Different Types Of Stress Research Articles

Goat hair as a bioindicator of environmental contaminants and adrenal activation during vertical transhumance.

Autochthonous breeds of livestock are considered a pivotal genetic resource for agriculture, rural development, and food and nutrition security. In the Italian Alps, local livestock breeds are maintained using the traditional alpine farming system based on vertical transhumance, with the use of alpine pastures from late spring to autumn and indoor housing with a hay-based diet for the remaining part of the year. Because of their tight link with the territory of origin, local breeds could be used to biomonitor environmental contaminations. Moreover, animal welfare should also be monitored during transhumance in animals, which are exposed to a sudden farming system change and different types of stressors. For these reasons, this investigation hypothesized that the content of trace elements, heavy metals, and cortisol in the hair of goats changes during vertical transhumance, possibly reflecting different dietary contents and activity of the hypothalamic-pituitary-adrenal (HPA) axis. This study aimed to assess the response of an Italian local goat breed to the change from indoor housing to alpine pasture in summer in terms of hair concentrations of (i) trace elements and heavy metals and (ii) cortisol. The regrown hair of Frisa goats was monthly collected for 2 consecutive years (n = 10 for heavy metals and trace elements and n = 6 for cortisol in 2021, n = 17 for both analyses in 2022), once before vertical transhumance and twice after that event. Hair was then analyzed for trace elements, heavy metals, and cortisol by inductively coupled plasma-optical emission spectrophotometer (ICP-OES) and enzyme immunoassay (EIA), respectively. Data were analyzed by multilevel models. The results showed an increase in As content during alpine pasture (p < 0.01), probably reflecting the soil and water As contents of the grazing area, while Mg, Zn, and Al (p < 0.01) followed the opposite trend, decreasing in the second month after vertical transhumance. Hair cortisol concentrations increased during 2 months of alpine pasture (p < 0.001), indicating an increase in the activation of the HPA axis, in agreement with previous studies. Future investigations can consider a longer study period and the development of ad hoc animal welfare indicators.

Glutathione Transferase Photoaffinity Labeling Displays GST Induction by Safeners andPathogen Infection.

Glutathione transferases (GSTs) represent a large and diverse enzyme family involved in the detoxification of small molecules by glutathione conjugation in crops, weeds and model plants. In this study, we introduce an easy and quick assay for photoaffinity labeling of GSTs to study GSTs globally in various plant species. The small-molecule probe contains glutathione, a photoreactive group and a minitag for coupling to reporter tags via click chemistry. Under UV irradiation, this probe quickly and robustly labels GSTs in crude protein extracts of different plant species. Purification and mass spectrometry (MS) analysis of labeled proteins from Arabidopsis identified 10 enriched GSTs from the Phi(F) and Tau(U) classes. Photoaffinity labeling of GSTs demonstrated GST induction in wheat seedlings upon treatment with safeners and in Arabidopsis leaves upon infection with avirulent bacteria. Treatment of Arabidopsis with salicylic acid (SA) analog benzothiadiazole (BTH) induces GST labeling independent of NPR1, the master regulator of SA. Six Phi- and Tau-class GSTs that are induced upon BTH treatment were identified, and their labeling was confirmed upon transient overexpression. These data demonstrate that GST photoaffinity labeling is a useful approach to studying GST induction in crude extracts of different plant species upon different types of stress.

Topoisomerase 1 Activity Is Reduced in Response to Thermal Stress in Fruit Flies and in Human HeLa Cells.

In the modern world with climate changes and increasing pollution, different types of stress are becoming an increasing challenge. Hence, the identification of reliable biomarkers of stress and accessible sensors to measure such biomarkers are attracting increasing attention. In the current study, we demonstrate that the activity, but not the expression, of the ubiquitous enzyme topoisomerase 1 (TOP1), as measured in crude cell extracts by the REEAD sensor system, is markedly reduced in response to thermal stress in both fruit flies (Drosophila melanogaster) and cultivated human cells. This effect was observed in response to both mild-to-moderate long-term heat stress and more severe short-term heat stress in D. melanogaster. In cultivated HeLa cells a reduced TOP1 activity was observed in response to both cold and heat stress. The reduced TOP1 activity appeared dependent on one or more cellular pathways since the activity of purified TOP1 was unaffected by the utilized stress temperatures. We demonstrate successful quantitative measurement of TOP1 activity using an easily accessible chemiluminescence readout for REEAD pointing towards a sensor system suitable for point-of-care assessment of stress responses based on TOP1 as a biomarker.

Effect of material bed compression on white fused corundum product particle shape and bulk density

Comminution of corundum is a challenging task, as it has outstanding mechanical strength and is highly abrasive and is consequently applied as a blasting and polishing agent in the abrasive industry. Thus, the selection of the best comminution methods to achieve the required dispersity properties has great importance. For this, first we must understand the effects of different type of stresses and their influence on the corundum particle fractions. Laboratory scale material bed compression experiments in a piston press were carried out to examine the effect of the pressure and material bed height on the product's particle size distribution, bulk density, and particle shape. The results showed that outstanding yield, high bulk density, and spherical particle shape can be achieved by particle bed breakage in a piston press, so the high-pressure grinding roll (HPGR) technology is a promising comminution method for corundum.

SAT284 Is Stress Vulnerability In CAH Related To Epinephrine Deficiency And CYP21A2 Genotype?

Abstract Disclosure: A. Nordenstrom: None. K. Ekbom: None. R. Said: None. A. Strandqvist: None. H. Lönnberg: None. M. Lindberg: None. N. Bertman: None. A.L. Hirschberg: None. H. Falhammar: None. A. Rickenlund: None. Introduction: Primary adrenal insufficiency due to CYP21A2 deficiency results in epinephrine deficiency.The lack of a sufficient increase in epinephrine during high intensity exercise has been described, and increased hydrocortisone doses cannot compensate and normalize glucose response. Clinically patients with CAH seem vulnerable to stress. A possible role of epinephrine deficiency for stress vulnerability has not been studied previously. Research question: Do patients with CAH show increased stress sensitivity, depression and anxiety compared to healthy controls? Is stress sensitivity related to the severity of CAH, e.g. CYP21A2 genotype? Can vulnerability to different types of stress be correlated to the individual’s capacity to produce epinephrine? Methodology: 26 patients, aged 18-52 years, (13 F, 13 M) and 14 sex-matched controls. Plasma metanephrines (metabolites of catecholamines) were measured at start and at the peak of physical exertion on a maximum work test using ergometer cycle. All participants answered validated questionnaires regarding perceived stress (PSS), depression and anxiety (HADS), signs of fatigue syndrome (KEDS).Plasma metanephrine (metabolite of epinephrine) was correlated to CYP21A2 genotype. The results of the psychological questionnaires were correlated to the metanephrine levels and to the CYP21A2 genotype. Results: Patients with CAH had lower metanephrine levels than controls and it was related to CYP21A2 genotype. The few included patients with null genotype had virtually no metanephrin and lower levels than individuals with I2G genotype which has not been shown before.The patients scored higher on anxiety and stress and for risk of fatigue syndromed than controls. However, the men with null genotype did not report increased anxiety and depression compared to controls. Men with I2G genotype had lower scores than I172N genotype.There was a clear sex difference in that women had higher scores than men and women with severe genotypes, null and I2G, had more signs of depression and anxiety. There were no differences for perceived stress. Interpretation/Conclusions: Over all the results for the patients on the questionnaires showed a similar pattern with increasing signs of stress vulnerability with milder genotype and increasing, but deficient, metanephrine levels. An interesting finding was that a total epinephrine deficiency, as in null genotype, with less somatic effects of stress (increased heart rate etc), may be beneficial for some aspects of perceived stress tolerance. However, it may put these patients at increased risk of fatigue or burn out syndrome. The psychological effects of the virilization due to CAH per se may partly overshadow the effects of the epinephrine deficiency in women with CAH. Larger studies are needed to be able to study what role the capacity to produce epinephrine, has for the psychological stress vulnerability in CAH. Presentation: Saturday, June 17, 2023

Emotional intelligence moderates the stress-depression link in college students before and during COVID

The COVID-19 pandemic has exacerbated college students’ normative experiences of stress, leading to a mental health crisis. One factor that may protect against the consequences of stress is emotional intelligence (EI), which is associated with a wide range of social, mental health, and academic outcomes. The present study aims to determine whether EI might buffer the effects of life, recent, spillover, and pandemic stress on students’ depression during the COVID-19 pandemic. A secondary aim is to assess whether the hypothesized EI-buffering effect is unique to stress experienced during the pandemic. In 2013, 90 undergraduate students completed measures of EI, recent and life stress, spillover stress, and depression. Another 382 students completed the same survey in 2021, with an additional measure of pandemic stress. Regression analyses investigated the moderating effects of EI on the impact of stress on depression. As hypothesized, EI significantly moderated associations between combined recent and life stress [F(1, 460) = 16.11, p < 0.001, η2 = 0.020], as well as spillover stress [F(1,460) = 6.43, p = 0.012, η2 = 0.008], and depression symptoms for both samples. Also as predicted, EI significantly moderated COVID-related stress and depression symptoms [F(1,373) = 7.44, p = 0.007, η2 = 0.011]. Findings indicate that EI serves as a stress buffer for college students during normatively stressful times as well as during the heightened stress of a global pandemic, although its benefit may differ by type of stress. Future research should explore the possible specificity of EI’s buffering effects on the relationship between different types of stress experienced by college students and depression.

Emergence of Lipid Droplets in the Mechanisms of Carcinogenesis and Therapeutic Responses.

Cancer shares common risk factors with cardiovascular diseases such as dyslipidemia, obesity and inflammation. In both cases, dysregulations of lipid metabolism occur, and lipid vesicles emerge as important factors that can influence carcinogenesis. In this review, the role of different lipids known to be involved in cancer and its response to treatments is detailed. In particular, lipid droplets (LDs), initially described for their role in lipid storage, exert multiple functions, from the physiological prevention of LD coalescence and regulation of endoplasmic reticulum homeostasis to pathological involvement in tumor progression and aggressiveness. Analysis of LDs highlights the importance of phosphatidylcholine metabolism and the diversity of lipid synthesis enzymes. In many cancers, the phosphatidylcholine pathways are disrupted, modifying the expression of genes coding for metabolic enzymes. Tumor microenvironment conditions, such as hypoxia, different types of stress or inflammatory conditions, are also important determinants of LD behavior in cancer cells. Therefore, LDs represent therapeutic targets in cancer, and many lipid mediators have emerged as potential biomarkers for cancer onset, progression, and/or resistance.

Phosphate starvation is accompanied by disturbance of intracellular cysteine homeostasis in Escherichia coli

Metabolic rearrangements that occur during depletion of essential nutrients can lead to accumulation of potentially dangerous metabolites. Here we showed that depletion of phosphate (Pi), accompanied by a sharp inhibition of growth and respiration, caused a transient excess of intracellular cysteine due to a decrease in the rate of protein synthesis. High cysteine level can be dangerous due to its ability to produce ROS and reduce Fe3+ to Fenton-reactive Fe2+. To prevent these negative effects, excess cysteine was mainly incorporated into glutathione (GSH), the intracellular level of which increased by 3 times, and was also exported to the medium and partially degraded to form H2S with participation of 3-mercaptopyruvate sulfotransferase (3MST). The addition of Pi to starving cells led to a sharp recovery of respiration and growth, GSH efflux into the medium and K+ influx into the cells. A pronounced coupling of Pi, GSH, and K+ fluxes was shown upon Pi depletion and addition, which may be necessary to maintain the ionic balance in the cytoplasm. We suggest that processes aimed at restoring cysteine homeostasis may be an integral part of the universal response to stress under different types of stress and for different types of bacteria.

Evaluation of the stress-reducing effect of injectable trace minerals in beef calves

Very few studies have shown that trace minerals supplementa­tion may have stress-reducing effects in humans. In beef cattle, to the best of our knowledge, no available information about the mechanistic effects of injectable trace-minerals supple­mentation (ITM) on beef calf’s stress response. The aim of the current study was, therefore, to address this gap in knowledge by evaluating the stress-mitigation effects of ITM in beef calves exposed to different types of stress.

Differential expression of meiosis and homologous recombination-related genes in the life cycle of Trypanosoma cruzi.

Trypanosoma cruzi has a complex life cycle consisting of four morphological and distinct biological stages. Although some authors suggest that T. cruzi primarily follows clonal reproduction, recent genomic and transcriptomic studies indicate an unorthodox capacity for recombination. We aimed to estimate the differential gene expression of 10 meiosis/homologous recombination-related genes during the T. cruzi life cycle, including epimastigotes, under two different types of stress (oxidative stressand pH changes). We performed RT-qPCR tests using novel-designed primers to estimate the differential gene expression (∆Ct and ∆∆Ct) of nine genes (SPO11, HAP2, RAD50, MRN complex, BRCA2, DMC1, MND1, and RPA1) and RAD51, which was previously reported. Our results show basal expression of all genes during the life cycle, indicating their hypothetical role in several cellular processes but with specific signatures of differential gene expression during the life cycle (HAP2, RPA, RAD50, BRCA2, MND1, and DMC1) and oxidative stress (RPA, MRE11, NBS1, BRCA2, MND1, and RAD51). Additionally, we found that the MRN complex has an independent level of expression in T. cruzi, with profiles of MRE11 and NBS1 upregulated in some stages. Recent studies on other trypanosomatids have highlighted the influence of HAP2 and RPA in recombination and hybridization. If T. cruzi uses the same repertoire of genes, our findings could suggest that metacyclogenesis may be the putative step that the parasite uses to undergo recombination. Likewise, our study reveals the differential profiles of genes expressed in response to oxidative and pH stress. Further studies are necessary to confirm our findings and understand the recombination mechanism in T. cruzi.

A Mixed-Methods Examination of the Effects of Organizational and Incident Stressors on the Mental Health of Navy Corpsmen

Military healthcare providers experience a unique combination of occupational stressors, which put them at risk for adverse mental health outcomes. However, little attention has been devoted to organizational and incident stressors. The current study used a mixed-methods approach to examine organizational and incident stressors and their associations with mental health symptoms in a sample of Navy corpsmen. Participants completed qualitative interviews assessing workplace stressors, followed by a quantitative questionnaire that assessed organizational stressors, incident stressors, and mental health symptoms (i.e., depression, posttraumatic stress, and anxiety). Qualitative analyses revealed that corpsmen most commonly discussed themes associated with heavy workload, high level of responsibility, long work hours, lack of leadership support, and feelings of burden associated with the responsibility for saving the lives of others. Quantitative analyses revealed that organizational stressors were associated with depression symptoms and incident stressors were associated with posttraumatic stress symptoms. The results indicated that different types of stressors are associated with distinct mental health outcomes and highlighted modifiable contextual factors that could reduce distress among Navy corpsmen. Interventions that address organizational and incident stressors and enhance resilience would ensure that corpsmen are well-prepared to withstand stressors and provide quality care to their patients.

Effect of four plant extracts on the mortality, population growth, and fluctuating asymmetry of Sitophilus oryzae

AbstractManagement of storage pest insects relies heavily on chemical control, and there is a need to develop more sustainable management practices. Here, we evaluated the impact of 2% ethanol plant extracts of Ajuga reptans L., Ajuga pyramidalis L. (both Lamiaceae), Urtica dioica L. (Urticaceae), and Cannabis sativa L. (Cannabaceae) plants on mortality, population growth, and developmental stability [measuring fluctuating asymmetry (FA)] of the rice weevil, Sitophilus oryzae (L.) (Coleoptera: Curculionidae), a worldwide stored product pest. FA refers to small, random deviations occurring between the left and right sides of bilaterally symmetrical organisms; these deviations increase in response to environmental stress, making FA a reliable method to measure the impact of stress. FA was measured by means of geometric morphometrics, a method that allows for analyzing the whole landmark configuration of the insect, rather than taking single measurements. Extracts of the mentioned plants were used to treat maize (Zea mays L., Poaceae) kernels on which experimental populations of the rice weevil were grown, and we assessed mortality after 24–72 h, population growth after 30–90 days, and developmental stability after 90 days. Screening bioassays showed that S. oryzae adults were most affected by Ajuga extracts; Ajuga spp., especially A. reptans, significantly reduced population growth. In concordance, Ajuga extracts increased FA. The effects of U. dioica and C. sativa extract were less pronounced. None of the extracts significantly affected insect mortality. Overall, it can be concluded that A. reptans and A. pyramidalis are potential sources of bioactive compounds that may be further used for S. oryzae control. The results obtained confirm that variation in body shape asymmetry can be used as an indicator of population disturbance when insects are exposed to different types of stressors.

Association between Stress in Clinical Training and Resilience among Nursing Students

Background: Previous literature illustrated that nursing students encounter different types of stress during their academic program. However, clinical education stress is the most important one. Few studies have addressed the association between clinical stress and resilience strategies. Purpose: The purpose of this literature review is to analyze previous research on stress degrees and types of clinical stressors that might be encountered by nursing students. Methods: The authors used the following databases: CINAHL, MEDLINE, PsycINFO and Google scholar. The forthcoming keywords were utilized: stress, nursing students and clinical practice. Results: It has been indicated that nursing students encountered the following clinical stressors: phobia of interactions with other healthcare providers and fear of committing mistakes. Nursing students utilize resilience for handling stressors successfully. Conclusion: The impact of using resilience on clinical education stress has received little attention in previous literature. This review highlights the relationship between clinical education stress and resilience. Implications for Nursing: The findings of this study give directions for practitioners, teachers and researchers in the nursing clinical education field so as to develop effective teaching programs. Keywords: Clinical education, Jordan, Perceived stress, Resilience, Undergraduate nursing students

Programmed Cell Death in Sea Urchins: A Review

The sea urchin embryo is a widespread model system useful to study fundamental biological processes, but also for the identification of molecular and cellular mechanisms activated in response to external stress factors. Programmed cell death (PCD) is a molecular mechanism regulated at the genomic level and conserved during evolution, playing a central role in the rearrangement and shaping of tissues in developing embryos, especially during metamorphosis, also activated in response to damages induced by abiotic stress. Currently, different types of PCD have been described, among which apoptosis and autophagy are the most conserved processes among metazoans. These processes can be activated as alternative or combined defense strategies in embryos exposed to different types of stress when repairing mechanisms (activation of Heath Shock Proteins and Metallothioneins, DNA repair), fail to rescue cell viability. In this review, we report on the available information concerning the possible involvement of PCD processes in sea urchin embryos following exposure to pollutants, including heavy metals, physical factors and toxic natural compounds. We also report information about the occurrence of physiological apoptosis during development.

Evaluation of the stress‐reducing effect of trace mineral injection in beef calves

Little is known about the effects of trace mineral supplementation on the stress response in beef calves. To investigate the effect of injectable trace mineral supplementation (ITM) on the stress response in beef calves exposed to different types of stress. Thirty weaned Angus and Angus crossbred calves. The enrolled calves were randomly assigned to 2 groups: ITM, 15 calves received modified-live virus vaccine (MLV) and ITM SC and 15 calves received MLV and saline SC (CONT). The calves were exposed to 3 types of stress: the stress of MLV vaccination (d0), nasal aerosol with bovine viral diarrhea virus-2 (BVDV-2) challenge (d5), and liver biopsy (d26). The calves' body weights and health status were monitored. Leukocyte counts, serum cortisol concentration ([cort]), BVDV-2 serum neutralizing antibodies (SNA), and percentages of CD4+ , CD8+ , WC1+ , and CD25+ T-lymphocytes were measured. Serum cortisol concentration ([cort]) showed strong associations with the percentage of CD8+ (rs = .50), BVDV2-SNA (rs = -.43), and WC1CD25+ (rs = .41) cells, and rectal temperature (rs = .40). The highest [cort] was reported 3 days after aerosol BVDV-2 challenge. Serum [cort] was decreased in ITM-treated calves 3 days post-BVDV-2 challenge, compared with CONT calves, with an average decrease of 18.5 ng/μL (95% confidence interval [CI], -6.07 to -31.3). The ITM-treated calves were heavier and healthier (P < .01)than the CONT calves. Trace mineral supplementation appears to have stress mitigation effects in beef cattle that may reflect positively on growth and health performance. Viral exposure is associated with a high degree of stress, which is considered a major welfare concern.

Epigenetic Changes Associated with Different Types of Stressors and Suicide.

Stress is associated with various epigenetic changes. Some stress-induced epigenetic changes are highly dynamic, whereas others are associated with lasting marks on the epigenome. In our study, a comprehensive narrative review of the literature was performed by investigating the epigenetic changes that occur with acute stress, chronic stress, early childhood stress, and traumatic stress exposures, along with examining those observed in post-mortem brains or blood samples of suicide completers and attempters. In addition, the transgenerational effects of these changes are reported. For all types of stress studies examined, the genes Nr3c1, OXTR, SLC6A4, and BDNF reproducibly showed epigenetic changes, with some modifications observed to be passed down to subsequent generations following stress exposures. The aforementioned genes are known to be involved in neuronal development and hormonal regulation and are all associated with susceptibility to mental health disorders including depression, anxiety, personality disorders, and PTSD (post-traumatic stress disorder). Further research is warranted in order to determine the scope of epigenetic actionable targets in individuals suffering from the long-lasting effects of stressful experiences.

Activation of AMPK promotes cardiac differentiation by stimulating the autophagy pathway.

Autophagy, a critical catabolic process for cell survival against different types of stress, has a role in the differentiation of various cells, such as cardiomyocytes. Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) is an energy-sensing protein kinase involved in the regulation of autophagy. In addition to its direct role in regulating autophagy, AMPK can also influence other cellular processes by regulating mitochondrial function, posttranslational acetylation, cardiomyocyte metabolism, mitochondrial autophagy, endoplasmic reticulum stress, and apoptosis. As AMPK is involved in the control of various cellular processes, it can influence the health and survival of cardiomyocytes. This study investigated the effects of an AMPK inducer (Metformin) and an autophagy inhibitor (Hydroxychloroquine) on the differentiation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs). The results showed that autophagy was upregulated during cardiac differentiation. Furthermore, AMPK activation increased the expression of CM-specific markers in hPSC-CMs. Additionally, autophagy inhibition impaired cardiomyocyte differentiation by targeting autophagosome-lysosome fusion. These results indicate the significance of autophagy in cardiomyocyte differentiation. In conclusion, AMPK might be a promising target for the regulation of cardiomyocyte generation by in vitro differentiation of pluripotent stem cells.

Principles, mechanisms, and biological implications of translation termination-reinitiation.

The gene expression pathway from DNA sequence to functional protein is not as straightforward as simple depictions of the central dogma might suggest. Each step is highly regulated, with complex and only partially understood molecular mechanisms at play. Translation is one step where the "one gene-one protein" paradigm breaks down, as often a single mature eukaryotic mRNA leads to more than one protein product. One way this occurs is through translation reinitiation, in which a ribosome starts making protein from one initiation site, translates until it terminates at a stop codon, but then escapes normal recycling steps and subsequently reinitiates at a different downstream site. This process is now recognized as both important and widespread, but we are only beginning to understand the interplay of factors involved in termination, recycling, and initiation that cause reinitiation events. There appear to be several ways to subvert recycling to achieve productive reinitiation, different types of stresses or signals that trigger this process, and the mechanism may depend in part on where the event occurs in the body of an mRNA. This perspective reviews the unique characteristics and mechanisms of reinitiation events, highlights the similarities and differences between three major scenarios of reinitiation, and raises outstanding questions that are promising avenues for future research.

Assessing the Impact of Technology Use, Social Engagement, Emotional Regulation, and Sleep Quality Among Undergraduate Students in Jordan: Examining the Mediating Effect of Perceived and Academic Stress.

The quality of sleep is affected by several psychological factors. University students experience different types of stress and develop various strategies to cope with it. This study assesses the impact of technology use, social engagement, emotional regulation, and sleep quality among undergraduate students in Jordan, while examining the mediating effect of perceived and academic stress. A convenience sample of 308 undergraduate students was selected from the University of Jordan. The results indicated that the study model was fit, with significant direct negative impacts of social engagement, time management, and emotional regulation on perceived stress. Additionally, there was a significant direct negative relationship between technology use, time management, and emotional regulation on academic stress. The results show indirect significant standardized effects of social engagement, time management, and emotional regulation on the quality of sleep through the mediation of perceived stress.

The Effect of the Nutritional Value Enhancing of the Diet Provided to Common Carp Cyprinus carpio L. by Adding Organic Selenium and Vitamin E on Growth Parameters and Food Utilization

Farmed fish are subjected to different types of stress, including grading, transfer, crowding and vaccination, which can expose the fish to different risks. Therefore, researchers are resorted to the use of many feed additives. The aim of the current research is to promote growth and reduce oxidative stress by adding different levels of organic selenium with or without vitamin α-tocopherol. A total of 24 glass aquariums are used to feed 168 common carp fingerlings, Cyprinus carpio L., with an average weight of 31 ± 2 gm/fish on eight experimental diets with three replications for each treatment. The diets offered to the fish include the control (diet 1), while organic selenium is added in the form of seleniumthionine, in proportions of 0.6, 0.7 and 0.8 mg/kg (second, third and fourth diets). The fifth, sixth and seventh diets all include the same amounts of organic selenium along with 300 mg/kg of α-tocopherol, while the eighth diet only has α-tocopherol. The statistical analysis reveals that the addition of organic selenium, α-tocopherol, or both lead to a significant increase (P ≤ 0.05) in the parameters of final weight, total weight gain, daily growth rate, relative growth rate, specific growth rate, feed conversion ratio, feed efficiency ratio, protein retention, protein efficiency ratio and protein productive value compared to the control diet.