This study conducted to utilized EEG measurements, one of the brain scientific research methods, to explore the differences in EEG activity to by the medium in young children’s picture books viewing activities using digital devices and paper picture books. The subjects of the study were to 21 five-year-old children, and the selected picture fairy tales were presented to infants using three media: paper picture books, smartphones, and laptops, and the frontal brain wave activity response was measured with a QEEG-4 System. The SPSS 22.0 program to was used for the data collection, and repeated treatment variance analysis was conducted to find out the difference in EEG activity response to based on the presented medium. The analysis results are as follows. First, to relative power index of to the alpha waves was to activated in the order of paper picture books, smartphones, and laptops, showing a significant difference. Second, the relative power index of beta waves was activated in the order of laptops, smartphones, and paper picture books, and there was a significant difference. The results of this study are expected to confirm that the brain's physiological response varies with the daily use of various digital media by young children in the new media era.