Diet Program Research Articles

A multicentral prospective cohort trial of a pharmacist-led nutritional intervention on serum potassium levels in outpatients with chronic kidney disease: The MieYaku-Chronic Kidney Disease project.

Although dietary potassium restriction is an acceptable approach to hyperkalemia prevention, it may be insufficient for outpatients with chronic kidney disease (CKD). Most outpatients with CKD use community pharmacies owing to the free access scheme in Japan. The MieYaku-CKD project included a community pharmacist-led nutritional intervention for dietary potassium restriction, with the goal of determining its efficacy for patients' awareness of potassium restriction and serum potassium levels in outpatients with CKD. This was a five-community pharmacy multicenter prospective cohort study with an open-label, before-and-after comparison design. Eligible patients (n = 25) with an estimated glomerular filtration rate (eGFR) < 45 mL/min/1.73 m2 received nutritional guidance from community pharmacists. The primary outcome was a change in serum potassium levels at 12 weeks post-intervention. The eligible patients' knowledge, awareness, and implementation of potassium restriction were evaluated using a questionnaire. The median value of serum potassium was significantly reduced from 4.7 mEq/L before to 4.4 mEq/L after the intervention [p < 0.001, 95% confidence interval (CI): 0.156-0.500], with no changes in eGFR (p = 0.563, 95% CI: -2.427-2.555) and blood urine nitrogen/serum creatinine ratio (p = 0.904, 95% CI: -1.793-1.214). The value of serum potassium had a tendency of attenuation from 5.3 to 4.6 mEq/L (p = 0.046, 95% CI: 0.272-1.114) in the eGFR < 30 mL/min/1.73 m2 group. A questionnaire revealed that after the intervention, knowledge and attitudes regarding dietary potassium restriction were much greater than before, suggesting that the decrease in serum potassium levels may be related to this nutritional guidance. Our findings indicate that implementing a dietary potassium restriction guidance program in community pharmacies is feasible and may result in lower serum potassium levels in outpatients with CKD.

Changes in ghrelin, GLP-1, and PYY levels after diet and exercise in obese individuals.

Diet and exercise, which are the building blocks of obesity management, provide weight loss by creating a negative energy balance. However, the effect of energy deficit induced by long-term diet and exercise on appetite hormones remains unclear. The study was designed to determine the effect of a 12-week diet and exercise program applied to obese individuals on the levels of appetite hormones, namely, ghrelin, GLP-1, and PYY. A total of 62 obese individuals (BMI≥30) and 48 healthy controls (BMI 18.50-29.99) participated in the study. Appropriate diet (1000-1500 kcal/day) and exercise (at least 5000 steps/day) programs were applied to obese individuals according to age, gender, and BMI. The ghrelin, GLP-1, and PYY values of the participants were analyzed by the ELISA method and commercial kit by taking venous blood samples before and after 12 weeks of treatment. While ghrelin levels of individuals decreased significantly after diet and exercise, PYY levels increased significantly. However, despite the treatment applied, the GLP-1 and PYY levels of the case group did not reach the levels of the control group. Long-term diet and exercise intervention had a positive effect on appetite regulation hormones. It reduced ghrelin levels after treatment. Associated weight loss was facilitated. In the case group, increased satiety hormones after combined treatment supported the maintenance of body weight by increasing satiety.

British Dietary Habits and Declining Nutrient Intakes

Vitamins, minerals and essential fatty acids are vital to health. In the UK, the National Diet and Nutrition survey rolling programme estimates the intake of a range of these essential nutrients and foods that contain them. Since this programme began in 2008/2009 nutrient intakes have not improved. The aim of this paper is to evaluate vitamin and mineral intakes in the latest iteration of the National Diet and Nutrition Survey and compare these intakes with those in 2008/2009 and where possible with similar data from UK surveys going back to 1997. This paper also analysed findings from a survey of reviewing people’s knowledge, habits and opinions on nutrition, vitamin and mineral intakes and supplementation to contribute to the interpretation of findings from the NDNS. Consumption of the majority of the micronutrients measured in the NDNS fell from 2008/2009 to 2018/2019. These decreases were greater in women than men and particularly worrying in younger women especially for vitamin A, riboflavin, folate, calcium, magnesium, iron, zinc, iodine and selenium. Reductions of the same micronutrients in young men were also evident and only zinc intakes have improved in older men. Poor dietary intakes are due to confusion and lack of knowledge as to what constitutes a healthy diet, lack of time and the cost of healthy eating which has increased during recent years. Nutrients can be provided from a healthy diet, but this is not being achieved. Hence a multivitamin and multi mineral food supplement is the best policy to bridge these dietary gaps.

Systematic Review and Meta-Analysis Steps for Choosing Suitable Packaging Material (Case Study: Food Safety)

Vitamins, minerals and essential fatty acids are vital to health. In the UK, the National Diet and Nutrition survey rolling programme estimates the intake of a range of these essential nutrients and foods that contain them. Since this programme began in 2008/2009 nutrient intakes have not improved. The aim of this paper is to evaluate vitamin and mineral intakes in the latest iteration of the National Diet and Nutrition Survey and compare these intakes with those in 2008/2009 and where possible with similar data from UK surveys going back to 1997. This paper also analysed findings from a survey of reviewing people’s knowledge, habits and opinions on nutrition, vitamin and mineral intakes and supplementation to contribute to the interpretation of findings from the NDNS. Consumption of the majority of the micronutrients measured in the NDNS fell from 2008/2009 to 2018/2019. These decreases were greater in women than men and particularly worrying in younger women especially for vitamin A, riboflavin, folate, calcium, magnesium, iron, zinc, iodine and selenium. Reductions of the same micronutrients in young men were also evident and only zinc intakes have improved in older men. Poor dietary intakes are due to confusion and lack of knowledge as to what constitutes a healthy diet, lack of time and the cost of healthy eating which has increased during recent years. Nutrients can be provided from a healthy diet, but this is not being achieved. Hence a multivitamin and multi mineral food supplement is the best policy to bridge these dietary gaps.

White Matter Lesion Volumes on 3-T MRI in People With MS Who Had Followed a Diet and Lifestyle Program for More Than 10 Years.

Background: Cerebral white matter lesion (WML) formation in people with multiple sclerosis (pwMS) is linked to the death of myelin-producing oligodendrocytes. Current MS treatment strategies focus on limiting WML accumulation and disability. Using a pathology-supported genetic testing (PSGT) program, we identified specific risk factors for MS, categorized as deficiencies and aggravators. We developed a novel clinical methodology to mitigate these risk factors, including personalized lifestyle interventions and optimization of cerebral nutrients to prevent oligodendrocyte demise and promote remyelination. Objective: To conduct a pilot case-control study over a 10-year period to ascertain whether the PSGT Program can reduce or prevent WML formation in pwMS. Methods: MRI was performed at baseline as well as after an interval period of at least 10 years or longer in 22 pwMS. WML volumes were determined using Sequence Adaptive Multimodal SEGmentation (SAMSEG) software, part of FreeSurfer 7.2. Other variables included age at MRI, disease duration, disability status, and medication. Results: PwMS (n = 13) who had followed the PSGT program for more than 10 years, had significantly smaller lesion volumes (mm3) compared to pwMS who did not adhere to the program (n = 9) (4950 ± 5303 vs. 17934 ± 11139; p = 0.002). WML volumes were significantly associated (p = 0.02) with disability (EDSS) but not with age (p = 0.350), disease duration (p = 0.709), or Interferon-β treatment (p = 0.70). Conclusion: Dietary and lifestyle changes may lower the risk of developing cerebral WMLs in pwMS and potentially slow disease progression. Larger studies are required to confirm the effectiveness of such interventions in pwMS.

The effects of dietary net energy on grow-finish performance and carcass characteristics of market gilts managed with immunological suppression of ovarian function and estrus (Improvest).

The objective was to determine the effects of net energy (NE) during the grow-finish period on live performance and carcass characteristics of market gilts managed with immunological suppression of ovarian function and estrus (Improvest®; IMP) compared with market gilts not managed with Improvest (CON). The 104-d study began when 1,008 gilts (11wk old; average starting weight of 30.8kg) were allocated by weight to 48 pens with 21 gilts/pen. Half of the pens were randomly selected to be managed with Improvest while the other half of the pens were not managed with Improvest. Three dietary programs differing in their NE were formulated over five dietary phases (according to standardized ileal digestible lysine requirements) to provide an average of 2,218 kcal/kg (low NE), 2,343 kcal/kg (medium NE), or 2,468 kcal/kg (high NE). The experiment was designed as a 2 × 3 factorial with main effects of Improvest management and NE. For the overall study period, there were no significant interactions (P ≥ 0.20) for average daily feed intake (ADFI), average daily gain (ADG), or Gain:Feed (G:F). There were also no significant interactions between Improvest management and NE (P ≥ 0.30) for carcass characteristics. However, IMP gilts consumed more feed (6.8% greater ADFI; P < 0.01), grew faster (5.0% greater ADG; P < 0.01), were less efficient (1.8% lower G:F; P < 0.01), heavier (3.5kg hot carcass weight; P < 0.01), and fatter (1.9mm greater backfat thickness and 1.26% less predicted lean carcass yield; P < 0.01). No difference (P = 0.21) in carcass dressing percentage between IMP and CON gilts was reported. For the overall study period, gilts fed low NE and medium NE diets consumed more feed compared with gilts fed high NE diets (6.8% more ADFI for low NE and 5.7% more for medium NE; P < 0.01), and gilts fed low NE diets grew 2.5% slower (P < 0.01) than gilts fed medium NE diets, while gilts fed high NE diets were intermediate and not different from the other NE treatments. This resulted in gilts fed Low NE diets being the least efficient (3.8% lower G:F than medium NE and 7.1% lower G:F than High NE; P < 0.01). Overall, these data indicate that typical Improvest response levels were sustained at each of the NE treatments evaluated in this study as there were no significant interactions for Improvest management and NE; however, consideration should still be provided to the known production impacts of low NE diets.

Almost one-third of people on low-calorie diet programme in remission from type 2 diabetes mellitus, study results show

Almost one-third of people on low-calorie diet programme in remission from type 2 diabetes mellitus, study results show

고등학생 대상의 포토보이스를 활용한 지속가능한 식생활에 대한 개념 인식 탐색

This study aimed to identify sustainable dietary practices, concepts, and factors that hinder practice from the perspective of high school students and suggest what the current sustainable dietary education should be supplemented. The study utilized photovoice to compare and analyze the differences in sustainable dietary practices based on the implementation of sustainable dietary education among high school students. A group of 7 participants, who did not provide sustainable dietary education, submitted 65 photos, while a group of 8 participants who underwent the education submitted 80 photos. The results of this study showed that the overall awareness of sustainable diet concepts among all participants was highest in the health area (66.54%), followed by the environment (23.74%) and consideration (9.73%). Categorizing the results according to the sustainable dietary area revealed a diverse range of concepts extracted through sustainable dietary education, with an increase in the number of small areas. It was observed that the majority of the research participants were consuming foods with high sugar and sodium content, and they tended to consume more delivery food or dining out rather than cooking meals themselves. Interview results also indicated that while students demonstrated a conceptual understanding of sustainable dietary habits, there were cases where this understanding needed to translate into practical actions. This study is significant in utilizing the qualitative research method of photovoice to uncover the meaning and practical examples of sustainable dietary habits from the perspective of high school students. The results can be utilized to enhance and guide sustainable dietary education programs.

Maternal Western diet programs cardiometabolic dysfunction and hypothalamic inflammation via epigenetic mechanisms predominantly in the male offspring

ObjectiveMaternal exposure during pregnancy is a strong determinant of offspring health outcomes. Such exposure induces changes in the offspring epigenome resulting in gene expression and functional changes. In this study, we investigated the effect of maternal Western hypercaloric diet (HCD) programming during the perinatal period on neuronal plasticity and cardiometabolic health in adult offspring. MethodsC57BL/6J dams were fed HCD for 1 month prior to mating with regular diet (RD) sires and kept on the same diet throughout pregnancy and lactation. At weaning, offspring were maintained on either HCD or RD for 3 months resulting in 4 treatment groups that underwent cardiometabolic assessments. DNA and RNA were extracted from the hypothalamus to perform whole genome methylation, mRNA, and miRNA sequencing followed by bioinformatic analyses. ResultsMaternal programming resulted in male-specific hypertension and hyperglycemia, with both males and females showing increased sympathetic tone to the vasculature. Surprisingly, programmed male offspring fed HCD in adulthood exhibited lower glucose levels, less insulin resistance, and leptin levels compared to non-programmed HCD-fed male mice. Hypothalamic genes involved in inflammation and type 2 diabetes were targeted by differentially expressed miRNA, while genes involved in glial and astrocytic differentiation were differentially methylated in programmed male offspring. These data were supported by our findings of astrogliosis, microgliosis and increased microglial activation in programmed males in the paraventricular nucleus (PVN). Programming induced a protective effect in male mice fed HCD in adulthood, resulting in lower protein levels of hypothalamic TGFβ2, NF-κB2, NF-κBp65, Ser-pIRS1, and GLP1R compared to non-programmed HCD-fed males. Although TGFβ2 was upregulated in male mice exposed to HCD pre- or post-natally, only blockade of the brain TGFβ receptor in RD-HCD mice improved glucose tolerance and a trend to weight loss. ConclusionsOur study shows that maternal HCD programs neuronal plasticity in the offspring and results in male-specific hypertension and hyperglycemia associated with hypothalamic inflammation in mechanisms and pathways distinct from post-natal HCD exposure. Together, our data unmask a compensatory role of HCD programming, likely via priming of metabolic pathways to handle excess nutrients in a more efficient way.

Longitudinal Associations of Diet, Food Insecurity, and Supplemental Nutrition Assistance Program Use with Global Cognitive Performance in Middle-Aged and Older Adults

BackgroundDiet quality, food access, and food assistance policies may be key modifiable factors related to cognitive decline. ObjectiveWe aimed to evaluate whether diet quality, food insecurity, and Supplemental Nutrition Assistance Program (SNAP) use are associated with longitudinal changes in cognition among older adults in the United States. MethodsFood intake data from the Health Care and Nutrition Study were linked with longitudinal health information from 5 waves of the Health and Retirement Study (2012–2020). The analytic sample (n = 6968) included community-dwelling United States adults aged ≥51 y without cognitive impairment. Global cognition was measured using a telephone-based cognitive status interview (range: 0–27). Diet quality was measured with the Healthy Eating Index, using participants’ average intake of 13 dietary components. Questions regarding food access and affordability were used to determine food insecurity and use of SNAP benefits. Linear mixed-effects regression models were used to estimate longitudinal associations between diet-related factors and cognitive score changes. ResultsPoorer diets [β: −0.24; 95% confidence interval (CI): −0.33, −0.15], food insecurity (β: −1.08; 95% CI: −1.31, −0.85), and SNAP use (β: −0.57; 95% CI: −0.82, −0.32) were associated with lower baseline cognitive scores. Poorer diets (β: −0.17; 95% CI: −0.29, −0.05) and food insecurity (β: −0.23; 95% CI: −0.47, −0.01) were associated with significantly steeper declines in cognitive scores over time, after 8 and 2 y of follow-up, respectively; however, SNAP use was not significantly associated with the rate of cognitive decline over time. Estimates were qualitatively similar when restricting the sample to participants aged ≥65 y. ConclusionsResults suggest that food access and adherence to healthy diet recommendations may be important elements to maintain cognitive health in aging. SNAP benefits may be insufficient to prevent negative cognitive effects of poor diet and limited access to nutritious foods.

Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age.

Sarcopenia is an age-related clinical complaint characterized by the progressive deterioration of skeletal muscle mass and strength over time. Type 2 diabetes (T2D) is associated with faster and more relevant skeletal muscle impairment. Both conditions influence each other, leading to negative consequences on glycemic control, cardiovascular risk, general health status, risk of falls, frailty, overall quality of life, and mortality. PubMed/Medline, Scopus, Web of Science, and Google Scholar were searched for research articles, scientific reports, observational studies, clinical trials, narrative and systematic reviews, and meta-analyses to review the evidence on the pathophysiology of di-abetes-induced sarcopenia, its relevance in terms of glucose control and diabetes-related outcomes, and diagnostic and therapeutic challenges. The review comprehensively addresses key elements for the clinical definition and diagnostic criteria of sarcopenia, the pathophysiological correlation be-tween T2D, sarcopenia, and related outcomes, a critical review of the role of antihyperglycemic treatment on skeletal muscle health, and perspectives on the role of specific treatment targeting myokine signaling pathways involved in glucose control and the regulation of skeletal muscle metabolism and trophism. Prompt diagnosis and adequate management, including lifestyle inter-vention, health diet programs, micronutrient supplementation, physical exercise, and pharmaco-logical treatment, are needed to prevent or delay skeletal muscle deterioration in T2D.

Appetite and its Regulation: Are there Palatable Interventions for Heart Failure?

Obesity is a major driver of heart failure (HF) incidence, and aggravates its pathophysiology. We summarized key reported and ongoing randomized clinical trials of appetite regulation and/or dietary energy restriction in individuals with HF. Weight loss can be achieved by structured supervised diet programs with behavioural change, medications, or surgery. The new glucagon-like peptide-1 receptor agonists alone or in combination with other agents (e.g., glucose-dependent insulinotropic polypeptide and glucagon receptor agonists or amylin analogues) potently and sustainably reduce appetite, and, taken together with dietary advice, can produce substantial, life-changing, weight loss approaching that achieved by surgery. To date, data from the STEP-HFpEF trial show meaningful improvements in health status (Kansas City Cardiomyopathy Questionnaire). Effective weight management could relieve several drivers of HF, to complement the existing treatments for HF with both reduced and preserved ejection fraction. Further trials of weight loss interventions will provide more definitive evidence to understand their effects on clinical events in patients with HF.

Equity and local health systems: a qualitative evaluation of the experiences of local health service leads during the first two years of the NHS Low Calorie Diet programme pilot

Background: Obesity and type 2 diabetes (T2DM) can both profoundly impact health and wellbeing. Their prevalence largely follows a social gradient. The National Health Service Low Calorie Diet programme in England aims to support people to achieve T2DM remission while also reducing health inequalities. We aimed to explore the experiences of local health service leads and identify barriers and facilitators in relation to the equitable mobilisation of the Low Calorie Diet programme. Methods: Twenty semi-structured interviews were completed with 24 locality leads across the first two years of the Low Calorie Diet programme. Interviewees were purposively sampled from the 10 localities who undertook the Low Calorie Diet programme pilot. Each interview explored a number of topics of interest, including referrals, training, communication, incentivisation, governance and engagement, before being subjected to a thematic analysis. Results: From the data, seven core themes were identified: COVID-19 and primary care capacity and engagement; methods of communication; approaches to training; approaches to incentivisation; approaches to referrals; barriers to referrals; and the importance of collaboration. COVID-19 presented a specific challenge to the mobilisation and delivery of the Low Calorie Diet programme; however, our findings demonstrate the large variation and differences in the approaches taken when delivering the programme across 10 geographically and demographically distinct pilot sites. We also identified a lack of a recognised approach or strategy to mobilisation and delivery support for the Low Calorie Diet programme, such as proportionate universalism, which is a social policy response to tackling health inequalities by ensuring that service delivery is equitable. Conclusions: Health inequalities remain a significant challenge, and health service leads have the potential to adopt an equity perspective from the start of programme mobilisation. In doing so, resources at their disposal can be managed equitably and can therefore contribute to efforts to reduce the potential occurrence of intervention-generated inequalities.

Food Taboos and Avoidance Practices affecting Pregnant Women at Larteh in the Akwapim North District, Eastern Region, Ghana

Purpose: The cultural beliefs of a group of people play a pivotal role in determining the nutritional status and well-being of the people. Understanding food beliefs and practices is critical to the development of dietary recommendations, nutritional programmes, and educational messages. An aspect of cultural beliefs that greatly affect majority of people especially children, pregnant women and the aged is food taboos and avoidance practices. The main aim of this study is to explore the various food taboos and its associated practices that affect pregnant women in Larteh.&#x0D; Materials and Methods: The study employed aspects of quantitative and qualitative approaches, and used the cross-sectional exploratory design. The random sampling technique was used to select 75 participants for the quantitative aspect, whilst the purposive sampling approach was used to select five opinion leaders for the qualitative aspect. A closed-ended structured questionnaire was used to obtain quantitative data, whilst a structured interview guide was used to collect the qualitative data. Whilst the quantitative data was analysed using frequencies and percentages in IBM-SPSS v9, the qualitative data was analysed using narratives. The results were presented in tables.&#x0D; Findings: Among the key findings were pregnant women were forbidden from eating snails, crabs, shellfish mudfish and eggs. It was further revealed that the people perceive these taboos as a way to protect pregnant women from experiencing stillbirths, deformities and delayed labour, among others.&#x0D; Implications to Theory, Practice and Policy: The sociological theory of functionalist perceptive anchored the study and its assertion that food taboos and avoidance practices are handed down to generations was affirmed. It was thus suggested that there should be public education on the nutritional needs of people in Larteh, especially the vulnerable so that adequate provision can be made for them because of food scarcity and limited choices of food commodities due to numerous food taboos and avoidance practices. Moreover, given the deep-rooted nature of the beliefs, it is advisable that when nutritious foods are restricted, nutritional interventions should rather search for alternative sources of nutrition, which are available and considered appropriate for pregnant women.

Astaxanthin Augmented the Anti-Hepatocellular Carcinoma Efficacy of Sorafenib Through the Inhibition of the JAK2/STAT3 Signaling Pathway and Mitigation of Hypoxia within the Tumor Microenvironment.

The optimization of anti-cancer drug effectiveness through dietary modifications has garnered significant attention among researchers in recent times. Astaxanthin (AST) has been identified as a safe and biologically active dietary supplement. The tumor-bearing mice are treated with sorafenib, along with supplementation of 60mgkg-1 AST during the treatment. The coadministration of AST and a subclinical dosage of 10mgkg-1 sorafenib demonstrates a tumor inhibition rate of 76.5%, which is notably superior to the 45% inhibition rate observed with the clinical dosage of 30mgkg-1 sorafenib (p<0.05). The administration of AST leads to a tumor inhibition increase of around 25% when combined with the clinical dose of 30mgkg-1 sorafenib (p<0.05). AST enhances the inhibitory effect of sorafenib on tumor angiogenesis through the JAK2/STAT3 signaling pathway. Furthermore, AST exhibits a reduction in hypoxia within the tumor microenvironment. The results suggest that AST supplement enhances the inhibitory effects of sorafenib on hepatocellular carcinoma. This study presents a new dietary management program for oncology patients.

Randomized Pilot Study Examining the Impact of an Online Diet Among Working Adults

The term “diet” is often associated with restricting certain foods or caloric intake; however, diet quality is defined as nutritional epidemiology to evaluate the population’s dietary habits and the efficacy of dietary interventions. There is a growing interest in diet quality, specifically increased intake of fruits and vegetables (F&amp;V), as a more appropriate approach for improving health outcomes. This study aimed to test an online, non-restrictive diet among the working population. Participants were randomized to complete an 8-week diet program using an online application or waitlist control that would receive the diet program after an 8-week waiting period. The diet program consisted of a technical application (app) that included ways to incorporate 800g of F&amp;V in their daily diet. The program included a competitive and gamified component to compare with others using a leaderboard. The primary research questions were if there was a differential change in body mass index (BMI), skeletal muscle mass (SMM), fat mass (FM), and work impairment between the control and intervention groups. Participants were asked to complete 2 study visits (Baseline &amp; 8 weeks). During each visit, the participants were asked to complete a standard Bioelectrical Impedance Analysis (BIA) protocol measuring BMI, SMM, and FM and questionnaires including the Lam Employment Absence and Productivity Scale (LEAPS) as a measure of work impairment. A two-way ANOVA was performed to compare BMI, SMM, and FM between the groups over time. There was no significant difference in BMI [F (20) = 0.83, p= .78], FM [ F (20) = 0.30, p= .59] between groups following the 8-week intervention. There was a significant difference in SMM [F (20) = 5.39, p= .03] following the 8-week intervention favoring the intervention group. There was no significant difference in work impairment [F (19) = 1.70, p= .21] between the groups following the 8-week intervention. More research should be conducted on whether a non-restrictive diet intervention focused on F&amp;V intake effectively improves overall health in adults.

Weight-Reducing Dietary Intervention Increases the Ability of Hyperinsulinemia to Suppress Serum Ghrelin Concentration in Individuals with Obesity

BackgroundGhrelin is an orexigenic peptide secreted mainly by the stomach. Serum ghrelin concentrations are suppressed after a meal, probably due to insulin release. Individuals with obesity are characterized by a lower fasting serum ghrelin and a lower ghrelin decrease after a meal. The effect of weight loss on the ability of insulin to suppress serum ghrelin concentration remains unknown. ObjectiveThe aim of the present study was to analyze the effect of weight-reducing dietary intervention on the ability of hyperinsulinemia to suppress serum ghrelin concentration in young individuals with uncomplicated obesity. MethodsWe examined 38 individuals with marked overweight or obesity, who underwent a 12-wk dietary intervention program. Serum ghrelin concentration was measured before and after a 2-h hyperinsulinemic–euglycemic clamp, both pre- and post-intervention. Twenty normal-weight individuals served as a control group and were examined at baseline only. ResultsIndividuals with overweight/obesity were characterized by a lower fasting serum ghrelin concentration than normal-weight individuals (P = 0.006). Insulin decreased serum ghrelin concentration in both groups (P < 0.001); however, this decrease was markedly lower in individuals with overweight/obesity than in normal-weight individuals (99.70 ± 136.37 vs. 215.45 ± 250.28 pg/mL; P = 0.026). Fasting serum ghrelin concentration increased after the intervention. After weight-reducing dietary intervention, the decrease in serum ghrelin concentration after the clamp was significantly greater than the pre-intervention value (99.70 ± 136.37 vs. 221.82 ± 228.75 pg/mL; P = 0.002). ConclusionsWeight-reducing dietary intervention restores the ability of hyperinsulinemia to suppress serum ghrelin concentration. It may suggest an enhanced feeling of satiety after moderate weight loss in individuals with overweight/obesity.

Randomised controlled trial combining vitamin E-functionalised chocolate with physical exercise to reduce the risk of protein–energy malnutrition in predementia aged people: study protocol for Choko-Age

ObjectiveProtein–energy malnutrition and the subsequent muscle wasting (sarcopenia) are common ageing complications. It is knowing to be also associated with dementia. Our programme will test the cytoprotective functions of vitamin...

The impacts of pharmacological drugs on vitamin B6, B9 and B12 intakes and levels among uk adults: National diet and nutrition survey rolling programme (NDNS) (2008–2017).

The impacts of pharmacological drugs on vitamin B6, B9 and B12 intakes and levels among uk adults: National diet and nutrition survey rolling programme (NDNS) (2008–2017).

South Asian individuals’ experiences on the NHS low-calorie diet programme: a qualitative study in community settings in England

BackgroundExisting literature examines barriers to the provision of ethnically diverse dietary advice, however, is not specific to total diet replacement (TDR). There is a lack of literature from the UK,...