Digoxin-like Immunoreactivity Research Articles

Digoxin-like immunoreactivity in the serum of neonates and uremic patients, as measured in the Abbott TDX.

Journal Article Digoxin-like immunoreactivity in the serum of neonates and uremic patients, as measured in the Abbott TDX. Get access R W Yatscoff, R W Yatscoff Search for other works by this author on: Oxford Academic Google Scholar P R Desjardins, P R Desjardins Search for other works by this author on: Oxford Academic Google Scholar J G Dalton J G Dalton Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 30, Issue 4, 1 April 1984, Page 588, https://doi.org/10.1093/clinchem/30.4.588 Published: 01 April 1984

Digoxin-like immunoreactivity in normal human plasma and urine, as detected by a solid-phase radioimmunoassay.

Reports on the presence of digoxin-like immunoreactive substance(s) (DLIS) in the plasma and urine of several animal species and a few human test subjects prompted us to undertake to confirm the presence of DLIS in plasma and urine of normal persons and to investigate some characteristics of this antibody-DLIS binding. For this purpose we used a modified radioimmunoassay kit involving antidigoxin antibody-coated test tubes and 125I-labeled digoxin to measure DLIS in urine and concentrated plasma of ostensibly healthy subjects. In 12 separate experiments with plasma the mean sensitivity was 5.12 (SD 1.11) pg per tube, expressed as digoxin. There was no significant cross reactivity with human serum albumin in concentrations up to 200 g/L. The mean DLIS value (in digoxin equivalents) for plasma from 24 normal subjects was 33.58 (SD 14.24) ng/L. Its mean concentration in urine from five subjects was 315.00 (SD 91.38) ng/L.

Digoxin-like immunoreactivity of a circulating (Na+ + K+)ATPase inhibitor (reply)

Digoxin-like immunoreactivity of a circulating (Na+ + K+)ATPase inhibitor (reply)

Digoxin-like immunoreactivity in premature and full term infants not receiving digoxin: M. Pudek, D. Seccombe, M. Whitfield, G. Taylor and B. Jacobson. Division of Clinical Chemistry, Vancouver General, V5Z 1M9, Department of Pathology, University of British Columbia and Department of Pediatrics, University of British Columbia

Digoxin-like immunoreactivity in premature and full term infants not receiving digoxin: M. Pudek, D. Seccombe, M. Whitfield, G. Taylor and B. Jacobson. Division of Clinical Chemistry, Vancouver General, V5Z 1M9, Department of Pathology, University of British Columbia and Department of Pediatrics, University of British Columbia

Reflections on what makes the heart grow.

Under conditions of experimental cardiac overload and hypertrophy in rats, a digoxinlike immunoreactivity appears in their serum which is correlated with cardiac growth. It is hypothesized that this is caused by the presence of an endogenous cardiotropic factor displaying cross immunoreactivity with digoxin. Additional evidence of the existence of the putative cardiotropic factor is provided by the finding that the sera of rats with cardiac overload displaying digoxinlike immunoreactivity stimulate the multiplication of rat cardiac myocytes in the tissue culture. This factor may be an adrenal steroid different from corticosterone and aldosterone. The name endocardin or endocardiotonin for this substance is suggested.

Digoxin-like immunoreactivity in the serum of rats with cardiac overload

Digoxin-like immunoreactivity in the serum of rats with cardiac overload