Differential Diagnosis Of Granulomatous Lesions Research Articles

Sarcoidosis: oral manifestations (case report)

Relevance. Sarcoidosis is a multisystem granulomatous disease of unknown origin, commonly presenting with bilateral hilar lymphadenopathy, pulmonary infiltrates, and involvement of the eyes, skin, gums, and oral mucosa. This clinical case illustrates the oral manifestations of this rare systemic disease. Gingival hypertrophy and soft tissue lesions on the lip mucosa were the initial signs of the condition. Following an extended diagnostic process, the patient underwent treatment by both a dentist and a rheumatologist, leading to a stable remission of the disease.Case description. This article presents a clinical case of sarcoidosis manifesting in the mouth as gingival hypertrophy and a soft tissue lesion on the upper lip. In most cases, a diagnosis of sarcoidosis is made before any oral symptoms appear. Diagnosing a systemic disease based on primary oral symptoms poses a unique challenge, as dental professionals may not always be familiar with the oral manifestations of systemic conditions. In cases of suspected sarcoidosis, the oral mucosa should be thoroughly examined, and systemic sarcoidosis should be considered in the differential diagnosis of granulomatous lesions in the mouth.Conclusion. Early initiation of treatment can significantly improve the patient's quality of life and prognosis.

Penile granuloma annulare: An uncommon entity

Granuloma annulare (GA) is a benign inflammatory disorder of unknown etiology, histologically characterized by dermal palisading granulomas with central degeneration of collagen. Involvement of the penis is exceptional and lesions restricted only to the glans penis are rarely reported. We report a middle-aged male, presenting with asymptomatic plaques on the glans penis which on biopsy proved to be interstitial GAs. Penile GA seldom shows spontaneous resolution as in our case. Penile GA although rare should be considered in the differential diagnosis of granulomatous lesions of the penis and histological examination is crucial for its diagnosis to avoid over-treatment.

Penile Tuberculosis in a Bull

We describe a case of penile tuberculosis in a bull. The prepuce was thickened, firm and pale with multifocal to coalescent caseous nodules, and the inguinal and mesenteric lymph nodes were moderately enlarged. Lesions in the prepuce, penis and lymph nodes were characterized by multifocal to coalescent areas of caseous necrosis and marked granulomatous inflammation. Acid-fast bacilli were seen within necrotic foci and Langhans giant cells. Mycobacteriumtuberculosis var. bovis was identified in inguinal lymph nodes by the polymerase chain reaction technique and by bacterial isolation. Although rare, tuberculosis should be considered in the differential diagnosis of granulomatous lesions in the genital tract of bulls.

Sarcoid granuloma of the iris (clinical cases and state of the problem)

To describe a clinical case of sarcoid lesion of the iris and provide an analysis of literature devoted to this problem in the context of its polyetiology. The article describes one case of sarcoid granuloma of the iris in a young patient with a relapsing course of the disease. The presented clinical case demonstrates the need for differential diagnosis to clarify the causes of the disease and the possibility of recurrence involving appearance of a multifocal lesion. The article also reviews literature on this problem reflecting the polyetiological nature of granulomatous lesions of the iris, and argues the use of interventional diagnostic methods in the absence of extraocular pathology. Analysis of the clinical case and literature clearly demonstrates the need for differential diagnosis of granulomatous lesions of the iris.

Granuloma inguinal (Donovanosis) de la encía y regiones submandibulares

El granuloma inguinal (Donovanosis) de la cavidad oral es muy raro, sin embargo representa lamanifestación extragenital mas frecuente de esta infección producida por la bacteria gramnegativa Calymmatobacterium granulomatis. Se describe un caso de donovanosis gingival en unhombre homosexual de 19 años de edad. Las lesiones gingivales se presentaron como úlcerasmicrogranulomatosas combinadas con zonas esponjosas. El paciente también tenía lesiones enlas regiones submandibulares y perianal. El diagnóstico se estableció por biopsia gingival. Eneste tejido, las secciones teñidas con hematoxilina - eosina mostraron una marcada reaccióngranulomatosa compuesta por histiocitos, mezclados con abundante cantidad de neutrófilos ypocas células plasmática. Los cuerpos de Donovan fueron identificados usando la coloración deWarthin-Starry . Se discute el diagnóstico clínico diferencial así como el cuadro histopatológico.Considerando el comportamiento sexual del paciente se sugiere que el compromiso gingival ysubmaxilar probablemente representaban múltiples sitios primarios de infección porC.granulomatis. Sin embargo, la autoinoculación no puede ser descartada. Donovanosis debe serconsiderado en el diagnóstico diferencial de lesiones granulomatosas que afectan la mucosa oral,particularmente cuando se presentan en pacientes promiscuos.

Foreign Body of Buccal Mucosa: Case Report

Foreign bodies in the upper airways are usually an emergency for doctors. Foreign bodies inside the buccal mucosa prompt a granulomatous body reaction, but the differential diagnosis must include sarcoidosis, Crohn's disease, and infections. Woman, 74, had multiple nodules in the buccal mucosa that were increasing progressively but remained painless. These developed after undergoing dental treatment. The clinical characteristics and differential diagnosis of granulomatous lesions of the oral cavity were discussed.

Differential Diagnosis of Granulomatous Lesions in a Population of Wild Grey Mullet from the Ligurian Sea in Italy

Differential Diagnosis of Granulomatous Lesions in a Population of Wild Grey Mullet from the Ligurian Sea in Italy

Penile granuloma annulare.

A case of granuloma annulare (GA) localised to the shaft of the penis is reported with a brief review of the current literature. We concluded that penile GA, although rare,...