Diagnosis Of Noise-induced Hearing Loss Research Articles

PENGARUH PAPARAN KEBISINGAN WEAVING MACHINE TERHADAP RESIKO TERJADINYA HEARING IMPAREMENT PADA KARYAWAN PT. KECUBUNG MOJOGEDANG

Noise-induced hearing loss is a sensorineural type of hearing loss caused by exposure to loud enough noise over a long period of time. Hearing loss due to noise has an impact on life. The diagnosis of noise-induced hearing loss was obtained from a hearing examination, pure tone audiometry and audiometric examination results. The impact of noise-induced hearing loss is in several aspects, namely functional, social and emotional aspects, as well as economic aspects. This study aims to determine the effect of the duration of exposure to weaving machine noise on the risk of hearing imparement on employees of PT. Kecubung Mojogedang. This research is a quantitative research using a cross sectional design. The sampling technique is Total Sampling. The sample used was 40 people. The data collected will be analyzed by univariate and bivariate, the data analysis technique in this study uses the contingency coefficient test. The results of the bivariate analysis using the Contingency C coefficient test obtained a value of 0.367 with a significance (p) of 0.013. The significance value (p) is smaller than = 0.05, meaning that Ho is rejected and Ha is accepted, which means that there is an effect of the duration of noise exposure with the risk of hearing loss in employees who work at PT. Kecubung Mojogedang

Occupational Noise Induced Hearing Loss in Motor Boat Fisherman

Introduction: Noise Induced Hearing Loss is a person's hearing loss either partially or completely which is permanent and can affect one or both ears caused by continuous exposure to noise in the work environment. One of the causes of Noise Induced Hearing Loss (NIHL) is working as a motorboat fisherman.
 Content: NIHL can arise as a result of the interaction between genetic factors and environmental factors with the role of internal and external risk factors. The diagnosis of NIHL can be established through history taking, physical examination such as otoscopy and tuning fork tests, as well as supporting examinations in the form of pure tone audiometry.
 Conclusion: NIHL will produce the impression of sensorineural deafness with a permanent nature so that the only treatment that can be given is supportive and preventive management.
 Keywords: Noisy; noise-induced hearing loss; motorboat fisherman

Predictive value of serum proteomic biomarkers for noise-induced hearing loss.

Early detection of noise-induced hearing loss (NIHL) in patients with long-term noise exposure is vital for improving public health and reducing social burden. However, at present, the diagnosis of NIHL mainly depends on audiometric testing, and the primary test is pure-tone audiometry. Moreover, testing requires professional operators and complex equipment; thus, NIHL is often diagnosed at a later disease stage. Using a liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomic approach, we identified 9 differentially expressed proteins (DEPs), namely, 6 upregulated serum proteins and 3 downregulated serum proteins, in samples from 50 ground crew personnel working at an air force station. Then, according to the results, we predicted that caldesmon (CALD1), myocilin (MYOC), zyxin (ZYX), creatine kinase M-type (CKM), insulin-like growth factor-binding protein 2 (IGFBP2), complement factor H-related protein 4 (CFHR4), prenylcysteine oxidase 1 (PCYOX1), heat shock cognate 71 kDa protein (HSPA8), and immunoglobulin lambda variable 3-21 (IGLV3-21) were associated with NIHL. We selected these DEPs as variables to perform logistic regression. Finally, a logistic regression model was constructed based on IGFBP2, ZYX, CKM, and CFHR4. The area under the curve was 0.894 (95% CI = 0.812 to 0.977). These findings suggested that IGFBP2, ZYX, CKM, and CFHR4 in serum are differentially expressed in NIHL patients and have the potential to be biomarkers for predicting the risk for NIHL. Further experiments in mice showed that ZYX and IGFBP2 in the cochlear were increased after noise exposure. ZYX and IGFBP2 may be involved in the occurrence and development of NIHL.

Diagnosing Noise-Induced Hearing Loss Sustained During Military Service Using Deep Neural Networks.

The diagnosis of noise-induced hearing loss (NIHL) is based on three requirements: a history of exposure to noise with the potential to cause hearing loss; the absence of known causes of hearing loss other than noise exposure; and the presence of certain features in the audiogram. All current methods for diagnosing NIHL have involved examination of the typical features of the audiograms of noise-exposed individuals and the formulation of quantitative rules for the identification of those features. This article describes an alternative approach based on the use of multilayer perceptrons (MLPs). The approach was applied to databases containing the ages and audiograms of individuals claiming compensation for NIHL sustained during military service (M-NIHL), who were assumed mostly to have M-NIHL, and control databases with no known exposure to intense sounds. The MLPs were trained so as to classify individuals as belonging to the exposed or control group based on their audiograms and ages, thereby automatically identifying the features of the audiogram that provide optimal classification. Two databases (noise exposed and nonexposed) were used for training and validation of the MLPs and two independent databases were used for evaluation and further analyses. The best-performing MLP was one trained to identify whether or not an individual had M-NIHL based on age and the audiogram for both ears. This achieved a sensitivity of 0.986 and a specificity of 0.902, giving an overall accuracy markedly higher than for previous methods.

Metabolomics Analysis Reveals Alterations in Cochlear Metabolic Profiling in Mice with Noise-Induced Hearing Loss.

Noise-induced hearing loss (NIHL) has always been an important occupational hazard, but the exact etiopathogenesis underlying NIHL remains unclear. Herein, we aimed to find metabolic biomarkers involved in the development of NIHL based on a mouse model using a gas chromatography coupled with mass spectrometry (GC-MS) metabolomics technique. We showed that the auditory brainstem response (ABR) thresholds at the frequencies of 4, 8, 12, 16, 24, and 32 kHz were all significantly elevated in the noise-exposed mice. Noise could cause outer hair cell (OHC) loss in the base of the cochlea. A total of 17 differential metabolites and 9 metabolic pathways were significantly affected following noise exposure. Spermidine acting as an autophagy modulator was found to be 2.85-fold higher in the noise-exposed group than in the control group and involved in β-alanine metabolism and arginine and proline metabolism pathways. Additionally, we demonstrated that LC3B and Beclin1 were expressed in the spiral ganglion neurons (SGNs), and their mRNA levels were increased after noise. We showed that SOD activity was significantly decreased in the cochlea of noise-exposed mice. Further experiments suggested that SOD1 and SOD2 proteins in the SGNs were all decreased following noise exposure. The upregulation of spermidine may induce LC3B- and Beclin1-mediated autophagy in the cochlear hair cells (HCs) through β-alanine metabolism and arginine and proline metabolism and be involved in the NIHL. ROS-mediated oxidative damage may be a pivotal molecular mechanism of NIHL. Taken together, spermidine can be regarded as an important metabolic marker for the diagnosis of NIHL.

The Significance of Audiometric Notching in Individuals With a History of Noise Exposure: A Systematic Review.

The diagnosis of noise-induced hearing loss (NIHL) is reliant on the appraisal of audiometric data. A notch, dip or bulge, centered at the 4-kHz frequency is considered to be pathognomonic. However, guidelines applied to assist the diagnosis of NIHL often allow for a notch centered between the 3- and 6-kHz frequencies. The primary outcome of this review is to document the relationship between audiometric notching at particular frequencies and the populations in which they have been identified. We included all population-based studies, cohort, cross-sectional, case-control, case-series, and case reports of adults and children, with exposure to noise and with a notch, dip or bulge. The review has been registered with Prospero (Registration: CRD42017079901) and prepared in line with the PRISMA guidelines. We included 84 articles in the final systematic review. There were a total of 1,438,987 individuals, aged 7 to 80 years old. The studies were conducted in 26 different countries. Fourteen studies identified notching at 3 kHz, 63 studies identified notching at 4 kHz, and 47 studies identified notching at 6 kHz. The Newcastle-Ottawa risk assessment tool was performed on 82 of the studies emphasizing the high risk of bias in observational studies. The overwhelming outcome of this systematic review demonstrates that the relationship between noise exposure and a 3- to 6-kHz audiometric notch is not straight-forward. A handful of articles have displayed a clear association between an individual's noise exposure and an audiometric notch. Unilateral notches, notches observed at 3 kHz and notches in the absence of continued high-intensity noise exposure must be scrutinized thoroughly. The ambiguous nature of NIHL directs its continued interest.

Trajetória de trabalhadores com perda auditiva induzida por ruído na rede de assistência à saúde do sul do país

Este artigo tem como objetivo analisar a percepção de trabalhadores com perda auditiva induzida ao ruído (PAIR) com relação às suas condições de trabalho e sua trajetória pela rede de atenção a saúde. Trata-se de um estudo exploratório com abordagem qualitativa, a partir das notificações por PAIR realizada pela principal referência auditiva em atenção secundária no período de 2016 a 2018. Os resultados mostram as percepções dos trabalhadores com PAIR e seus efeitos a exposição ao ruído, os riscos químicos e ergonômicos, as condições penosas de trabalho, uso de equipamentos de proteção, a satisfação com o trabalho, a procura pelos serviços de saúde. O atendimento na rede de serviço de saúde vai permitir a identificação do provável problema auditivo, a percepção sobre o acolhimento recebido pela unidade básica de saúde e os desdobramentos do caso. Conclui-se que a unidade básica de saúde precisa de ajustes a fim de aprimorar sua função na rede, no que tange ao retorno e acompanhamento do usuário trabalhador após o diagnóstico de PAIR, bem como revisão do monitoramento e avaliação nas linhas-guia (fluxo e contrafluxo) e reajustar o processo de gestão da saúde do trabalhador.

High-Resolution Computed Tomography of the Inner Ear: Effect of Otosclerosis on Cochlear Aqueduct Dimensions.

The cochlear aqueduct is a bony duct connecting the scala tympani with the subarachnoid space. Given the pathophysiology of otosclerosis, including bone resorption and new bone deposition, we hypothesize that the cochlear aqueduct in otosclerotic ears is narrowed. A retrospective review of patients with otosclerosis who have undergone high-resolution computed tomography (HRCT) of the temporal bone was completed. The control cohort included 20 patients with the diagnosis of noise-induced hearing loss, without the diagnosis of otosclerosis. Uniform measurements of cochlear aqueduct dimensions were performed using the axial plane. The otosclerosis cohort included 25 males and 52 females with mean age of 52.2 ± 17.6 years. The control group included 10 males and 10 females with mean age of 64.0 ± 18.5 years. The mean cochlear aqueduct length, width mid canal, aperture base, aperture widest diameter, and funnel diameter in millimeters were 12.19 ± 1.66, 0.68 ± 0.28, 4.21 ± 1.67, 3.23 ± 1.47, and 2.70 ± 1.05 in the ears with otosclerotic foci and 11.57 ± 1.66, 0.69 ± 0.29, 2.56 ± 1.59, 2.77 ± 1.67, and 2.58 ± 1.03 in control group, respectively. Statistical difference was seen in length of cochlear aqueduct, aperture base, and aperture widest diameters (P = .017, <.001, .007). The length of the cochlear aqueduct and the funnel width are statistically longer in the otosclerotic population compared to control. The width of the cochlear aqueduct is not statistically different.

Экспертная значимость профиля аудиометрической кривой при диагностике потери слуха, вызванной шумом

Экспертная значимость профиля аудиометрической кривой при диагностике потери слуха, вызванной шумом

Occupational noise exposure, hearing loss, and notched audiograms in the HUNT Nord-Trøndelag hearing loss study, 1996-1998.

Objectives/HypothesisTo study the prevalence and usefulness of audiometric notches in the diagnosis of noise‐induced hearing loss (NIHL).Study DesignAudiograms and data on noise exposure from 23,297 men and 26,477 women, aged 20 to 101 years, from the Nord‐Trøndelag Hearing Loss Study, 1996–1998.MethodsThe prevalence of four types of audiometric notches (Coles, Hoffman, Wilson) and 4 kHz notch were computed in relation to occupational noise exposure, age, sex, and report of recurrent ear infections.ResultsThe prevalence of notches in the 3 to 6 kHz range (Wilson, Hoffman, and Coles) ranged from 50% to 60% in subjects without occupational noise exposure, and 60% to 70% in the most occupationally noise‐exposed men. The differences were statistically significant only for bilateral notches. For 4 kHz notches, the prevalence varied from 25% in occupationally nonexposed to 35% in the most occupationally exposed men, and the differences were statistically significant for both bilateral and unilateral notches. For women, the prevalence of notches was lower than in men, especially for 4 kHz notches, and the differences between occupationally noise exposed and nonexposed were smaller. Recreational exposure to high music was not associated with notched audiograms.ConclusionsThe detection of bilateral notches and unilateral 4 kHz notches is of some value in diagnosing NIHL, especially in men.Level of Evidence4 Laryngoscope, 127:1442–1450, 2017

Guidelines for quantification of noise-induced hearing loss in a medicolegal context.

Guidelines published in 2000 by the authors are widely used by medical and legal professionals in the UK for diagnosis of noise-induced hearing loss in a medicolegal context. However, they cannot be used for quantification of the noise-induced hearing loss, which is required in most cases. This requirement is addressed. A method is developed here to quantify noise-induced hearing loss, thereby overcoming this shortcoming. Assessment of noise-induced hearing loss in medicolegal cases. A consecutive series of 124 cases of noise-induced hearing loss is used for evaluation. Magnitude of noise-induced hearing loss based on hearing threshold levels averaged over the frequencies 1, 2 and 3 kHz. The rationale of the method, practical application and three worked examples are developed. A simpler short-cut method is developed and shown to be equivalent to the full method in most cases. The method offers a practical approach to quantification of noise-induced hearing loss.

High-frequency audiometry: A means for early diagnosis of noise-induced hearing loss

Noise-induced hearing loss (NIHL), an irreversible disorder, is a common problem in industrial settings. Early diagnosis of NIHL can help prevent the progression of hearing loss, especially in speech frequencies. For early diagnosis of NIHL, audiometry is performed routinely in conventional frequencies. We designed this study to compare the effect of noise on high-frequency audiometry (HFA) and conventional audiometry. In a historical cohort study, we compared hearing threshold and prevalence of hearing loss in conventional and high frequencies of audiometry among textile workers divided into two groups: With and without exposure to noise more than 85 dB. The highest hearing threshold was observed at 4000 Hz, 6000 Hz and 16000 Hz in conventional right ear audiometry, conventional left ear audiometry and HFA in each ear, respectively. The hearing threshold was significantly higher at 16000 Hz compared to 4000. Hearing loss was more common in HFA than conventional audiometry. HFA is more sensitive to detect NIHL than conventional audiometry. It can be useful for early diagnosis of hearing sensitivity to noise, and thus preventing hearing loss in lower frequencies especially speech frequencies.

Guidelines on the diagnosis of noise-induced hearing loss for medicolegal purposes.

These guidelines aim to assist in the diagnosis of noise-induced hearing loss (NIHL) in medicolegal settings. The task is to distinguish between possibility and probability, the legal criterion being 'more probable than not'. It is argued that the amount of NIHL needed to qualify for that diagnosis is that which is reliably measurable and identifiable on the audiogram. The three main requirements for the diagnosis of NIHL are defined: R1, high-frequency hearing impairment; R2, potentially hazardous amount of noise exposure; R3, identifiable high-frequency audiometric notch or bulge. Four modifying factors also need consideration: MF1, the clinical picture; MF2, compatibility with age and noise exposure; MF3, Robinson's criteria for other causation; MF4, complications such as asymmetry, mixed disorder and conductive hearing impairment.

Noise; is it a health problem?

The permanent hearing loss produced by extended exposure to certain occupational noises constitutes a serious health problem. The solution to this problem lies in active programs of hearing conservation. Hearing conservation is primarily a medical responsibility. The importance of the physician's recognition of his role in meeting the threat to health cannot be overemphasized. The physician must acquaint himself with the current knowledge of the relations of hearing loss to noise exposure. Misconceptions about the hazardous effects of noise are widespread. Auditory effects of noise exposure and nonauditory effects are frequently related without justification. For example, the fact that a noise produces annoyance does not, contrary to popular belief, mean that exposure to that noise will necessarily produce a hearing loss. The annoyance caused by noise is a highly individual phenomenon and, as such, is not easily measured or predicted. The fact that a noise produces annoyance does not mean that it is bad for health. The total amount of hearing loss produced by noise exposure depends on more variables than was thought originally. Before the diagnosis of noise-induced hearing loss can be made the physician must have adequate information about (1) the over-all sound pressure level of the noise, (2) the way the energy in the noise is distributed among the various frequencies present, (3) the typical pattern of daily exposure to the noise, and (4) the years of expected work life in the noise. Answers given by the patient cannot be assumed to be reliable, and the physician must make the necessary effort to obtain the pertinent information from reliable sources.