<h3>Purpose</h3> To commission for HDR brachytherapy a Varian CT/MR compatible universal endometrial applicator set used to treat inoperable endometrial cancer (i.e., vagina, cervix, paracervical area, endometrium, uterus, and ovaries), and to develop all necessary documents and procedures for clinical implementation. The kit contains a straight central tandem, Left/Right tandems (20 deg. angle, 60, 70, and 80 mm length), clamping unit, and a vaginal cylinder with lever. <h3>Materials and Methods</h3> The tests performed for commissioning and clinical implementation are described in the following. <i>Functionality tests</i>: All kit components were checked for structural integrity. The applicator was assembled using the information received from the manufacturer. A GYN source guide tube (SGT) was connected to each tandem and the total length was checked using the gauge wire. GYN dummy wires were placed inside tandems and digital radiographic images (kVp 85, mA 80, ms 200, small focal spot, no buildup) were acquired to check the pathway and assess for any obstruction. <i>Autoradiographs</i>: A piece of XR-SP2 GafChromic film was placed on the conventional simulator couch, then the seven tandems were placed over the film, with a 2-cm solid water slab used as buildup. Tandems were connected via GYN SGTs to the HDR unit and a test plan was delivered with 9 dwell positions/channel, 0.8 sec/position, starting at 129.5 cm distally, with a 1-cm step size. GYN dummy wires were then placed inside tandems and the film was exposed twice with 135 kV, 80 mA, 400 mAs. Alternation of source positions and dummy dots displayed on the film was assessed. <i>Clinical implementation tests</i>: The applicator was assembled and placed in a small water-filled container and CT-scanned with GYN dummy wires inserted in each tandem. Sagittal/Coronal T2 and Axial MDIXON MR images were acquired for the applicator (without dummy wires) using a 1.5 T scanner. The CT and MR images were imported to Eclipse and rigidly registered, matching the tandems and cylinder. The device can be clinically used with two or three tandems. Test plans were generated for all clinical scenarios. Radiation Oncologists provided information regarding planning goals and fractionation regimen (number of fractions/number of implants, Rx dose). The physics team generated all necessary documents and procedures for clinical implementation. <h3>Results</h3> All set components were found to be functional with no obstruction. Their length was within 1 mm from nominal. Autoradiographs showed that source positions were within 1 mm from designed locations. To simulate a clinical scenario, a CTV was contoured to cover "cervical area" (above cylinder), entire "uterus" (up to the tip of the tandems), and a portion of the "upper vagina" (a portion of the cylinder). The tandems were manually digitized, paying attention to their curvature on sagittal and coronal images. The applicator was also loaded from the library of applicators to assess if that approach is more efficient than manual digitization. We found that Left and Right tandems loaded from the library are reversed (Varian was notified). An HDR plan was generated, assuming 500 cGy/fraction. The three tandems were loaded with sources inside the CTV and the plan was 3D optimized to cover the CTV with D90>90%. The process was repeated for combinations of two tandems. Treatment and Plan checklists, a BED Cumulative form, and a Planning Note document were developed, to be evaluated and refined after the first clinical case. A live demo with a manufacturer representative was organized to discuss the applicator assembly/disassembly in the OR setting. Sterilization procedures were developed based on the manufacturer's instructions. An in-service was organized for therapists/nurses, and pre-treatment huddles will be incorporated into the process for the first several cases. <h3>Conclusions</h3> The applicator set was validated and procedural documents are ready for clinical use. Coronal MRI series proved to be essential for the CT-MR registration process and tandem digitization. Via dose shaping, the dose distribution can be fine-tuned and adjusted to cover a longer portion of the upper vagina if needed. Also, a differential prescription may be used, as needed, for the uterus and upper vagina. The ability to rotate and shift the tandems allows adaptation to patient anatomy. An annual QA procedure was developed, including the tests performed for commissioning. A 3D printed holder with a 2-cm buildup was designed to ensure consistency in the autoradiographs.