A novel strain energy-based method for analyzing fatigue crack growth (FCG) in pseudoelastic Nickel-Titanium (NiTi) -based shape memory alloys (SMAs) is proposed. It uses the dissipated energy to predict the FCG. This parameter can be computed either by volume integration of near-crack-tip strain energy or by the force–displacement hysteresis measured at the loading pins of the sample. Eccentrically-loaded single Edge Crack tension samples (ESE(T)) were used for FCG tests. High resolution Digital Image Correlation (DIC) was used to capture near-crack-tip displacement and strain fields. DIC data were also used to estimate the effective stress intensity range by regressing the William’s expansion series. Furthermore, a constitutive model for SMAs was used for FE simulations of ESE(T) samples, and the evolution of the dissipated energy during FCG tests was computed. Experimental FCG rate, plotted against the cyclic dissipated energy, are well fitted by a power law equation (R2 = 0.99). This result would open new perspectives to develop predictive models for FCG in SMAs considering intricate thermomechanical coupling mechanisms and material non-linearities.