Differential Diagnosis Of Anemia Research Articles

Evaluation of a packaged kit assay of serum ferritin and application to clinical diagnosis of selected anemias.

The reliability of a radioimmunometric assay of serum ferritin concentration by a packaged kit was evaluated. In addition, application of the serum ferritin assay to the clinical evaluation of selected anemias was assessed. When appropriate serum dilutions were utilized, this method was sufficiently reproducible and reliable for application to the clinical laboratory. Serum ferritin was found to be a valuable tool in the differential diagnosis of anemia accompanied by hypoferremia, although iron depletion coexisting with either the anemia of chronic disease or active hepatocellular disease may not be clearly appreciated. The primary advantage of the determination was to help characterize the iron status of the patient with a hypochromic microcytic anemia or hypoferremia who would ordinarly require a bone-marrow examination for iron stores.

Differential Diagnosis of Anemia and Cancer

Differential Diagnosis of Anemia and Cancer

The Differential Diagnosis of Anemia

The Differential Diagnosis of Anemia

Differential Diagnosis of Anemia

When anemia develops rapidly without time for physiologic adjustment, nonspecific symptoms tend to be prominent. When it develops slowly, physiologic adjustment may be so perfect that even very anemic patients may have few or no nonspecific symptoms. Specific symptoms are related largely to individual organs involved in the underlying disease.

Hematologic Problems in the Newborn.

To hematologists the neonatal period is full of challenges, pitfalls, and mysteries. Not only do more problems related to blood occur during this brief interval than at any other time throughout life (cf, the differential diagnosis of anemia of the newborn), but the physician must consider whether the observed disease represents the consequences of an inherited disorder, or of fetal-maternal interaction, or is due to an illness in the infant himself. This decision must be made at a time when normal hematologic processes are in a state of rapid change and thereby complicate the diagnostic process. Perhaps because of such complexity, it was not until recently that answers were found to many of the hematologic puzzles of the newborn. The only reasonably comprehensive book on the subject in the English language was the first edition of the present volume, published in 1966. It met with an enthusiastic response, obviously filling

Iron-deficiency anemia at birth. Two examples secondary to chronic fetal-maternal hemorrhage.

Iron-deficiency anemia in the newborn infant frequently is not recognized. This paper provides two illustrations of this disorder in the neonate, and out lines the pathogenesis as well as the laboratory tests necessary to establish the diagnosis. The discussion includes a differential diagnosis of anemia at birth.

Clinical Haematology in Medical Practice.

This book deserves to be better known among American physicians. Written by an Australian hematologist noted for his studies of red cell metabolism and hemolytic anemia, it is a masterpiece of clarity and organization. Less detailed and bulky than Wintrobe's standard text, it is nevertheless comprehensive and thorough. Each chapter is developed so logically and written so well that it reads like the lecture of a master teacher. Among the sections of special merit are those on interpretation of marrow morphology, differential diagnosis of anemia and pancytopenia, and the numerous comparative tables. A few minor criticisms are pertinent. The category of normoblastic macrocytic anemias, as defined by de Gruchy, is not really meaningful or useful. It includes both anemias characterized by reticulocytosis (such as bleeding and hemolysis) and those with macronormoblastic marrow (such as liver disease and malnutrition). But the marrow morphology in the latter is characterized by changes in

Use of the Prussian blue reaction in the differential diagnosis of anemias.

Article1 September 1962Use of the Prussian Blue Reaction in the Differential Diagnosis of AnemiasWARREN D. BOWMAN JR., M.D.WARREN D. BOWMAN JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-3-412 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough Rath and Finch introduced the technique of staining bone marrow preparations for iron over a decade ago (1), this simple and useful procedure has not yet found wide application. The significance of the presence or absence of stainable iron, or hemosiderin, in marrow particles and normoblasts has been discussed elsewhere (2-6) and will be reviewed briefly below. The purpose of this paper is to illustrate the use of the Prussian blue reaction for hemosiderin in solving diagnostic problems commonly encountered by the internist, pathologist, and hematologist.MATERIALS AND METHODSMarrow is aspirated in the usual manner from the sternum,...

The clinical use of radioisotopes in the differential diagnosis of anemia.

The clinical use of radioisotopes in the differential diagnosis of anemia.

Adenocarcinoma of the Jejunum Diagnosed Pre-Operatively

Summary A case is reported in which anemia, disturbances of the central nervous system, and occult blood in the stool were striking findings in a patient ill with primary urological complaints. These findings obscured the correct diagnosis of carcinoma of the jejunum which was established by x-ray and confirmed by histological examination of the surgical specimen. The patient was treated successfully by surgery. The need is emphasized for: (1) more frequent consideration of malignancy of the small bowel in the differential diagnosis of anemia due to gastrointestinal blood loss, and (2) more frequent performance of x-ray studies of the small bowel in the face of persistent occult blood in the stool associated with normal upper and lower gastrointestinal studies.

Causes, Classification and Differential Diagnosis of Anemias*†

Article1 May 1932Causes, Classification and Differential Diagnosis of AnemiasBased on the Detailed Examination of Over Two Hundred Patients and a Study of the LiteratureEDWIN E. OSGOOD, M.D., F.A.C.P., HOWARD D. HASKINS, M.D.EDWIN E. OSGOOD, M.D., F.A.C.P.Search for more papers by this author, HOWARD D. HASKINS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-11-1367 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis is a presentation of the views formulated during a seven years' study of the clinical and laboratory phases of anemias and the literature pertaining thereto. Details of the subjects chosen, technic used, and results of the color, volume and saturation index studies are given elsewhere.1It has long been customary to divide anemias into two groups. Under the term primary anemia were included cases of pernicious anemia and, sometimes, chlorosis; and under the name secondary anemia, all others. These names were given as the cause was supposed to be unknown in primary anemias and known in secondary anemias. Since...References1 OSGOODHASKINSTROTMAN EEHDFE: The value of accurately determined color, volume and saturation indices in anemias, Jr. Lab. and Clin. Med. To be published. Google Scholar2 ROBSCHEIT-ROBBINS FS: The regeneration of hemoglobin and erythrocytes, Physiol. Rev., 1929, ix, 666-709. CrossrefGoogle Scholar3 BAAR H: Progressive postinfektiöse Erythrophthise, Folia haemat, 1927, xxxv, 111-115. Google Scholar4 SELLING L: Benzol as a leucotoxin. Studies on the degeneration and regeneration of the blood and haematopoietic organs, Johns Hopkins Hosp. Rep., 1916, xvii, 83-142. Google Scholar5 MARTLAND HS: Occupational poisoning in manufacture of luminous watch dials; general review of hazard caused by ingestion of luminous paint, with especial reference to the New Jersey cases, Jr. Am. Med. Assoc., 1929, xcii, 466, 552-559. CrossrefGoogle Scholar6 ORDWAYGORHAM TLW: Diagnosis and treatment of diseases of the blood, Oxford Monographs, 1929, ix, Oxford University Press, New York. Google Scholar7 OSGOOD EE: Hemoglobin, color index, saturation index, and volume index standards; redeterminations based on the findings in one hundred and thirty-seven healthy young men, Arch. Int. Med., 1926, xxxvii, 685-706. CrossrefGoogle Scholar8 OSGOODHASKINS EEHD: Relation between cell count, cell volume, and hemoglobin content of venous blood of normal young women; redeterminations of color index, volume index, and saturation index standards based on observations in one hundred cases, Arch. Int. Med., 1927, xxxix, 643-655. CrossrefGoogle Scholar9 AUB JC: Lead poisoning, Med., 1925, iv, 1-250. Google Scholar10 HARTMANBROWNELL FAKA: The hormone of the adrenal cortex, Science, 1930, lxxii, 76. CrossrefGoogle Scholar11 MINOTMURPHY GRWP: Treatment of pernicious anemia by a special diet, Jr. Am. Med. Assoc., 1926, lxxxvii, 470-476. CrossrefGoogle Scholar12 JONESPHILLIPSLARSELLNOKES NWBIOHT: The hemopoietic effect of nuclear extractives in human anemias, Ann. Int. Med., 1929, ii, 603-621. Google Scholar13 STURGISISAACS CCR: Desiccated stomach in the treatment of pernicious anemia, Jr. Am. Med. Assoc., 1929, xciii, 747-749. CrossrefGoogle Scholar14 OSGOODWILHELM EEMM: Reticulocytes. Proc. Soc. Exper. Biol. and Med., 1931, xxix, 53-54. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Portland, Oregon*From the Departments of Medicine and Biochemistry, University of Oregon Medical School, Portland, Oregon.†Received for publication, July 30, 1931.Acknowledgment is due to P. Blakiston's Son & Co., Inc., 1012 Walnut St., Philadelphia, for permission to include in this article excerpts from the Textbook of Laboratory Diagnosis by Edwin E. Osgood and Howard D. Haskins. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Erkrankungen des erythrocytären Systems 1 May 1932Volume 5, Issue 11Page: 1367-1376KeywordsAnemiaBiochemistryClinical laboratoriesPernicious anemiaResearch laboratories Issue Published: 1 May 1932 PDF downloadLoading ...

HEMOGLOBIN, COLOR INDEX, SATURATION INDEX AND VOLUME INDEX STANDARDS

value of color index, volume index and hemoglobin determinations in the differential diagnosis of anemias is well known. But the absence of correct normal standards for the number, volume and hemoglobin content of red cells and the inaccuracy of almost all the clinical hemoglobin methods is a great handicap. Kern1calls attention to the number of widely different hemoglobin figures used as 100 per cent by various authors and instrument makers (e. g., 13.8, 15.0, 15.6, 16.92 and 17.3 Gm. of hemoglobin per hundred cubic centimeters of blood). He emphasizes the importance of knowing the normal amount of hemoglobin per hundred cubic centimeters of blood calculated to a count of 5 million red cells, since this figure forms the basis for the calculation of the color index. Brown and Rowntree2state: The normal standard of hemoglobin is as yet unsettled; this is somewhat surprising in a substance so important.