Different Types Of Stimuli Research Articles

FOUR-DIMENSIONAL BIOPRINTING FOR REGENERATIVE MEDICINE: MECHANISMS TO INDUCE SHAPE VARIATION AND POTENTIAL APPLICATIONS

Regenerative medicine is an exciting field of research, in which significant steps are being taken that are leading to the translation of the technique into clinical practice. In the near future, it is expected that clinicians will have the opportunity to bioprint tissues and organs that closely mimic native human tissues. To do so, imaging of patients must be translated to digital models and then fabricated in a layer-by-layer fashion. The main aim of this review is to elaborate on the possible mechanisms that support four-dimensional bioprinting, as well as provide examples of current and future applications of the technology. This technology, considering time as the fourth dimension, emerged with the aim to develop bioactive functional constructs with programmed stimuli responses. The main idea is to have three-dimensional-printed constructs that are responsive to preplanned stimuli. With this review, the authors aim to provoke creative thinking, highlighting several issues that need to be addressed when reproducing such a complex network as the human body. The authors envision that there are some key features that need to be studied in the near future: printed constructs should be able to respond to different types of stimuli in a timely manner, bioreactors must be developed combining different types of automated stimuli and aiming to replicate the in vivo ecology, and adequate testing procedures must be developed to obtain a proper assessment of the constructs. The effective development of a printed construct that supports tissue maturation according to the anticipated stimuli will significantly advance this promising approach to regenerative medicine.

A Car-Following Model Considering Preceding Vehicle’s Lane-Changing Process

Car following and lane changing are two common driving behaviors in the traffic flow. Preceding vehicle's lane changing is affected by the surroundings and will have a greater influence on the followers' driving decision. The existing car-following theory does not fully take it into consideration that the followers' driving behavior may change during a lane-changing process. In order to reflect the driving decision in a complex traffic flow more precisely, the influence on the following vehicle during the preceding vehicle's lane-changing process is studied. First, the different types of stimulus during the preceding vehicle's lane-merging (LM) process and the space gain effect produced by the preceding vehicle's lane-passing (LP) behavior are analyzed. Then, the LM-FVDM and LP-FVDM are proposed based on the classical car-following model-FVD model. Finally, the linear stability theory, numerical simulation, and NGSIM data sets are used to analyze and validate the performance of the LM-FVDM and LP-FVDM. The numerical simulation results show that the model can reasonably reflect the driving decision of the following vehicle in various scenarios, and verification based on NGSIM shows that the $R$ -squared of vehicles' speed and distance is significantly better than the FVD model, which can more effectively reflect the speed adjustment process of the following vehicle during the preceding vehicle's lane-changing process in the real traffic flow.

Hsp60 in Skeletal Muscle Fiber Biogenesis and Homeostasis: From Physical Exercise to Skeletal Muscle Pathology.

Hsp60 is a molecular chaperone classically described as a mitochondrial protein with multiple roles in health and disease, participating to the maintenance of protein homeostasis. It is well known that skeletal muscle is a complex tissue, rich in proteins, that is, subjected to continuous rearrangements, and this homeostasis is affected by many different types of stimuli and stresses. The regular exercise induces specific histological and biochemical adaptations in skeletal muscle fibers, such as hypertrophy and an increase of mitochondria activity and oxidative capacity. The current literature is lacking in information regarding Hsp60 involvement in skeletal muscle fiber biogenesis and regeneration during exercise, and in disease conditions. Here, we briefly discuss the functions of Hsp60 in skeletal muscle fibers during exercise, inflammation, and ageing. Moreover, the potential usage of Hsp60 as a marker for disease and the evaluation of novel treatment options is also discussed. However, some questions remain open, and further studies are needed to better understand Hsp60 involvement in skeletal muscle homeostasis during exercise and in pathological condition.

POSITIVITY EFFECT IN CHINESE OLDER ADULTS: AROUSAL ALSO MATTERS

Objectives: Age-related positivity effect – a tendency in older adults to remember relatively more positive than negative information – has been extensively studied among Westerners. However, there is still inconsistency whether or not Chinese older adults also exhibit positivity effect. In the present work, two experiments were conducted, aiming at testing whether older Chinese adults exhibited positivity effect in memory with a variety of stimuli (e.g., facial expressions in Study 1 and standardized pictures from IAPS in Study 2). Moreover, the present work also tested whether arousal could moderate the manifestation of positivity effect in Chinese older adults, given their preference for low-arousal positive emotions. Method: Participants were instructed to view 5 different types of stimulus (namely, neutral pictures, high arousal positive pictures, low arousal positive pictures, high arousal negative pictures, and low arousal negative pictures), and their recognition memories for these pictures were later tested in both experiments. Results: Significant age × picture type interaction was found in both experiments, such that older Chinese adults underperformed their younger counterparts in recognizing high arousal positive pictures, as well as negative pictures regardless of arousal, but performed equally well (if not better) in recognizing low arousal positive pictures, which confirmed our original hypothesis. Conclusion: The present work highlights the importance of arousal in modulating emotional memory in Chinese older adults.

Stimuli-Responsive Nano-Architecture Drug-Delivery Systems to Solid Tumor Micromilieu: Past, Present, and Future Perspectives.

The microenvironment characteristics of solid tumors, renowned as barriers that harshly impeded many drug-delivery approaches, were precisely studied, investigated, categorized, divided, and subdivided into a complex diverse of barriers. These categories were further studied with a particular perspective, which makes all barriers found in solid-tumor micromilieu turn into different types of stimuli, and were considered triggers that can increase and hasten drug-release targeting efficacy. This review gathers data concerning the nature of solid-tumor micromilieu. Past research focused on the treatment of such tumors, the recent efforts employed for engineering smart nanoarchitectures with the utilization of the specified stimuli categories, the possibility of combining more than one stimuli for much-greater targeting enhancement, examples of the approved nanoarchitectures that already translated clinically as well as the obstacles faced by the use of these nanostructures, and, finally, an overview of the possible future implementations of smart-chemical engineering for the design of more-efficient drug delivery and theranostic systems and for making nanosystems with a much-higher level of specificity and penetrability features.

Exploring lateralization during memory through hemispheric pre-activation: Differences based on the stimulus type

ABSTRACTThe original approach of the Hemispheric Encoding/Retrieval Asymmetry model (HERA) was aimed at the operations of encoding and retrieving episodic memories. However, whether HERA presumptions can apply to different types of stimuli (e.g., words and pictures) continues to be a matter of debate. Therefore, in order to analyse the effects of brain pre-activation on subsequent memory, HERA was tested through a hand-clenching paradigm using four types of stimuli: words, fractal images, silhouettes of common objects, and pseudowords. Results revealed that only the memory of words and pseudowords was enhanced by hand-clenching pre-activation, according to HERA predictions. Since the cognitive processes underlying recognition of verbal stimuli are considered to follow a cognitive route involving grapheme-morpheme conversion, it could be hypothesized that hand-clenching pre-activation might be associated with a selective pre-activation of the brain circuits participating in that pathway. Hence, the present work broadens possible interpretations behind the effects of hand-clenching on memory, based on the process engaged and the type of stimulus to be remembered.

The role of virtual reality intervention on young adult smokers' motivation to quit smoking: a feasibility and pilot study

The objective of our research was to compare the initial efficacy and acceptability, in this special population, of different motivational stimuli to improve motivation to quit smoking. We enrolled 40 young adult smokers, between their twenties and their thirties, not motivated to quit. Our study adopted a visual analog scale to assess the motivation to quit at first visit (baseline) and after three different types of stimuli: a packet of cigarettes containing shocking images; a brief film showing pulmonary effects of smoking; a virtual reality period based on the progression of smoking-related illnesses. We compared the motivation to quit smoking between the series of stimuli and between the stimuli and the baseline assessment. Compared with the first assessment, all stimuli were significant in improving the motivation for smoking cessation. There was a statistically significant modification between the packet of cigarettes and the movie. The difference between the packet of cigarettes containing shocking images and the virtual reality was significant. The difference between the film and the virtual reality was also highly significant. The application of virtual reality would appear to greatly increase the motivation to smoking cessation in young adult smokers not motivated to quit.

Challenging One Model With Many Stimuli: Simulating Responses in the Inferior Colliculus.

SummaryExisting models to explain human psychophysics or neural responses are typically designed for a specific stimulus type and often fail for other stimuli. The ultimate goal for a neural model is to simulate responses to many stimuli, which may provide better insights into neural mechanisms. We tested the ability of modified same-frequency inhibition-excitation models for inferior colliculus neurons to simulate individual neuron responses to both amplitude-modulated sounds and tone-in-noise stimuli. Modifications to the model were guided by receptive fields computed with 2nd-order Wiener kernel analysis. This approach successfully simulated many individual neurons’ responses to different types of stimuli. Other neurons suggest limitations and future directions for modeling efforts.

Insights into the evolution of polymodal chemoreceptors

Respiratory chemoreceptors in vertebrates are specialized cells that detect chemical changes in the environment or arterial blood supply and initiate autonomic responses, such as hyperventilation or changes in heart rate, to improve O2 uptake and delivery to tissues. These chemoreceptors are sensitive to changes in O2, CO2 and/or H+. In fish and mammals, respiratory chemoreceptors may be additionally sensitive to ammonia, hypoglycemia, and numerous other stimuli. Thus, chemoreceptors that affect respiration respond to different types of stimuli (or modalities) and are considered to be "polymodal". This review discusses the polymodal nature of respiratory chemoreceptors in vertebrates with a particular emphasis on chemoreceptors of the carotid body and pulmonary epithelium in mammals, and on neuroepithelial cells in water- and air-breathing fish. A major goal will be to examine the evidence for putative polymodal chemoreceptors in fish within the context of studies on mammalian models, for which polymodal chemoreceptors are well described, in order to improve our understanding of the evolution of polymodal chemoreceptors in vertebrates, and to aid in future studies that aim to identify putative receptors in air- and water-breathing fish.

Music of brain and music on brain: a novel EEG sonification approach.

Can we hear the sound of our brain? Is there any technique which can enable us to hear the neuro-electrical impulses originating from the different lobes of brain? The answer to all these questions is YES. In this paper we present a novel method with which we can sonify the electroencephalogram (EEG) data recorded in"control" state as well as under the influence of a simple acoustical stimuli-a tanpura drone. The tanpura has a very simple construction yet the tanpura drone exhibitsvery complex acoustic features, which is generally used for creation of an ambience during a musical performance. Hence, for this pilot project we chose to study the nonlinear correlations between musical stimulus (tanpura drone as well as music clips) and sonified EEG data. Till date, there have been no study which deals with the direct correlation between a bio-signal and its acoustic counterpart and also tries to see how that correlation varies under the influence of different types of stimuli. This study tries to bridge this gap and looks for a direct correlation between music signal and EEG data using a robust mathematical microscope called Multifractal Detrended Cross Correlation Analysis (MFDXA). For this, we took EEG data of 10 participants in 2min "control condition" (i.e. with white noise) and in 2min 'tanpura drone' (musical stimulus) listening condition. The same experimental paradigm was repeated for two emotional music, "Chayanat" and "Darbari Kanada". These are well known Hindustani classical ragas which conventionally portray contrast emotional attributes, also verified from human response data. Next, the EEG signals from different electrodes were sonified and MFDXA technique was used to assess the degree of correlation (or the cross correlation coefficient γx) between the EEG signals and the music clips. The variation of γx for different lobes of brain during the course of the experiment provides interesting new information regarding the extraordinary ability of music stimuli to engage several areas of the brain significantly unlike anyother stimuli (which engages specific domains only).

Attentional guidance from two representations of the same or different dimensions in visual working memory

Previous studies have only focused on the interference effect induced by multiple task-irrelevant representations from the same dimensions in visual working memory (VWM). The present study reexamined the issue by not only focusing on interference effect but also facilitation effect induced by multiple task-irrelevant representations from the same dimension in VWM. Furthermore, the guidance effect of multiple task-irrelevant representations from different dimensions in VWM was also investigated. Participants were instructed to complete a gap-location search task while holding two items in VWM. In Experiment 1, one of the colors (match-1) or both colors in VWM (match-2) matched with one or two targets or distractors in the search array. No guidance effects were found for match-1 trials, but there was a reliable interference effect when both colors in VWM were presented as distractors and a facilitation effect when they matched the color of two search targets. Experiment 2 was carried out to examine the guidance effect produced by multiple task-irrelevant representations from different dimensions in VWM. Participants were required to memorize the color and direction of an arrow. Attentional guidance effects were found when each one of the VWM features matched the search target, but there was no additive facilitation effect when both features were validated in visual search. These results provide evidence that multiple items in VWM can guide the attention simultaneously, but the guidance effects are flexible and various across different types of stimuli.

Use and Usefulness of Dynamic Face Stimuli for Face Perception Studies-a Review of Behavioral Findings and Methodology.

Faces that move contain rich information about facial form, such as facial features and their configuration, alongside the motion of those features. During social interactions, humans constantly decode and integrate these cues. To fully understand human face perception, it is important to investigate what information dynamic faces convey and how the human visual system extracts and processes information from this visual input. However, partly due to the difficulty of designing well-controlled dynamic face stimuli, many face perception studies still rely on static faces as stimuli. Here, we focus on evidence demonstrating the usefulness of dynamic faces as stimuli, and evaluate different types of dynamic face stimuli to study face perception. Studies based on dynamic face stimuli revealed a high sensitivity of the human visual system to natural facial motion and consistently reported dynamic advantages when static face information is insufficient for the task. These findings support the hypothesis that the human perceptual system integrates sensory cues for robust perception. In the present paper, we review the different types of dynamic face stimuli used in these studies, and assess their usefulness for several research questions. Natural videos of faces are ecological stimuli but provide limited control of facial form and motion. Point-light faces allow for good control of facial motion but are highly unnatural. Image-based morphing is a way to achieve control over facial motion while preserving the natural facial form. Synthetic facial animations allow separation of facial form and motion to study aspects such as identity-from-motion. While synthetic faces are less natural than videos of faces, recent advances in photo-realistic rendering may close this gap and provide naturalistic stimuli with full control over facial motion. We believe that many open questions, such as what dynamic advantages exist beyond emotion and identity recognition and which dynamic aspects drive these advantages, can be addressed adequately with different types of stimuli and will improve our understanding of face perception in more ecological settings.

COMPLEXITY-BASED ANALYSIS OF THE DIFFERENCE IN SPEECH-EVOKED AUDITORY BRAINSTEM RESPONSES (s-ABRs) BETWEEN BINAURAL AND MONAURAL LISTENING CONDITIONS

One of the important research areas in behavioral neuroscience is to investigate the brain response to different types of stimuli. Speech-evoked Auditory Brainstem Response (s-ABR) is a tool to study the brainstem processing of speech sounds. During years, scientists have employed different techniques to analyze the influence of auditory stimulation on s-ABR signal in different conditions. One important category of works, which aroused the attention of scientists, has been the analysis of the variations of s-ABR signal in binaural and monaural stimulations. In this research, we analyze the variations of s-ABR signal due to auditory stimulation in the form of speech syllable, in binaural and monaural (right or left ear) listening conditions. For this purpose, we have employed fractal analysis in order to analyze the complexity of s-ABR signal in three stimulation conditions (both ears, right ear, left ear). The results of our analysis showed that s-ABR signal in case of binaural stimulation shows significant lower complexity compared to monaural stimulation. In comparison of s-ABR signals between left ear and right ear using fractal dimension, no significant difference was observed.

Working memory capacity predicts search accuracy for novel as well as repeated targets

ABSTRACTVisual search behaviour is guided by mental representations of targets that direct attention toward relevant features in the environment. Electrophysiological data suggests these target templates are maintained by visual working memory during search for novel targets and rapidly transfer to long term memory with target repetition. If this account is correct, an individual’s working memory capacity should be more predictive of search performance for novel targets than repeated targets. Across six experiments, we tested this hypothesis using both single (Experiments 5 and 6) and multiple (Experiments 1–4) target search tasks with three different types of stimuli (real world objects, letters, and triple conjunction shapes). Each target set was repeated for six consecutive trials. In addition, we estimated visual working memory capacity using a change detection working memory task. Overall, working memory capacity did not predict response time or efficiency in the visual search task. However, working memory capacity was equally predictive of search accuracy for both novel and repeated targets. These results suggest that working memory requirements do not substantially differ between novel and repeated target search, and working memory capacity may continue to play an important role in the encoding or maintenance of target representations after they are presumed to be in long term memory.

Systematic spatial patterns of the sense of familiarity: Hierarchical modelling based on eye-tracking experiments.

Using different types of stimuli, such as pictures, horizontally written Japanese words, and vertically written Japanese words, this study investigated the spatial patterns of the sense of familiarity within the visual field. The perceptual asymmetry theory predicted that stimuli in the lower visual field would be processed more fluently and would therefore be perceived as more familiar. The working memory theory, originally proposed in space-number research, envisaged type-specific spatial patterns for different stimuli. Participants made old/new recognition memory judgements for stimuli, presented at random positions, while their eye movements were recorded. The observed spatial patterns changed according to the stimulus type (e.g., "more left = older" for horizontally written words and "upper = older" for vertically written words), and this flexibility is encapsulated by the working memory theory as follows: (a) stimulus-type-specific spatial configurations are encoded in long-term memory on the basis of one's experience (e.g., vertically written words are empirically associated with the "upper = older" spatial configuration), (b) the presentation of a stimulus automatically cues the temporal activation of the associated spatial configuration in working memory, and (c) the referential process between the stimulus and configuration unconsciously affects the viewer's sense of familiarity.

Emotions as guardians of group norms: expressions of anger and disgust drive inferences about autonomy and purity violations

ABSTRACTOther people’s emotional reactions to a third person’s behaviour are potentially informative about what is appropriate within a given situation. We investigated whether and how observers’ inferences of such injunctive norms are shaped by expressions of anger and disgust. Building on the moral emotions literature, we hypothesised that angry and disgusted expressions produce relative differences in the strength of autonomy-based versus purity-based norm inferences. We report three studies (plus three supplementary studies) using different types of stimuli (vignette-based, video clips) to investigate how emotional reactions shape norms about potential norm violations (eating snacks, drinking alcohol), and contexts (groups of friends, a university, a company). Consistent with our theoretical argument, the results indicate that observers use others’ emotional reactions not only to infer whether a particular behaviour is inappropriate, but also why it is inappropriate: because it primarily violates autonomy standards (as suggested relatively more strongly by expressions of anger) or purity standards (as suggested relatively more strongly by expressions of disgust). We conclude that the social functionality of emotions in groups extends to shaping norms based on moral standards.

Negative attentional bias for positive recovery-related words as a predictor of treatment success among individuals with an alcohol use disorder

IntroductionThis study assessed relationships between clients' attentional bias (AB) for different types of stimuli and their treatment outcomes. Alcohol AB during detoxification has previously been shown to predict relapse, but further research was needed to clarify this relationship. The current study determined whether AB for recovery-related words would also predict treatment outcome. MethodsParticipants were 45 clients undergoing alcohol detoxification, and a control group of 36 staff members. They rated words for personal relevance in four categories (alcohol-related, neutral, positive change-related, and negative change-related). Participants completed an individualized Stroop task containing their chosen words. They were also assessed on readiness-to-change, difficulties with emotion regulation, drinking problems, anxiety, and depression. Clients were interviewed at a three-month follow-up to determine their treatment outcome. ResultsAs predicted, questionnaire measures did not predict clients' treatment outcome (p > .05). A logistic regression model indicated that the best predictor of treatment outcome was AB for positive change-related words (p = .048), with successful individuals having less AB for these words than for the other word categories. Although this finding was unexpected, it was supported by significant relationships between positive change-related interference scores and continuous measures of drinking at follow-up [i.e. number of units drunk (p = .039) and number of drinking days (p = .018)]. ConclusionsThe results suggest that positive change-related words are a better predictor of treatment outcome than are either alcohol-related words or negative change-related words.

The Winding Road to Relapse: Forging a New Understanding of Cue-Induced Reinstatement Models and Their Associated Neural Mechanisms.

In drug addiction, cues previously associated with drug use can produce craving and frequently trigger the resumption of drug taking in individuals vulnerable to relapse. Environmental stimuli associated with drugs or natural reinforcers can become reliably conditioned to increase behavior that was previously reinforced. In preclinical models of addiction, these cues enhance both drug self-administration and reinstatement of drug seeking. In this review, we will dissociate the roles of conditioned stimuli as reinforcers from their modulatory or discriminative functions in producing drug-seeking behavior. As well, we will examine possible differences in neurobiological encoding underlying these functional differences. Specifically, we will discuss how models of drug addiction and relapse should more systematically evaluate these different types of stimuli to better understand the neurobiology underlying craving and relapse. In this way, behavioral and pharmacotherapeutic interventions may be better tailored to promote drug use cessation outcomes and long-term abstinence.

Functional Imaging of Visuospatial Attention in Complex and Naturalistic Conditions.

One of the ultimate goals of cognitive neuroscience is to understand how the brain works in the real world. Functional imaging with naturalistic stimuli provides us with the opportunity to study the brain in situations similar to the everyday life. This includes the processing of complex stimuli that can trigger many types of signals related both to the physical characteristics of the external input and to the internal knowledge that we have about natural objects and environments. In this chapter, I will first outline different types of stimuli that have been used in naturalistic imaging studies. These include static pictures, short video clips, full-length movies, and virtual reality, each comprising specific advantages and disadvantages. Next, I will turn to the main issue of visual-spatial orienting in naturalistic conditions and its neural substrates. I will discuss different classes of internal signals, related to objects, scene structure, and long-term memory. All of these, together with external signals about stimulus salience, have been found to modulate the activity and the connectivity of the frontoparietal attention networks. I will conclude by pointing out some promising future directions for functional imaging with naturalistic stimuli. Despite this field of research is still in its early days, I consider that it will play a major role in bridging the gap between standard laboratory paradigms and mechanisms of brain functioning in the real world.

You prime what you code: The fAIM model of priming of pop-out.

Our visual brain makes use of recent experience to interact with the visual world, and efficiently select relevant information. This is exemplified by speeded search when target- and distractor features repeat across trials versus when they switch, a phenomenon referred to as intertrial priming. Here, we present fAIM, a computational model that demonstrates how priming can be explained by a simple feature-weighting mechanism integrated into an established model of bottom-up vision. In fAIM, such modulations in feature gains are widespread and not just restricted to one or a few features. Consequentially, priming effects result from the overall tuning of visual features to the task at hand. Such tuning allows the model to reproduce priming for different types of stimuli, including for typical stimulus dimensions such as ‘color’ and for less obvious dimensions such as ‘spikiness’ of shapes. Moreover, the model explains some puzzling findings from the literature: it shows how priming can be found for target-distractor stimulus relations rather than for their absolute stimulus values per se, without an explicit representation of relations. Similarly, it simulates effects that have been taken to reflect a modulation of priming by an observers’ goals—without any representation of goals in the model. We conclude that priming is best considered as a consequence of a general adaptation of the brain to visual input, and not as a peculiarity of visual search.