In an earlier work (Castillo et al. in J Math Phys 61:103505, 2020), it was established, from a hypergeometric-type difference equation, tractable sufficient conditions for the monotonicity with respect to a real parameter of zeros of classical discrete orthogonal polynomials on linear, quadratic, q-linear, and q-quadratic grids. In this work, we continue with the study of zeros of these polynomials by giving a comparison theorem of Sturm type. As an application, we analyze in a simple way some relations between the zeros of certain classical discrete orthogonal polynomials.
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