Vascular endothelial inflammation (VEI) contributes to the pathophysiology underlying heart failure. Angiopoietin-like 2 (Angptl2) is a secreted glycoprotein with homology to the angiopoietins and play a pivotal role in vascular inflammation particularly associated with metabolic disorders such as diabetes. We thus examined a link between VEI in HFREF without active coronary artery disease (CAD). Fourty five consecutive patients of HFREF (mean EF; 29.9±10.0%, mean BNP; 293.0±424.6 pg/ml) without CAD were retrospectively evaluated. VEI was monitored by 3 surrogate markers, Angptl2, sDPP4, and soluble ICAM (sICAM). Vascular atherosclerotic remodeling was assessed by mean IMT value and plaque score measured by carotid echography. Angptl2 was positively associated exclusively to sDPP4. Angptl2 and DPP4 was correlated with diastolic indices (R=0.43 for E/A (P<0.01) and R=0.44 for E/e (P<0.01), respectively), which was augmented by comorbid diabetes (R=0.64 for E/e (PP<0.01)). The sICAM exhibited no association with neither systolic and diastolic functional indices. Furthermore, we found sICAM exclusively correlated to IMT value not in sDPP4 and Angptl2. The present study supports the pivotal role of Angplt2 and DPP4 that presumably reflect microvascular inflammation contributing to progression of diastolic dysfunction. The sICAM, another vascular inflammatory marker, may reflect vascular inflammation occurred in large vessel such as carotid artery, which was found as an independent factor for cardiac dysfunction.