Dietary Lysophospholipids Research Articles

1003 Effects of dietary lysophospholipids (LipidolTM) on intestinal morphology and gene expression of inflammatory cytokines in weaned rats

1003 Effects of dietary lysophospholipids (LipidolTM) on intestinal morphology and gene expression of inflammatory cytokines in weaned rats

Effect of Dietary Lysophospholipid (LIPIDOL™) Supplementation on the Improvement of Forage Usage and Growth Performance in Hanwoo Heifer

The present study investigated the effects of Lysophospholipid (LPLs, LIPIDOL™) on the growth performance and nutrient digestibility of Hanwoo heifers. A feeding trial was performed for 120 days until slaughter using a herd of 24 Hanwoo heifers. Eight heifers were assigned to each of 3 experimental groups (control, 0.3% LIPIDOL™ and 0.5% LIPIDOL™). Growth performance, nutrient digestibility, and carcass characteristics were investigated. Significantly improved nutrient digestibility was found in the LIPIDOL™ treatment group compared to the control (p 0.05). However, interestingly, greater carcass weight was detected in the treatment of LIPIDOL™ where less daily gain was found. Although not a significant effect, greatly decreased back-fat thickness and increased loin area were detected in the treatment of LIPIDOL™. In meat characteristics, LIPIDOL™ increased intramuscular fat and tenderness. Therefore, the present study results suggest that the inclusion of LIPIDOL™ in the diet of Hanwoo heifers can improve carcass performance and meat quality by increasing the carcass index and the meat quality index. The results also suggest that a level of 0.3% might be more efficient than 0.5% with regard to economic effectiveness.

Biological Relevance of Lysophospholipids and Green Solutions for Their Synthesis

Lysophospholipids (LPLs), including glycerolysophospholipids and lysosphingolipids, constitute a group of important lipid mediators. What is more, dietary LPLs have a positive impact towards health, apparently without meaningful side effects. Since the total chemical synthesis of fully active, enantiomerically pure LPLs is a very complicated challenge, the present review is devoted to biotransformations based on the action of various phospholipases and lipases that additionally fully meet the green chemistry concept. We also discuss the benefficial effects of bioactive lysophospholipids, focusing on lysophosphatidic acid, lysophosphatidylcholine, lysophosphatidylglycerol, sphingosylphosphorylcholine, lysophosphatidylinositol, lysophosphatidylserine, lysophosphatidylethanolamine, cyclic phosphatidic acid, and sphingosine- 1-phosphate. Besides, we detail their structure, enzymatic routes of in vivo generation, the main routes of enzymatic digestion in the gut and isolation of phospholipids from natural sources with carbon dioxide supercritical extraction-based processes. Keywords: Beneficial effects, digestion, extraction, lipases, lysophospholipids, phospholipases.

Investigation of Dietary Lysophospholipid (LipidolTM) to Improve Nutrients Availability of Diet with In Vitro Rumen Microbial Fermentation Test

This study was conducted to investigate the effect of biological membrane transfer modifier, lysophospholipd (LPLs) on the parameters from in vitro rumen simulated fermentation. Commercially available LPLs product (Lipidol<TEX>$^{TM}$</TEX>) was supplemented into experimental diets which consisted of orchard grass and concentrate diet (60:40) in different levels (0.1%, 0.3% and 0.5%). Then in vitro rumen simulated fermentation was performed. Although, a declining trend of pH was found in treatments, all pH values were detected in a range relevant to normal rumen fermentation. Gas production, ammonia nitrogen and total VFA production were greatly influenced by the supplementation of LPLs. All parameters were increased along with increased levels of LPLs in diet. As a result, 0.1% of Lipidol<TEX>$^{TM}$</TEX> is recommended based on the determined in vitro rumen fermentative parameters in this study.