The clinical courses of 37 consecutive patients undergone distal pancreatectomy between January 1990 and December 1991 were prospectively studied for the usefulness of fibrin glue to prevent postoperative pancreatic fistula. The 37 cases were allocated to fibrin glue used group (18 cases) and without fibrin glue group (19). There was no significant difference in background factors between the both groups. In all patients pancreatic ducts were ligated with a 3-0 silk thread and the stumps of the pancreas were sutured continuously with a 3-0 prolene thread. Pancreatic fistula occurred postoperatively in 13 out of 37 patients (35.1%). Ten pancreatic fistulas (52.6%) occurred among 19 patients without fibrin glue, versus 3 pancreatic fistulas (16.7%) among 18 patients with fibrin glue, with a significant difference (p<0.05). These results suggest that, in patients undergone distal pancreatectomy, application of fibrin glue to the stumps of the pancreas after ligation of pancreatic duct might be useful to prevent from postoperative pencreatic fistula.