ABSTRACT Valuable information about the neutron star (NS) interior can be obtained by comparing observations of thermal radiation from a cooling NS crust with theoretical models. Nuclear burning of lighter elements that diffuse to deeper layers of the envelope can alter the relation between surface and interior temperatures and can change the chemical composition over time. We calculate new temperature relations and consider two effects of diffusive nuclear burning (DNB) for H–C envelopes. First, we consider the effect of a changing envelope composition and find that hydrogen is consumed on short time-scales and our temperature evolution simulations correspond to those of a hydrogen-poor envelope within ∼100 d. The transition from a hydrogen-rich to a hydrogen-poor envelope is potentially observable in accreting NS systems as an additional initial decline in surface temperature at early times after the outburst. Second, we find that DNB can produce a non-negligible heat flux, such that the total luminosity can be dominated by DNB in the envelope rather than heat from the deep interior. However, without continual accretion, heating by DNB in H–C envelopes is only relevant for <1–80 d after the end of an accretion outburst, as the amount of light elements is rapidly depleted. Comparison to crust cooling data shows that DNB does not remove the need for an additional shallow heating source. We conclude that solving the time-dependent equations of the burning region in the envelope self-consistently in thermal evolution models instead of using static temperature relations would be valuable in future cooling studies.