Event Abstract Back to Event Fronto-striatal involvement in strategic adjustments of response caution: A combined DWI and ERP study Elise Mansfield1, Birte Forstmann2, Andrew Heathcote1 and Frini Karayanidis1* 1 University of Newcastle, School of Psychology, Australia 2 University of Amsterdam, Cognitive Science Center Amsterdam, Netherlands Recent evidence suggests that cortico-basal ganglia networks underpin the ability to flexibly adjust response threshold (an index of response caution) on a trial-by-trial basis depending on changing environmental demands. We used a task switching paradigm and combined evidence from diffusion weighted imaging (DWI) and event-related potentials (ERPs) to build on current neural models of response threshold adjustment. Firstly, we examined whether structural differences in cortico-basal ganglia networks were responsible for individuals’ tendency to adopt an overall lower (more risky) or higher (more cautious) threshold setting. We also examined whether structural integrity within these networks could explain trial-by-trial proactive adjustment of response threshold. Separate fronto-striatal networks were associated with adopting an overall more risky or more cautious response threshold. Taking a riskier approach was associated with increased white matter integrity in a network comprising the pre-supplementary motor area and the external capsule, while adopting a more cautious strategy was associated with increased integrity in a network comprising the inferior frontal gyrus and anterior limb of the internal capsule. In addition, structural integrity in the two striatal regions accounted for the relationship between a cue-locked ERP component and response threshold. These findings suggest that the striatum is instrumental in mediating both overall and trial-by-trial setting of response caution. Keywords: cognitive control, event-related potential (ERP), diffusion weighted imaging (DWI), response threshold, frontostriatal circuitry Conference: ACNS-2012 Australasian Cognitive Neuroscience Conference, Brisbane, Australia, 29 Nov - 2 Dec, 2012. Presentation Type: Oral Presentation Topic: Executive Processes Citation: Mansfield E, Forstmann B, Heathcote A and Karayanidis F (2012). Fronto-striatal involvement in strategic adjustments of response caution: A combined DWI and ERP study. Conference Abstract: ACNS-2012 Australasian Cognitive Neuroscience Conference. doi: 10.3389/conf.fnhum.2012.208.00064 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 25 Oct 2012; Published Online: 07 Nov 2012. * Correspondence: Prof. Frini Karayanidis, University of Newcastle, School of Psychology, Newcastle, NSW 2308, Australia, frini.karayanidis@newcastle.edu.au Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Elise Mansfield Birte Forstmann Andrew Heathcote Frini Karayanidis Google Elise Mansfield Birte Forstmann Andrew Heathcote Frini Karayanidis Google Scholar Elise Mansfield Birte Forstmann Andrew Heathcote Frini Karayanidis PubMed Elise Mansfield Birte Forstmann Andrew Heathcote Frini Karayanidis Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.