Differences In Particle Size Distribution Research Articles

Bioequivalence risk assessment of oral formulations containing racemic ibuprofen through a chiral physiologically based pharmacokinetic model of ibuprofen enantiomers

The characterization of the time course of ibuprofen enantiomers can be useful in the selection of the most sensitive analyte in bioequivalence studies. Physiologically based pharmacokinetic (PBPK) modelling and simulation represents the most efficient methodology to virtually assess bioequivalence outcomes. In this work, we aim to develop and verify a PBPK model for ibuprofen enantiomers administered as a racemic mixture with different immediate release dosage forms to anticipate bioequivalence outcomes based on different particle size distributions. A PBPK model incorporating stereoselectivity and non-linearity in plasma protein binding and metabolism as well as R-to-S unidirectional inversion has been developed in Simcyp®. A dataset composed of 11 Phase I clinical trials with 54 scenarios (27 per enantiomer) and 14,452 observations (7129 for R-ibuprofen and 7323 for S-ibuprofen) was used. Prediction errors for AUC0-t and Cmax for both enantiomers fell within the 0.8–1.25 range in 50/54 (93 %) and 42/54 (78 %) of scenarios, respectively. Outstanding model performance, with 10/10 (100 %) of Cmax and 9/10 (90 %) of AUC0-t within the 0.9–1.1 range, was demonstrated for oral suspensions, which strongly supported its use for bioequivalence risk assessment. The deterministic bioequivalence risk assessment has revealed R-ibuprofen as the most sensitive analyte to detect differences in particle size distribution for oral suspensions containing 400 mg of racemic ibuprofen, suggesting that achiral bioanalytical methods would increase type II error and declare non-bioequivalence for formulations that are bioequivalent for the eutomer.

Feasibility of replacing waxy rice with waxy or sweet-waxy corn viewed from the structure and physicochemical properties of starches

To explore the feasibility of substituting waxy rice with waxy or sweet-waxy corn, eight varieties of waxy and sweet-waxy corns were selected, including three self-cultivated varieties (Feng nuo 168, Feng nuo 211, and Feng nuo 10). Their starches were isolated and used as research objects, and commercially available waxy rice starch (CAWR) and waxy corn starch (CAWC) were used as controls. X-ray diffraction, scanning electron microscopy, differential scanning calorimetry, rapid viscosity analyzer, and rotational rheometer were used to analyze their physicochemical and structural characteristics. The morphologies of all corn starch granules were generally oval or round, with significant differences in particle size distributions. All ten starches exhibited a typical A-type crystal structure; however, their relative crystallinity varied from 20.08% to 31.43%. Chain length distribution analysis showed that the A/B ratio of Jing cai tian nuo 18 and Feng nuo 168 was similar to that of CAWR. Peak viscosities of corn starches were higher than that of CAWR, except for Feng nuo 10, while their setback values were lower than that of CAWR. Except for Feng nuo 10, the paste transparency of corn starches was higher than that of CAWR (10.77%), especially for Jing cai tian nuo 18 (up to 24%). In summary, Jing cai tian nuo 18 and Feng nuo 168 are promising candidates to replace CAWR in developing various rice-based products.

Exploring the Hemostatic Effects of Platelet Lysate-Derived Vesicles: Insights from Mouse Models.

Platelet transfusion has various challenges, and platelet-derived extracellular vesicles have been reported to have more significant procoagulant activity than platelets themselves. Furthermore, platelet products derived from platelet-rich plasma and platelet lysates (PLs) have gained attention for their physiological activity and potential role as drug delivery vehicles owing to the properties of their membranes. We aimed to investigate the characteristics of the fractions isolated through ultracentrifugation from mouse-washed PLs and assess the potential clinical applications of these fractions as a therapeutic approach for bleeding conditions. We prepared PLs from C57BL/6 mouse-washed platelets and isolated three different fractions (20K-vesicles, 100K-vesicles, and PLwo-vesicles) using ultracentrifugation. There was a notable difference in particle size distribution between 20K-vesicles and 100K-vesicles, particularly in terms of the most frequent diameter. The 20K-vesicles exhibited procoagulant activity with concentration dependence, whereas PLwo-vesicles exhibited anticoagulant activity. PLwo-vesicles did not exhibit thrombin generation capacity, and the addition of PLwo-vesicles to Microparticle Free Plasma extended the time to initiate thrombin generation by 20K-vesicles and decreased the peak thrombin value. In a tail-snip bleeding assay, pre-administration of 20K-vesicles significantly shortened bleeding time. PL-derived 20K-vesicles exhibited highly potent procoagulant activity, making them potential alternatives to platelet transfusion.

Fractal Characteristics of the Particle Size Distribution of Soil along an Urban–Suburban–Rural–Desert Gradient

In order to investigate the difference in particle size distribution of soil along an urban–suburban–rural–desert (USRD) gradient in an arid zone, surface soil (0–20 cm) samples were gathered at the urban, suburban, rural, and desert gradients in Urumqi, a northwestern Chinese city. Laser diffraction technology was adopted for determining the particle size distribution of the soil. Comparisons were made regarding the particle size distribution traits and soil properties in different gradient zones based on parameters such as the mean particle size (MG), fractal dimension (Dv), sorting coefficient (ơG), kurtosis (KG), and skewness (SKG). Results indicate that (1) particle size distribution in the urban, suburban, and rural soils was mainly sand particle sizes, whereas the desert soil was mainly composed of silt particle sizes. The average Dv value ranking for soil in each gradient is desert > suburban > urban > rural. (2) The width and peak of the soil particle size frequency curve ranged within 0–500 μm, and the width and peak of the soil particle size frequency curve of each gradient were different. (3) The MG of rural soil was the highest, whereas the MG of desert soil was the lowest. The ơG values of the surface soil of each gradient were all greater than 4.0, and the sorting performance was extremely poor. The SKG of the desert and urban soil particle size showed extremely positive and negative skewness, respectively, while the SKG of the rural and suburban soil particle size showed extremely negative skewness. The KG values of the particle sizes of the rural and suburban soils exhibited narrow and medium peaks, whereas those of the urban and desert soils exhibited very broad and flat peaks. (4) The Dv of the soil in each gradient was strongly influenced by the soil particle size distribution, with the clay content of the soil playing a dominant role. Finally, the fractal dimension was identified as an indicator of the characteristics of the fine particle matter content in the soil structure. The novel contribution of this work is to clarify the fractal differences in the particle size distribution of soil along an urbanization gradient. The present research findings can offer fundamental information relating to the characteristics of soil particle size distribution along an urbanization gradient zone.

Important Role and Properties of Granular Nanocellulose Particles in an In Vitro Simulated Gastrointestinal System and in Lipid Digestibility and Permeability.

This research evaluated the role and feasibility of the granular nanocellulose particles (GNC) from sugarcane bagasse obtained from enzymatic hydrolysis in reducing lipid digestibility and permeability in an in vitro simulated gastrointestinal (GI) system. GNC concentration (0.02%, w/v) had significantly affected the released free fatty acids (FFA), with a reduction of approximately 20%. Pickering emulsion of a GNC and olive oil simulation mixture revealed higher oil droplet size distribution and stability in the initial stage than the vortexed mixture formation. The difference in particle size distribution and zeta potential of the ingested GNC suspension and GNC-olive oil emulsion were displayed during the in vitro gastrointestinal simulation. GNC particles interacted and distributed surrounding the oil droplet, leading to interfacial emulsion. The GNC concentration (0.01-0.10%, w/v) showed low toxicity on HIEC-6 cells, ranging from 80.0 to 99% of cell viability. The release of FFA containing the ingested GNC suspension and GNC-olive oil emulsion had about a 30% reduction compared to that without the GNC digestion solution. The FFA and triglyceride permeability through the HIEC-6 intestinal epithelium monolayer were deceased in the digesta containing the ingested GNC and emulsion. This work indicated that GNC represented a significantly critical role and properties in the GI tract and reduced lipid digestion and absorption. This GNC could be utilized as an alternative food additive or supplement in fatty food for weight control due to their inhibition of lipid digestibility and assimilation.

Elaborative collection of condensed combustion products of solid propellants: Towards a real Solid Rocket Motor (SRM) operational environment

A novel constant-pressure and constant-quenching distance Condensed Combustion Products (CCPs) collection system was developed, coupled with a timing control system, to collect the CCPs formed in the course of burning of aluminum-based composite propellants. The effects of adiabatic graphite plating, collection zone, quenching distance, time series of collection, and propellant burning rate on the microscopic morphology, particle size distribution and unburned aluminum content of CCPs were investigated. It was verified that the graphite plating can provide a high-fidelity high-temperature environment for propellant combustion. The combustion efficiency is improved by 2.44% compared to the bare propellant case. The time series of collection has a significant effect on the combustion efficiency of aluminum, and the combustion efficiency of aluminum in the thermal state (1.2–2.4 s) is 2.75% higher than that in the cold state (0–1.2 s). Similarly, the characteristics of the CCPs in different collection zones are different. At the quenching distance of 5 mm, the combustion efficiency of aluminum in the core zone (85.39%) is much lower than that in the outer zone (92.07%), while the particle size of the CCPs in the core zone (172 μm) is larger than that in the outer zone (41 μm). This indicates that the core zone is more likely to produce large-sized and incompletely burned agglomerates during the propellant combustion process. Different burning rates also lead to a significant difference in particle size distribution and combustion efficiency. High burning rates result in higher combustion efficiency. A detailed sequence of the elaborative collection process of CCPs is proposed, mainly including the setting of ignition delay time, burning rate, working pressure, plating length and time series of collection. The findings of this study are expected to provide a reliable tool for the evaluation of the combustion efficiency of solid propellants.

Particle size distribution of growing media constituents using dynamic image analysis: Parametrization and comparison to sieving

AbstractGrowing media constituents have heterogeneous particle size and shape, and their physical properties are partly related to them. Particle size distribution is usually analyzed through sieving process, segregating the particles by their width. However, sieving techniques are best describing more granular shapes and are not as reliable for materials exhibiting large varieties of shapes, like growing media constituents. A dynamic image analysis has been conducted for a multidimensional characterization of particle size distribution of several growing media constituents (white and black peats, pine bark, coir, wood fiber, and perlite), from particles that were segregated and dispersed in water. Diameters describing individual particle width and length were analyzed, then compared to particle size distribution obtained by dry and wet sieving methods. This work suggests the relevance of two parameters, FeretMAXand ChordMINdiameters for assessing particle length and width, respectively. They largely varied among the growing media constituents, confirming their non‐spherical (i.e., elongated) shapes, demonstrating the advantages of using dynamic image analysis tools over traditional sieving methods. Furthermore, large differences in particle size distribution were also observed between dynamic image analysis and sieving procedures, with a finer distribution for dynamic image analysis. The discrepancies observed between methodologies were discussed (particle segregation, distribution weighing, etc.), while describing in details methodological limitations of dynamic image analysis.

Fungi, mites/ticks, allergens, and endotoxins in different size fractions of house dust from long-term uninhabited houses and inhabited houses

Considering the necessity of countermeasures against microbial contamination in long-term uninhabited houses after the Fukushima accident, fungi, mites/ticks, allergens, and endotoxins in house dust from long-term (6–7 years) uninhabited houses (N = 37) and inhabited houses (N = 17) were investigated. In addition, the particle size dependence of microbial concentrations was evaluated to know what sieving size is desirable for microbial hazard and exposure assessments in dust. No difference in particle size distribution was observed between the two types of houses. Fungal concentrations were much higher in the long-term uninhabited houses than those in the inhabited houses, with the values decreasing with increase in particle size. Aspergillus spp. was dominant in 78% of the long-term uninhabited houses but in only 31% of the inhabited houses. Mite concentrations were not different between long-term uninhabited and inhabited houses; in both, the highest mite concentrations were observed in 63–180 μm dust particles while the highest Der 1 and Der 2 concentrations were observed in 20–63 μm dust particles. In inhabited houses, Dermatophagoides were predominant, whereas they represented <50% of mite population in long-term uninhabited houses. Endotoxin concentrations were lower in inhabited houses than in long-term uninhabited houses. The endotoxin concentration in the long-term uninhabited houses increased with increasing particle size. In conclusion, residents should reduce fungal and mite concentrations through careful cleaning prior to occupancy. The dependence of microbial concentration on particle size varied with microbial species and location, confirming that sieving size deserves attention in microbial hazard and exposure assessment.

Comprehensive effects of grain-size modification of electrolytic manganese residue on deep dehydration performance and microstructure of sludge

As the by-product accompanied by sewage treatment, sludge has complex composition and high moisture content, therefore, its reutilization and disposal are still a challenge. In this paper, five kinds of quartz sand conditioners with different particle sizes (denoted as QS1, QS2, QS3, QS4 and QS5, respectively) were used to explore the effect of particle size distribution of conditioners on sludge dewatering performance. The moisture content, capillary suction time (CST), time to filter (TTF), specific resistance of filtration (SRF), particle size distribution curve, pore distribution law, scanning electron microscopy, isothermal adsorption-desorption curve and extracellular polymeric substances distribution were employed to characterize the modified sludge and explore the improvement mechanism. The results show that the particle size distribution of the conditioner significantly affects the efficiency of sludge dewatering. The wt% of sludge regulated with QS1 (QS1-S) could be reduced to 52%, and its CST value, TTF value and SRF value is 57.93 s, 278 s and 1.84 × 108 s2 g−1, respectively. The conjecture about the effect of difference of particle size distribution on sludge dewatering performance was verified with the original Electrolytic Manganese Residue (EMR) and the grain-size modified Electrolytic Manganese Residue (EMR6). Compared with those of the EMR-conditioned sludge, the CST, TTF and SRF of EMR6-conditioned sludge was decreased by 8.7%, 22.3% and 11.2%, respectively. According to analysis of surface microstructure, the surface of the sludge cake modified with QS1 is rough and sparse with rich pore structure. Compared with those of the undisturbed sludge (A0), the pore volume and specific surface area of the sludge modified with QS1 was increased by 61.65% and 38.62%, respectively. After grain-size modification, the dehydration effect of EMR6 (D10 4.25 μm, D50 19.65 μm, D90 73.26 μm) was significantly enhanced, and the D10, D50 and D90 value was close to that of QS1. It can be concluded that the particle size of QS1 (D10 3.27 μm, D50 15.66 μm, and D90 62.23 μm) can improve the dewatering performance of sludge by shearing the sludge particles to change the original sludge particle size distribution and improving the blockage of sludge dewatering channels.

Particle size distributions inside and around the artificial crater produced by the Hayabusa2 impact experiment on Ryugu

Japanese Hayabusa2 spacecraft has successfully carried out an impact experiment using a small carry-on impactor (SCI) on an asteroid (162173) Ryugu. We examine the size distribution of particles inside and outside an artificial impact crater (the SCI crater) based on the images taken by the optical navigation camera onboard the Hayabusa2 spacecraft. The circumferential variation in particle size distribution inside the SCI crater is recognized and we interpret that major circumferential variation is caused by the large boulders inside the SCI crater that existed prior to the impact. The size distribution inside the SCI crater also shows that the subsurface layer beneath the SCI impact site had a large number of particles with a characteristic size of – 9 cm, which is consistent with the previous evaluations. On the other hand, the size distribution outside the SCI crater exhibits the radial variation, implying that the deposition of ejecta from the SCI crater is involved. The slope of the size distribution outside the crater at small sizes differs from the slope of the size distribution on the surface of Ryugu by approximately 1 or slightly less. This is consistent with the claim that some particles are buried in fine particles of the subsurface origin included in ejecta from the SCI crater. Thus, the particle size distributions inside and outside the SCI crater reveal that the subsurface layer beneath the SCI impact site is rich in fine particles with – 9 cm in size while the particles on the surface have a size distribution of a power-law form with shallower slopes at small sizes due to the deposition of fine ejecta from the subsurface layer. Finally, we discuss a process responsible for this difference in particle size distribution between the surface and the subsurface layers. The occurrence of segregation in the gravitational flow of particles on the surface of Ryugu is plausible.Graphical

Effect of powder variability on laser powder bed fusion processing and properties of 316L

To date, the effects of powder properties, both physical and chemical, on the printed properties of as-built components is still a topic that is poorly understood. A contributing factor is the lack of relevant methods for evaluating the rheological properties of powder, or flowability. This study presents a review of different 316 L powder grades that were produced using various atomization techniques. The physical powder properties were evaluated using powder metallurgical techniques, a powder rheometer (FT4) and a rotating drum analyser (RPA). The results indicate that both the FT4 and RPA are suitable for powder characterization. However, the parameter selection for evaluation must be done keeping in mind the application, in this case thin layer powder spreading. It was found that all bulk powder density measurements, basic flow energy and the break energy were able to both differentiate between powder grades and predict how suitable the powder will be for the laser-based powder-bed fusion process. Despite some printability challenges of the water atomized grades at higher layer thicknesses, it was found that both gas atomized grades performed similarly despite minor differences in particle size distribution. Furthermore, powder variability did not show any detrimental effects on the resulting mechanical properties.

Material and Manufacturing Properties of Bracket Mural Paintings of Daeungjeon Hall in Gaeamsa Temple, Buan

This study examined the production technique of bracket murals in Daeungjeon Hall, Gaeamsa Temple by conducting a analysis of their wall structure, material characteristics, and painting layers. Wall was a single-branch structure with support layer, middle layer, finishing layer, and painting layer. The support layer, middle layer and finishing layer, were produced by mixing sand (quartz, feldspars etc.), and loess. The ratio of above medium sand to below fine sand was approximately 0.7 : 9.3 in the support layer, 4 : 6 in the middle layer and 6 : 4 in the finishing layer, which had a more percentage of above medium sand than the support layer. The analysis of the painting layer showed that natural soil pigment was used to establish a relatively ground layer of up to 50 μm, and pigments such as Lead sulfate, atacamite and mercury sulfide were painted on top of the layer. This study’s results confirmed that the bracket mural paintings in Gaeamsa Temple are within the category of the production style of murals during the Joseon period. However, the points that the middle layer was formed several times, the significant difference in particle size distribution between the wall, and the absence of chopped straw in the support layer are a feature of bracket mural paintings in Gaeamsa Temple. These properties of murals as material and structure may be viewed for correlation with the degree of damage to wall structure of mural painting and would serve as an important reference to diagnosis the conservation conditions of murals or prepare conservation treatments.

Powder HIP of pure Nb and C-103 alloy: The influence of powder characteristics on mechanical properties

In this work, pure Nb processed by Powder Metallurgy Hot Isostatic Pressing (PM HIP) was investigated as a potential alternative to C-103 Nb-based alloy for the manufacture of near-net-shape thruster combustion chambers. Three Nb powders with varied particle size range (fine, mid-range and coarse) and C-103 powder were investigated to understand the differences in particle size distribution (PSD), morphology and oxygen (O) content present in the alloy chemistry. The as-HIPed microstructures of pure Nb and C-103 are characterised by a near to fully dense microstructure and the absence of PPBs. Microstructural analyses performed on pure Nb highlighted the influence of particle size on the average as-HIPed grain size. Additionally, it was observed that O content plays a crucial role in the microhardness of pure Nb. Tensile tests performed on Nb mid-range and on Nb mid-range sieved showed that a simple sieve operation was effective in increasing the strength of the material while maintaining good levels of elongation. Alternatively, it was also demonstrated that pure Nb powder heat treatment can be regarded as an effective way to increase the O levels in pure Nb powders as witnessed by the high hardness levels. On the other hand, as-HIPed C-103 powder showed superior tensile properties if compared to the minimum specifications for wrought C-103. Finally, to summarise, the work performed on pure Nb, a simple structure-property relation model was developed to predict the YS of pure Nb based on the O levels and grain size of the as-HIPed microstructure.

Comparison of bacterial filtration efficiency vs. particle filtration efficiency to assess the performance of non-medical face masks

As a result of the current COVID-19 pandemic, the use of facemasks has become commonplace. The performance of medical facemasks is assessed using Bacterial Filtration Efficiency (BFE) tests. However, as BFE tests, require specific expertise and equipment and are time-consuming, the performance of non-medical facemasks is assessed with non-biological Particle Filtration Efficiency (PFE) tests which are comparatively easier to implement. It is necessary to better understand the possible correlations between BFE and PFE to be able to compare the performances of the different types of masks (medical vs. non-medical). In this study BFE results obtained in accordance with the standard EN 14683 are compared to the results of PFE from a reference test protocol defined by AFNOR SPEC S76-001 with the aim to determine if BFE could be predicted from PFE. Our results showed a correlation between PFE and BFE. It was also observed that PFE values were higher than BFE and this was attributed to the difference in particle size distribution considered for efficiency calculation. In order to properly compare these test protocols for a better deduction, it would be interesting to compare the filtration efficiency for a similar granulometric range.

Case study of spontaneous heating of metal powder – Calorimetric solution

Two samples of mixed metal powders taken from one workplace of surface metallisation were studied with respect to self-heating risk. Irrespective of the similar chemical composition, one of the powders proved significantly increased reactivity in aerial oxygen resulting in self-heating occurrence in situ. As the main reason for the distinct behaviour of the samples, a difference in particle size distribution was found. From a technical point of view, the different grain size of the powders arose from the nonsymmetric branching of the suction piping.

Direct Analysis of Soil Composition for Source Apportionment by Laser Ablation Single-Particle Aerosol Mass Spectrometry.

Soil has always been the most complex biomaterial on the planet. The rapid determination of the components in the soil and their original source is a prerequisite for soil quality, environmental, and human health risk assessments. In this study, the chemical compositions and source apportionment of surface soil samples collected from five sites in Shanghai, China, were successfully investigated using a laboratory-developed laser ablation single-particle aerosol mass spectrometry (LA-SPAMS) instrument combined with an adaptive resonance theory-based neural network algorithm (ART-2a) data-processing method for the first time. In total, more than 35,000 particles, ranging from 200 to 2000 nm, were sized, and around 15-20% of the particles were chemically analyzed by LA-SPAMS to generate both positive and negative mass spectra. The results show that there are significant differences in particle size distribution among the five samples, with peaks of various sizes and different profiles, while all five soil samples contain crustal elements, heavy metals, organic and inorganic components, and so forth. The chemical composition of each sample varied considerably, so different classes of SPAMS particle classes were identified, which were later grouped into seven general categories: EC-rich (containing elemental carbon), secondary components, organic nitrogen, crust, HM (containing heavy metal), PAH (containing polycyclic aromatic hydrocarbons), and NaK-rich particles, based on the dominant marked ions. The composition analysis and source apportionment showed that soil components in different areas have been affected by the local environment, such as local industrial emissions and automobile exhaust, which are usually characterized by varying degrees of mixing between the crust and environmental aerosols. In combination with the ART-2a method, LA-SPAMS enables rapid and direct analysis of soil samples based on real-time single-particle measurements, which will help in understanding the distribution, transport, and fate of the soil components, thus providing new insights into soil-quality assessment. Moreover, the established LA-SPAMS can also be practically applied to other daily inspection tasks, such as rocks, minerals, metals, ceramics, polymers, and other solid materials for ingredient analysis and quality evaluation.

Aircraft Measurements of the Microphysical Properties of Stratiform Clouds with Embedded Convection

The presence of embedded convection in stratiform clouds strongly affects ice microphysical properties and precipitation formation. In situ aircraft measurements, including upward and downward spirals and horizontal penetrations, were performed within both embedded convective cells and stratiform regions of a mixed-phase stratiform cloud system on 22 May 2017. Supercooled liquid water measurements, particle size distributions, and particle habits in different cloud regions were discussed with the intent of characterizing the riming process and determining how particle size distributions vary from convective to stratiform regions. Significant amounts of supercooled liquid water, with maxima up to 0.6 g m−3, were observed between −3°C and −6°C in the embedded convective cells while the peak liquid water content was generally less than 0.1 g m−3 in the stratiform regions. There are two distinct differences in particle size distributions between convective and stratiform regions. One difference is the significant shift toward larger particles from upper −15°C to lower −10°C in the convective region, with the maximum particle dimensions increasing from less than 6000 μm to over 1 cm. The particles larger than 1 cm at −10°C are composed of dendrites and their aggregates. The other difference is the large concentrations of small particles (25–205 μm) at temperatures between −3°C and −5°C in the convective region, where rimed ice particles and needles coexist. Needle regions are observed from three of the five spirals, but only the cloud conditions within the convective region fit into the Hallett-Mossop criteria.

Characterization, in vitro dissolution, and pharmacokinetics of different batches of efavirenz raw materials

Objective To perform the solid-state characterization and the in vitro-in vivo correlation (IVIVC) of three batches of efavirenz (EFV) active pharmaceutical ingredients. Significance EFV is an effective anti-HIV drug. Due to the poor aqueous solubility, the rate and extent of EFV absorption deeply depend on its dissolution characteristics. Methods Thermal analyses, x-ray diffraction, and particle size distribution were performed. The saturation solubility and dissolution profiles were assessed in 0.5% (w/v) sodium lauryl sulfate (SLS), fasted-state simulated intestinal fluid (FaSSIF), and fed-state simulated intestinal fluid (FeSSIF) using a flow-through cell. Each batch was orally administered to Wistar rats and the pharmacokinetic parameters were correlated with those obtained from in vitro dissolution. Results All batches of EFV consisted polymorph I. EFV-A presented the lowest particle size distribution [d(v,0.5) = 197.8 µm; d(v,0.9) = 444.6 µm] followed by EFV-B [d(v,0.5) = 223.9 µm; d(v,0.9) = 481.1 µm], and EFV-C [d(v,0.5) = 240.8 µm; d(v,0.9) = 497.3 µm]. The saturated solubility in FaSSIF was 36% and 40% of that in FeSSIF and SLS, respectively. EFV-A presented the fastest rate and largest extension of dissolution than EFV-B and C (79.15%, 69.93% and 54.22%, respectively, as well as the highest maximum plasma concentration. Levels B, C, and multiple-C of IVIVC models were achieved. Conclusion The FaSSIF medium discriminated the dissolution profiles of EFV APIs. Small differences in particle size distribution had a significant impact on the biopharmaceutical parameters of EFV, suggesting that strict control of such parameter is an important aspect during API development and drug formulation.

Effect of SO2 and SO3 on the distribution of Na/S/Cl and ashes characteristics of Zhundong coal during circulating fluidized bed O2/CO2 combustion

The high concentration of SO2 and SO3 under oxy-fuel combustion atmosphere is conducive to the sulfation of alkali metals. In order to investigate the effect of SO2 and SO3 on the distribution of Na/S/Cl and ashes characteristics of Zhundong coal during oxy-fuel combustion, a series of experiments were carried out in a 50 kW CFB oxy-fuel combustor system. The results showed that both SO2 and SO3 could realize the sulfation reaction of NaCl. It would enhance the distribution of sodium to the bottom ash and the circulating ash, the chlorine to the flue gas, so as to reduce the content of sodium and chlorine in deposit. In addition, the contents of Ca and Mg increased in the deposits and decreased in the fly ashes as the SO2 and SO3 were added, while the contents of Fe were all decreased in the deposits and fly ashes. Compared with SO2, SO3 is more prone to the sulfation reaction. While increasing the addition of SO2 and SO3 could strengthen the sulfation reaction. In addition, the deposit and fly ash generated by Zhundong coal combustion could be divided into two parts: particles less than 10 μm formed by condensation of sodium, chlorine and other components; particles larger than 10 μm formed by crushing of coal ash. Introducing SO2 and SO3 made the surface structure of deposit more porous, but the BET surface area of fly ash declined. There was no obvious difference of particle size distribution of deposit.

Assessment of the standardized training residency Exposure Level and Concentration of the Indoor Microbial Aerosols in Hospital Buildings in Winter

In order to deeply analyze the pollution situation, distribution characteristics and exposure level of microbial aerosol in different functional buildings, the concentration, particle size distribution and resident exposure level of bacterial aerosol in different functional places of hospitals were studied in this paper. The results show that: 1) There are harmful environmental exposure and environmental health risks in the standardized training of residents in China, which need to be paid enough attention to improve their occupational environment. 2) the concentration level of indoor bacterial aerosol in various places of hospital in winter is outpatient hall > nurse station > doctor’s office > outdoor > general ward. 3) The median diameter of indoor bacterial aerosols in hospital buildings is smaller than that of outdoor ones, and there are differences in particle size distribution of indoor bacterial aerosols in different types of places. When indoor pollution sources are strong or indoor ventilation is poor, the particle size distribution characteristics of bacterial aerosols are mainly affected by indoor pollution sources.