This article analyses the salience of and governmental positions on differentiated integration (DI) in Portugal in the 2004-2020 period. Employing quantitative and qualitative analyses, it first examines the salience and position of the successive Portuguese governments towards DI using documents such as government programmes, Prime-Ministerial speeches, parliamentary debates, and statements by the Prime Minister in European Council meetings. The results from the salience analysis demonstrate a low saliency of DI. Salience was enhanced by an increasing intersection between domestic and European politics during the euro crisis period, politicising the debate especially around DI instances of an economic nature. The position of Portuguese governments regarding DI during the period analysed was overwhelmingly negative. A wide consensus stood out among Portuguese political parties that DI models clearly go against both the European – by risking a disaggregation of the EU – and the national interest – by possibly pushing Portugal into an even more peripheral position.