A fractal structure featuring symmetric/asymmetric airfoil fins is embedded within the smooth channels of the printed circuit heat exchanger (PCHE), significantly enhancing its heat transfer performance. In this study, a horizontally installed two-layer channel configuration is examined, with hot CO2 flowing through the upper channel and cold CO2 through the lower channel. Two distinct airfoil fin designs, namely NACA 0021 symmetric and NACA 4822 asymmetric, are tested for their channel reinforcement effect. The numerical analysis reveals that channels equipped with these fins exhibit substantially improved heat transfer compared to smooth channels. Notably, the comprehensive evaluation index for the asymmetric airfoil fin channel is enhanced by a factor ranging from 1.05 to 3.76. Moreover, despite a modest increase in pressure drop, indicated by a dimensionless friction factor of 0.67–1.31, the heat transfer performance remains superior. Crucially, optimal heat transfer does not rely solely on high fluid flow rates but instead demands an apt flow matching between the hot and cold fluid channels.