An analytical model is developed to investigate the sound transmission loss from orthogonally rib-stiffened plate structure under diffuse acoustic field excitation. The validity and feasibility of the model are verified by comparing the present theoretical predictions with the numerical results published previously. The influences of structure geometrical parameters on sound transmission loss are subsequently presented. The optimization algorithm is used to search for the optimal structural parameters with the objective to maximize the sound transmission loss over a frequency band. Furthermore, the sensitivity of structural parameters on the overall vibration and acoustic performance of the stiffened plates structure is also analyzed.