Tumors of the nasopharynx present a perplexing problem from the standpoints of both diagnosis and management. The anatomical peculiarities of the nasopharynx make adequate clinical examination and early diagnosis difficult. When the symptoms develop, the tumor may have reached such an advanced stage that the results of treatment will be unsatisfactory. Diagnosis is rarely made clinically because the complaints are seldom related to the nasopharynx. The difficulties encountered in the recognition of these lesions have been shown by New. 42 In his series of 194 patients with malignant tumors of the nasopharynx, 185 different types of operations had been performed for relief of symptoms prior to admission to the Mayo Clinic. For practical purposes, any patient with unexplained otological complaints should have a thorough examination of the nasopharynx. When a patient complains of nasal obstruction, epistaxis, persistent sore throat, or other nasopharyngeal symptoms, one should suspect the possibility of a tumor of the nasopharynx with extension to the oropharynx. Cranial nerve paralysis, particularly of the sixth to third nerves, should lead to a suspicion of a nasopharyngeal tumor. Any enlargement of the cervical lymph nodes should merit a nasopharyngeal examination. A palpable deep node under the sternocleidomastoid muscle is almost pathognomonic of a malignant tumor of the nasopharynx. 15 Roentgen examination is a valuable adjunct in the diagnosis of these tumors. In interpreting roentgenograms of the nasopharynx, a knowledge of regional anatomy of the head and neck and of the routes of spread of the disease is imperative. For a presumptive diagnosis, demonstration of a soft tissue mass is essential; bony sclerosis of the base of the skull is highly suggestive of a malignant process, and destruction of the base of the skull is reliable evidence of neoplastic disease. For the final diagnosis of tumors of the nasopharynx, the clinical and roentgen findings must be confirmed by tissue biopsy. Once the diagnosis is established, the gross limits of disease as demonstrated roentgenologically provide a firm basis for treatment planning.