The detection and evaluation of gait kinematics is vital for patient diagnosis and rehabilitation. Aiming at limitations of commonly used optical capture and wearable sensing systems in clinical applications, this paper proposes a thigh attitude angle prediction method based on the hip error tolerance from the kinematic data of two shank-mounted IMUs (Inertial Measurement Unit). The novelties of the proposed method are summarized as follows: i) It develops a parallel approach to regress variation of hip error tolerance for different subjects. This parallel approach, by simultaneously deconstructing the shank kinematics data via different regression algorithm including support vector machine, boosting tree, and stepwise linearity regression, is able to well accommodate the characteristics of both health subjects and patients. ii) It develops some evaluation indices based on gait symmetry, consistency, and activity to fully evaluate the human lower limbs motion performance in gait by only two IMUs. The effectiveness of the proposed method is verified by the experimental results among 8 healthy subjects and 16 cerebral infarction patients. For the healthy subjects, the estimated error of thigh prediction compared with Xsens and Vicon are <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$3.3 \pm {0.3^ \circ }$</tex-math> </inline-formula> and <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$3.5 \pm {0.7^ \circ }$</tex-math> </inline-formula> , respectively. For the patients, the estimated error compared with Xsens-measured angle is <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$4.8 \pm {1.7^ \circ }$</tex-math> </inline-formula> . Its broad significance in actual intelligent healthcare and robotics-assisted rehabilitation is three-fold: First, it is a recursive real-time method as it only needs data from the previous gait cycle to predict the thigh angle. Second, its accuracy meets the actual clinical needs. Third, it is a low-cost method that only needs two IMUs and has high potentials of clinical applications. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Note to Practitioners</i> —Gait is of great significance to quantify the degree of movement disorders in clinical practice, and the existing equipment is rarely able to meet the needs of full dimension, low cost, and low place constraints in clinical practice. This paper presents an innovative gait kinematic prediction method, which only uses two IMUs attached to the shanks to predict the orientation of thigh. Compared with related works, the proposed methods have achieved high-precision, real-time and low-cost acquisition. This paper is inspired by the problems of large number, high motion interference, and high cost of wearable gait measurement devices in clinical practice. The proposed method have potential to be integrated into exoskeletons and medical walking AIDS, which could greatly improve the comfort and control precision of the wearable system.