ABSTRACT Over the past four decades, the framework of the innovation system has undergone continuous refinement and concretization, establishing itself as an effective tool for analyzing institutional innovation. The Triple Helix framework provides a quantitative direction and dynamic perspective for studying the Regional Innovation System. Due to exchanges on the market, scholarly communication in knowledge production, and political discourse, scholars have proposed introducing additional dimensions to explain local-global knowledge flow [Leydesdorff, L. 2012. “The Triple Helix, Quadruple Helix, … , and an N-Tuple of Helices: Explanatory Models for Analyzing the Knowledge-Based Economy?” Journal of the Knowledge Economy 3 (1): 25–35. https://doi.org/10.1007/s13132-011-0049-4]. This study presents a cross-system framework between the Regional Innovation System and the National Innovation System based on an investigation of regional sociotechnical experiments conducted in Japan, which provides insights for extending the Triple Helix framework. Furthermore, we distinguish different patterns of knowledge flow and highlight the potential hubs played by the universities, multinational enterprises, and local governments, offering practical guidance for facilitating cross-system knowledge flow.
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