Introduction: currently, the consumption of addictive substances is closely related to digestive, psychiatric, neurological and infectious pathologies, as well as to various types of cancer, cardiovascular diseases and family problems. Objective: to characterize the influence of health interventions in the management and prevention of substance abuse in young students during the last 10 years. Method: the systematic literature review was conducted following the guidelines of the PRISMA 2020 statement. In addition, the PICOT structure was used to formulate the research question. MEDLINE, IBECS, LILACS, CUMED, WILEY, ScienceDirect, Emerald Insigh and EBSCO Host databases were searched. DeCS and MeSH descriptors were used, in Spanish, English and Portuguese with AND, OR and NOT operators. Eligibility criteria: experimental and quasi-experimental studies published between 2013 and 2023.Results: 140 research studies were identified based on the inclusion criteria, of which, based on the screening, 21 were eliminated for duplication, 52 for title, 44 for abstract reading and 20 for full-text reading, leaving three articles for analysis. Conclusions: the present systematic literature review made it possible to identify, evaluate, analyze and synthesize the available scientific evidence with methodology of interventions in the Latin American and Caribbean context that can serve as references for updating and new generation of knowledge