Dietary Fiber Supplementation Research Articles

Effects of dietary fiber and biotic supplementation on apparent total tract macronutrient digestibility and the fecal characteristics, metabolites, and microbiota of healthy adult dogs.

Dietary fibers and biotics have been shown to support gastrointestinal health in dogs, but are usually tested individually. There is value in testing fiber-biotic combinations that are commonly used commercially. Therefore, this study was conducted to determine the apparent total tract macronutrient digestibility (ATTD) of diets supplemented with fibers or biotics and to evaluate their effects on the fecal characteristics, metabolites, microbiota, and immunoglobulin A (IgA) concentrations of dogs. Twelve healthy adult female beagle dogs (age= 6.2 ± 1.6 yr; body weight = 9.5 ± 1.1kg) were used in a replicated 3 x 3 Latin square design to test three treatments: 1) control diet based on rice, chicken meal, tapioca starch, and cellulose + a placebo treat (CT); 2) diet based on rice, chicken meal, garbanzo beans, and cellulose + a placebo treat (GB); 3) diet based on rice, chicken meal, garbanzo beans, and a functional fiber/prebiotic blend + a probiotic-containing treat (GBPP). In each 28-day period, a 22-day diet adaptation was followed by a 5-day fecal collection phase. Fasted blood samples were collected on day 28. Data were analyzed using the Mixed Models procedure of SAS 9.4, with P<0.05 being significant and P<0.10 being trends. ATTD of dry matter, organic matter, and energy were lower (P<0.001) and DM fecal output was higher (P<0.01) in dogs fed GBPP than CT or GB, whereas ATTD of crude protein was higher (P<0.001) in dogs fed CT and GBPP than GB. ATTD of fat was higher (P<0.001) and wet fecal output was lower (P<0.01) in dogs fed CT than GB or GBPP. Fecal DM% was higher (P<0.001) in dogs fed CT than GBPP or GB, and higher in dogs fed GBPP than GB. Fecal short-chain fatty acid concentrations were higher (P<0.001) in dogs fed GB than CT or GBPP, and higher in dogs fed GB than GBPP. Fecal IgA concentrations were higher (P<0.01) in dogs fed GB than CT. Fecal microbiota populations were affected by diet, with alpha diversity being higher (P<0.01) in dogs fed GB than CT, and beta diversity shifting following dietary fiber and biotic supplementation. The relative abundance of 24 bacterial genera were altered in dogs fed GB or GBPP than CT. Serum triglyceride concentrations were lower in dogs fed GB than GBPP or CT. Our results demonstrate that legume-based dietary fibers, with or without prebiotics and probiotics, reduce ATTD, increase stool output, beneficially shift fecal metabolites and microbiota, and reduce blood lipids of adult dogs.

Increasing dietary fiber intake for type 2 diabetes mellitus management: A systematic review.

Type 2 diabetes is a chronic, non-communicable disease with a substantial global impact, affecting a significant number of individuals. Its etiology is closely tied to imbalanced dietary practices and sedentary lifestyles. Conversely, increasing die-tary fiber (DF) intake has consistently demonstrated health benefits in numerous studies, including improvements in glycemic control and weight management. To investigate the efficacy of DF interventions in the management of type 2 diabetes mellitus (T2DM). A systematic literature review was conducted to explore the association between DF intake and the management of T2DM. Following the inclusion and exclusion criteria, a total of 26 studies were included in this review. The main strategies implied to increased DF intake were: High DF diet plus acarbose (2 studies); DF supplements (14 studies); and high DF diets (10 studies). Overall, most studies indicated that increased DF intake resulted in im-provements in glycemic control and weight management in T2DM patients. DF represents a valuable strategy in the treatment of type 2 diabetes, improving health outcomes. DF intake offers the potential to improve quality of life and reduce complications and mortality associated with diabetes. Likewise, through supplements or enriched foods, DF contributes significantly to the control of several markers such as HbA1c, blood glucose, triglycerides, low-density lipoprotein, and body weight.

Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity

BackgroundNon-toxic approaches to enhance radiotherapy outcomes are beneficial, particularly in ageing populations. Based on preclinical findings showing that high-fibre diets sensitised bladder tumours to irradiation by modifying the gut microbiota, along with clinical evidence of prebiotics enhancing anti-cancer immunity, we hypothesised that dietary fibre and its gut microbiota modification can radiosensitise tumours via secretion of metabolites and/or immunomodulation. We investigated the efficacy of high-fibre diets combined with irradiation in immunoproficient C57BL/6 mice bearing bladder cancer flank allografts.ResultPsyllium plus inulin significantly decreased tumour size and delayed tumour growth following irradiation compared to 0.2% cellulose and raised intratumoural CD8+ cells. Post-irradiation, tumour control positively correlated with Lachnospiraceae family abundance. Psyllium plus resistant starch radiosensitised the tumours, positively correlating with Bacteroides genus abundance and increased caecal isoferulic acid levels, associated with a favourable response in terms of tumour control. Psyllium plus inulin mitigated the acute radiation injury caused by 14 Gy. Psyllium plus inulin increased caecal acetate, butyrate and propionate levels, and psyllium alone and psyllium plus resistant starch increased acetate levels. Human gut microbiota profiles at the phylum level were generally more like mouse 0.2% cellulose profiles than high fibre profiles.ConclusionThese supplements may be useful in combination with radiotherapy in patients with pelvic malignancy.C3P3Z-i-BEWcsPG8U_9P4fVideo

170 Feeding the modern sow: Unlocking the value of dietary fiber

Abstract Our understanding of dietary fiber in sow nutrition is evolving rapidly, shifting from a once-overlooked portion of the diet to a critical component influencing intestinal functionality, gut microbiota, and modulation of digestion and metabolism. Recent advancements in fiber nutrition and analytical methods have highlighted its significance in optimizing sow lifetime productivity and welfare through its impact on nutrient utilization and overall health. Growing evidence supports the benefits of dietary fiber in gestation diets, notably contributing to sow well-being by reducing stress and behavioral issues observed in group housing systems (Sapkota et al., 2016). Accordingly, dietary fiber supplementation in gestation diets has been linked to the reduction of stillborn pigs, heavier piglet weights at birth, increased lactation feed intake, and reduced pre-wean mortality (Feyera et al., 2017). Supplementing dietary fiber during the peripartum phase has been shown to reduce the farrowing duration and the stillborn incidence (Theil et al., 2014); possibly linked to a reduction in constipation (Cardona et al., 2024) and enhanced sow energy status through greater short-chain fatty acids availability (Feyera et al., 2017). Despite the positive evidence, the practical application of dietary fiber supplementation in US sow diets has been limited due to insufficient characterization of fiber components in available ingredients. Recent advancements in analytical techniques, defining fiber components as total dietary fiber (TDF), soluble fiber (SF), and insoluble fiber (ISF), offer improved reliability and accessibility, overcoming previous barriers. Recent studies showed that a high fiber gestation diet (TDF 18% and 9% for high and low fiber diets, respectively) did not affect reproductive performance, liter size, individual piglet weight, or pre-wean mortality but it reduced weight loss during lactation (Paz et al., 2022). Moreover, studies conducted by Martinez et al. (2022) demonstrated that top-dressing dietary fiber during the peripartum phase reduced the wean-to-estrus interval (top-dress 0.45 kg or 0.90 kg/d, TDF 35%, ISF:SF ratios ranging from 2.6 to 7.4). These studies highlight the potential value of dietary fiber in US sow diets. However further research is warranted to determine the optimal level and desirable fiber characteristics to fully unlock its nutritional value in sow diets.

Recipient microbiome-related features predicting metabolic improvement following fecal microbiota transplantation in adults with severe obesity and metabolic syndrome: a secondary analysis of a phase 2 clinical trial

ABSTRACT Microbial-based therapeutics in clinical practice are of considerable interest, and a recent study demonstrated fecal microbial transplantation (FMT) followed by dietary fiber supplements improved glucose homeostasis. Previous evidence suggests that donor and recipient compatibility and FMT protocol are key determinants, but little is known about the involvement of specific recipient factors. Using data from our recent randomized placebo-control phase 2 clinical trial in adults with obesity and metabolic syndrome, we grouped participants that received FMT from one of 4 donors with either fiber supplement into HOMA-IR responders (n = 21) and HOMA-IR non-responders (n = 8). We further assessed plasma bile acids using targeted metabolomics and performed subgroup analyzes to evaluate the effects of recipient parameters and gastrointestinal factors on microbiota engraftment and homeostatic model assessment of insulin resistance (HOMA2-IR) response. The baseline fecal microbiota composition at genus level of recipients could predict the improvements in HOMA2-IR at week 6 (ROC-AUC = 0.70). Prevotella was identified as an important predictor, with responders having significantly lower relative abundance than non-responders (p = .02). In addition, recipients displayed a highly individualized degree of microbial engraftment from donors. Compared to the non-responders, the responders had significantly increased bacterial richness (Chao1) after FMT and a more consistent engraftment of donor-specific bacteria ASVs (amplicon sequence variants) such as Faecalibacillus intestinalis (ASV44), Roseburia spp. (ASV103), and Christensenellaceae spp. (ASV140) (p < .05). Microbiota engraftment was strongly associated with recipients’ factors at baseline including initial gut microbial diversity, fiber and nutrient intakes, inflammatory markers, and bile acid derivative levels. This study identified that responders to FMT therapy had a higher engraftment rate in the transplantation of specific donor-specific microbes, which were strongly correlated with insulin sensitivity improvements. Further, the recipient baseline gut microbiota and related factors were identified as the determinants for responsiveness to FMT and fiber supplementation. The findings provide a basis for the development of precision microbial therapeutics for the treatment of metabolic syndrome.

Using Chia Powder as a Binder to Obtain Chewable Tablets Containing Quinoa for Dietary Fiber Supplementation

The consumption of fiber in the human diet is a global recommendation to ensure a healthy diet. Quinoa (Chenopodium quinoa Willd.), a gluten-free grain, and chia (Salvia hispanica), a seed, contain a high fiber content, and both have the potential to be used in the development of nutraceutical and pharmaceutical formulations. An interesting characteristic of chia is its ability to form viscous mucilage when in contact with water, making it a potential binder in solid formulations. However, there are no studies on chia as a binder, and therefore, the objective of the present study was to evaluate the feasibility of using chia as a binder to produce quinoa granules and, subsequently, develop chewable tablet formulations. The quinoa and chia were in a powder form and then transformed into a wet mass with the help of mixer torque rheometer (MTR) equipment. In the wet granulation form, the following parameters were tested: multiple additions, 15 g of material, and 25 timepoints for the addition of 1 mL of water. An experimental design was carried out to evaluate the impact of the variables on the MTR results for subsequent granulation. The granulation point was possible for T1–T9, and most formulations gave satisfactory results, such as an acceptable resistance of the granules. In the end, a formulation was selected for the development of chewable tablets containing quinoa and chia fibers.

Effects of Supplementation of Insoluble Dietary Fiber Obtained from Cinnamon Spent Bark Waste on the Performance of Nile Tilapia (&lt;em&gt;Oreochromis niloticus&lt;/em&gt;) Fingerlings

Dietary fiber supplementation has proven benefits on fish health and growth. Cinnamon spent bark waste is the cinnamon bark residue after oil distillation. It is a rich source of insoluble dietary fiber with very low contents of soluble dietary fiber. This study aimed to investigate the potential of using water-extracted insoluble fiber from cinnamon spent bark waste as a functional ingredient in the diets of Oreochromis niloticus fingerlings. Four experimental diets were prepared by replacing a commercial feed with extracted dietary fiber at 0 (control), 0.5%, 1%, and 1.5% levels. Fingerlings of O. niloticus were assigned to the four experimental diets and the feeding trial was conducted for 12 weeks. The results revealed that the weight gain, specific growth rate, feed conversion ratio, Fulton’s condition factor, and survival rate of fish were not significantly different among the experimental groups. Fiber supplementation at 1.5% significantly increased (p&lt;0.05) the total aerobic bacteria population in feces, whereas the coliform counts in feces at 0.5% and 1% fiber supplementation were significantly lower (p&lt;0.05) than the control. There was a significant increase (p&lt;0.05) in red blood cells count at 0.5% fiber supplementation. Moreover, insoluble dietary fiber supplementation significantly (p&lt;0.05) increased the white blood cell counts in blood. Results suggested that insoluble fiber supplementation affected gut microbial populations and blood parameters of O. niloticus fingerlings. However, further investigations on gut microbiology and hematology are needed to ensure the use of insoluble dietary fiber from cinnamon spent bark waste as a functional ingredient in the diets of O. niloticus fingerlings.

Dietary fibre from seeds of Australia native Plantago species as modulators of quality and glycaemic response in starch gels

Dietary fibre (DF) is a non-digestible nutrient which has important roles in the digestive system including mantaining regularity, and reducing the risk of certain cancers and non-communicable diseases, such as metabolic syndrome. Even though the positive health effects of DF have long been established, it has been shown that DF intake for children and adults in Australia is below the recommended range – less than 20% of adults met the suggested intake for reducing risk of chronic diseases(1). Plantago ovata, also known as psyllium, is widely used as DF supplement with evidence showing positive effects on weight control, hyperglycaemic response, cholesterol levels, and irritable bowel syndrome(2). P. ovata seed husk produces a highly viscous gel called mucilage when seeds are exposed to moisture. This mucilage is nearly pure DF and has an intricately layered structure which can be further fractionated and studied as a proxy for different gelling systems. Interestingly, Australia is home to many mucilage-producing Plantago species, most of which are underexplored and underutilised, but show remarkable gelling properties and hypoglycaemic potential(3). In this work, we compare structural and functional properties of fractionated DF from P. ovata, and two promising Australian native relatives, P. turrifera and P. drummondii, and their effect on enzymatic hydrolysis in potato starch gels. Using a 3-step fractionation method, we have separated distinct fractions and explored their individual properties(4). P. turrifera and P. drummondii have higher water absorbing capacity, DF yield, and viscosity compared to P. ovata. Monosaccharide composition of all three species is similar – they are highly substituted heteroxylans with minor pectic component. Notably, arabinose to xylose ratio in all species increases with further extraction steps, which is different from cereal arabinoxylans. In an attempt to explore impact of DF in starch-rich systems, we have fabricated DF-potato starch gels and measured enzymatic hydrolysis (with porcine pancreatic α-amylase), freeze-thaw stability, and colour change. Addition of DF reduced syneresis (water separation) during 15 day freeze-thaw cycle measurement, which can lead to prolonged storage stability and has positive implications for shelf life. Colour change was most noticeable when P. drumondii DF were added, while colour of P. ovata and P. turiferra DF gels was similar to control potato starch gel. Effects on α-amylase starch hydrolysis were significant as well, and depended on species and fractions. Certain DFs had impacts on constant k (speed of hydrolysis), while effects on the extent of hydrolysis are still being explored. In conclusion, utility of Australia native P. turrifera and P. drumondii DFs are evident when applied to starch gels, and should be further explored in food products such as bread to increase DF intake and possibly lower glycaemic index.

Study of various dietary interventions in patients with hypertension and metabolic syndrome

Obesity is an independent risk factor оf cardiovascular diseases (CVD), type 2 diabetes mellitus and arterial hypertension (HT). Optimization of CVD control methods is one of the most relevant and urgent problems for Russia. Many studies have shown that body weight correlates with blood pressure, and this relationship is due to complex pathogenetic mechanisms. Therefore, therapeutic approaches in a patient with obesity, metabolic syndrome and HT require consideration of all pathophysiologic changes associated with these diseases. Non-pharmacological treatments such as lifestyle changes including weight loss, following dietary guidelines and increasing physical activity can directly affect of BP levels and improve BP control. A wide range of nutritional interventions are effective in treating obesity and comorbidities, and clinicians must consider all options and provide personalized interventions. The Mediterranean diet, vegetarian diets, DASH-diet, Nordic diet, and low-carbohydrate diets have all been associated with improved metabolic health with or without changes in body weight. Recent evidence reinforce more the role of dietary fiber supplementation to the daily diet in patients with HT and metabolic syndrome, although no evidence of significant benefit has been found. Taking into account national dietary characteristics, we have proposed a study in which we plan to study the effect of the Russian diet with fiber supplementation on metabolic parameters in patients with HT. It is planned to evaluate the effect of diet therapy on indicators of metabolic disorders of intestinal metabolites.

Impacts of Fiber Supplementation in Sows during the Transition Period on Constipation, Farrowing Duration, Colostrum Production, and Pre-Weaning Piglet Mortality in the Free-Farrowing System.

This study investigated how dietary fiber supplementation during the transition period in sows affects constipation, farrowing duration, colostrum production, milk yield, and pre-weaning piglet mortality in the free-farrowing system. A total of 92 Landrace × Yorkshire sows and their 1272 offspring were included in the study. Sows were divided into two groups by parity: control (n = 41) and treatment (n = 51). The control group was fed a standard lactation diet 7 days before farrowing, whereas the treatment group received the same diet with 75 g/day of a dietary fiber supplement. The dietary fiber content analyses were 4.30% and 5.53% in the control and treatment groups, respectively. Sows were fed with 3.89 ± 0.92 kg per day with a diet containing 17.8% crude protein, 3732 kcal/kg of metabolizable energy, and 1.1% lysine. Parameters including farrowing duration, litter characteristics, and the fecal condition of sows were measured. Piglet mortality rates were recorded at 3, 7, and 21 days of lactation. Sows had an average farrowing duration of 216 ± 159 min, with litter sizes of 13.8 ± 4.2 piglets per litter, and a 7.4% stillbirth rate. The treatment group showed a lower constipation rate compared to the control group (17.6% vs. 46.3%, p = 0.003). Farrowing duration did not significantly differ between groups, but the treatment group experienced a 43.6 min shorter duration. In sows with litter sizes of ≥16 piglets per litter, the farrowing duration for sows in the treatment group tended to be shorter than that of the control groups (202.0 ± 37.9 vs. 287.5 ± 41.3 min, p = 0.115). The mean colostrum intake of piglets in the control and treatment groups averaged 424.0 ± 13.7 g and 421.8 ± 12.6 g, respectively (p = 0.908). Likewise, the milk production of sows from Days 3 to 10 and from Days 10 to 17 of lactation in the treatment group (7.34 ± 0.27 and 8.76 ± 0.43 kg/day, respectively) did not differ from that of the control group (7.85 ± 0.30 and 9.55 ± 0.47 kg/day, respectively, p > 0.05). Pre-weaning piglet mortality was slightly lower in the treatment group (13.4% vs. 17.3%, p = 0.085). Across groups, piglet mortality rates within 3, 7, and 21 days were 10.3%, 11.9%, and 15.4%, respectively. Piglets with a ≤200 g colostrum intake had a higher pre-weaning mortality compared to those with a higher intake (p < 0.05), except for the 201-300 g intake (p = 0.472). In conclusion, introducing dietary fiber to sows during the transition period reduced constipation and tended to decrease farrowing duration, especially in sows with large litters. Additionally, it lowered pre-weaning piglet mortality by 3.9% in the free-farrowing system. Nonetheless, providing sows with a 75 g/day dietary fiber supplement for only 7 days before farrowing was not enough to enhance colostrum and milk production, nor did it lead to an increase in piglet colostrum consumption.

Effects of different dietary fiber supplement strategies on incidence of acute gastrointestinal injury in ICU patients: A prospective observational study

ObjectiveThis study aimed to explore the effects of dietary fiber (DF) supplement strategies on the incidence of acute gastrointestinal injury (AGI) in critically ill patients. DesignA prospective observational study. SettingThe study was conducted in the First Affiliated Hospital of Soochow University from April 2021 to March 2023. MethodsUsing a five-day dietary log counted the amount of DF supplement. The best fitting trajectories of DF supplement were determined based on the latent class trajectory modelling (LCTM). The data of AGI were evaluated on the day 5 (D5) and day 7 (D7) after intensive care unit admission. ResultsA total of 179 patients were included in the study. The LCTM yielded a four-trajectories of models, named; Sustained Low – Group, Slowly Rising – Group, Early Supplement & Slowly Rising – Group and Rapidly Rising – Group, respectively. The incidences of AGI on D5 and D7 were 51.4 % and 40.0 %, respectively. There was an increased risk in the grade of AGI in the Sustained Low – Group compared with the Rapidly Rising – Group on D5 [odds ratio (OR), 4.8; 95 % confidence interval (CI), 1.9–12.1] and D7 (OR, 12.0; 95 % CI, 3.9–37.0); and an increased risk in the Slowly Rising – Group on D5 (OR, 3.6; 95 % CI, 1.3–9.9). ConclusionThe supplement of DF in critically ill patients may be insufficient and the incidence of AGI is high. Sustained low and slow rising DF supplement may be associated with an increased risk in the AGI. Implications for clinical practiceThe clinical staff could focus on the supplementation of not only the three macronutrients, but also DF in critically ill patients.

Development of technological solutions to increase the biological value of gluten-free bread

The industry of gluten-free bakery products has not been studied properly, so this topic is gaining popularity among scientists. The subject of the research was the development of recipes for gluten-free flour mixtures. To improve the taste characteristics of the product and increase the biological value, it was decided to introduce plant raw materials non-traditional for bread. Chia seeds and carrot powder were chosen as additives. The goal of the research was to develop recipes for gluten-free flour mixtures. The research was carried out in several stages: 1. determination of the component composition of the gluten-free mixture recipe and production of prototypes; 2. analysis of organoleptic indicators; 3. carrying out physical and chemical studies of dough and finished products. To carry out the analysis instrumental and visual research methods were used. During the experiment three samples of bread were obtained from different types of gluten-free flour (No. 1 – green buckwheat; No. 2 amaranth flour; No. 3 – gram flour) in combination with rice flour, carrot powder and chia seeds. The control sample was bread made from rice flour, potato and corn starch. The rate of dietary fiber supplementation was calculated on the basis of the recommended daily intake. Thus, 2.8 g of dietary fiber was added with carrots, and 4.4 g of dietary fiber with chia seeds. According to all the studies carried out, sample No. 3 from gram flour turned out to be the best. The research results can be used in the baking industry to expand the range of bakery products. A mixture for making gluten-free bread can be a very useful product, especially for those categories of the population who have a need for such products. Also, given that for the majority of the population bread is a commodity of everyday demand, the production of such mixtures will be in great demand.

Proximate, nutraceutical composition and antimicrobial activities of Uvaria chamea (Udagu) seeds and oil

The study investigated proximate, nutraceutical composition and Antimicrobial activities of Uvaria chamea (Udagu) seeds. Standard methods were used to analyze the plant seeds for the present of nutraceutical and proximate component of the plant Uvaria chamea (Udagu) seeds. While disk diffusion method was employed to assay the the potent of the seed oil as an antimicrobial agent. Result of the proximate revealed that Uvaria chamea (Udagu) seeds contains ash (10.19 %), moisture (5.2 %), crude protein (0.09 %), crude fiber (51.81 %), total fat (26.19 %) and carbohydrate (6.52 %). While nutraceutical study showed that Uvaria chamea (Udagu) seeds contains cardiac glycosides (0.046 %), tannins (0.2 %), saponins (0.01 %) and alkaloids (0.45 %).The proximate result implies that the plant contains essential component such as crude fiber, total fat and ash in significant quantities, and can be utilized as food and in treating several ailments. The presences of alkaloids, tannins, Cardiac glycoside, and saponins in the plant seed indicate it can be used as a medicinal source. The oil presented no antimicrobial and antibiotic activities against Staphylococcus aureus and Salmonella typhi. The results suggest that Uvaria chamae seed have a potential role as a new source of health-promoting diets (can be used as a dietary fiber supplement in obesity management) with high oxidative stability. And the oil is a fixed oil that could be an acceptable substitute for cooking vegetable oil that do not have antimicrobial/antibiotic activities. Keywords: Proximate; nutraceutical; fiber; alkaloids; tannins

The Impact of Fiber Source on Digestive Function, Fecal Microbiota, and Immune Response in Adult Dogs.

This study evaluated the impact of different fiber sources on intestinal function, fecal microbiota, and overall health in dogs. Twelve dogs were used in a crossover design, involving three periods of 6 weeks and three diets: a low-fiber diet (CTR), a cereal-fiber and beet-pulp-supplemented diet (BRA), and a fruit-fiber-supplemented diet (FRU). Each period included a digestibility trial and fecal and blood sampling in the last week. Short-chain fatty acids (SCFAs) and microbiota taxonomy (16S rRNA Illumina-MiSeq) and functionality (Shotgun-NovaSeq 6000) were determined in the feces. General biochemistry, complete blood cells, and lymphocyte subsets were also analyzed. The fiber-supplemented diets showed lower digestibility without significant changes in the fecal consistency. The BRA diet showed higher total SCFA concentrations (p = 0.056), with increases in alpha diversity and particular beneficial genera, such as Lachnospira, Bifidobacterium, and Faecalibacterium. The BRA microbiota was also associated with an overabundance of genes related to carbohydrate and amino acid metabolism. The FRU diet had a distinct impact on the microbiota composition and functionality, leading to higher levels of CD8 lymphocytes. These findings emphasize the importance of selecting the right fiber source when formulating dog diets, as it can have a differential impact on gut microbiota and animal health.

Insoluble/soluble fraction ratio determines effects of dietary fiber on gut microbiota and serum metabolites in healthy mice.

Both soluble dietary fiber (SDF) and insoluble dietary fiber (IDF) play pivotal roles in maintaining gut microbiota homeostasis; whether the effects of the different ratios of IDF and SDF are consistent remains unclear. Consequently, we selected SDFs and IDFs from six representative foods (apple, celery, kale, black fungus, oats, and soybeans) and formulated nine dietary fiber recipes composed of IDF and SDF with a ratio from 1 : 9 to 9 : 1 (NDFR) to compare their impact on microbial effects with healthy mice. We discovered that NDFR treatment decreased the abundance of Proteobacteria and the ratio of Firmicutes/Bacteroidetes at the phylum level. The α diversity and relative richness of Parabacteroides and Prevotella at the genus level showed an upward trend along with the ratio of IDF increasing, while the relative abundance of Akkermansia at the genus level and the production of acetic acid and propionic acid exhibited an increased trend along with the ratio of SDF increasing. The relative abundance of Parabacteroides and Prevotella in the I9S1DF group (the ratio of IDF and SDF was 9 : 1) was 1.72 times and 5.92 times higher than that in the I1S9DF group (the ratio of IDF and SDF was 1 : 9), respectively. The relative abundance of Akkermansia in the I1S9DF group was 17.18 times higher than that in the I9S1DF group. Moreover, a high ratio of SDF (SDF reaches 60% or more) enriched the glycerophospholipid metabolism pathway; however, a high ratio of IDF (IDF reaches 80% or more) regulated the tricarboxylic acid cycle. These findings are helpful in the development of dietary fiber supplements based on gut microbiota and metabolites.

Dietary Fiber Supplementation in Type I Glycogen Storage Disease; Could it Contribute to a Better Metabolic Control?

Dietary Fiber Supplementation in Type I Glycogen Storage Disease; Could it Contribute to a Better Metabolic Control?

Supplementation with Complex Dietary Fiber during Late Pregnancy and Lactation Can Improve Progeny Growth Performance by Regulating Maternal Antioxidant Status and Milk Quality.

This study investigated the nutritional benefits of complex dietary fiber (beta-glucan and fructo-oligosaccharides, CDF) supplementation in sows and piglets during late pregnancy and lactation. Twenty-four sows were randomly divided into two groups: the control group was fed a basal diet (n = 12), and the experimental group was fed a CDF diet (0.25% CDF replaced the same proportion of corn in the basal diet, n = 12). Dietary treatment was given from day 107 of pregnancy to day 25 of lactation. The results of this experiment showed that CDF increased the average daily feed intake (ADFI) of sows during lactation and the weaning body weight (BW) and average daily gain of piglets. Dietary CDF supplementation improved the antioxidant capacity and immune level of sows and decreased the serum zonulin level. Dietary supplementation with CDF increased the levels of antioxidant activity, immunoglobulin, and anti-inflammatory factor interleukin-10 (IL-10) in milk. Meanwhile, piglets in the CDF group had increased serum antioxidant activity, immunoglobulin, and growth-related hormone levels; decreased malondialdehyde (MDA), interleukin-6 (IL-6), and D-lactic acid (D-LA) levels; and increased fecal short-chain fatty acid content. In addition, the CDF group increased the diversity of microorganisms in sow feces. In conclusion, the supplementation of a diet with CDF in late pregnancy and lactation can alleviate the oxidative stress of sows, improve milk quality, and have significant positive effects on the antioxidant capacity and growth performance of piglets.

Microbiota-accessible fiber activates short-chain fatty acid and bile acid metabolism to improve intestinal mucus barrier in broiler chickens.

The intestinal mucus barrier, located at the interface of the intestinal epithelium and the microbiota, is the first line of defense against pathogenic microorganisms and environmental antigens. Dietary polysaccharides, which act as microbiota-accessible fiber, play a key role in the regulation of intestinal microbial communities. However, the mechanism via which dietary fiber affects the intestinal mucus barrier through targeted regulation of the gut microbiota is not clear. This study provides fundamental evidence for the benefits of dietary fiber supplementation in broiler chickens through improvement in the intestinal mucus barrier by targeted regulation of the gut ecosystem. Our findings suggest that the microbiota-accessible fiber-gut microbiota-short-chain fatty acid/bile acid axis plays a key role in regulating intestinal function.

Effects of four different dietary fibre supplements on weight loss and lipid and glucose serum profiles during energy restriction in patient with traits of metabolic syndrome: Comparative, randomized placebo-controlled study

Effects of four different dietary fibre supplements on weight loss and lipid and glucose serum profiles during energy restriction in patient with traits of metabolic syndrome: Comparative, randomized placebo-controlled study

A Comparative Study of Resistant Dextrins and Resistant Maltodextrins from Different Tuber Crop Starches.

The anti-digestibility of resistant dextrin (RD) and resistant maltodextrin (RMD) is usually significantly affected by processing techniques, reaction conditions, and starch sources. The objective of this investigation is to elucidate the similarities and differences in the anti-digestive properties of RD and RMD prepared from three different tuber crop starches, namely, potato, cassava, and sweet potato, and to reveal the associated mechanisms. The results show that all RMDs have a microstructure characterized by irregular fragmentation and porous surfaces, no longer maintaining the original crystalline structure of starches. Conversely, RDs preserve the structural morphology of starches, featuring rough surfaces and similar crystalline structures. RDs exhibite hydrolysis rates of approximately 40%, whereas RMDs displaye rates lower than 8%. This disparity can be attributed to the reduction of α-1,4 and α-1,6 bonds and the development of a highly branched spatial structure in RMDs. The indigestible components of the three types of RDs range from 34% to 37%, whereas RMDs vary from 80% to 85%, with potato resistant maltodextrin displaying the highest content (84.96%, p < 0.05). In conclusion, there are significant differences in the processing performances between different tuber crop starches. For the preparation of RMDs, potato starch seems to be superior to sweet potato and cassava starches. These attributes lay the foundation for considering RDs and RMDs as suitable components for liquid beverages, solid dietary fiber supplements, and low glycemic index (low-GI) products.