This paper aims to explore the enhancement effect of spiral stirrup on concrete-filled cold-formed steel built-up box (CF-CFB) columns. Herein, four specimens were designed and fabricated to explore the impact of the spiral stirrup and riveted form on the axial compression performance of CF-CFB columns. Then, the finite element model of spiral stirrup-reinforced concrete-filled cold-formed steel built-up box (RCF-CFB) stub columns was established, and a systemic parametric investigation was conducted to explore the impact of geometric and material parameters on the compression performance of RCF-CFB stub columns. Afterwards, the analysis included an assessment of contact stress and stress distribution was conducted to uncover the confining effect. The analysis results revealed that the failure mode of the RCF-CFB column was tube buckling and concrete crush, accompanied by the spliced tube separating at the buckling area. The built-in reinforcement could significantly improve the performance of the built-up column, while riveted forms of spliced steel tubes had little effect. Furthermore, the axial bearing capacity of the RCF-CFB column would increase with the enhancement in steel yield strength, concrete strength, tube thickness, and longitudinal bar diameter. Finally, a calculating method to predict the axial bearing capacity of the RCF-CFB column was proposed, and the applicability of the method was demonstrated by comparison with experimental and FE data.