Differential Diagnosis Of Soft Tissue Tumors Research Articles

A Malignant Solitary Fibrous Tumor of the Parotid Gland: A Case Report

A Solitary Fibrous Tumor (SFT) is a soft tissue tumor that appears exceedingly rare in the parotid gland. The literature review suggested that approximately 12%-22% of these cases behave aggressively. Besides, only 4 cases of histological malignant parotid gland SFT are reported in the English literature. We presented a 65-year-old cigarette-smoker man with a fix and tender mass over the left parotid and submandibular areas. On physical examination, the marginal branch of the facial nerve was paralyzed. The left total parotidectomy and neck dissection levels 1 and 2 were performed with preoperative embolization procedure and adjuvant radiotherapy for the patient. The results of the follow-up examination were unremarkable after 11 months. In this case report, we aimed to increase awareness on SFTs, although rare, among clinicians and pathologists. Accordingly, it should be considered in the differential diagnosis of soft-tissue tumors in the major salivary glands for better management.

A rare case report of orbital malignant solitary fibrous tumor

A rare case report of orbital malignant solitary fibrous tumor - IJCEO- Print ISSN No: - 2395-1443 Online ISSN No:- 2395-1451 Article DOI No:- 10.18231/j.ijceo.2019.135, Indian Journal of Clinical and Experimental Ophthalmology-Indian J Clin Exp Ophthalmol

Apparent diffusion coefficient measurements with diffusion-weighted imaging for differential diagnosis of soft-tissue tumor.

To evaluate the diagnostic potential of apparent diffusion coefficient (ADC) values of diffusion-weighted imaging (DWI) in distinguishing malignant and benign soft-tissue tumors. Published studies were retrieved through comprehensive search in various computerized databases. High-quality studies relevant to ADC values of DWI in differential diagnosis of soft-tissue tumors were screened using our stringent inclusion and exclusion criteria for this meta-analysis. The standard mean difference with 95% confidence interval (95% CI) was estimated. Statistical analyses were performed using the STATA statistical software (Stata Co., College Station, TX, USA). Thirteen cohort studies were finally included, and these studies provided the required information on the diagnostic value of diffusion magnetic resonance imaging in soft-tissue tumors. The 13 studies contained a combined total of 344 malignant soft tumors and 315 benign soft tumors. The results of our meta-analysis revealed that mean ADC value in patients with malignant soft-tissue tumor decreased significantly in comparison with the ADC values obtained in patients with benign soft-tissue tumor (P < 0.001). Country-stratified analysis suggested that ADC value might play a predictive role in the differential diagnosis of soft-tissue tumors in China (P = 0.007), Egypt (P < 0.001), Germany (P = 0.001), Japan (P = 0.049), and The Netherlands (P < 0.001). Our results provide strong evidence that patients diagnosed with malignant soft-tissue tumors have low ADC values of DWI compared to those with benign soft-tissue tumors. Therefore, ADC measurements with DWI may be reliable in differential diagnosis of soft-tissue tumors.

Solitary fibrous tumor of the submandibular region

Solitary fibrous tumors (SFTs) are a rare type of neoplasm that originate from the pleura. Although SFTs may occur in a variety of extrathoracic regions, they are considered to be rare in the submandibular region. The current study presents the case of a 39-year-old female with a 3×4-cm, fibro-elastic, movable, painless nodule in the right side of the submandibular region. The patient exhibited no other clinical manifestations in the head and neck region. A computed tomography scan demonstrated the presence of a well-defined, slightly low-density nodular shadow measuring 2.6×3.3×3.8 cm, in proximity to the right submandibular gland, with mild contrast enhancement and no association with the adjacent lymph nodes. The lesion was surgically excised, and following histopathological and immunohistochemical analysis, immunohistochemical staining determined that the lesion was positive for cluster of differentiation (CD)34, CD99 and vimentin, and negative for desmin, CD31 and S-100; therefore, a diagnosis of an SFT was determined. The patient has so far been followed up for 22 months, with no signs of recurrence or metastases. The present study also discusses the clinical, histopathological and immunohistochemical features, treatment strategies and potential clinical outcomes of SFTs. The study proposes that, although rare, SFTs of the submandibular region should be included in the differential diagnosis of soft-tissue tumors in the submandibular region.

Application of diffusion-weighted imaging for the differential diagnosis of soft-tissue tumors

Objective To explore the potential value of diffusion weighted imaging(DWI) in the clinical diagnosis of soft-tissue tumors.Methods Diffusion-weighted MRI was performed in 48 histologically proven soft-tissue tumor cases using diffusion-weighted spin-echo sequences.Of the 48 soft-tissue tumor cases,there were 28 cases of sarcoma and 20 cases of benign tumor.The apparent diffusion coefficient(ADC) values of a large region with no necrosis,scar tissue,hemorrhage or calcification representing the lesion were measured.ADC values of benign tumors,malignant tumors and normal muscles were compared.Results The ADC value of the malignant tumors (0.95 ± 0.31 )× 10-3mm2/s was significantly lower than that of benign lesions( 1.87 ±0.66) × 10-3mm2/s and muscles( 1.62 ±0.50) × 10 -3mm2/s.There was no significant difference in ADC value between benign lesions and muscles.Sensitivity(75％ ) and specificity(89％ ) were obtained when the ADC value was 1.38 × 10-3mm2/s in the differentiation of benign and malignant tumors.Conclusion Diffusion-weighted MRI had potential value in differentiating benign softtissue tumors from malignant ones. Key words: Magnetic resonance imaging diffusion; Soft tissue neoplasms

Soft-tissue Tumor Differentiation Using 3D Power Doppler Ultrasonography With Echo-contrast Medium Injection

We aimed to evaluate the ability of 3-dimensional power Doppler ultrasonography to differentiate soft-tissue masses from blood flow and vascularization with contrast medium. Twenty-five patients (mean age, 44.1 years; range, 12-77 years) with a palpable mass were enrolled in this study. Volume data were acquired using linear and convex 3-dimensional probes and contrast medium injected manually by bolus. Data were stored and traced slice by slice for 12 slices. All patients were scanned by the same senior sonologist. The vascular index (VI), flow index (FI), and vascular-flow index (VFI) were automatically calculated after the tumor was completely traced. All tumors were later confirmed by pathology. The study included 8 benign (mean, 36.5 mL; range, 2.4-124 mL) and 17 malignant (mean, 319.4 mL; range, 9.9-1,179.6 mL) tumors. Before contrast medium injection, mean VI, FI and VFI were, respectively, 3.22, 32.26 and 1.07 in benign tumors, and 1.97, 29.33 and 0.67 in malignant tumors. After contrast medium injection, they were, respectively, 20.85, 37.33 and 8.52 in benign tumors, and 40.12, 41.21 and 17.77 in malignant tumors. The mean differences between with and without contrast injection for VI, FI and VFI were, respectively, 17.63, 5.07 and 7.45 in benign tumors, and 38.15, 11.88 and 16.55 in malignant tumors. Tumor volume, VI, FI and VFI were not significantly different between benign and malignant tumors before and after echo-contrast medium injection. However, VI, FI and VFI under self-differentiation (differences between with and without contrast injection) were significantly different between malignant and benign tumors. Three-dimensional power Doppler ultrasound is a valuable tool for differential diagnosis of soft-tissue tumors, especially with the injection of an echo-contrast medium.

Extrarenal rhabdoid tumours outside the central nervous system in infancy

Malignant rhabdoid tumours (RT) are increasingly recognized in young children, probably as a consequence of advances in accurate histological diagnosis rather than a true increase in frequency. Although typically presenting as renal tumours in infancy, extrarenal tumours outside the central nervous system (CNS) in children less than 12 months of age are now well recognized, but previous literature on their imaging features is very limited. To demonstrate the imaging features of extrarenal RTs outside the CNS. A retrospective database review was made from 1989 to 2007 of patients diagnosed with extrarenal RT in infancy, i.e. below 12 months of age. There were nine patients (six boys and three girls). The age at presentation varied from 1 to 11 months (average 6 months). Tumours were located in the thorax/mediastinum (n=3), liver (n=3), neck (n=1), shoulder (n=1) and axilla (n=1). The imaging modalities used included US (n=8), CT (n=7) and MRI (n=6). Bone scan was positive in one patient, while metastases at the time of diagnosis occurred in four patients. On MRI the tumours tended to show nonspecific hypointensity on T1-W images and heterogeneous hyperintensity on T2-W images, with heterogeneous enhancement. This is the largest radiological series of extrarenal RTs outside the CNS in infancy. In our series no imaging features were found specific to the diagnosis. A tendency towards large size and mediastinal/paravertebral location were noted. A hypodense solid component on CT and a heterogeneous hyperintensity on T2-W MR images suggest that this tumour should be considered in the routine differential diagnosis of soft-tissue tumours in infancy, in addition to rhabdomyosarcoma.

Perineal Angiomyxomas: Can a Differential Diagnosis Be Made with Imaging Studies?

HomeRadiologyVol. 245, No. 2 PreviousNext CommunicationsLetters to the EditorPerineal Angiomyxomas: Can a Differential Diagnosis Be Made with Imaging Studies?Mustafa Kemal Demir, Hakan Genchellac, Hüseyin ÖzdemirMustafa Kemal Demir, Hakan Genchellac, Hüseyin ÖzdemirAuthor AffiliationsDepartment of Radiology, Trakya University School of Medicine, 11 kisim, Yasemin Apt, D blok, Daire 35 Ataköy, Istanbul, Turkey 34158 e-mail: [email protected]Mustafa Kemal DemirHakan GenchellacHüseyin ÖzdemirPublished Online:Nov 1 2007https://doi.org/10.1148/radiol.2452070211MoreSectionsFull textPDF ToolsImage ViewerAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinked In References1 Sinha R, Verma R. Case 106: aggressive angiomyxoma. Radiology 2007;242:625–627. Link, Google Scholar2 Ustun C, Malazgirt Z, Kandemir B, Kocak I, Bolat I, Gumus S. Angiomyofibroblastoma of the vulva: case report. Pathol Int 1998;48:964–966. Crossref, Medline, Google Scholar3 Mortele KJ, Lauwers GJ, Mergo PJ, Ros PR. Perineal angiomyofibroblastoma: CT and MR findings with pathologic correlation. J Comput Assist Tomogr 1999;23:687–689. Crossref, Medline, Google Scholar4 Fletcher CD, Tsang WY, Fisher C, Lee KC, Chan JK. Angiomyofibroblastoma of the vulva: a benign neoplasm distinct from aggressive angiomyxoma. Am J Surg Pathol 1992;16:373–382. Crossref, Medline, Google Scholar5 Stewart ST, McCarthy SM. Case 77: aggressive angiomyxoma. Radiology 2004;233:697–700. Link, Google ScholarArticle HistoryPublished in print: 2007 FiguresReferencesRelatedDetailsCited BySolución del caso 20: Angiomixoma agresivoRadiología, Vol. 52, No. 4Radiologic Evaluation of Mesenchymal Tumors of the Female Genital TractSurgical Pathology Clinics, Vol. 2, No. 4Recommended Articles Rare Mesenchymal Tumors of the Pelvis: Imaging and Pathologic CorrelationRadioGraphics2021Volume: 42Issue: 1pp. 143-158Radiologic-Pathologic Correlation of Primary Retroperitoneal NeoplasmsRadioGraphics2020Volume: 40Issue: 6pp. 1631-1657Spectrum of Fat-containing Soft-Tissue Masses at MR Imaging: The Common, the Uncommon, the Characteristic, and the Sometimes ConfusingRadioGraphics2016Volume: 36Issue: 3pp. 753-766Neurofibromatosis from Head to Toe: What the Radiologist Needs to KnowRadioGraphics2022Volume: 42Issue: 4pp. 1123-1144Pediatric Fibroblastic and Myofibroblastic Tumors: A Pictorial ReviewRadioGraphics2016Volume: 36Issue: 4pp. 1195-1214See More RSNA Education Exhibits Spectrum of Smooth Muscle Tumors in the Female Pelvis: Radiology-Pathology CorrelationDigital Posters2018Pediatric Soft Tissue Tumors and Tumor-Like Conditions: Focused Imaging Overview with Pathologic CorrelationDigital Posters2019Mesenchymal Pelvic Floor Tumors With Locally Aggressive Growth Patterns: Differentiating Benign From MalignantDigital Posters2020 RSNA Case Collection Vaginal MyofibroblastomaRSNA Case Collection2022Male mammary myofibroblastoma RSNA Case Collection2022Intramuscular SchwannomaRSNA Case Collection2021 Vol. 245, No. 2 Metrics Altmetric Score PDF download

Foci of decreased signal on T2-weighted MR images in leiomyosarcomas of soft tissue: correlation between MR and histological findings

Objective: Leiomyosarcomas are rare soft tissue sarcomas with varying MR signal characteristics and histologic pictures. The purpose of this study was to investigate the histological features of foci, which showed decreased signal on T2-weighted images in leiomyosarcomas of soft tissue. Material and methods: We reviewed the MR images of six histologically proved cases of leiomyosarcomas of soft tissue and correlated the foci, which showed decreased signal on T2-weighted images with the histologic findings. Result: Microscopic examination revealed that these foci were composed of hyalinization of neoplastic tissue, internal septations, deposition of hemosiderin, or corresponded to metaplastic bone. Conclusion: The authors explain that the foci of decreased signal on T2-weighted MR images correspond to tissue components of the lesion, particularly fibrous tissue, hemosiderin and metaplastic bone. So, the suggestion is that leiomyosarcoma should be considered in the differential diagnosis of soft-tissue tumors that show foci of decreased signal on T2-weighted MR images.

The Role of Immunohistochemistry in the Differential Diagnosis of Soft-Tissue Tumors.

This regular feature presents special issues in oncologic pathology.

Epithelioid Sarcoma of the Upper Extremity

Three cases of epithelioid sarcoma of the upper extremity are presented. Information regarding 112 previously published cases is reviewed. It is concluded that epithelioid sarcoma must be included in the differential diagnosis of soft-tissue tumors of the extremities. Moreover, the diagnosis of epithelioid sarcoma demands prompt and aggressive surgical intervention. Irradiation therapy and chemotherapy have not been proven to be of value in the management of epithelioid sarcoma.

Neck and mediastinal angiography by computed tomography scan.

CT scanning of the neck and upper mediastinum is a valuable tool in the differential diagnosis of soft-tissue tumors. Visualization of the major vessels in the neck, which aids in the study, can be accomplished by a rapid intravenous drip infusion technique during the actual scanning, a new approach to contrast enhancement.