Exercise Of Different Intensities Research Articles

The effect of pedalling cadence on respiratory frequency: passive vs. active exercise of different intensities.

Pedalling cadence influences respiratory frequency (fR) during exercise, with group III/IV muscle afferents possibly mediating its effect. However, it is unclear how exercise intensity affects the link between cadence and fR. We aimed to test the hypothesis that the effect of cadence on fR is moderated by exercise intensity, with interest in the underlying mechanisms. Ten male cyclists performed a preliminary ramp incremental test and three sinusoidal experimental tests on separate visits. The experimental tests consisted of 16min of sinusoidal variations in cadence between 115 and 55rpm (sinusoidal period of 4min) performed during passive exercise (PE), moderate exercise (ME) and heavy exercise (HE). The amplitude (A) and phase lag (φ) of the dependent variables were calculated. During PE, fR changed in proportion to variations in cadence (r = 0.85, P < 0.001; A = 3.9 ± 1.4 breaths·min-1; φ = -5.3 ± 13.9 degrees). Conversely, the effect of cadence on fR was reduced during ME (r = 0.73, P < 0.001; A = 2.6 ± 1.3 breaths·min-1; φ = -25.4 ± 26.3 degrees) and even more reduced during HE (r = 0.26, P < 0.001; A = 1.8 ± 1.0 breaths·min-1; φ = -70.1 ± 44.5 degrees). No entrainment was found in any of the sinusoidal tests. The effect of pedalling cadence on fR is moderated by exercise intensity-it decreases with the increase in work rate-and seems to be mediated primarily by group III/IV muscle afferents, at least during passive exercise.

Parameters of lipid and oxidative-antioxidant status in persons aged 18-23 from radiation-contaminated areas under conditions of moderate physical activity

Background and Study Aim. There is a significant amount of data on the stressful effects of exercise, which contain conflicting results. Some publications testify to the adaptive processes and the benefits of optimized exercise for various physiological systems, some deny such an effect. Much controversial is the question of combination the physical exercises of different intensity with other stressors. The purpose of the study: to analyze the parameters of lipid metabolism and oxidative-antioxidant system in persons aged 18-23 who lived in territories with different radioecological status, under conditions of moderate physical activity during exercise. Material and Methods. There were examined 50 students from relatively ecologically clean areas (control group) and 50 students from the IV radiation zone (experimental group). The radiation zone is selected by the dosimetry of soil contamination with 137Cs isotopes after the Chornobyl catastrophe. Age of the examined is 18-23 years. Within the framework of the experimental group there were formed two subgroups: the main group for physical training classes (without signs of morphological-functional disorders) and the group for therapeutic physical training classes (TPTC, persons with signs of vegetative-vascular dystonia syndrome). For the control and experimental main group, classes contained all the planned exercises due to the standard curriculum. The program included a combination of aerobic and strength exercises of moderate intensity. For students with signs of vegetative-vascular dystonia, teachers used specially designed therapeutic exercise complexes. The first analysis of parameters was carried out the day before physical training classes, the second one – immediately after the class. Results. Higher levels of total cholesterol and its lipoprotein fractions (LDL-C and HDL-C), triglycerides, oxidative stress index are detected in the experimental group compared to the control group. At the same time lower levels of sulfhydryl groups (SH) were marked. The absence of statistically significant changes in the analyzed parameters in the control group and the experimental therapeutic group after physical exercises is shown in the study. There were evident tendencies of ceruloplasmin level increase in the control along with the absence of such trends in persons with signs of vegetative-vascular dystonia syndrome. This led to the formation of a significant difference between groups for this antioxidant. There is a significant increase in cortisol level and oxidative stress index in the main group of students from radiation contaminated areas. Conclusions. Potentiation of various stress factors in persons who experienced the prolonged exposure to Chornobyl accident reduces the adaptive potential of homeostatic systems. This eliminates the optimization of lipid metabolism and oxidative-antioxidant system through moderate exercise. Exercise therapy does not cause a pronounced stress effect.

Bilateral asymmetry of pedaling force at different levels of exercise intensity in cycle ergometer

Background and Study Aim. To investigate how bilateral pedaling asymmetries change at exercises with different levels of intensity.&#x0D; Material and Methods. Eight students of cycling, average age 25.4 years, were investigated. In the experiment, we recorded the pedal force of the right and left legs during three consecutive exercises of different intensity 35%, 55% and 85% respectively. To quantify the difference in physical parameters of pedaling between the left and right legs, we used two approaches that complement each other in the analysis of bilateral asymmetry. One approach involved determining an asymmetry index, and other was statistical analysis.&#x0D; Results. The Student's t-test indicated that the difference between the power samples for the left and right pedals decreased at 85% exercise intensity vs. 55% with a statistical significance of α = 0.05. The bilateral asymmetry in most cases decreased or in two cases remained unchanged. The cases where there was no statistically significant difference between the power samples for both legs at 85% and 55% intensity levels had the lowest asymmetry index.&#x0D; Conclusions. The bilateral pedaling asymmetry is reduced at 85% exercise intensity compared to the 55% one. The reduction in asymmetry index ranges from 1% to 14.1%, Combining the asymmetry index and the Student's t-test can increase the informativeness of pedaling power data when analyzing bilateral asymmetry.

Functional Recovery in Parkinson's Disease: Current State and Future Perspective.

Parkinson’s disease (PD) is one of the most frequent neurodegenerative disorders, affecting not only the motor function but also limiting the autonomy of affected people. In the last decade, the physical exercises of different intensities carried out by kinetic therapeutic activities, by robotic technologies or with the participation of sensory cues, have become increasingly appreciated in the management of Parkinson’s disease impairments. The aim of this paper was to evaluate the impact of physical exercises with and without physical devices on the motor and cognitive variables of PD patients. In order to achieve our objectives, we performed a systematic review of available original articles based on the impact of kinetic therapeutic activity. Through the search strategy, we selected original papers that were laboriously processed using characteristics related to physical therapy, or the tools used in physiological and psychological rehabilitation strategies for PD patients. In this study, we presented the most current intervention techniques in the rehabilitation programs of patients with Parkinson’s disease, namely the use of assisted devices, virtual imagery or the performing of physical therapies that have the capacity to improve walking deficits, tremor and bradykinesia, to reduce freezing episodes of gait and postural instability, or to improve motor and cognitive functions.

Lack of Correlation between Accelerometers and Heart-Rate Monitorization during Exercise Session in Older Adults

Aging is increasing worldwide; hence, aging-related health is also more relevant. Well-programmed physical exercise is now an indispensable tool to achieve active aging and preserve older people’s health. Such “well-programmed” exercise requires efficient and useful tools to measure the activity. The objective of this study is to evaluate the effectiveness of accelerometers to estimate two different intensities of physical exercise in older people. Thirty-eight subjects (64.5 ± 5.3 years) were measured during two different sessions of physical exercise: one moderate in intensity, the other of low intensity. Heart rate and accelerometry were recorded and analyzed. The results showed that the two variables in the physical exercise sessions were not highly correlated, and that accelerometry did not seem useful to assess low-intensity sessions not based on walking.

MicroRNAs in Extracellular Vesicles in Sweat Change in Response to Endurance Exercise.

BackgroundTo date, microRNAs (miRs) carried in extracellular vesicles (EVs) in response to exercise have been studied in blood but not in non-invasively collectable body fluids. In the present study, we examined whether six exercise–responsive miRs, miRs-21, -26, -126, -146, -221, and -222, respond to acute endurance exercise stimuli of different intensities in sweat.MethodsWe investigated the response of miRs isolated from sweat and serum EVs to three endurance exercise protocols: (1) maximal aerobic capacity (VO2max), (2) anaerobic threshold (AnaT), and (3) aerobic threshold (AerT) tests. Sauna bathing was used as a control test to induce sweating through increased body temperature in the absence of exercise. All protocols were performed by the same subjects (n = 8, three males and five females). The occurrence of different miR carriers in sweat and serum was investigated via EV markers (CD9, CD63, and TSG101), an miR-carrier protein (AGO2), and an HDL-particle marker (APOA1) with Western blot. Correlations between miRs in sweat and serum (post-sample) were examined.ResultsOf the studied miR carrier markers, sweat EV fractions expressed CD63 and, very weakly, APOA1, while the serum EV fraction expressed all the studied markers. In sweat EVs, miR-21 level increased after AerT and miR-26 after all the endurance exercise tests compared with the Sauna (p < 0.050). miR-146 after AnaT correlated to sweat and serum EV samples (r = 0.881, p = 0.004).ConclusionOur preliminary study is the first to show that, in addition to serum, sweat EVs carry miRs. Interestingly, we observed that miRs-21 and -26 in sweat EVs respond to endurance exercise of different intensities. Our data further confirmed that miR responses to endurance exercise in sweat and serum were triggered by exercise and not by increased body temperature. Our results highlight that sweat possesses a unique miR carrier content that should be taken into account when planning analyses from sweat as a substitute for serum.

Effect of different exercise training intensities on musculoskeletal and neuropathic pain in inactive individuals with type 2 diabetes – Preliminary randomised controlled trial

AimsPeople with type 2 diabetes (T2D) have a greater prevalence of musculoskeletal and neuropathic pain. This exploratory analysis investigated whether exercise of different intensities leads to changes in self-reported musculoskeletal pain or symptoms of diabetic neuropathy in inactive individuals with type 2 diabetes. MethodsThirty-two inactive adults with T2D (59% male, mean age 58.7 ± 9.1yrs, median HbA1c 7.8%) were randomised to usual care (CON), supervised combined aerobic and resistance moderate-intensity continuous training (C-MICT), or supervised combined high-intensity interval training (C-HIIT). At baseline and 8-weeks, musculoskeletal and neuropathic pain were evaluated using a modified Nordic Musculoskeletal Questionnaire and the Neuropathy Total Symptom Score-6 respectively. Quantitative sensory testing was used to determine thermal, mechanical and vibration detection thresholds, as well as pain pressure thresholds. Adverse events were recorded throughout the intervention. ResultsCompared to CON, reduction in musculoskeletal pain intensity was significantly greater for C-HIIT (MD −5.4, 95% CI [−10.6 to −0.2], p = 0.04) and non-significantly greater for C-MICT (MD −5.9 [−12.4 to 0.7], p = 0.08). Changes in neuropathy symptoms were not different between C-HIIT and CON (MD 1.0 [−0.9 to 2.8], p = 0.31), or C-MICT and CON (MD 0.2 [−3.1 to 3.6], p = 0.89). No differences in sensory function were observed between groups. Similar rates of adverse events were seen in both exercise interventions (19 C-HIIT; 17 C-MICT), all but one of which were mild. ConclusionsPreliminary data suggests 8-weeks of high-intensity combined aerobic and resistance exercise may be safely prescribed for inactive individuals with T2D and may reduce musculoskeletal pain but not neuropathic symptoms.Trial Registration:ACTRN12615000475549.

The affective interval: An investigation of the peaks and valleys during high- and moderate-intensity interval exercise in regular exercisers

Evidence supports the notion that people generally feel worse during high(er) intensity exercise but experience an affective rebound immediately following cessation that often exceeds pre-exercise feeling states. Considering rest/recovery is an integral part of interval exercise, it is of interest to determine the degree of affective reactivity and recovery that may occur during interval exercise of different intensities. The purpose of the present study was to examine affective reactivity to and recovery from an acute bout of moderate-intensity (MIIE) and high-intensity interval exercise (HIIE). Participants (N = 25, 13 females, 23.3 ± 4.0 yrs, BMI = 25.7 ± 4.1 kg m−2) completed 4 sessions at the same time of day with at least 24-h between each session: a baseline session to record resting affect, a graded exercise test on a stationary bike (cycle ramp protocol 25 W·min-1) to volitional exhaustion, and then completed a high- (HIIE) and moderate-intensity interval exercise (MIIE) session where affect was recorded prior to, during, and up to 30-min post exercise. Participants reported more negative feeling states during the HIIE session compared to the MIIE session, but these states recovered similarly as early as 5-min post-exercise. In addition, while affective change (reactivity and rebounds) were relatively equal during the MIIE, declines in affect during the HIIE outweighed the affective rebounds associated with rest, resulting in a large decline in affective state from pre-exercise.

Different continuous training modalities result in distinctive effects on muscle structure, plasticity and function.

The effects of training on muscle structure are dependent on adaptive changes induced by different intensities of physical exercise. Evidence has shown that aerobic training is able to induce adaptive changes to muscle structure based on intensity. The aim of the present study was to investigate the effects of different methods of continuous aerobic training in mice using functional, morphological and biomolecular approaches. The continuous aerobic training methods used in the present study were uniform continuous training (UC), varying continuous training (VC) and progressive continuous training (PC). Mice were made to run 3 times a week for 12 weeks on a motorized RotaRod, following one of the three different training methods at different speeds. The results of the present study demonstrated that the various training methods had different effects on sarcomere length. Ultrastructural analysis demonstrated that UC training resulted in a shortening of sarcomere length, PC training resulted in an elongation of sarcomere length and VC training showed similar sarcomere length when compared with the control sedentary group. Additionally, succinate dehydrogenase complex flavoprotein subunit A levels in muscle tissue following VC training were higher compared with UC and PC training. Overall, the present study showed that varying exercise methods resulted in different types of muscle plasticity, and that the VC protocol resulted in increased coordination and strength endurance in the functional tests, in agreement with the ultrastructural and biochemical profile. These observations support the view that VC training may be more efficient in increasing performance and may thus form the basis of training regimens when an improvement of motor efficiency is required.

Skeletal muscle V̇o2kinetics by the NIRS repeated occlusions method during the recovery from cycle ergometer exercise

Near-infrared spectroscopy (NIRS) has been utilized as a noninvasive method to evaluate skeletal muscle mitochondrial function in humans, by calculating muscle V̇o2 (V̇o2m) recovery (off-) kinetics following short light-intensity plantar flexion exercise. The aim of the present study was to determine V̇o2m off- kinetics following standard cycle ergometer exercise of different intensities. Fifteen young physically active healthy men performed an incremental exercise (INCR) up to exhaustion and two repetitions of constant work-rate (CWR) exercises at 80% of gas exchange threshold (GET; MODERATE) and at 40% of the difference between GET and peak pulmonary V̇o2 (V̇o2p; HEAVY). V̇o2p and vastus lateralis muscle fractional O2 extraction by NIRS (Δ[deoxy(Hb+Mb)]) were recorded continuously. Transient arterial occlusions were carried out at rest and during the recovery for V̇o2m calculation. All subjects tolerated the repeated occlusions protocol without problems. The quality of the monoexponential fitting for V̇o2m off-kinetics analysis was excellent (0.93≤r2≤0.99). According to interclass correlation coefficient, the test-retest reliability was moderate to good. V̇o2m values at the onset of recovery were ~27, ~38, and ~35 times higher (in MODERATE, HEAVY, and INCR, respectively) than at rest. The time constants (τ) of V̇o2m off-kinetics were lower (P < 0.001) following MODERATE (29.1 ± 6.8 s) vs. HEAVY (40.8 ± 10.9) or INCR (42.9 ± 10.9), suggesting an exercise intensity dependency of V̇o2m off-kinetics. Only following MODERATE the V̇o2m off-kinetics were faster than the V̇o2p off-kinetics. V̇o2m off-kinetics, determined noninvasively by the NIRS repeated occlusions technique, can be utilized as a functional evaluation tool of skeletal muscle oxidative metabolism also following conventional cycle ergometer exercise.NEW & NOTEWORTHY This is the first study in which muscle V̇o2 recovery kinetics, determined noninvasively by near-infrared spectroscopy (NIRS) by utilizing the repeated occlusions method, was applied following standard cycle ergometer exercise of different intensities. The results demonstrate that muscle V̇o2 recovery kinetics, determined noninvasively by the NIRS repeated occlusions technique, can be utilized as a functional evaluation tool of skeletal muscle oxidative metabolism also following conventional cycle ergometer exercise, overcoming significant limitations associated with the traditionally proposed protocol.

Two-dimensional finite element model to study the effect of periodic physical exercise on temperature distribution in peripheral regions of human limbs

The human body regulates the body core temperature at a uniform temperature to maintain the structure and function of various physical and physiological processes. The physical exertion causes thermal stress which can disturb these mechanisms of thermoregulation under various environmental conditions and can lead to impairment of physiological functions. In view of the above, a finite element model has been developed to study thermal stress in peripheral regions of human limbs during periodic exercise and rest. It is assumed that the subject is doing exercise periodically by taking rest at regular intervals. The human limb is assumed to be of cylindrical shape. The peripheral region of a limb is divided into three natural components, namely epidermis, dermis and subdermal parts. Appropriate boundary conditions have been framed based on physical conditions of the problem. Finite element has been employed along radial and angular directions, and the finite difference is employed for time variable to obtain the solution. The numerical results have been used to obtain temperature profiles and study the effect of light-, moderate- and vigorous-intensity activities on thermal distribution in human limbs under moderate and hot climatic conditions. The results obtained by the present model are in agreement with the physiological facts and can be employed to predict the amount of acclimatization and rest required to cope up with such thermal stresses. Such models can be developed further to obtain thermal information in human organs involving physical exercise. This thermal information can be useful for developing strategies for the time period of different intensities of physical exercise and rest required for optimum performance of sportsman, labourers, workers and military person. Also the thermal information obtained from such models can be useful for developing protocols for heat stress required for therapeutic purposes during infection and physical exercise prescriptions for healthy lifestyles.

Hypertrophic cardiomyopathy and exercise restrictions: time to let the shackles off?

The health benefits of physical activity are well documented. Patients with hypertrophic cardiomyopathy (HCM) are often discouraged from participating in physical activity due to a perceived increase in the risk of sudden cardiac death (SCD). As a result, only 45% of patients with HCM meet the minimum guidelines for physical activity, and many report an intentional reduction in exercise following diagnosis. Despite most SCD being unrelated to HCM, guidelines traditionally focused on the avoidance of potential risk through restriction of exercise, without clear recommendations on how to negate the negative health impact of inactivity. Retrospective reviews have demonstrated that the majority of cardiac arrests in patients with HCM occurred at rest or on mild exertion and that the overall incidence of HCM-related SCD is significantly lower than previously reported. We will discuss current international guidelines and recommendations and consider the outcomes of various studies that have investigated the effects of exercise of different intensities on patients with HCM. In light of the growing evidence suggesting that carefully guided exercise can be both beneficial and safe in patients with HCM, we ask whether it is time to let the shackles off exercise restriction in HCM.

Exponential model for analysis of heart rate responses and autonomic cardiac modulation during different intensities of physical exercise.

The aim of this study was to compare the heart rate (HR) dynamics and variability before and after high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) protocols with workloads based on treadmill workload at which maximal oxygen uptake was achieved . Ten participants performed cardiopulmonary exercise testing (CPET) to obtain oxygen uptake . All training protocols were performed on a treadmill, with 0% grade, and had similar total distance. The MICT was composed by 21 min at 70% of . The first HIIT protocol (HIIT-30 : 30) was composed by 29 repetitions of 30 s at 100% of and the second HIIT protocol (HIIT-4 : 3) was composed by three repetitions of 4 min at 90% of . Before, during and after each training protocol, HR dynamics and variability (HRV) were analysed by standard kinetics and linear (time and frequency domains). The repeated measures analysis of variance indicated that the HR dynamics, which characterizes the speed of HR during the rest to exercise transition, was statistically (p < 0.05) slower during MICT in comparison to both HIIT protocols. The HRV analysis, which characterizes the cardiac autonomic modulation during the exercise recovery, was statistically higher in HIIT-4 : 3 in comparison to MICT and HIIT-30 : 30 protocols (p < 0.005 and p = 0.012, respectively), suggesting that the HIIT-4 : 3 induced higher sympathetic and lower parasympathetic modulation during exercise in comparison to the other training protocols. In conclusion, HIIT-4 : 3 demonstrated post-exercise sympathetic hyperactivity and a higher HRpeak, while the HIIT-30 : 30 and MICT resulted in better HRV and HR in the exercise-recovery transition. The cardiac autonomic balance increased in HIIT-30 : 30 while HIIT-4 : 3 induced sympathetic hyperactivity and cardiac overload.

Platelet Chemiluminescence during Physical Exercise of Various Intensity.

Generation of ROS (including free radicals) in rat platelets during physical exercises of different intensities was evaluated by the chemiluminescent method. The acute or chronic submaximal exercises increased the platelet chemiluminescence by 2.5-3.0 times. In the control, platelet activation with physiological aggregant ADP enhanced their chemiluminescence by 7.5 times. Addition of ADP to platelets isolated from animals subjected to exercise of any intensity increased chemiluminescence by 4-5 times. In a trained organism, functional reserve of the platelets is preserved during long-term physical exercise of any intensity, but is exhausted after acute physical exercise. Thus, intensive physical exercises enhanced the hemostatic potential of the blood, which is associated with the risk of thrombohemorrhagic complications, especially in acute or submaximal long-term exercises.

Efficacy of nasal CPAP and aerobic exercise of different intensity in patients with obstructive sleep apnea hypopnea syndrome and type 2 diabetes mellitus

Objective: To explore the therapeutic efficacy of nasal Continuous Positive Airway Pressure (CPAP) and aerobic exercise of different intensity in patients with Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) and Type 2 Diabetes Mellitus (T2DM). Methods: A total of 112 patients with OSAHS and T2DM, including 53 males and 59 females, with a mean age of (66.9±7.8) years old, from the Fourth Rehabilitation Hospital of Shanghai and the Second Affiliated Hospital of Soochow University from January 2017 to December 2018 were enrolled prospectively. There were divided into two groups based on whether received nasal CPAP therapy: 50 cases in nasal CPAP+aerobic exercise group and 62 cases in aerobic exercise group. Subsequently, patients in nasal CPAP+aerobic exercise group were randomly divided into two subgroups: moderate and low intensity aerobic exercise (26 and 24 cases respectively). All patients completed nasal CPAP and (or) aerobic exercise of different intensity for 20 weeks. The therapeutic efficacy of polysomnography (PSG) parameters, glycolipid metabolism, 6 minutes walking distance (6 MWD), and rate of perceived exertion (RPE) were compared between each group before and after treatment. Results: Pre-and post-intervention, PSG parameters, body mass index (BMI) [(26.6±3.7) vs (24.3±2.8) kg/m(2)], RPE [(16.4±1.3) vs (12.2±2.6) score], 6 MWD [(372.6±59.7) vs (441.5±75.6) m] and glucolipid metabolism indexes were improved significantly in nasal CPAP+aerobic exercise group (all P<0.05), such as fasting blood glucose [(7.4±2.4) vs (6.2±1.6) mmol/L], glycosylated hemoglobin [(7.6±1.2)% vs (6.6±0.7)%], fasting insulin [(10.8±4.4) vs (6.9±3.4) μU/L], insulin resistance index [(3.5±1.9) vs (1.9±1.2)], total cholesterol [(4.0±0.9) vs (3.5±0.9) mmol/L], low density lipoprotein cholesterol [(4.2±0.6) vs (3.1±0.8) mmol/L]; BMI, exercise endurance, some glucolipid metabolism indexes and PSG parameters were also improved in aerobic exercise group (P<0.05). After 20 weeks' intervention, it showed statistically significant differences in PSG parameters, glycometabolism, some lipid metabolism indexes and RPE (all P<0.05), and no significantly difference in BMI [(24.3±2.7) vs (24.3±2.8) kg/m(2)] between the two groups. Compared with the low intensity subgroup, there were significant improvement in 2 hours' postprandial insulin, insulin resistance index, low density lipoprotein cholesterol, lipoprotein A, RPE, 6 MWD in moderate subgroup (P<0.05). Conclusion: Nasal CPAP combined with moderate intensity aerobic exercise can effectively improve the glucolipid metabolism, insulin resistance and exercise tolerance in patients with OSAHS and T2DM.

Comparison of cardiac biomarker dynamics in marathon, semi-marathon and untrained runners: what is the impact on results interpretation?

Background: Cardiac biomarkers elevations have been described after running exercise. Objective of our study was to check cardiac biomarker dynamics in well trained athletes and untrained middle aged apparently healthy men and to highlight the impact on the lab results interpretation in emergency department. Methods: Cardiac biomarkers for ischemic condition, cardiac stretch and fibrotic processes were tested in different type of runners before, directly after and 3 hours after running. Markers for inflammation, muscle disease and renal function were also measured. Results: Cardiac biomarker levels between groups were not statistically different in the pre-exercise samples for natriuretic peptides [B-type natriuretic peptide (BNP), N-terminal Pro BNP (NT-ProBNP)] and galectin-3 (Gal-3), only Troponin I levels were higher. Directly after exercise, all cardiac biomarker levels were higher compared to the baseline, Gal-3 and BNP levels decreased 3 hours after completion of the run. Troponin values continued to increase with highest levels 3 hours after exercise. Troponin T, NT-Pro-BNP and Gal-3 also showed significant correlation to markers of inflammation, fibrosis and renal function. Conclusions: Exercises of different intensity can be associated with biochemical abnormalities and long-term consequences are unknown. In chest pain patients presenting to the emergency department possible impact of exercise on test results, especially Troponin, should be checked.

Physical Exercise in the Management of Erectile Dysfunction in Patients with Heart Failure

Abstract Erectile dysfunction (ED) is a highly prevalent problem that affects the quality of life, prognosis and survival of patients with heart failure (HF). In the management of ED, physical exercise is a therapeutic strategy that reduces disease-related symptoms and optimizes drug use. However, the repercussions of physical exercise on ED in individuals with HF still need to be elucidated. In this sense, the objective of this study was to evaluate the effects of physical exercise on erectile function (EF) in HF patients. This was a systematic review conducted according to PRISMA guidelines. Patients with HF, male and ejection fraction ≤ 45% were submitted to physical exercise of different modalities. The search for scientific articles was conducted in the electronic databases (PubMed, LILACS, Cochrane-Library, Science Direct) from the inception until October 2018, according to the MeSH dictionary descriptors, which were suitable for all databases. Results: Three studies were analyzed, includinng 99 male subjects, age ranging from 53 years (± 7.48) to 58 years (± 12). Seventy subjects were submitted to a physical exercise program and 29 were in the control group. In all studies, physical exercise showed positive results in the management of ED regardless of erectile dysfunction (ED) classification status and intensity of exercise used. It was concluded that physical exercise of different intensities was considered an effective therapeutic intervention to improve EF in individuals with HF and ED.

PO-172 The effect of exercise on teenagers' attention

Objective At present, domestic researches on attention mainly focus on the fields of special education, neuropsychiatry and mental health, and the subjects are mostly children with ADHD and elderly people with cognitive dysfunction. Therefore, it is necessary to carry out researches on normal students and find training methods suitable for improving their attention quality.&#x0D; Methods In this study, literature review and logical analysis were used to sort out, analyze and reason the literature about the influence of physical exercise on teenagers' attention in the past five years at home and abroad.&#x0D; Results (1)in the comparative study of ordinary students and students in sports schools who participated in regular training, it was found that those with training had better attention level than ordinary students in quiet state.The attention span of trampoline athletes was better than that of students.(2) different projects have different effects on students' attention characteristics: compared with football training, table tennis has a significant impact on students' attention persistence and concentration.Compared with table tennis, football has a significant effect on the attention span of students.Compared with athletics, basketball has a significant impact on students' attention distribution ability, attention transfer ability and attention span.(3) exercise of different intensity has different effects on the intentional attention of primary and middle school students.Moderate intensity exercise works best for your body.Intense exercise initially increased attention, but after 45 minutes the brain's ability to work and focus decreased significantly.&#x0D; Conclusions Primary and middle school students of a certain intensity, regular physical exercise on attention the quality, especially to pay attention to the note has a positive role in the development of essential quality, but also should strengthen the exercise can bring attention to improving the sustainability of research, and different intensity exercise on youth blood oxygen content in concrete quality research and attention.

PO-176 The Effects of Different Intensity Treadmill Exercise to Kidney Functions

Objective To provide more scientific and authoritative theoretical basis for body-building exercises after analyzing the changes of exercises of different intensities for the kidney functions.&#x0D; Methods The objects of the research are eight male students from Guangzhou Sport College, being exerted the treadmill exercises according to their own maximum oxygen intake. The intensities of exercises are respectively 55%VO2max, 75%VO2max, 85%VO2max, 95%VO2max. The urine 40ml and venous blood 3ml will be collected and tested before sport and 15minutes after the exercises.&#x0D; Results After four different intensities of exercise, the renin of each exercise group increased compared with the quiet value, and the greater the intensity, the more obvious the trend of change. Compared with the quiet value, the expression of angiotensin II increased in all groups after exercise, but there was no significant difference between the 55%VO2max intensity group and the 75%VO2max intensity group (P &gt; 0.05), and there was significant difference between the 85%VO2max intensity group and the 95%VO2max intensity group (P &lt; 0.05). Compared with the quiet value, the expression of aldosterone increased after each exercise. The mean value of 55%VO2max intensity group, 75%VO2max intensity group and 85%VO2max intensity group increased, but the difference was not significant (P &gt; 0.05), and the 95%VO2max intensity group had a very significant difference (P &lt; 0.01). The expression of urine beta 2 microglobulin was compared with the quiet value. There was significant difference in 85%VO2max intensity group and 95%VO2max intensity group (P&lt;0.05).&#x0D; Conclusions High-intensity exercise causes renal function and body function decline. It is more appropriate to select 75% intensity exercise for body-building.

The therapeutic effects of lipoxin A4 during treadmill exercise on monosodium iodoacetate-induced osteoarthritis in rats

Lipoxin A4 (LXA4), a kind of adipokines, is a potent stop signal of inflammation. Our preliminary study found that LXA4 of serum and intra-articular lavage fluid (IALF) was rapidly elevated in 2 h and rapidly reduced to normal level at 4 h after moderate-intensity treadmill exercise. The aim was to confirm the therapeutic effects of LXA4 during treadmill exercise on rat model of monosodium iodoacetate (MIA)-induced OA and the detailed mechanism of LXA4 on OA. One hundred and twenty-four male Sprague-Dawley rats were submitted to two different protocols. A single session of treadmill exercise: sixty-four rats were randomly divided into treadmill exercise of different intensities for 60 min only once (n = 4). Formal treadmill exercise: sixty rats were randomly divided into six groups (n = 10): control group (CG), knee OA group (OAG), OA with treadmill exercise of different intensities (OAL, OAM and OAH), and OAM + BOC-2 (an antagonist of LXA4 receptor). The rats were evaluated by ELISA, histology, immunohistochemistry and western blotting. Fibroblast-like synoviocytes (FLSs) were obtained from knee joint of rats. The effects of LXA4 on interleukin (IL)-1β induced FLSs were evaluated by western blotting and immunofluorescence. The results of ELISA, histological evaluation, western blotting and immunohistochemistry indicated that OAM had a better treatment which could be suppressed by BOC-2. Moreover, LXA4 could attenuate the expression of matrix metalloproteinase (MMP)-3 and MMP-13 and suppress the expression of nuclear factor-kappa B (NF-κB) p65 induced by IL-1β in FLSs. The therapeutic effects of LXA4 during treadmill exercise on MIA-induced OA via inhibiting NF-κB signaling pathway.