In a prospective study, plasma levels of T3, T4, thyroid stimulating hormone (TSH), cortisol, testosterone, growth hormone, and somatomedin-C were tested in 20 consecutive adolescent patients with slipped capital femoral epiphysis (SCFE) in an effort to identify any occult endocrinopathy. All patients had the clinical diagnosis of SCFE confirmed on radiographs. The patients were examined by the pediatric endocrinology service and were without clinical evidence of an endocrinopathy. Of 140 hormonal determinations only four different patients had four abnormal values. Routine sampling of these hormones in patients without clinical evidence of endocrinopathy is not indicated.