Relative to men, women report clinical pain more frequently, with longer duration, and greater severity, as well as higher sensitivity to some forms of experimental pain. Although the mechanisms underlying these sex differences are likely to be manifold, sex differences in emotional modulation of pain may contribute. Indeed, sex differences in the experience and processing of emotion have been observed, and emotional processes are known to modulate pain, such that negative emotions enhance pain and positive emotions inhibit pain. In the present study (N = 114), emotionally-charged pictures of different contents (mutilation, attack scenes, death/grieving, neutral, families, adventure, erotica) were presented, during which electrocutaneous stimuli were delivered to elicit pain and the nociceptive flexion reflex (NFR, a physiological measure of spinal nociception). To assess the influence of emotion on nociceptive processing, pain responses were averaged by picture content and analyzed. Additionally, participants rated their emotional reactions to each picture to determine whether there were sex differences in emotional experience. All procedures were IRB approved. Consistent with previous research, results suggested there were sex differences in subjective emotional reactions to the pictures. Relative to men, women rated pictures of families as more pleasurable and pictures of erotica as less pleasurable. Also, women reported higher subjective pain ratings to the electrocutaneous stimuli than men. However, there were no sex differences in emotional modulation of pain and nociception. In both sexes, mutilation pictures enhanced pain ratings and NFR, and erotic pictures inhibited pain ratings and NFR. These results suggest that sex differences may exist in the subjective experience of emotionally-charged visual stimuli, but this does not influence how emotion modulates nociceptive processes. (This work was supported by a health research grant from the Oklahoma Center for the Advancement of Science and Technology (OCAST).)