This research originates from the challenges faced in the teaching of depth, systematization, and coherence in the current blended teaching mode, which is based on an innovatively constructed P-TMDRE blended teaching mode of the “E-commerce foundation course” in secondary vocational schools, which is belived to improve students’ grades, due to its emphasis of in-depth systemic learning. The sample uses the method of target sampling to select 17 experts; the course practice is aimed at 80 sophomores majoring in e-commerce, divided into 40 participants in the experimental group and 40 participants in the control group. Four rounds of expert review using the Delphi method: first round: brainstorming; second round: expert opinion review stage; third round: re-evaluation stage based on the previous round of evaluation opinions; fourth round: identify, resolve, and report Workable ideas. Through the pre-test and post-test of the quasi-experimental method, the student’s grades and deep system learning ability are tested, and the effectiveness of the P-TMDRE blended teaching mode is further confirmed. Using Delphi technology to build five modules of the P-TMDRE blended teaching mode of the “E-commerce foundation course” course. After the teaching application, the average post-test scores of the control group and the experimental group were 64.765 and 75.252, with a difference of 10.487 points, indicating that the learners’ academic performance has been significantly improved. On the motivation dimension of deep systems learning, the pre-test and post-test averages are 2.91 and 4.14. In terms of learning engagement, the mean values of the pre-test and post-test were 2.93 and 4.15. In terms of deep system learning strategies, the mean values of the pre-test and post-test of the learners in the experimental group were 2.96 and 4.17, indicating that the deep system learning ability of the learners has been significantly improved.