Diagnosis Of Odontogenic Tumor Research Articles

Molecular-Genetic Features In The Diagnosis Of Odontogenic Tumors

Benign odontogenic formations cause one and the same controversial situation known to pathologists for the last century. Some researchers believe that they are indeed benign. These formations are often asymptomatic, and the X-ray picture is not always reliable. There are currently no clear criteria for predicting the development of relapse. Based on modern molecular morphological techniques, it is important to identify the molecular mechanisms of recurrence, formation and growth of ameloblastoma and develop appropriate treatment methods. This review summarizes the background, current status, and future perspectives of odontogentic tumor in the multimodal treatment. The further trials to investigate the clinical benefits of diagnosis and treatment of odontogenic tumor were needed.

Cistos e tumores odontogênicos: estudo retrospectivo dos casos diagnosticados no período de 10 anos em um hospital no sul do Brasil

Introduction: odontogenic lesions (OLs) represent a heterogeneous group of oral and maxillofacial pathologies presenting distinct characteristics. The present study aimed to identify the clinical and pathological characteristics of OLs diagnosed in a southern Brazilian hospital. Materials and methods: a retrospective study was performed to evaluate cases with histopathological diagnosis of OLs identified in the period between 2007 and 2017. The patient's medical records were evaluated in order to obtain the clinical and pathological characteristics and the histopathological diagnosis from each case. Results: a total of 255 cases of OLs were identified. From these, 197 (77%) odontogenic cysts and 58 (23%) odontogenic tumors were surveyed, with only one case (0,39%) of a malignant odontogenic neoplasm. The most prevalent diagnosis were radicular cyst (32.5%) and dentigerous cyst (31.76%), followed by odontogenic keratocyst (10.98%), odontoma (10%) and ameloblastoma (10%). The majority of the cases affected the mandible (53.7%) with a slight preference by female individuals (51%). The mean age was 34±20.53 years old. Discussion: the presented data are in accordance with the literature regarding the rarity of the diagnosis of odontogenic tumors. Conclusion: the present study demonstrated the main clinical and pathological characteristics of OLs diagnosed in a southern Brazilian hospital, contributing to a better understanding of these injuries profiles.

New diagnostic molecular markers and biomarkers in odontogenic tumors

Odontogenic tumors comprised of complex heterogeneous lesions that diverse from harmatomas to malignant tumors with different behavior and histology. The etiology of odontogenic tumors is not exactly determined and pathologists deal with challenges in diagnosis of odontogenic tumors because they are rare and obtained experiences are difficult to evaluate. In this study, we describe immunohistochemical and molecular markers in diagnosis of odontogenic tumors besides advanced diagnostic technique. Immunohistochemical features of odontogenic tumors beside the clinical features and radiological finding can help us to determine the correct diagnosis. Although these markers are neither specific nor sensitive enough, but analysis of gene expression provides definitive confirmation of diagnosis. In addition, “-omics” technology detected specific molecular alternation associated with etiology such as genomics, epigenomics, transcriptomics, proteomics and metabolomics. The post transcriptional events such as DNA methylation and chromatin remodeling by histone modification affect the changes in epigenome. Furthermore, non-coding RNAs like micro-RNAs, long noncoding RNA (lncRNA) and small non-coding RNA (snoRNA) play regulatory role and impact odontogenesis. Molecular marker propose their potential role in etiopathogenesis of odontogenic tumors and suitable candidate in diagnostic, prognostic and therapeutic approaches in addition to patient management. For future evaluations, organoid represents in vitro tumor model-study for tumor behavior, metastasis and invasion, drug screening, immunotherapy, clinical trial, hallmarks association with prognosis and evolution of personalized anti-cancer therapy. Moreover, organoid biobank help us to check genetic profile. We think more investigation and studies are needed to gain these knowledges that can shift therapeutic approaches to target therapy.

A Prospective Study on Odontogenic Tumors Among Patients Attending Muhimbili National Hospital, Dar Es Salaam, Tanzania

Introduction: Odontogenic tumors which may be benign or malignant, constitute a group of heterogeneous lesions that are derived from the tooth-producing tissues or their remnants that are entrapped either within the jawbones or into the adjacent soft tissues. Aim of the study was to determine the pattern of occurrence and clinicopathological presentation of odontogenic tumors among patients attending the oral and maxillofacial unit at Muhimbili National Hospital (MNH), Dar es Salaam, Tanzania using 2005 WHO classification. Material and Methods: This was a cross-sectional hospital-based study that included patients with oral and maxillofacial tumors. Patients’ information was gathered using a structured questionnaire. Clinical and histological examination was done, and the findings were recorded in a specially designed form. Data was processed and analyzed using Statistical Package for Social Sciences (SPSS) version 19. Results: A total of 102 patients with histological diagnosis of odontogenic tumors comprising 52 (51%) males and 50 (49%) females, were included in this study. The mean age of the patients was 34.07 ± 14.8 SD years and the most affected age group was 20-29 years. Majority 76 (74.5%) of the patients had odontogenic tumors comprised of odontogenic epithelium with mature fibrous stroma without odontogenic ectomesenchyme. Ameloblastoma was the most (65.7%) common odontogenic tumor followed by odontogenic myxoma/myxofibroma (5.9%) and Keratocystic Odontogenic Tumor (5.9%). Conclusion: Generally, the sociodemographic distribution and frequency of occurrence, of odontogenic tumors seen in this study is similar to that reported in other African and Asian studies but differed with American and European studies. Ameloblastoma was the most common odontogenic tumor with a high propensity for the mandible compared to the maxilla.

Maxillary Ameloblastoma: A Review With Clinical, Histological and Prognostic Data of a Rare Tumor.

Diagnosis of odontogenic tumors can be challenging due to their rarity and diverse morphology, but when arising near the tooth, the diagnosis could be suspected. When their location is not typical, like inside the paranasal sinuses, the diagnosis is less easy. Maxillary ameloblastomas are exceedingly rare with only sparse information on their epidemiological, histological and genetic characteristics. The aim of this report is to thoroughly review the available literature in order to present the characteristics of this tumor. According to available data, maxillary ameloblastomas can occur in all ages but later than mandible ones, and everywhere within the maxillary region without necessarily having direct contact with the teeth. No sex preference has been shown. The most common histological patterns seen in this location are the follicular and plexiform ones. Maxillary ameloblastomas are locally aggressive neoplasms, thus therapy aims for excision including normal bone beyond the lesion. In contrast to mandible ameloblastomas, maxillary ones most commonly show mutations of the SMO gene. Furthermore, differential tumor diagnosis is thoroughly discussed in the present review.

Profiling of odontogenic tumors in western Uttar Pradesh population in India

Objective: This institutional study was sought to determine the relative frequency of odontogenic tumors (OTs) in a western Uttar Pradesh population and to compare these data with previous reports. Study Design: In this retrospective study, all the accessioned cases were retrieved from the histopathology records of Subharti Dental College and Hospital between January 2003 and December 2015. Lesions with histological diagnosis of OTs (based on the World Health Organization classification, 2005) were analyzed. Clinical data were reviewed, and microscopic diagnoses were confirmed for cases in which diagnoses were ambiguous. The relative incidence of each tumor type, patient age, gender, and site of occurrence are compared with similar reports from other selected large series. Results: From a total of 3182 oral biopsies accessioned during 13-year interval, 255 lesions were diagnosed histopathologically as OTs, which constituted 8.01% of all the oral biopsies. Of these cases, 98.43% of the tumors were benign. The most frequent histological type was keratinizing cystic OTs (41.96%), followed by ameloblastoma (34.50%) and while odontomas, generally regarded as the most frequent OT in many large series, only accounted for 7.45%, the third most common tumor in the present study. In general, the OTs showed a predilection for the mandible and the posterior regions of the jaws. Males outnumbered females for benign tumors while the reverse was true for malignant tumors. Conclusions: OTs show a definite geographic variation. In western Uttar Pradesh population in India, the most frequent OTs had a comparatively younger age predilection.

Multidisciplinary approach to improving concordance in diagnosis of odontogenic tumors

Background: The diagnosis of benign odontogenic tumors (BOTs) may occasionally be fraught with problems. Diagnosis of BOTs includes joint consideration of clinical features observed, appearance on radiographs and histopathologic slides. Aim: The aim of this study therefore is to ascertain the level of concordance between preoperative and postoperative histopathological diagnoses of surgically treated BOT and highlight modalities that improve it. Materials and Methods: A retrospective review of all cases with postoperative histopathological reports of BOT seen at the Dental and Maxillofacial Surgery Department of Aminu Kano Teaching Hospital, Kano, Nigeria, from January, 2012 to December, 2013 was done. Demographic information, clinical, radiological (plain radiographs), preoperative incisional biopsy and postoperative excisional biopsy results were collated. The preoperative incisional biopsy and postoperative excisional biopsy results were analyzed for concordance. Results: Thirty-three cases of BOT were reviewed (male:female = 1.4:1). Age ranged from 11 to 70 years (mean = 32 ± 18.1 years). An overall concordance of 78.8% was observed between preoperative and postoperative biopsy results. Twenty-eight histology request cards were reviewed and this showed that 14.3% of specimens were <1 cm while complete clinical information was provided in 50% of cases. Conclusion: The interaction between the pathologist and other relevant specialties that are required for effective management of BOT may be best nurtured when clinico-pathologic conferences are made a routine practice.

The diagnostic usefulness of immunohistochemistry for odontogenic lesions.

The diagnosis of odontogenic tumors can be challenging, largely due to their rarity and consequent difficulties in gaining experience in their assessment. In most cases, careful attention to morphology, in conjunction with clinical and radiological features will allow a diagnosis to be made. However, in some cases, immunohistochemical analysis of the tumor may be useful. In this review we will outline the immunohistochemical expression profile of normal developing odontogenic tissues and a range of odontogenic tumors. In many cases the immunohistochemical markers are neither specific nor sensitive enough to be of help in diagnosis, but in some cases such analysis may prove very useful. Thus we have outlined a limited number of circumstances where immunohistochemistry may be of use to the practicing diagnostic pathologist.

The relative frequency of odontogenic tumors in the Black Sea region of Turkey: an analysis of 86 cases

To determine the relative frequency and distribution of different types of odontogenic tumors in southeastern Europe, focusing on the Black Sea region of Turkey. Materials and methods: In total 1165 oromaxillofacial biopsy records were evaluated for histologic diagnosis of odontogenic tumors over a 7-year period from patients referred to the Department of Oral and Maxillofacial Surgery and Department of Pathology, Karadeniz Technical University, Faculty of Dentistry and Medicine, Trabzon, Turkey. Results: A total of 86 odontogenic tumors were reported. Malignant transformation only occurred in 6 cases (6.8%), while the others were benign (93.2%). Odontoma was the most common odontogenic tumor (41.8%), followed by keratocystic odontogenic tumor (17.4%), ameloblastoma (12.7%), and odontogenic myxoma (9.3%). Conclusion: The relative frequencies of odontogenic tumors exhibited variability between geographic regions. In the Black Sea region of Turkey, odontoma and keratocystic odontogenic tumors are the most common benign odontogenic tumors with distinct anatomic predilections.

Fine-needle aspiration biopsy of ameloblastic carcinoma of the mandible: a case report

The use of fine-needle aspiration biopsy (FNAB) in the diagnosis of odontogenic tumors seems to have attracted little attention. The presence of a firm preoperative diagnosis helps preventing suboptimal surgery, contributing to avoid recurrence of these tumors. A case of ameloblastic carcinoma of the mandible diagnosed by FNAB is presented in this report, illustrating its effectiveness for preoperative diagnosis of odontogenic tumors. A 74-year-old female presented with a painless swelling in the right mandibular angle. A panoramic radiograph revealed a radiolucent lesion in the body of the mandible. Cytological smears from FNAB in the area revealed basaloid cells with a palisade arrangement and presence of stellate-shaped cells. These cytological features lead to the diagnosis of ameloblastoma. However, when there are atypical cells and atypical mitoses, as in the present case, diagnosis of ameloblastic carcinoma may be established. The patient underwent chemotherapy, showing remission of the lesion after treatment. FNAB is a minimally invasive, safe, fast and inexpensive method for diagnosing benign and malignant ameloblastomas, which ensures that patients have a proper treatment without the need of performing an incisional biopsy, especially in neoplastic cases.

Odontogenic tumors in Nigerian children and adolescents- a retrospective study of 92 cases

BackgroundTumours arising from odontogenic tissues are rare and constitute a heterogenous group of interesting lesions. The aim of this study was to determine the relative frequency of odontogenic tumors (OT) among Nigerian children and adolescents 19 years or younger.Patients and methodsThe histopathology records were retrospectively reviewed for all the tumors and tumor-like lesions of the oral cavity and the jaws seen in children and adolescents ≤ 19 years seen between January 1980 and December 2003. Hematoxylin and eosin-stained sections were re-evaluated and the diagnosis in each case was confirmed or modified according to World Health Organization (WHO) classification, 1992; and were subjected to analysis of age, sex, site of tumor and histopathologic type.ResultsA total of 477 tumors and tumor-like lesions were seen in patients ≤ 19 years during the period of the study. Of these, 92 (19.3%) were odontogenic tumors. Benign odontogenic tumors constituted 98.9% of the cases seen, while only 1 case (1.1%) of malignant variety was seen during the period. The mean (SD) age of patients was 14.9 (± 3.1) years (range, 4–19 years). Male-to-female ratio was 1:1; and mandible-to-maxilla ratio was 2.7:1. OT's were most frequently seen in patients aged 16–19 years (46.7%) and the least number (2.2%) were found in patients aged 0–5 years. Among nine histologic types of OT seen, ameloblastoma (48.9%), adenomatoid odontogenic tumor (19.6%) and odontogenic myxoma (8.7%) were predominant. Multicystic/solid and unicystic variants of ameloblastoma were diagnosed in 40 (89%) and 5 (11%) cases respectively.ConclusionsOdontogenic tumors are relatively common in children and adolescents in Nigeria. One out of every 5 children and adolescents with tumors and tumor-like lesions of oral cavity and the jaws seen in this study had a diagnosis of odontogenic tumor.