Event Abstract Back to Event Event Related Oscillatory Activity in Euthymic and Manic Phases of Bipolar Disorder Aysegul Ozerdem1, 2, 3*, B. Güntekin4, Z. Tunca1 and Erol Basar4 1 Dokuz Eylül University Medical School, Department of Psychiatry, Turkey 2 Dokuz Eylül University Health Sciences Institute, Department of Neurosciences, Turkey 3 Dokuz Eylül University, Turkey 4 İstanbul Kültür University, Turkey Objectives: We aimed to detect oscillatory responses and effect of valproate, a mood stabilizer with GABA/Glutamate modulating and neuroprotective effect on the oscillatory activity in patients with bipolar disorder. Methods: Twenty medication free, manic (n=10) or euthymic (n=10) bipolar patients and 20 sex and age matched healthy controls were enrolled in the study. In the patient group, event related potentials (ERPs) to target stimuli in visual odd-ball paradigm was measured before and after six weeks of valproate monotherapy. Same measurement was done twice with six week difference in the healthy controls. Different frequency band responses were obtained by digital filtration of ERPs. Repeated measures and one-way ANOVA, Wilcoxon and Mann Whitney U tests were used. Results: Manic patients showed significantly higher baseline occipital beta (18-30 Hz) (p: 0.014) response than healthy controls and did not have the occipito-frontal alpha (8-13 Hz) dominance presented by the control group. Occipital beta response reduced significantly (p: 0.009) and became similar to controls after treatment. Post-treatment alpha responses were significantly lower than baseline in anterior temporal (p: 0.038) and occipital (p: 0.027) locations. Healthy controls displayed a significantly increased frontal alpha response at the second assessment but the patients did not. Euthymic patients showed significantly higher baseline delta response compared to healthy controls in the left frontal location (p: =0.03). After valproate, delta responses in Fz (p: 0.04) F3 (p: 0.03), and temporal T3 (p: 0.02), T4 (p: 0.01), T5 (p: 0.01) channels decreased compared to baseline Conclusions: Bipolar patients show different patterns of disturbed oscillatory activity at different phases of the illness on which valproate seems to have a selectively corrective effect. This may be through modulation of GABA/glutamate and indicative of medication's neuroprotective effect. Conference: 10th International Conference on Cognitive Neuroscience, Bodrum, Turkey, 1 Sep - 5 Sep, 2008. Presentation Type: Oral Presentation Topic: Symposium 9: Cognitive electrophysiology in neuropsychriatric disorders Citation: Ozerdem A, Güntekin B, Tunca Z and Basar E (2008). Event Related Oscillatory Activity in Euthymic and Manic Phases of Bipolar Disorder. Conference Abstract: 10th International Conference on Cognitive Neuroscience. doi: 10.3389/conf.neuro.09.2009.01.042 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Nov 2008; Published Online: 27 Nov 2008. * Correspondence: Aysegul Ozerdem, Dokuz Eylül University Medical School, Department of Psychiatry, Izmir, Turkey, aysegul.ozerdem@deu.edu.tr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Aysegul Ozerdem B. Güntekin Z. Tunca Erol Basar Google Aysegul Ozerdem B. Güntekin Z. Tunca Erol Basar Google Scholar Aysegul Ozerdem B. Güntekin Z. Tunca Erol Basar PubMed Aysegul Ozerdem B. Güntekin Z. Tunca Erol Basar Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.