Using an artificial neural network and the Bayesian Regularization Technique (NNs-BRT), the stochastic method’s strength is used to analyze the differential system, illustrating a nonlinear smoke epidemic differential model (NSED). This allows for a more precise, dependable, cost-effective, dynamic calculating approach. In addition to experiments utilizing nonlinear mathematical structures through five distinct classes of differential operators-smokers contemplating quitting, infrequent smokers, regular smokers, those who have temporarily abstained from smoking, and those who have permanently quit smoking the NSED framework has been established. By allocating 25% of the data for testing and validation and 75% for training, the proposed NNs-BRT can determine the estimated solutions of five different examples based on the numerical computation of the NSED system employing Adams techniques. To prove the accuracy of the given NNs-BRTs, a comparison of the results from the dataset obtained using the Adam method for different scenarios reflecting variance in recruitment rate, effective contact rate between C and A, natural death rate, how quickly occasional smokers become regular smokers, contact rate between smokers, and temporary quitters, number of smokers quitting, and percentage of smokers who are still leaving for good is made. The use of error histograms, mean square error, regression, correlation, and state transitions is also examined in numerical replications of the NNs-BRTs to verify their competence, dependability, accuracy, consistency, and proficiency.