Dimethyl Sulfoxide Solvent Research Articles

Tailoring the optical and spectroscopic properties of ascorbic acid via solvation with DMSO: A theoretical study using different quantum models

The anti-oxidizing properties and physiological action of ascorbic acid have recently attracted considerable research attention. This study employs dimethyl sulfoxide (DMSO) solvent to examine the interaction of solvent molecules and the resulting structural modifications in ascorbic acid through trial and error with three quantum solvation models (CPCM, IEFPCM, and SMD). DMSO was selected from the models to analyze changes in the optical bandgap and spectroscopic properties using first-principles methods. Geometry optimization was performed at two different levels of theory: Hartree-Fock (HF) and density functional theory (DFT). The DFT method was employed with a 6–311 G/B3LYP basis set to yield the ground-state energy. The electronic orientation was investigated through potential energy mapping, while spectroscopic analysis encompassed ultraviolet (UV–VIS) and nuclear magnetic resonance (NMR) techniques. Additionally, Fourier transform infrared spectroscopy was used to gain a deeper understanding of the chemical structures of the compound. The findings shed light on the DMSO-Ascorbic acid interactions and revealed structure-property correlation.

LiAsF6 SOLUTIONS IN THE MIXED SOLVENTS OF PROPYLENE CARBONATE – DIMETHYL SULFOXIDE: ELECTRIC CONDUCTIVITY AND ELECTROCHEMICAL STABILITY

The specific conductivities of LiAsF6 solutions in a mixed solvent of propylene carbonate (PC) –dimethyl sulfoxide (DMSO) were measured at temperatures of 253.15, 263.15, 273.15, 283.15, 293.15, 303.15, 313.15, 323.15 and 333.15 K being a ionophore concentration of 0.2 to 1.4 mol / kg. The portion of DMSO in the mixed solvent was varied in the range of (0.2 - 0.75) mole fractions. The specific conductivities of LiAsF6 in DMSO were studied in the temperature range of (293.15 – 333.15) K. Concentration dependences of specific conductivity of the system can be described by the Casteel-Amis equation. The contributions of the solvent and ionophore to the activation energy of the ionic conduction process are determined on the base of the transition state theory. It has been found that the LiAsF6 solutions in a mixed PC – DMSO solvent have a narrower electrochemical window compared to the solutions of this ionophore in pure PC and DMSO solvents.

Electrical and mechanical response of spin-coated PVDF-TrFE formed from MIBK and DMSO solvents under external excitations

Flexible polymer piezoelectric materials are of interest in electro-mechanical applications; however, the mechanical and electrical properties of these materials can be affected by their formation. In this study vibrational analysis was performed to explore the mechanical and electrical properties of piezoelectric PVDF-TrFE polymer using external excitations. Frequency response study of cantilever cantilevers was used to explore the natural mechanical response of a flexible KAPTON cantilever coated with PVDF-TrFE of different concentrations, and with different solvent formations. It is found that the mechanical response of the PVDF-TrFE coated KAPTON cantilever has reduced vibration amplitude when a combined Methyl Isobutyl Ketone (MIBK) and Dimethyl Sulfoxide (DMSO) is used, but it is not affected with only MIBK is used. When using a combined MIBK and DMSO solvent, the 1.25%w/v PVDF-TrFE material was easily mixed, and it possessed a higher piezoelectric electrical response to the MIBK solutions. The piezoelectrical coefficients were also calculated by applying a dynamic force to the cantilevers and found that q31 of cantilever coated with the PVDF formed using the mixture of DMSO and MIBK solution is higher than that formed using MIBK.

Conformations of borneol and isoborneol in the gas phase: Their monomers and microsolvation clusters.

Borneol is a natural monoterpene with significant applications in various industries, including medicine and perfumery. It presents several diastereomers with different physical and chemical properties, influenced by their unique structures and interactions with molecular receptors. However, a complete description of its inherent structure and solvent interactions remains elusive. Here, we report a detailed investigation of the gas-phase experimental structures of borneol and isoborneol, along with the description of their microsolvation complexes with the common solvents water and dimethyl sulfoxide. The molecules and complexes were studied using chirped-pulse Fourier transform microwave spectroscopy coupled to a supersonic expansion source. Although three rotamers are potentially populated under the conditions of the supersonic expansion, only one of them was observed for each monomer. The examination of the monohydrated complexes revealed structures stabilized by hydrogen bonds and non-covalent C-H⋯O interactions, with water as the hydrogen bond donor. Interestingly, in the clusters with dimethyl sulfoxide, borneol and isoborneol change their roles acting as donors. We further identified a higher-energy rotamer of the borneol monomer in one of the complexes with dimethyl sulfoxide, while that rotamer was missing in the experiment for the monomer. This observation is not common and highlights a specific position in borneol especially favorable for forming stable complexes, which could have implications in the understanding of the unique physical and chemical properties of the diastereomers.

Transformation of glucose to 5‐hydroxymethylfurfural with Al and Sn mixed‐metal metal–organic frameworks as catalyst

5‐hydroxymethylfurfural (5‐HMF) has been considered as an important biomass‐based platform chemical for its wide applications. Currently, the production of 5‐HMF from the catalytic dehydration of glucose is preferred, in which the Brønsted and Lewis acids in catalysts play an important role. Here, it was found that MIL‐53(Al) modified with tin was an active, selective, and reusable catalyst for the transformation of glucose to 5‐HMF in dimethyl sulfoxide (DMSO) solvent. Around 42.3% yield of 5‐HMF with 93% glucose conversion was achieved, when the prepared metal‐organic frameworks (MOFs) was used as the catalyst, showing superior catalytic performance compared with most of other MOFs. Moreover, the catalyst possessed inert catalytic properties in water with almost no any influence on the conversion of glucose, suggesting a compelling opportunity to act as a support material.

Fabrication of molecularly imprinted polymer‐based interdigital sensor for L‐ascorbic acid

The level of L‐ascorbic acid (AA) in various natural and artificial foods, medicines and other substances must be determined for biological and agricultural purposes. In this study, an AA‐imprinted poly (methacrylic acid)‐based receptor was synthesized by thermal free‐radical bulk polymerization for the detection of ascorbic acid using the methacrylic acid as monomer, ethylene glycol dimethacrylate (EGDMA) as cross‐linker, and azobisisobutyronitrile (AIBN) as initiator, in the presence of a porogenic solvent dimethyl sulfoxide (DMSO). The synthesized molecularly imprinted polymer (MIP) was used as a receptor. Immobilization of the receptor layer on IDEs provided a suitable sensor for AA detection by measuring changes in electrical parameters including inductance, capacitance, and resistance with the help of LCR meter. In the series and parallel inductance, the lowest detection limits were 0.13 and 0.001 ppm, respectively. While, for series and parallel capacitance, the lowest detection limits were 0.01548 and 1.3698 ppm, respectively. In the case of resistance, the lowest limit of detection was 0.0076 and 0.08121 ppm in series and parallel, respectively. The imprinted polymer‐based sensor showed sensitivity, selectivity, and reversibility for ascorbic acid.

Comparative analysis of isopropyl alcohol dehydration using ionic liquids and deep eutectic solvent

The current article deals with the separation of the azeotropic mixture of isopropyl alcohol (IPA) and water using an ionic liquid, 1-ethyl-3-methylimidazolium tetrafluoroborate ([EMIM][BF4]) and Deep Eutectic Solvents (DESs), Choline Chloride/glycerol (Glyceline) and Choline Chloride/Ethylene Glycol (Ethaline). Conventional dimethyl sulfoxide (DMSO) solvents are used to compare the results for IPA dehydration. Process modelling and simulation were carried out in the Aspen Plus simulator (v.8.6). The NRTL model was used to calculate the thermodynamic properties as well as the vapour-liquid equilibria of the ternary systems. The process parameters such as entrainer flow rate, binary feed stage, entrainer feed stage, column stages, reflux ratio, reboiler and condenser duties were evaluated using sensitivity analysis and design spec tools of the simulator. The industrial process for both systems, containing a separation column and a recovery column, was simulated at a steady state. Both processes were optimised using the optimisation tool of the simulator and compared based on the energy requirement. Further, based on the simulation results, we proposed an alternate process design for solvent recovery using a flash drum. The results show that more than 99.9 mol% IPA purity can be achieved using both ILs as well as DESs. The overall energy requirement for the separation of IPA-water mixture using [EMIM][BF4] entrainer in a conventional process was found to be lower than DMSO. The proposed alternate process further reduces the energy requirement compared to the conventional process for both IL and DESs systems.

Hydrogen-Bonded Complexes in Binary Mixture of Imidazolium-Based Ionic Liquids with Organic Solvents.

Though local structures in ionic liquids are dominated by strong Coulomb forces, directional hydrogen bonds can also influence the physicochemical properties of imidazolium-based ionic liquids. In particular, the C-2 position of the imidazolium cation is acidic and can bind with suitable hydrogen bond acceptor sites of molecular solvents dissolved in imidazolium-based ionic liquids. In this report, we identify hydrogen-bonded microenvironments of the model ionic liquid, 1-ethyl-3-methylimidazolium tris(pentafluoroethyl) trifluorophosphate, and the changes that occur when molecular solvents are dissolved in it by using a C-D infrared reporter at the C-2 position of the cation. Our linear and nonlinear infrared experiments, along with computational studies, indicate that the molecular solvent dimethyl sulfoxide can form strong hydrogen-bonded dimers with the cation of the ionic liquid at the C-2 position. In contrast, acetone, which is also a hydrogen bond acceptor similar to dimethyl sulfoxide, does not show evidence of cation-solvent hydrogen-bonded conformers at the C-2 position. The outcome of our study on a broad scale strengthens the importance of cation-solute interactions in ionic liquids.

Recycling of Cathode active materials from Spent Lithium-ion Batteries (LIBs): Effective Methodology for Environmental Remediation

In this work, three different solvents such as N, N-Dimethylformamide (DMF), N-Methyl-2-pyrrolidone (NMP) and Dimethyl sulfoxide (DMSO) were used to recycle cathode active materials (CAM) from spent lithium ion batteries (LIBs). Both calcination and solvent dissolution processes were used. The cathode active materials recycled from DMF, NMP and DMSO solvent dissolution process were named as CAM 1, CAM 2 and CAM 3, respectively. Initially, cathode electrode cut into small pieces and then baked at 600 °C for 7 h in tube furnace under argon environment. In the send step baked electrode transferred to solvent and then continue reflux reaction 24 h. In the final step the Al foils were separated from the solution and the cathode active material were collected by vacuum filtration and heat treatment. The structure and morphology of the cathode active materials were characterized by using XRD, Raman, SEM and TEM instruments. The SEM morphology shows that PVDF polymer and acetylene black removed from the cathode active materials by calcination and solvent dissolution process. EDAX and mapping shows that CAM 3 is more pure and uniform morphology than CAM 1 and CAM 2 cathode active materials. The elemental analysis shows that CAM 1, CAM 2 and CAM 3 are NMC 532 cathode powder with a chemical formula Li (Ni5Mn3Co2) O2. XRD results show that R3m layered structure with strong crystalline peaks for all three recycled cathode active materials. Raman analysis confirms the presence of metal oxide.

Dimethyl sulfoxide’s impact on epileptiform activity in a mouse model of chronic temporal lobe epilepsy

In the quest for novel treatments for patients with drug-resistant seizures, poor water solubility of potential drug candidates is a frequent obstacle. Literature indicated that the highly efficient solvent dimethyl sulfoxide (DMSO) may have a confounding influence in epilepsy research, reporting both pro- and antiepileptic effects. In this study, we aim to clarify the effects of DMSO on epileptiform activity in one of the most frequently studied models of chronic epilepsy, the intrahippocampal kainic acid (IHKA) mouse model, and in a model of acute seizures. We show that 100 % DMSO (in a volume of 1.5 µl/g corresponding to 1651 mg/kg) causes a significant short-term anti-seizure effect in epileptic IHKA mice of both sexes, but does not affect the threshold of acute seizures induced by pentylenetetrazol (PTZ). These findings highlight that the choice of solvent and appropriate vehicle control is crucial to minimize undesirable misleading effects and that drug candidates exclusively soluble in 100 % DMSO need to be modified for better solubility already at initial testing.

Quantum Chemical Investigation of the Interaction of Thalidomide Monomeric, Dimeric, Trimeric, and Tetrameric Forms with Guanine DNA Nucleotide Basis in DMSO and Water Solution: A Thermodynamic and NMR Spectroscopy Analysis.

Thalidomide (TLD) was used worldwide as a sedative, but it was revealed to cause teratogenicity when taken during early pregnancy. It has been stated that the (R) enantiomer of TLD has therapeutic effects, while the (S) form is teratogenic. Clinical studies, however, demonstrated the therapeutic efficacy of thalidomide in several intractable diseases, so TLD and its derivatives have played an important role in the development and therapy of anticancer drugs. Therefore, it is important to know the molecular mechanism of action of the TLD, although this is still not clear. In what molecular interactions are concerned, it is known that drug molecules can interact with DNA in different ways, for example, by intercalation between base pairs. Furthermore, the ability of the TLD to interact with DNA has been confirmed experimentally. In this work, we report a theoretical investigation of the interaction of the R and S enantiomers of TLD, in its monomeric, dimeric, trimeric, and tetrameric forms, with guanine (GUA) DNA nucleotide basis in solution using density functional theory (DFT). Our initial objective was to evaluate the interaction of TLD-R/S with GUA through thermodynamic and spectroscopic study in dimethyl sulfoxide (DMSO) solvent and an aqueous solution. Comparison of the experimental 1H nuclear magnetic resonance (NMR) spectrum in DMSO-d6 solution with calculated DFT-PCM-DMSO chemical shifts revealed that TLD can undergo molecular association in solution, and interaction of its dimeric form with a DNA base ((TLD)2-GUA and (TLD)2-2GUA, for example) through H-bond formation is likely to take place. Our results strongly indicated that we must consider the plausibility of the existence of TLD associations in solution when modeling the complexation of the TLD with biological targets. This is new information that may provide further insight into our understanding of drug binding to biological targets at the molecular level.

Computational modeling and simulation for endovascular embolization of cerebral arteriovenous malformations with liquid embolic agents

Endovascular embolization of arteriovenous malformations (AVMs) in the brain usually requires injecting liquid embolic agents (LEAs) to reduce blood flow through the malformation. In clinical procedures, the feeding artery into which the LEAs are injected, and the amount of LEAs needs to be carefully planned preoperatively. Computational fluid dynamics can simulate the injecting process of LEAs in nidus and evaluate the therapeutic effects of different procedures preoperatively. Applying a porous media model avoided the difficulties of geometric modeling of AVMs, and the complex vascular network structure within the nidus was reproduced. The multi-phase flow was applied to simulate the interaction between LEAs and blood. The viscosity of LEAs is determined by the concentration of its solute ethylene-vinyl alcohol copolymer (EVOH). The diffusion process of the solvent dimethyl sulfoxide (DMSO) was calculated by solving the species transport equation. The coagulation of LEAs was simulated by constructing the relationship between the concentration of EVOH and viscosity. The numerical simulation method of LEAs for injection and coagulation was tested on two patient-specific AVMs. The calculations predicted the flow direction of the LEAs in the nidus. The morphology of the injected LEAs could be well visualized by 3D rendering. Quantitative analysis was conducted, including flow rate changes at the feeding arteries and draining veins. The embolization process of AVMs with LEAs can be simulated by computational fluid dynamics (CFD) methods to show the therapeutic effects of different embolization procedure planning, the optimal treatment plan can be determined.

New separation process for elastane from polyester/elastane and polyamide/elastane textile waste

Elastane, also known as spandex, is a synthetic polymer fibre based on polyurethane, which increases the flexibility and comfort of textile products but causes profound challenges in textile waste recycling. Although the elastane problem is widely known, no process has been demonstrated that allows separation of elastane from other materials. In this study, a feasible and up-scalable elastane separation process based on a non-hazardous selective solvent is successfully realised. Six different organic solvents were chosen and investigated by Hansen solubility parameters and experiments were conducted on polyester/elastane and polyamide/elastane textile waste samples. The non-hazardous solvent dimethyl sulfoxide (DMSO) was determined the most favourable and runs circular within a three-step purification. Principle component analysis (PCA) of spectroscopic measurements (ATR-FTIR) revealed excellent results for the recovered polyester and polyamide. Differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM) on textile samples proved the success of the developed process.

Bypassing the non-perovskite yellow phase: Revealing and regulating the crystallization pathways for efficient all-inorganic perovskite solar cells

All-inorganic CsPbX3 perovskites have shown great potential in the photovoltaic community due to their excellent thermal stability and suitable bandgap for tandem applications. However, the formation of high-quality all-inorganic perovskite films remains a grand challenge, which requires delicate control over the high-temperature annealing process as the photo-inactive orthorhombic δ-phase is more stable than the photoactive perovskite phase at room temperature. This study revealed the formation of a black γ-phase at low temperature (LT-γ-phase), which is temporarily stabilized by the dimethyl sulfoxide (DMSO) solvent. It collapses to δ-phase when DMSO evaporates and restores to γ-phase at high temperature (HT-γ-phase). Remarkably, we found that an additional methylammonium chloride (MACl) treatment further stabilizes the LT-γ-phase, allowing a direct transition from LT-γ-phase to HT-γ-phase while bypassing the δ-phase, resulting in a uniform and pinhole-free film with reduced defects and released strain. An efficiency as high as 20.1 % was obtained and the device stability under illumination and humidity were both enhanced. This work demonstrates that understanding and control over the crystallization pathway are essential for developing high-performance and high-stability perovskite solar cells for real-life applications.

Effect of NMR solvent on 1,4-dinitrocyclohexane-2,3,5,6-tetranitrate structure

It is very difficult to characterize cyclohexane structures due to the presence of chair and boat conformers. These conformers are continuously converting into each other, and an intermediate form of them is observed. In this research, 1,4-dinitrocyclohexane-2,3,5,6-tetranitrate was synthesized and investigated for structural studies by 1H NMR in chloroform and dimethyl sulfoxide solvents. The very special structure of 1,4-dinitrocyclohexane-2,3,5,6-tetranitrate in the chair conformer was well observed in the chloroform solvent, and in this solvent, the chair conformer was observed without converting the two conformers. While in dimethyl sulfoxide solvent, no such special conformer was observed. This research showed that the choice of NMR solvent could affect the spatial structure of 1,4-dinitrocyclohexane-2,3,5,6-tetranitrate, and to observe the unique conformer of the chair, chloroform solvent is a suitable solvent.

Computational study: Synthesis, spectroscopic (UV–vis, IR, NMR), antibacterial, antifungal, antioxidant, molecular docking and ADME of new (E)-5-(1-(2-(4-(2,4-dichlorophenyl)thiazol-2-yl)hydrazineylidene)ethyl)-2,4-dimethylthiazole

In this paper, we describe the synthesis of a novel (E)-5-(1-(2-(4-(2,4-dichlorophenyl)thiazol-2-yl)hydrazineylidene)ethyl)-2,4-dimethylthiazole (DCPTHT) via multicomponent reaction between 1-(2,4-dimethylthiazol-5-yl)ethan-1-one, thiosemicarbazide and 2-bromo-1-(2,4-dichlorophenyl)ethan-1-one. The structure of DCPTHT was confirmed on the basis of FT-IR, 1HNMR and 13C NMR characterizations. The molecular structure of the novel thiazole derivative was examined using density functional theory (DFT) simulations at the B3LYP/6-311G (d,p) level of theory. Molecular simulations were made for total energy, HOMO and LUMO energy, and Mulliken atomic charges. In a dimethyl sulfoxide solvent, the electronic absorption spectra were acquired, and TD-DFT calculations were used to discuss the band assignments. By correlating the experimental and simulated spectra, NMR assignments and interpretations were also established. Remarkably, antibacterial and antifungal screening was used to examine the biological profile of DCPTHT. Antibacterial screening was performed against E. coli, B. subtilis, P. aeruginosa, and MRSA while the antifungal screening was performed against A. niger and C. albicans. It was found that the newly synthesized thiazole derivative demonstrated potent antifungal activity on the investigated fungal species. Molecular docking study against cytochrome P450 14α-sterol demethylase (CYP51) (PDB id: 5v5z). Furthermore, ADME predictions are also discussed. The molecular docking studies revealed mostly hydrophobic and van der Waals interactions with different amino acid residues.

Fabrication of cellulose-based polymer electrolyte membrane with green solvent DMSO via N-TIPS technique

Solid polymer electrolyte membrane for Li-ion battery was fabricated via N-TIPS technique. To substitute commercially available polyolefin-based separator with more sustainable source, cellulose-based membrane was employed as polymer matrix. Green solvent dimethylsulfoxide (DMSO) was used to replace conventional solvents. Impedance measurement using electrochemical impedance spectroscopy was performed to determine ionic conductivity of the solid polymer electrolyte membrane. Room temperature ionic conductivity of the membrane in CR2032 battery cell was 1.1×10−4 mS/cm, indicating good performance and feasibility for Li-ion battery application. This result is hundred times higher compared to cellulose-based membrane fabricated via similar route using conventional N-methyl pyrrolidone (NMP) solvent (1.38×10−6 S/cm). Further dielectric properties measurement using temperature variation in an enclosed chamber showed that the polymer electrolyte membrane obeys Arrhenius behaviour.

Effect of differences in solvent ethanol extract of dayak onion bulbs and incubation time of Propionibacterium acnes on the antibacterial activity test

Background: Acne (acne vulgaris) is still a major health problem. Treatment with antibiotics raises problems in the form of resistance, irritation, and immune hypersensitivity. Alternatives derived from natural ingredients are needed to avoid these problems, namely Dayak onions. Objective: To find out the activity of the ethanol extract of onion bulbs in inhibiting the growth of P. acnes based on the variation of the incubation time duration of the bacteria as well as the solvent. Method: Phytochemical screening tests looked for alkaloids, flavonoids, phenols, steroids, tannins, and saponins. Testing of the extract’s ability to inhibit bacteria was carried out with variations in the incubation times (24 and 48 hours) and solvents, namely Na-CMC and DMSO. The bacteria growth inhibition test employed the well-diffusion method, and the resulting data was analyzed using SPSS software. Results: Dayak onion extract contains alkaloids, saponins, flavonoids, and triterpenoids. Na-CMC solvent obtained the highest inhibition ability of Dayak onion extract at a concentration of 40% with an inhibition value of 10.12±1.840mm (24 hours), and 11.575±1.694 mm (48 hours) while DMSO solvent showed the highest inhibition at a concentration of 20% with inhibition values of 15.48±1.198 mm (24 hours) and 15.91±1.625 mm (48 hours). Interpretation of the results of the Wilcoxon test based on ranking showed a positive difference at 48 hours of incubation. Conclusion: The optimal incubation time of P. acnes was 48 hours with dimethyl sulfoxide (DMSO) as the best solvent.

Dual Salt Cation-Swing Process for Electrochemical CO2 Separation.

Electrochemical CO2 separations, which use electricity rather than thermal energy to reverse sorption of CO2 from concentrated point sources or air, are emerging as compelling alternatives to conventional approaches given their isothermal, ambient operating conditions, and ability to integrate with renewable energy inputs. Despite several electrochemical approaches proposed in previous studies, further explorations of new electrochemical CO2 separation methods are crucial to widen choices for different emissions sources. Herein, we report an electrochemical cation-swing process that is able to reversibly modulate the CO2 loading on liquid amine sorbents in dimethyl sulfoxide (DMSO) solvent. The process exploits a reversible carbamic acid-to-carbamate conversion reaction that is induced by changing the identity of Lewis acid cations (e.g. K+, Li+, Ca2+, Mg2+, and Zn2+) coordinated to the amine-CO2 adduct in the electrolyte. Using ethoxyethylamine (EEA) as a model amine, we present NMR-based speciation studies of carbamic acid-to-carbamate conversion as a function of amine/salt concentrations and cation identity. The reaction is further probed using gas-flow reaction microcalorimetry, revealing the energetic driving forces between cations and the amine-CO2 adduct that play a key role in the described re-speciation. A prototype electrochemical cell was further constructed comprising a Prussian white (PW) potassium (K+) intercalation cathode, zinc (Zn) foil anode, and EEA/DMSO electrolyte containing a dual KTFSI/Zn(TFSI)2 salt. A low CO2 separation energy of ∼22-39 kJ/mol CO2 (0.1-0.5 mA cm-2) was achieved with a practical CO2 loading delta of ∼0.15 mol CO2/mol amine. Further optimizations in electrolyte design and cell architectures toward continuous CO2 capture-release are expected to enhance rate performance while retaining favorable separation energies.

Crystal structure of the nucleoside 2'-de-oxy-guanosine dimethyl sulfoxide disolvate.

The title com-pound, C10H13N5O4·2C2H6OS, which is of inter-est with respect to its biological activity, at 183 K has ortho-rhom-bic (P212121) crystal symmetry. The structure displays a network of inter-molecular N-H⋯N, N-H⋯O and O-H⋯O hydrogen bonds. 2'-De-oxy-guanosine mol-ecules are linked to each other and to the two dimethyl sulfoxide solvent mol-ecules by hydrogen bonding.