nm SMPL is widely used clinically, there are no standardized protocols for SMPL. Additionally, some important problems regarding the treatment of SMPL require further discussion and exploration.

The Impact of the Number and Duration of Treatments With a 1064 nm Diode Laser on Adipocyte Apoptosis: Implications for Noninvasive Fat Reduction Strategies.

Noninvasive treatment with a 1064 nm diode laser, generating hypodermal temperatures between 42 and 47 °C, induces adipocyte cell death, offering a solution to reduce fat in problematic areas. The objective of the authors of this study is to determine whether a 15 min treatment provides similar efficacy as the standard 25 min treatment. Pigs underwent a 15 or 25 min 1064 nm laser treatment on 6 × 6 cm areas of abdominal skin. Single treatments were administered 14 or 28 days before biopsy, whereas dual treatments were performed at both 14 and 28 days prebiopsy. Hematoxylin and TUNEL staining were used to detect histological changes and apoptosis in harvested skin tissue. Pig skin subjected to a 25 min diode laser treatment exhibited nearly twice the apoptotic counts in the hypodermis compared with the 15 min treatment (10.5 vs 5.7) at 28 days following treatment. The degree of apoptosis increased with time following the treatment, with nearly twice the apoptosis counts at 28 days than at 14 days following a single 25 min treatment (10.5 vs 5.8). When testing 1 vs 2 treatments, 2 treatments (28 and 14 days before harvesting the tissue) did not result in significantly higher apoptosis than 1 treatment 28 days before harvesting. Apoptosis was primarily localized to adipocytes in the hypodermis and the dermis/hypodermis junction. There were no adverse side effects in the animals. The degree of apoptosis following a 1064 nm laser treatment was proportional to the treatment duration. The 25 min treatment produced significantly more apoptosis than the 15 min treatment. The process of apoptosis continued over several weeks.

Comparative Efficacy of Diode Laser System versus Intense Pulse Light (Ipl) In Management of Unwanted Hair

Unwanted hair growth can be caused by several factors, including genetics, systemic illness, and even drug reactions. According to the underlying medical condition, excessive hair growth was labelled as either hirsutism or hypertrichosis. Objective: To compare the efficacy of diode laser system versus intense pulse light in the management of unwanted hair among female patients. Methods: Patients in this randomized controlled study had hirsutism. Group A received powerful pulse light therapy for three sessions, one month apart, while Group B received diode laser treatment. To determine the effectiveness and side effects in both groups, patients were monitored for four months and subsequently assessed clinically. Results: Out of these total 60 patients, intense pulse light system was more efficacious in achieving patient satisfaction (73.3%) at the end of three months as compared to diode laser (26.7%) (p value &lt; 0.001). Conclusions: This randomized controlled trial showed that intense pulse light therapy was more efficacious in management of unwanted hair compared to diode laser therapy.

New Protocol: EndoliftX Laser and Hyaluronic Ac+ Calcium Hydroxiapaptite as an Effective Approach for Facial Rejuvenation- Case Series of 7 Patients

Background: Excessive submental fat and tissue laxity can significantly impact an individual's aesthetic appearance, leading to cosmetic dissatisfaction and concerns about aging. Non-invasive and minimally invasive treatments have gained popularity as alternatives to surgical interventions. Laser lipolysis, such as EndoliftX®, has emerged as a promising approach for submental fat reduction, and hybrid fillers, like HArmonyCa, have shown potential for enhancing tissue laxity. Objective: This study aimed to evaluate the efficacy and long-term outcomes of a novel combined treatment protocol utilizing laser lipolysis and hybrid filler injection for submental fat reduction and tissue tightening. Methods and Materials: A single-center, prospective, quasi-experimental controlled study was conducted, enrolling seven patients aged between 49 and 67 years. The protocol EndoliftX®, involved a 1470nm diode laser (LASEmaR 1500® Eufoton® Trieste,Italy) treatment (Endolift) followed by hybrid filler (HArmonyCa) injection. Various assessments, including clinical examination, Glogau Scale scoring, and 3D imaging, were performed at baseline and follow-up visits. Results: The results demonstrated significant reductions in submental fat, improved cutaneous elasticity, and reduced wrinkle severity according to the Glogau Scale. Notably, these improvements were visible almost immediately post-procedure and continued to enhance over time, remaining prominent even after 12 months of observation. The treatment was associated with minimal discomfort and downtime. Conclusion: The study highlights the effectiveness and longevity of the combined treatment protocol, making it a valuable option for individuals seeking non-surgical solutions for submental fat reduction and tissue tightening. While further research with control groups is warranted, laser lipolysis with EndoliftX®, and hybrid filler injection with HArmonyCa offer a minimally invasive and well-tolerated approach to address submental concerns and achieve favorable aesthetic outcomes, particularly in patients looking to avoid more invasive techniques.

Wound treatment Q-switched Nd: YAG Laser tattoo removal rat model by Photobiomodulation Therapy PBMT

The Q-switched laser method is the most effective method of tattoo removal compared to other methods of i.e. chemical, mechanical and surgical. The objective of this study is to investigate the effect of Nd:YAG laser to remove the tattoo and also to utilize 808 nm diode laser to enhance the wound healing at post-treatment. Q-switched Nd: YAG laser with fundamental wavelength of 1064 nm is applied to remove tattoo pigment with different energy fluencies. Additionally, 808 nm diode laser will be applied on wound created after tattoo removal to enhance the healing process. More than 15 Sprague Dawley rats will be involved and tattooed with black inks on their back by a tattoo gun. A single session treatment is use in the energy about 400mj for tattoo removal. The exposure to diode laser treatment will be conducted daily. The experimental observation will be hold for 9 days, and 5 rats from each group will be sacrificed on day 3, 6 and 9 respectively. The skin biopsy will be removed for H&amp;E and Masson’s trichrome histology examination. The effect of tattoo removal and healing progress of skin analyzed via photothermal.. The preliminary findings of this study indicate that 1064 nm wavelengths of Q-switched Nd-YAG laser treatment with 400mj pulse energy exhibit significant progress of black tattoo removal.

Effects of topical fluoride on primary tooth enamel microhardness after diode laser treatment

ObjectivesTooth decay is controlled and prevented using fluorides. Specifically, a combination of laser irradiation and topical fluoride application can improve fluoride absorption. Although laser irradiation is recommended in traditional technology for caries prevention, little is known about the efficacy of caries-inhibiting laser diodes. Further, most studies have focused on permanent teeth. The objective of this study was to explore the effect of laser diode radiation mixed with topical fluoride on the enamel surface microhardness of primary teeth. Material and methodThe 60 primary teeth were divided into 60 plates. Baseline Vickers microhardness was established for each enamel surface. The samples were then divided into three groups. 4 % NaF varnish (group A) and 4 % NaF varnish using diode 2 and 3 W lasers (groups B and C, respectively). The final microhardness was measured and statistically evaluated using SPSS version 16. ANOVA was used to compare the means of the tested groups, which had a P-value of 0.05, indicating significance. ResultThe mean and standard deviation of microhardness for the different groups was tested. Group C (4 % NaF with a diode laser at 3 W) showed a higher average Vickers hardness (VHN) than Group B (4 % NaF with a diode laser at 2 W), whereas group A showed the lowest average VHN. There was a significant difference in microhardness between groups (P 0.05). ConclusionThis study explored the effect of laser mixed with topical fluoride on enamel surface microhardness of primary teeth. The use of a diode laser (Quanta System, Italy) with a fluoride varnish applied to the enamel surface has a greater effect on the resistance of the enamel to caries.

Association of Positive Bacterial Cultures Obtained from the Throat, Anus, Ear, Bronchi and Blood in Very-Low-Birth-Weight Premature Infants with Severe Retinopathy of Prematurity-Own Observations.

The causative factors responsible for the development of Retinopathy of Prematurity (ROP) are still unexplored. Therefore, one of the most important factors can be perinatal inflammation. This retrospective study included 114 premature infants (228 eyes) meeting a birth criteria of ≤ 32 weeks gestational age (GA) and a birth weight (BW) ≤ 1710. Examined Group (EG) n = 51 of BW 852.7 ± 255.7; GA 26.3 ± 2.0 with severe ROP treated by diode laser or anti-VEGF intravitreal injection. Control Group (CG) n = 63 of BW 1313.9 ± 284.5; GA 28.8 ± 1.6 without ROP. Microbiological bacterial and fungal cultures of the ear, anus, bronchial throat and blood were taken. Medical data and laboratory tests in correlation to 3 ROP and A-ROP were analysed. Positive bacterial tests dominated in EG, 47% vs. CG, 23%. Significant correlations between positive cultures obtained from natural cavities: anus (p < 0.001), throat (p = 0.002), as well as from blood (p = 0.001) and severe ROP which requires diode laser and anti-VEGF treatment were noted. Significant inflammation markers which correlate with the development of severe ROP are Klebsiella pneumoniae (KP) (p = 0.002) and Coagulase-negative Staphylococci (CoNS) (p < 0.001). CoNS, p < 0.001; KP, p = 0.002; the remaining Maltophilia stenotrophomonas (MS); Staphylococcus aureus (SA), p = 0.005; and Enterobacter cloacae (EC), p = 0.02 were the most frequent bacteria in severe ROP. High levels of white blood cells (WBC), C-reactive protein (CRP), lymphocytes (LYM) and low thrombocytes (PLT) correlated sequentially with (Odds Ratio, OR) CoNS (2.3); MS (5.9); KP (3.1); and all positive cultures (APC) (9.5). An important correlation between the BPD-EC (4.3); intrauterine inflammation-KP (3.4); PDA-EC (3.9); and asphyxia-CoNS (3.0) was identified. It cannot be ruled out that positive microbiological results of blood, anal and pharyngeal cultures may become prognostic markers for the early development of ROP, which would enable early initiation of ophthalmological treatment in premature infants from the VLBW group.

Efficacy of a Diode Vaginal Laser in the Treatment of the Genitourinary Syndrome of Menopause.

Genitourinary syndrome of menopause (GSM) and vulvovaginal atrophy (VVA) are the most frequent menopause-related clinical entities and are consistently included in the definition of pelvic floor disorders (PFDs). Nonhormonal therapies, such as lubricants and moisturizers, are indicated as first-line treatments, while the "gold standard'' is represented by topical estrogen products; however, in cancer survivors hormonal treatment is not indicated. For this reason, energy-based therapeutic approaches-for instance, through laser technologies-may be employed as alternative options in this kind of patient; however, there are no studies evaluating the efficacy of a pure diode vaginal laser in the treatment of GSM. As a consequence, with our study, we aimed to evaluate outpatient nonablative diode laser treatment in sexually active women, with contraindications, no response, or refusal of local estrogenic therapy. This prospective study included patients with GSM, aged ≥ 18 years old, with contraindications, or refusal of local estrogen therapies. Women were evaluated via the use of their Vaginal Health Index (VHI) scores, which consists of five measures: elasticity, fluid volume, pH, epithelial integrity, and moisture. Moreover, the intensity of VVA symptoms (vaginal burning, vaginal itching, vaginal dryness, dyspareunia, and dysuria) was measured using a 10 cm visual analog scale (VAS), where the left extreme of the scale (score = 0) indicated "absence of symptom" and the right indicated "symptom as bad as it could be" (score = 100). Sexual function was evaluated with the Female Sexual Function Index (FSFI-19) questionnaire. The treatment was performed using a Leonardo Dual diode laser (Biolitec Italia Srl, Milano, Italy). The laser treatment consisted of three sessions, one per month. One month after the third session, the VHI, symptom VAS, and FSFI-19 were re-evaluated. In addition, the Patient Global Impression of Improvement (PGI-I) questionnaire was collected. Our study enrolled a total of 26 consecutive patients. All patients were either in menopause or under treatment with gonadotropin-releasing hormone (GnRH). None of the patients reported adverse effects after laser treatment. In total, 19 (73.1%) patients referred improvements of their symptoms according to PGI-I scores. All domains of the FSFI-19 questionnaire, significantly improved after the diode laser treatment. The mean VHI score increased by 3.2 points, from 12.2 to 15.4 (p < 0.001). Additionally, we documented a significant improvement in symptoms affecting the VAS score, from 69.2 to 43.5 points (p < 0.001). A diode vaginal laser is an effective and easily tolerated ambulatory procedure for vaginal functional restoration in the treatment of GSM and VVA.

Comparative evaluation of efficacy of gluma desensitiser vs diode laser in treating dentinal hypersensitivity: an in vivo study

Background: There are different types of adhesives and resins available today for the treatment of dentinal hypersensitivity. Literature search showed fewer comparative studies using gluma desensitizing agent and diode laser (940nm) in the treatment of dentinal hypersensitivity. Hence, the aim of present study is to compare the efficacy of gluma desensitizing agent and diode laser (940 nm) in the treatment of dentinal hypersensitivity. Methods: Patients were selected using VAS scale and randomly divided into group 1 (gluma) and group 2 (diode laser). Gluma and laser treatment was done for the patients on the contralateral sides. The follow up was done at an interval of 1 month and 3 months. Results: Statistically significant difference was seen in intra group comparison for both gluma and laser treatment but no statistically significant difference was seen in the intergroup comparison of both the groups. Conclusions: Both gluma and diode laser treatment were found to be equally effective for the treatment of dentinal hypersensitivity.

The 1450-nm Diode Laser Reduces Redness and Porphyrin Density: An Image-Based, Patient-Oriented Appraisal.

Acne vulgaris remains the leading dermatological condition. The efficacy of laser treatment has been supported by many clinical studies, but studies investigating its multidimensional action are lacking. To comprehensively investigate the efficacy of 1450-nm diode laser treatment in patients with inflammatory acne and provide objective and subjective data for doctors in clinical practice. This retrospective study included patients with inflammatory acne lesions who underwent three courses of 1450-nm diode laser treatment between October 2019 and August 2020. Facial surface analysis was performed via objective computer assessments using the Canfield VISIA imaging system. Post-treatment subjective assessments were retrieved and analyzed using the clinical global impression-improvement index (CGI-I) and patient global impression of improvement scales (PGI-I). The final analysis included 20 patients. The changes in the porphyrin VISIA system scores demonstrated significant improvement, with median scores being 35.83, 48.83, and 54.83, respectively. The changes in the red area VISIA scores also showed improvement, with the median scores being 48, 50.33, and 58.83, respectively. The average CGI-I scale scores were 2.2 ± 1.01, 1.70 ± 0.80, and 1.50 ± 0.76, respectively (p = 0.001), and the average PGI-I scale scores were 3.10 ± 0.85, 3.10 ± 0.97, and 3.05 ± 0.95, respectively (p = 0.727), with no significant changes observed in sebum production. The present study is the first to provide objective and subjective evidence proving that the 1450-nm diode laser can reduce inflammatory acne lesions.

Short- and mid-term results of diode laser treatment in pilonidal sinus disease and the role of endoscopic camera use on outcomes.

Nowadays, surgical treatment of pilonidal sinus disease (PSD) with novel techniques is a topic of interest since conventional methods are associated with longer return to daily life and higher complication and recurrence rates. Recently, use of laser as a minimally invasive approach has become popular in the surgical treatment of PSD. In this study, we analyze the short- and mid-term results after laser treatment and the effect of endoscopic camera use on outcomes. A total of 106 patients with PSD who underwent laser treatment between November 2017 and September 2021 were included in this study. All patients were treated with a 1470-nm diode laser. Endoscopic camera was used in 73 patients and results of these were compared with those in whom camera was not used. Follow-up period was determined as a minimum of 1year. Data were analyzed retrospectively. There were 80 (75%) male and 26 female patients. The median age was 26 (range 13-50) years. On the first postoperative day, 26 (26.5%) patients did not have any pain and 42(42.8%) patients reported low-grade pain. The mean time to return to daily life was 4.5 ± 5.5 (median 2, range 1-30) days. The complication rate was 10.4%. Eighty-six (87.8%) patients completely recovered and the mean complete recovery time was 27.4 ± 15.9days. The patient satisfaction rate was 99.0%. The recurrence rate was 11.0%. Neither history of previous surgery nor abscess was associated with recurrence. Use of an endoscopic camera had no effect on postoperative pain, complete recovery, complications, patient satisfaction, and recurrence (p < 0.05). Laser treatment for PSD is a promising approach with the advantages of less postoperative pain, early return to daily life, high patient satisfaction, and acceptable complication and recurrence rates. Nevertheless, further studies are needed to investigate the role of endoscopic camera use in this procedure since its possible advantages could not be clarified.

Management of oral leukoplakia with an 808-nm high-power diode laser: a single-center experience.

High-power diode laser emerges as a promising approach to the treatment of oral leukoplakia (OL); however, its short- and long-term effects have been barely explored. This study evaluated the postoperative endpoints and the recurrence rate of high-power diode laser treatment in a well-defined series of patients with OL. A prospective analysis was performed on 22 individuals comprising 31 OL. The lesions were irradiated using the following protocol: Indium-Gallium-Arsenide diode laser, 808nm, continuous-wave mode, 1.5-2.0 W, 780.0 ± 225.1J, and 477.1 ± 131.8s. Postoperative pain was assessed with a visual analog scale at three endpoints. Clinical follow-up was performed on all patients and the Kaplan-Meier test was used to analyze the probability of recurrence. The series consisted mostly of women (72.7%) with a mean age of 62.8years. A single laser session was performed in 77.4% of cases. The median score on the scale that assessed pain on the 1st, 14th and 42nd postoperative day was 4, 1, and 0, respectively. The mean follow-up period per lesion was 28.6months (range: 2-53months). A complete response was observed in 93.5% of OL cases, while 6.5% had recurrence. The probability of recurrence at 39months was 6.7%. No patient experienced malignant transformation. High-power diode laser for the treatment of OL is safe and effective during the trans- and postoperative period. These findings represent an alternative approach to the management of OL, mainly because a low recurrence rate was observed.

A SEM Evaluation of the Permeability of Different Desensitizing Methods on Occlusion of Dentinal Tubules: An In-vitro Study.

The purpose of the current research was to assess the permeability of three various desensitizing techniques on dentinal tubule occlusion using a scanning electron microscope (SEM). For this research, 100 human sound premolar teeth that were extracted for orthodontic purposes were gathered. With the aid of a water-cooled diamond saw, the teeth were divided in a mesiodistal (vertically) orientation. A sectioned sample (5 mm long by 5 mm wide by 3.5 mm deep), including the cervical region, was taken from each buccal side. To fully open the dentinal tubules, these samples were then kept in 17% ethylenediaminetetraacetic acid (EDTA) for 40 minutes. The samples were divided into four groups (n = 25), each receiving the following dentin surface treatments: Group I: Control, Group II: Samples received NaF 5% varnish treatment, Group III: Samples received diode laser treatment, and Group IV: Samples received CPP-ACP treatment. An SEM was used to inspect each specimen at a magnification of about × 3000 and photomicrographs was assessed. The maximum occlusion of dentinal tubules was found in samples were treated with Diode laser (2.96 ± 0.14) followed by samples treated with NaF 5% varnish (3.38 ± 0.10), samples were treated with CPP-ACP (3.42 ± 0.06) and control group (4.26 ± 0.19). There was a statistically significant difference found between the groups. In conclusion, all three desensitizing methods used in the present study were successful in the occlusion of dentin tubules. But the application of the Diode laser was effective in the reduction of dentin permeability compared to NaF 5% varnish and CPP-ACP. Dentin hypersensitivity (DH) is characterized by a brief period of intense discomfort. One approach to managing DH is to obstruct dentin tubules in order to decrease dentin permeability. There are many substances that can reduce hypersensitivity, but the finest commercially available substance for treating the condition by occluding the tubes should be acknowledged.

The 980-nm diode laser treatment for oral venous lakes: report of a series of 11 cases

The 980-nm diode laser treatment for oral venous lakes: report of a series of 11 cases