Diagnosis Of Nasal Allergy Research Articles

Diagnosis of Nasal Allergy

Diagnosis of Nasal Allergy

Mast cells, eosinophils and goblet cells in nasal allergy

This work was taken up to assess the mast cell population in nasal allergy both in nasal smear and nasal tissue in correlation with the eosinophils and goblet cells. An attempt had been made to find out the significance of these cells in arriving at a diagnosis of nasal allergy.

Basic study of nasal provocative test. Second report: assessment method on provocative reaction.

Because no simple and precise method is available to test intensity of the reaction resulted from a nasal provocative test in diagnosis of nasal allergy, comparisons were made among the conventional test methods of rhinoscopy (RS), rhinomanometry (RM) and the carbon powder elimination test (CET) devised by the authors. The rhinoscopy shows high positive rates and has advantages being free from any special equipment, prolonged time or the patients' cooperation, but also had disadvantages such as requirement of skill of examiner and problems in objectivity. The carbon powder elimination test is a preferable method in that it is not only equipped with the advantages of the rhinoscopy but also makes up for its disadvantages, but a disadvantage of CET is requirement of longer time than RS. Rhinomanometry had lower positive rates and requires a special equipment, prolonged time and the skillful patients' cooperation. The disadvantage is that its impracticableness in many patients--26% impracticableness even in adult patients, but the method is fully objective. From these findings the value of Carbon Powder Elimination Test in judging provoked reactions is recognized.

Modern trends in diagnosis and treatment of nasal allergy.

Modern trends in diagnosis and treatment of nasal allergy.

Round Table Discussion

Specific Diagnostic Practice Chairman Collins-Williams: The specific diagnosis of the child with respiratory allergy comprises the following: (1) general pediatric care; (2) careful allergic history; (3) complete physical examination; (4) indicated laboratory procedures including nasal smears; (5) skin testing. Skin testing is necessary in order to help determine the specific etiologic allergens. The allergens tested with should include the common foods and the common inhalants, pollens and molds in the environment. Eosinophiles and Eosinophilia Eosinophilia occurs in a great many conditions other than allergy and these must be taken into account in interpreting differential blood counts. The nasal smear is a useful laboratory test in the diagnosis of nasal allergy. Eosinophiles may temporarily appear in considerable numbers in the nasal smear of the nonallergic child during recovery from a respiratory infection, but otherwise a predominance of eosinophiles in the nasal smear is diagnostic of nasal allergy. Office Treatment of Respiratory Allergy The office treatment of a child with respiratory allergy includes the following: (1) general pediatric care; (2) symptomatic relief of allergic symptoms; (3) removal of incriminated foods from the diet; (4) as complete an elimination of environmental allergens as possible; (5) specific desensitization. Specific Desensitization Dr. Ratner: The method of specific desensitization which we use in practice is as follows: The treatment extract consists of a 1:5,000 dilution of each of the inhalants, pollens and molds with which the patient gave a positive reaction. Each week the patient receives one injection from a tuberculin syringe containing 0.15 cc. of this treatment extract, 0.15 cc. of a 1:20 dilution of mixed bacterial vaccine, 0.15 cc. of a 1:20 dilution of pertussis vaccine, and 2 minims of adrenaline.

The diagnosis of nasal allergy and its relation to other manifestations: Hansel, French K.: South. M. J. 31: 1003, 1938

The diagnosis of nasal allergy and its relation to other manifestations: Hansel, French K.: South. M. J. 31: 1003, 1938

INCIDENCE OF ALLERGY IN RHINOLOGIC PRACTICE

It has seemed to me that the frequency with which allergic manifestations appear in rhinologic practice is not recognized, and that the diagnosis of nasal allergy is largely neglected by rhinologists. The prevalence of sinus disease, as such, has been sharply emphasized in rhinologic literature during recent years, but it is startling to see the number of papers on diagnosis and surgical intervention in sinus disease from which even the barest mention of allergy is omitted. One is forced to conclude that allergic changes in the membranes of the nose and sinuses are rarely seen in the practice of many writers, and I have been surprised to note that many papers on sinus disease as a cause of asthma and other bronchial involvements have failed to suggest that some of the changes seen in the mucous membranes might be allergic. In making these observations I do not wish to ignore

NASAL SECRETIONS: THE VALUE OF CYTOLOGIC EXAMINATION TO THE RHINOLOGIST

Attention has been drawn in recent years to the value of the cytologic examination of nasal secretions in the diagnosis of diseases of the nose and accessory sinuses. Sewall 1 stressed the presence of polymorphonuclear leukocytes in chronic sinusitis; Hansel, 2 Kahn and Stout, 3 Johnson and Goldstein 4 and others noted the importance of eosinophils in the diagnosis of nasal allergy. We wish to present the results of a hundred routine examinations of nasal smears taken from patients with acute and chronic rhinitis and sinusitis, and to emphasize the value of cytologic examination to the rhinologist. Results of Investigation in a Hundred Cases Number of Cases Showing Given Percentage of Eosinophils in Nasal Smear Condition 0 1-5% 5-10% 10-100% Total Acute infections of upper respiratory tract........ 11 0 0 0 11 Vasomotor rhinotis* (with and without superadded infection) 2† 0 9 58 69 Chronic suppurative sinusitis 18 2 0 0 20