Diffuse Small B-cell Lymphoma Research Articles

Diffuse Small B-Cell Lymphoma: A High-Grade Malignancy.

The most common subtype of lymphoma in the dog is diffuse large B-cell lymphoma (DLBCL). The remaining forms of B-cell lymphoma in dogs are categorized as small-to-intermediate in size and include marginal zone, follicular, mantle cell, and small-cell lymphocytic lymphoma. Marginal zone lymphoma and follicular lymphoma have readily identifiable unique histologic features while other forms of small B-cell lymphoma in the dog are poorly described by histopathology. Forty-seven cases of nodal small B-cell lymphoma identified by flow cytometry (small cell size based on forward scatter) with concurrent histopathology were reviewed. These cases fell into 3 histologic subtypes: marginal zone lymphoma, follicular lymphoma, and a diffuse form of small B-cell lymphoma with consistent features. As a descriptive term, we refer to the latter subtype as diffuse small B-cell lymphoma (DSBCL) until it can be further characterized by gene expression profiling and other molecular tools. Clinical presentation of DSBCL was compared to cases of histologically confirmed DLBCL and clinical follow-up was obtained for 22 of the 27 cases of DSBCL. This subset of diffuse small B-cell lymphoma had an overall median survival of 140 days. The expression of CD21, class II MHC and CD25 by flow cytometry did not differ between DSBCL and the other histologic subtypes of small cell B-cell lymphoma making histopathology the only current method of classification.

Triple Haplotypes of the TP53 Gene in Patients with Diffuse Small B-Cell Lymphoma

The role of genetic susceptibility to the development of lymphoma is confirmed by the accumulating data on common genetic variants of the genes involved in lymphomogenesis. The varieties of disease variants, as well as the small effect of each of the polymorphisms, require the analysis of these markers in individual histological lymphoma subtypes in haplotype groups. This study was carried out to analyze the frequencies of rs1042522, rs1625895, and rs17878362, their triple haplotypes, and linkage disequilibrium in patients with diffuse small B-cell lymphoma and a control group. The absence of pronounced linkage disequilibrium between the rs17878362, rs1042522, and rs1625895 markers of the TP53 gene in the population control sample was revealed. At the same time, data on significant linkage disequilibrium between rs1625895 and rs1042522, as well as rs1625895 and rs17878362, and on moderate linkage disequilibrium between rs17878362 and rs1042522 in the group of patients with lymphoma were obtained. An association of the haplotype wArgG in the homozygous state with a predisposition to the development of diffuse small B-cell lymphoma was found.

Non-Hodgkin’s Lymphoma of the Breast: Report of Five Cases and Review of the Literature

SUMMARY Non-Hodgkin's lymphoma (NHL) of the breast can be either primary or secondary. Both are rare diseases accounting less than 0.6% of all breast malignancies. In this study we report our experience with five cases of breast lymphoma, 3 of them being primary and 2 of them being secondary breast lymphoma, retrospectively. All patients were female with a median age of 47 years and presen- ted with breast masses (3 in the right breast and 2 in the left). The histologic subtype showed broad spectrum, one patient had pe- ripheral T-cell lymphoma and 4 patients had B-cell lymphomas; 2 were diffuse large B-cell lymphomas, 1 was a diffuse small B-cell lymphoma, and the last patient was a marginal zone lymphoma. Partial mastectomy was performed in 2 patients to carry out diag- nosis. Anthracycline-based chemotherapy regimens were employed in 4 patients. Radiotherapy was added to other treatment mo- dalities in 3 cases. At a median follow-up of 5 years, all patients were alive other than one who had been diagnosed with periphe- ral T-cell lymphoma just after pregnancy and showed resistance to the applied treatment. The treatment and the prognosis of bre- ast lymphomas were not different from the currently indicated for nodal NHL with the same stage and histological subtype.