AbstractA case is presented of long‐term survival with metastatic melanoma since 1954. Metastatic disease in the lower extremity has been controlled for 7 years following isolation perfusions with alkylating agents. A further metastasis in the left buttock was eradicated by internal iliac artery infusion with dimethyl triazeno imidazole carboxamide, the first reported use of this agent intra‐arterially.