Sericulture, the cultivation of silkworms for silk production, has a long and significant history, particularly in rural economies. In recent years, the industry has undergone transformative innovations that have enhanced efficiency, sustainability, and silk quality. This review explores key advancements in sericulture, focusing on technological innovations, genetic improvements, sustainable farming practices, and the role of biotechnology in reshaping the industry. Notable technological developments, such as automated silk reeling machines and climate-controlled rearing houses, have streamlined production, reducing labor demands while ensuring consistent silk quality. Additionally, digital monitoring systems now allow for real-time tracking of silkworm health and environmental conditions, empowering farmers with data-driven insights for better management. Genetic advancements, including selective breeding and genetic engineering, have led to high-yield, disease-resistant silkworm strains, significantly boosting silk output and quality. Moreover, innovations in producing naturally colored silk via genetic modification have minimized the need for chemical dyes, reducing the environmental footprint of the dyeing process. Sustainability has become a focal point, with organic farming methods, integrated pest management (IPM), and waste recycling practices becoming more widespread. These practices not only safeguard the environment but also enhance the economic viability of sericulture, benefiting rural communities and driving social development. Biotechnology has expanded the horizon of sericulture, enabling the engineering of silk proteins and the creation of transgenic silkworms for specialized medical and industrial applications. Overall, these advancements have transformed sericulture into a more efficient, sustainable, and economically viable industry, offering significant benefits to both global silk markets and rural livelihoods.