Background: Fractures of forearm bones are common in direct trauma often while protecting one’s head, road traffic accidents, fall from height and sports activities. Open reduction and internal fixation are the treatment of choice in these cases. Locking Compression Plate (LCP) is a new fixation device in treating these fractures. This study has been carried out to compare the role of Locking Compression Plate (LCP) with Dynamic Compression Plate (DCP) in treating these fractures. Methods: A prospective study was done from September 2017 to March 2019, including forty eight patients with fractures of radius and ulna. In Group I (DCP group), twenty four patients were subjected to open reduction and internal fixation with 3.5 mm stainless steel DCP and non-locking screws. In Group II (LCP group), 24 patients were managed by open reduction and internal fixation using 3.5mm stainless steel LCP and locking head/non-locking screws. All patients were followed up at monthly interval until union. Clinical assessment regarding functional outcome was done at the final follow-up.Results & Conclusion: The mean union time in Group I (DCP group) was 13.67 weeks (range, 8-24 weeks, SD3.67). In Group II (LCP group), the mean union time was 16.25 weeks (range, 12-24weeks, SD3.14). Excellent & satisfactory results were observed in 87.5% cases in Gp I and 91.67% cases in Gp II. On statistical analysis, there was no significant difference in the mean union time and functional outcome in Gp I and Gp II. Both internal fixation devices were equally effective in treating diaphyseal fractures of forearm.