The current study was focused on identifying how interpersonal communication affects teamwork effectiveness and organizational commitment in nurses. The sample of (N = 150) nurses were recruited through purposive sampling technique from a public hospital of Lahore. To test the study assumptions, Socio- Communicative Orientation Scale (Richmond & McCroskey, 1990), Teamwork Effectiveness Self-Assessment Questionnaire (Sterling & Selesnick, 1988), and Organization Commitment Scale (Allen & Meyer, 1990) were used. Results showed that interpersonal communication was directly proportionate to teamwork effectiveness and all measures of organizational commitment. Whereas, team effectiveness was partially linked with dimensions of organizational commitment. Furthermore, findings showed that organizational commitment (affective commitment and normative commitment) was predicted by measures of interpersonal communication that is assertiveness and responsiveness. Interpersonal communication may play a leading role in developing organization commitment, therefore, efforts should be made to improve and enhance the interpersonal communication skills of nurses in Pakistan.