ABSTRACTArtificial intelligence (AI) technology has brought groundbreaking changes to the healthcare domain. Specifically, the integration of a medical dialogue system (MDS) has facilitated interactions with patients, identifying meaningful information such as symptoms and medications from their dialogue history to generate appropriate responses. However, shortcomings arise when MDS lacks access to the patient's cumulative history or prior domain knowledge, resulting in the generation of inaccurate responses. To address this challenge, we propose a medical domain‐incremental task‐oriented dialogue generator using experience replay (MeDi‐TODER) that applies the continual learning technique to the medical task‐oriented dialogue generator. By strategically sampling and storing exemplars from previous domains and rehearsing it as it learns, the model effectively retains knowledge and can respond to the novel domains. Extensive experiments demonstrated that MeDi‐TODER significantly outperforms other models that lack continual learning in both natural language generation and natural language understanding. Notably, our proposed method achieves the highest scores, surpassing the upper‐class benchmarks.