Diabetic Mononeuropathy Research Articles

Sensory nerve conduction in the upper limbs at various stages of diabetic neuropathy.

In 59 diabetic patients, sensory nerve potentials were recorded at various sites along the course of the median nerve. Pathological responses were characterized by reduced amplitude, desynchronization and decreased conduction velocity (CV). Four groups of patients with increasingly severe nerve dysfunction were distinguished. The presence and severity of clinical neuropathy in the upper limbs could be related to decreased maximal sensory nerve CV in the proximal segment of the limbs. When maximal sensory nerve CV was normal above the wrist, neuropathy usually remained latent. In severe cases where no sensory nerve potentials could be recorded, the cerebral evoked potentials nonetheless permitted a precise evaluation of the somatosensory conduction. In these cases, maximal sensory nerve CV was very low. In five patients with a so-called diabetic mononeuropathy, abnormal nerve potentials were recorded in the median nerve, although no clinical signs could be seen in the corresponding territory. It is proposed that the diabetic nature of a mononeuropathy can be assessed by the finding of latent abnormalities in seemingly normal nerve.

Ischemic mononeuropathy multiplex associated with diabetes mellitus.

MONONEUROPATHY multiplex is a syndrome characterized by simultaneous or successive dysfunction of several peripheral nerve trunks remote from one another. It thus differs from polyneuropathy which implies a more diffuse and symmetrical disorder. The causes of mononeuropathy multiplex include polyarteritis nodosa, disseminated lupus erythematosis, sarcoidosis, amyloidosis, hemophilia, leprosy, trauma, and involvement of nerve by tumor. It also occurs in patients with diabetes mellitus, and when no other cause is found, it is attributed to the diabetes and is classified among the diabetic neuropathies. However, its relationship to the other forms of diabetic neuropathy is unclear, and as is the case for all of them, the pathology and the pathogenesis are unsettled. Diabetic mononeuropathy multiplex tends to affect elderly patients with mild, or undiscovered, diabetes. It has an acute or subacute onset with a tendency to recover over a period of months, and usually causes a painful, asymmetrical, often proximal